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Оказывает фибринолитическое противовоспалительное (за счет присутствия экстракта Серае), антитромбическое (за счет присутствия гепарина) и кератолитическое (за счет присутствия аллантоина) действие. Стимулирует клеточную регенерацию без гиперплазии. Ингибирует пролиферацию келлоидных фибробластов."}},{"type":"paragraph","data":{"text":"Фармакокинетика:"}},{"type":"paragraph","data":{"text":"В эксперименте было показано, что гепарин в течение 4 ч в клинически достаточном количестве проникает в соединительную ткань дермы. Глубокое проникновение обеспечивается комбинацией гепарина с экстрактом луковиц Серае и аллантоином (трансэпидермальная гепаринизация)."}},{"type":"paragraph","data":{"text":"При использовании препарата Контрактубекс системная абсорбция не наблюдается."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"list","data":{"style":"ordered","items":["Гипертрофические и келоидные рубцы, возникающие после хирургических операций, ампутаций, ожогов и травм","Анкилозы (контрактуры) суставов","Контрактура Дюпюитрена","Травматические сухожильные контрактуры","Растяжки после беременности","Атрофические рубцы (в частности, возникающие после acne или фурункулеза)","Профилактика образования патологических рубцов в послеоперационном периоде или после несчастного случая Возможно применение у детей."]}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность к компонентам препарата, беременность, период грудного вскармливания, детский возраст до 1 года."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"\n\nНаружно."}},{"type":"paragraph","data":{"text":"Расход препарата в одно применение в среднем 0,5 см геля на рубцовую поверхность площадью 20-25 см². 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Чаще всего отмечались кожные реакции в месте нанесения."}},{"type":"paragraph","data":{"text":"Классификация частоты возникновения побочных реакций: очень часто (≥1/10). часто (≥1/100 до Со стороны кожных покровов: часто: зуд, эритема, телеангиэктазия, атрофия рубца; нечасто: гиперпигментация кожи, атрофия кожи."}},{"type":"paragraph","data":{"text":"Также сообщалось о следующих спонтанных побочных реакциях:"}},{"type":"paragraph","data":{"text":"Инфекционные заболевания: частота не установлена: пустулезные высыпания."}},{"type":"paragraph","data":{"text":"Со стороны иммунной системы: частота не установлена: гиперчувствительность (аллергические реакции)."}},{"type":"paragraph","data":{"text":"Со стороны нервной системы: частота не установлена: парестезия."}},{"type":"paragraph","data":{"text":"Со стороны кожных покровов: частота не установлена: крапивница, сыпь, зуд, эритема, раздражение кожи, папулы, чувство жжения, чувство натяжения, контактный дерматит."}},{"type":"paragraph","data":{"text":"Общие расстройства и нарушения в месте нанесения: частота не установлена: отек, боль и шелушение в месте нанесения. Зуд, который является проявлением естественных процессов при формировании рубца, обычно не требует прекращения применения препарата."}},{"type":"paragraph","data":{"text":"Если любые из указанных в инструкции побочных эффектов усугубляются, или отмечаются любые другие побочные эффекты не указанные в инструкции, следует немедленно сообщить об этом врачу.\n\n"}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Не описано."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Не описано."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nДля усиления действия препарата наносить на предварительно распаренную кожу. Возможно его применение в сочетании с физиотерапевтическими мероприятиями. При лечении свежих рубцов следует избегать ультрафиолетового облучения, воздействия холода и интенсивного массажа."}},{"type":"paragraph","data":{"text":"Действие препарата во время беременности, в период грудного вскармливания и у детей до 1 года не изучалось.\n\n"}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Не влияет."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Гель для наружного применения по 20 или 50 г в тубу алюминиевую. Тубу вместе с инструкцией по применению помещают в картонную пачку."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"При температуре не выше 25°С в сухом месте. Хранить в местах, недоступных для детей."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"\n\n3 года."}},{"type":"paragraph","data":{"text":"6 месяцев с момента вскрытия тубы. Не применять по истечении срока годности.\n\n"}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"«Мерц Фарма ГмбХ и Ко. КГаА» D-60318, Германия, Франкфурт-на-Майне"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ООО «Мерц Фарма»"}}]}],"source":null},"description_toggle":false,"short_description":"Фармакодинамика: Комбинированный препарат, действие которого обусловлено свойствами входящих в его состав компонентов. 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