Тошнота и рвота различного генеза (в т.ч. на фоне функциональных и органических заболеваний, инфекции, при токсемии, лучевой терапии, нарушениях диеты, лекарственного генеза - прием морфина, апоморфина, леводопы и бромокриптина; при проведении эндоскопических и рентгеноконтрастных исследований ЖКТ)
Икота
Атония ЖКТ (в т.ч. послеоперационная)
Необходимость ускорения перистальтики при проведении рентгеноконтрастных исследований ЖКТ
Противорвотный препарат, антагонист допаминовых рецепторов центрального действия. В отличие от метоклопрамида, домперидон плохо проникает через ГЭБ. Блокирует в большей степени периферические и в меньшей степени центральные (в триггерной зоне рвотного центра) допаминовые рецепторы. Устраняет ингибирующее влияние допамина на моторную функцию ЖКТ и повышает эвакуаторную и двигательную активность желудка.; Оказывает противорвотное действие, успокаивает икоту и устраняет тошноту. Не оказывает действия на желудочную секрецию.; Повышает концентрацию пролактина в сыворотке крови.
Показания к применению
Тошнота и рвота различного генеза (в т.ч. на фоне функциональных и органических заболеваний, инфекции, при токсемии, лучевой терапии, нарушениях диеты, лекарственного генеза - прием морфина, апоморфина, леводопы и бромокриптина; при проведении эндоскопических и рентгеноконтрастных исследований ЖКТ)
Икота
Атония ЖКТ (в т.ч. послеоперационная)
Необходимость ускорения перистальтики при проведении рентгеноконтрастных исследований ЖКТ
Диспептические симптомы на фоне замедленного опорожнения желудка, гастроэзофагеального рефлюкса и эзофагита: чувство переполнения в эпигастрии, ощущение вздутия живота, метеоризм, гастралгия, изжога, отрыжка с забросом или без заброса желудочного содержимого в полость рта
Противопоказания
Кровотечения из ЖКТ
Механическая кишечная непроходимость
Перфорация желудка или кишечника
Пролактинома
Период лактации
Детский возраст до 5 лет
Дети с массой тела до 20 кг
Повышенная чувствительность к компонентам препарата
С осторожностью следует применять препарата при выраженной почечной и/или печеночной недостаточности.
Применение при беременности и в период грудного вскармливания
Данных о применении домперидона при беременности недостаточно. К настоящему времени не имеется данных о повышении риска пороков развития у человека. Однако назначать домперидон при беременности следует только в случае, когда ожидаемая терапевтическая польза для матери превышает потенциальный риск для плода.; У женщин концентрация домперидона в грудном молоке составляет от 10% до 50% от соответствующей концентрации в плазме и не превышает 10 нг/мл. Общее количество домперидона, выделяющегося с грудным молоком составляет менее 7 мкг/сут при применении домперидона в максимально допустимых дозах. Неизвестно, оказывает ли домперидон в этой концентрации отрицательное воздействие на грудных детей. В связи с этим при применении домперидона в период лактации следует прекратить грудное вскармливание.
Способ применения и дозы
Препарат принимают внутрь за 15-20 мин до еды.; Взрослым и детям старше 5 лет при хронических диспептических симптомах - по 10 мг 3-4 раза/сут, в т.ч. и перед сном в случае необходимости.; При выраженной тошноте и рвоте - по 20 мг 3-4 раза/сут, последний прием - перед сном.; Максимальная суточная доза - 80 мг.; Для пациентов с почечной недостаточностью необходима коррекция дозы, кратность приема не должна превышать 1-2 раза/сут.
Побочное действие
Со стороны пищеварительной системы: желудочно-кишечные расстройства (преходящие спазмы кишечника).; Со стороны нервной системы: экстрапирамидные расстройства (у детей у лиц с повышенной проницаемостью ГЭБ, у взрослых - единичные случаи). Эти явления полностью обратимы и исчезают после прекращения приема препарата.; Аллергические реакции: кожная сыпь, крапивница.; Прочие: гиперпролактинемия (галакторея, гинекомастия, аменорея).
Передозировка
Симптомы: сонливость, дезориентация, экстрапирамидные расстройства (особенно у детей).; Лечение: прием активированного угля, при экстрапирамидных нарушениях - м-холиноблокаторы, противопаркинсонические лекарственные средства или антигистаминные препараты с антихолинергическими свойствами.
Особые указания
Домперидон и антацидные препараты или препараты, уменьшающие желудочную секрецию, не следует принимать вместе, в одно и то же время. При приеме домперидона до еды, указанные лекарственные средства следует принимать после еды.
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