Фокусин Капсулы, 90 шт, 0,4 мг

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Благодаря такой высокой селективности препарат не вызывает какого-либо клинически значимого снижения системного АД как у пациентов с артериальной гипертензией, так и у пациентов с нормальным исходным АД.;"}}]},{"id":3,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Лечение функциональных расстройств при доброкачественной гиперплазии предстательной железы"}}]},{"id":4,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Ортостатическая гипотензия (в т.ч. в анамнезе);"}},{"type":"list","data":{"style":"unordered","items":["Выраженная печеночная недостаточность","Возраст до 18 лет (эффективность и безопасность не установлены)","Повышенная чувствительность к компонентам препарата"]}},{"type":"paragraph","data":{"text":"С осторожностью следует применять препарат при хронической почечной недостаточности (КК менее 10 мл/мин), артериальной гипотензии (в т.ч. ортостатической), запланированной операции по поводу катаракты, при одновременном применении мощных и умеренно активных ингибиторов изофермента CYP3А4 (например, кетоконазол, вориконазол)."}},{"type":"paragraph","data":{"text":"Противопоказано применение препарата при выраженной печеночной недостаточности."}},{"type":"paragraph","data":{"text":"Применение при нарушениях функции почек; С осторожностью следует применять препарат при хронической почечной недостаточности (КК менее 10 мл/мин)."}}]},{"id":5,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Фокусин не предназначен для применения у женщин;"}}]},{"id":6,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Препарат принимают внутрь в дозе 400 мкг (1 капс.)/сут.; Капсулы следует принимать после первого приема пищи, не разжевывая, запивая достаточным количеством воды.; Фокусин может применяться как в качестве монотерапии, так и в сочетании с ингибиторами 5-редуктазы (финастерид, дутастерид);"}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Частота нежелательных реакций представлена в соответствии с классификацией MedDRA: очень часто (\u003e10%), часто (≥1%, \u003c10%), нечасто (≥0.1%, \u003c1%), редко (≥0.01%, \u003c0.1%), очень редко (\u003c0.01%), частота неизвестна (определить частоту встречаемости по имеющимся данным не представляется возможным).; Со стороны иммунной системы: очень редко - реакции гиперчувствительности.; Со стороны нервной системы: часто - головокружение; нечасто - головная боль; редко - синкопальные состояния; частота неизвестна - нарушение сна (сонливость или бессонница).; Со стороны органа зрения: частота неизвестна - нечеткость зрения, нарушение зрения.; Со стороны сердечно-сосудистой системы: нечасто - ощущение сердцебиения, ортостатическая гипотензия; частота неизвестна - тахикардия.; Со стороны дыхательной системы: нечасто - ринит; частота неизвестна - носовое кровотечение.; Со стороны пищеварительной системы: редко - тошнота, рвота, запор или диарея.; Со стороны кожи и подкожных тканей: нечасто - кожная сыпь, зуд, крапивница; редко - ангионевротический отек; очень редко - синдром Стивенса-Джонсона; частота неизвестна - многоформная эритема, эксфолиативный дерматит. ; Со стороны половых органов и молочной железы: очень редко - приапизм; частота неизвестна - нарушения эякуляции (в т.ч. ретроградная эякуляция), снижение либидо.; Общие расстройства: нечасто - астенический синдром; частота неизвестна - боль в спине, боль в грудной клетке.;"}}]},{"id":8,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Симптомы: выраженное снижение АД.; Лечение: проведение кардиотропной терапии, общей поддерживающей терапии, контроль функции почек, введение объемозамещающих растворов или сосудосуживающих препаратов. Для предотвращения дальнейшей абсорбции тамсулозина возможно промывание желудка, прием активированного угля или осмотического слабительного.;"}}]},{"id":9,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"До начала терапии препаратом Фокусин необходимо исключить наличие других заболеваний, которые могут вызывать такие же симптомы, как и доброкачественная гиперплазия предстательной железы. Перед началом лечения и регулярно во время терапии следует проводить обследование предстательной железы (пальцевое ректальное обследование, определение ПСА).; Как и при применении других альфа1-адреноблокаторов, при лечении препаратом Фокусин в отдельных случаях может наблюдаться снижение АД, которое может приводить к обморочному состоянию. Препарат Фокусин следует применять с осторожностью у пациентов с предрасположенностью к ортостатической гипотензии.; При первых признаках ортостатической гипотензии (головокружение, слабость) пациента следует усадить или уложить.; При развитии ангионевротического отека, а также других иммунологических реакций, таких как синдром Стивенса-Джонсона, применение препарата следует немедленно прекратить. Пациент должен находиться под наблюдением врача до ликвидации данного патологического состояния; повторное назначение тамсулозина не допускается.; При проведении хирургических операций по поводу катаракты у некоторых пациентов, получавших тасмулозина гидрохлорид на момент операции и в прошлом, имело место развитие синдрома интраоперационной нестабильности радужной оболочки глаза (синдром узкого зрачка). Возникновение синдрома интраоперационной нестабильности радужной оболочки глаза может приводить к повышению риска осложнений со стороны органа зрения во время и после операции.; Тамсулозина гидрохлорид не следует применять в комбинации с мощными ингибиторами изофермента CYP3А4 у пациентов с фенотипом \"медленного метаболизма\" по изоферменту CYP2D6.; Влияние на способность к вождению автотранспорта и управлению механизмами; Следует соблюдать осторожность при управлении транспортными средствами и занятиях, требующих повышенной концентрации внимания и быстроты психомоторных реакций. В случае возникновения головокружения необходимо воздержаться от управления автотранспортом и выполнения других потенциально опасных видов деятельности;"}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"Тамсулозин избирательно и конкурентно блокирует постсинаптические 1А-адренорецепторы гладкой мускулатуры предстательной железы, шейки мочевого пузыря и простатической части уретры и 1Д-адренорецепторы мочевого пузыря, что приводит к снижению тонуса гладкой мускулатуры предстательной железы, шейки мочевого пузыря и простатической части уретры, улучшению функции детрузора и уменьшению симптомов обструкции и раздражения, связанных с доброкачественной гиперплазией предстательной железы.; Как правило, терапевтический эффект развивается через 2 нед. после начала приема препарата, хотя у ряда пациентов уменьшение выраженности симптомов отмечается после приема первой дозы.; Способность тамсулозина воздействовать на 1А-адренорецепторы в 20 раз превосходит его способность воздействовать на 1Д-адренорецепторы гладких мышц сосудов. 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