Снижает базальную и стимулированную гастрином, пентагастрино... Инструкция
Показания к применению
Язвенная болезнь двенадцатиперстной кишки и желудка в фазе обострения, симптоматические язвы и их профилактика, рефлюкс-эзофагит, синдром Золлингера-Эллисона, предупреждение аспирации желудочного сока при проведении общей анестезии (синдром Мендельсона), кровотечения из верхних отделов ЖКТ (в составе комплексного лечения).
Противопоказания
Беременность, период лактации (грудного вскармливания), детский возраст, повышенная чувствительность к компонентам препарата, повышенная чувствительность к другим блокаторам гистаминовых H2-рецепторов.
Таблетки Квамател содержат фамотидин, который уменьшает объем желудочного сока и содержание соляной кислоты в нем, повышает рН содержимого желудка.
Фармакологические свойства
Снижает базальную и стимулированную гастрином, пентагастрином, бетазолом, кофеином, гистамином, ацетилхолином и физиологическим вагусным рефлексом секрецию соляной кислоты. При этом возрастает рН и снижается активность пепсина. Практически не влияет на уровни гастрина натощак и после приема пищи. Не влияет на моторику желудка, экзокринную активность поджелудочной железы, кровообращение в портальной системе, на уровни гормонов, не оказывает антиандрогенного действия.
Показания к применению
Язвенная болезнь двенадцатиперстной кишки и желудка в фазе обострения, симптоматические язвы и их профилактика, рефлюкс-эзофагит, синдром Золлингера-Эллисона, предупреждение аспирации желудочного сока при проведении общей анестезии (синдром Мендельсона), кровотечения из верхних отделов ЖКТ (в составе комплексного лечения).
Противопоказания
Беременность, период лактации (грудного вскармливания), детский возраст, повышенная чувствительность к компонентам препарата, повышенная чувствительность к другим блокаторам гистаминовых H2-рецепторов.
Применение при беременности и в период грудного вскармливания
Противопоказано при беременности и кормлении грудью.
Способ применения и дозы
Внутрь, целиком, запивая небольшим количеством воды. В случае появления изжоги или других симптомов диспепсии следует принять 1 таблетку препарата Квамател Мини. Не следует применять более 2 таблеток в сутки.
Побочное действие
Со стороны пищеварительной системы: сухость во рту, тошнота, рвота, боли в животе, метеоризм, запор, диарея, снижение аппетита, повышение активности трансаминаз печени, гепатоцеллюлярный, холестатический или смешанный гепатит, острый панкреатит. Со стороны системы кроветворения: очень редко - агранулоцитоз, панцитопения, лейкопения, тромбоцитопения, гипо- или аплазия костного мозга. Аллергические реакции: крапивница, кожная сыпь, зуд, бронхоспазм, ангионевротический отек, анафилактический шок. Со стороны сердечно-сосудистой системы: аритмия, брадикардия, AV-блокада, снижение АД. Со стороны ЦНС: головная боль, головокружение, сонливость, галлюцинации, спутанность сознания, повышенная утомляемость, депрессия, возбуждение, тревога. Со стороны органов чувств: снижение остроты зрения, шум в ушах. Со стороны половой системы: при длительном применении в высоких дозах - гиперпролактинемия, гинекомастия, аменорея, снижение либидо. Со стороны костно-мышечной системы: артралгия, мышечные спазмы. Дерматологические реакции: алопеция, обыкновенные угри, сухость кожи, токсический эпидермальный некролиз. Прочие: лихорадка.
Передозировка
Симптомы: рвота, двигательное возбуждение, тремор, снижение АД, тахикардия, коллапс. Лечение: промывание желудка, симптоматическая и поддерживающая терапия, гемодиализ.
Особые указания
Применение Кваматела может маскировать симптомы рака желудка, поэтому прежде, чем приступить к лечению фамотидином, необходимо исключить наличие злокачественного новообразования. При резком прекращении лечения фамотидин может вызвать синдром отмены, поэтому лечение прекращают, постепенно снижая его дозу.
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