Буденофальк Капсулы, 20 шт, 3 мг

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Ингибируя фосфолипазу А2 эти протеины участвуют в метаболизме арахидоновой кислоты и таким образом предупреждают образование медиаторов воспаления лейкотриенов и простагландинов. Так как процесс индукции синтеза протеинов требует некоторого промежутка времени полный терапевтический эффект будесонида развивается постепенно."}},{"type":"header","data":{"text":"Фармакокинетика:","level":3}},{"type":"paragraph","data":{"text":"Будесонид обладает выраженными липофильными свойствами и быстро абсорбируется в кишечнике вследствие хорошей тканевой проницаемости."}},{"type":"paragraph","data":{"text":"По сравнению с классическими глюкокортикостероидами будесонид имеет очень высокую степень сродства к рецепторам. Благодаря этим свойствам Буденофальк обладает целенаправленным местным действием."}},{"type":"paragraph","data":{"text":"Приблизительно 90% будесонида метаболизируется в печени при \"первом прохождении\" и только около 10% оказывает системное воздействие. Из этого количества 90% будесонида связано с альбумином и за счет этого находится в биологически неактивной форме."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"- Легкая и среднетяжелая формы болезни Крона с вовлечением подвздошной и/или восходящей ободочной кишки;"}},{"type":"paragraph","data":{"text":"- коллагенозный (коллагеновый) колит аутоиммунный гепатит без гистологических признаков цирроза печени."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Гиперчувствительность к будесониду или другим компонентам препарата цирроз печени инфекционные заболевания кишечника (бактериальная грибковая амебная вирусная инфекции) период лактации (грудное вскармливание) непереносимость лактозы фруктозы галактозы дефицит лактазы дефицит сахаразы/изомальтазы глюкозо-галактозная мальабсорбция детский возраст до 3 лет."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Следует применять при туберкулезе артериальной гипертензии сахарном диабете остеопорозе пептической язве глаукоме катаракте отягощенном семейном анамнезе по диабету или глаукоме беременность."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Во время беременности применение Буденофалька возможно только в тех случаях когда ожидаемая польза для матери превышает потенциальный риск для плода. У женщин детородного возраста до начала терапии Буденофальком должна быть исключена возможная беременность а во время лечения должны применяться надежные методы контрацепции."}},{"type":"paragraph","data":{"text":"До настоящего времени неизвестно способен ли будесонид проникать в грудное молоко поэтому в период лечения необходимо отказаться от грудного вскармливания."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Болезнь Крона"}},{"type":"paragraph","data":{"text":"Взрослые ( старше 18 лет)"}},{"type":"paragraph","data":{"text":"Рекомендуемая суточная доза составляет три капсулы один раз в день утром или одну капсулу (содержащую 3 мг будесонида) 3 раза в сутки (утром днем и вечером)."}},{"type":"paragraph","data":{"text":"Коллагенозный (коллагеновый) колит"}},{"type":"paragraph","data":{"text":"Взрослые (старше 18 лет)"}},{"type":"paragraph","data":{"text":"Рекомендуемая суточная доза составляет три капсулы один раз утром до завтрака (соответствует суточной дозе 9 мг будесонида)."}},{"type":"paragraph","data":{"text":"Курс лечения при болезни Крона и коллагенозном (коллагеновом) колите обычно составляет 8 недель."}},{"type":"paragraph","data":{"text":"Как правило полный эффект наступает через 2-4 недели."}},{"type":"paragraph","data":{"text":"Аутоиммунный гепатит"}},{"type":"paragraph","data":{"text":"Взрослые (старше 18 лет)"}},{"type":"paragraph","data":{"text":"Лечение активного гепатита"}},{"type":"paragraph","data":{"text":"Рекомендуемая суточная доза составляет 1 капсулу 3 раза в день (утром днем и вечером)."}},{"type":"paragraph","data":{"text":"Поддерживающее лечение"}},{"type":"paragraph","data":{"text":"1 капсулу два раза в день (утром и вечером)."}},{"type":"paragraph","data":{"text":"Курс лечения длительный и может составлять до 6-12 месяцев при активном гепатите (обострении) и до 24 месяцев при поддерживающей терапии."}},{"type":"paragraph","data":{"text":"Продолжительность и частота приема препарата определяется лечащим врачом."}},{"type":"paragraph","data":{"text":"Капсулы необходимо принимать приблизительно за 30 минут до еды проглатывая их целиком с достаточным количеством жидкости."}},{"type":"paragraph","data":{"text":"Если у пациента имеются проблемы с глотанием он может вскрыть твердые капсулы и принять содержащиеся там устойчивые к действию желудочного сока гранулы не разжевывая их и запивая достаточным количеством жидкости что не повлияет на эффективность препарата."}},{"type":"paragraph","data":{"text":"Нельзя резко прекращать прием препарата. Препарат необходимо отменять постепенно (медленно снижая дозировку). В течение первой недели дозировка должна быть уменьшена до 2 капсул в день (по 1 капсуле утром и вечером). В течение второй недели пациент должен принимать по 1 капсуле в день только утром. Затем лечение может быть прекращено."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Иногда могут возникать типичные для системных ГКС побочные эффекты (синдром Кушинга). Эти побочные эффекты зависят от дозы, длительности лечения, сопутствующего или предшествующего лечения другими ГКС и индивидуальной чувствительности."}},{"type":"paragraph","data":{"text":"Клинические испытания показали, что частота побочных эффектов, характерных для ГКС, при использовании Буденофалька значительно меньше (приблизительно в 2 раза) по сравнению с частотой нежелательных эффектов при пероральном приеме эквивалентных доз преднизолона. Тем не менее, нельзя полно­стью исключить возникновение побочных эффектов, типичных для ГКС."}},{"type":"paragraph","data":{"text":"Могут возникать следующие побочные эффекты"}},{"type":"paragraph","data":{"text":"Со стороны кожных покровов: аллергическая экзема, красные стрии, петехии, экхимоз, стероидные угри, ухудшение заживления ран, контактный дерматит."}},{"type":"paragraph","data":{"text":"Со стороны опорно-двигательного аппарата: мышечная слабость, остеопороз, асептический некроз костей (бедренной и головки плечевой)."}},{"type":"paragraph","data":{"text":"Со стороны органов чувств: глаукома, катаракта."}},{"type":"paragraph","data":{"text":"Психические нарушения: депрессия, эйфория, раздражительность."}},{"type":"paragraph","data":{"text":"Со стороны эндокринной системы: синдром Кушинга (лунообразное лицо, ожирение, сахарный диабет, снижение толерантности к глюкозе, задержка натрия с формированием отеков, гипокалиемия, снижение функции или атрофия коры надпочечников, нарушение секреции половых гормонов (аменорея, гирсутизм, импотенция)."}},{"type":"paragraph","data":{"text":"Со стороны сердечно-сосудистой системы: повышение АД, повышенный риск тромбообразования, васкулит (синдром отмены после длительного лечения)."}},{"type":"paragraph","data":{"text":"Со стороны иммунной системы: влияние на иммунный ответ (повышенный риск возникновения инфекционных заболеваний)."}},{"type":"paragraph","data":{"text":"При переводе больных с приема системных ГКС на будесонид могут усиливаться или вновь возникать внекишечные симптомы (особенно поражение кожи и суставов)."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Случаев передозировки не выявлено."}},{"type":"paragraph","data":{"text":"В случае передозировки проводят симптоматическое лечение."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Сердечные гликозиды:"}},{"type":"paragraph","data":{"text":"Действие сердечных гликозидов может усиливаться из-за дефицита калия."}},{"type":"paragraph","data":{"text":"Салуретики:"}},{"type":"paragraph","data":{"text":"Гипокалиемия может увеличиваться."}},{"type":"paragraph","data":{"text":"Ингибиторы цитохрома Р450 (кетаконазол итраконазол ритонавир кларитромицин тролеандомицин эритромицин циклоспорин):"}},{"type":"paragraph","data":{"text":"Глюкокортикостероидный эффект может усиливаться."}},{"type":"paragraph","data":{"text":"Во время лечения данным препаратом нельзя пить грейпфрутовый сок так как он может повлиять на эффективность препарата."}},{"type":"paragraph","data":{"text":"Есть данные о повышенных концентрациях эстрогенов в плазме и об усилении эффектов кортикостероидов у женщин принимавших эстрогены или оральные контрацептивы в сочетании с будесонидом. Однако этот эффект не наблюдался в случае приема низкодозированных оральных контрацептивов."}},{"type":"paragraph","data":{"text":"Одновременное назначение циметидина и будесонида может приводить к незначительному повышению уровня будесонида в плазме однако это не имеет клинического значения. Одновременное назначение омепразола не влияет на фармакокинетику будесонида. Теоретически нельзя исключить взаимодействие со смолами способными связывать стероиды (например холестирамином) а так же антацидами. При одновременном приеме этих препаратов с Буденофальком в результате взаимодействия может уменьшаться лечебный эффект будесонида. В этой связи вышеназванные препараты должны приниматься с Буденофальком по крайней мере с интервалом в 2 часа."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Буденофальк может подавлять функцию гипоталамо-гипофизарно-адреналовой системы. Перед оперативным вмешательством или воздействием другого стрессового фактора рекомендуется дополнительное назначение системных глюкокортикостероидов."}},{"type":"paragraph","data":{"text":"Буденофальк 3 мг содержит лактозу и сахарозу. Препарат не следует принимать пациентам с редкими наследственными состояниями непереносимости галактозы или фруктозы недостаточностью сахаразы-изомальтазы или мальабсорбцией глюкозы-галактозы а также лактазной недостаточностью или врожденной недостаточностью лактазы."}},{"type":"paragraph","data":{"text":"У пациентов с аутоиммунным гепатитом следует регулярно контролировать уровень трансаминаз (АЛТ ACT) в сыворотке (каждые 2 недели в течение первого месяца лечения и как минимум через каждые 3 месяца в дальнейшем) с целью возможной коррекции дозировки будесонида."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Необходимо соблюдать осторожность при управлении транспортными средствами и занятиями потенциально опасными видами деятельности требующими повышенной концентрации внимания и быстроты психомоторных реакций так как препарат может вызвать головную боль слабость нарушения со стороны органов зрения и другие побочные эффекты которые могут влиять на указанные способности."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Капсулы кишечнорастворимые 3 мг."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить при температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Не применять после истечения срока годности указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Д-р Фальк Фарма ГмбХ, Leinenweberstrasse 5, 79108 Freiburg, Germany, Германия"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"Д-р Фальк Фарма ГмбХ"}}]}],"source":null},"description_toggle":false,"short_description":"Будесонид является негалогеновым глюкокортикостероидом с противовоспалительными противоаллергическими антиэкссудативными и противоотечными свойствами. Эти свойства основаны на: - уменьшении выделения медиаторов из тучных клеток базофилов и макрофагов; перераспределении и подавлении миграции воспалительных клеток ингибировании воспалительных реакций; - мембраностабилизирующем действии. Индукция некоторых протеинов (например макрокортина) является одним из специфических механизмов действия будесонида. Ингибируя фосфолипазу А2 эти протеины участвуют в метаболизме арахидоновой кислоты и таким образом предупреждают образование медиаторов воспаления лейкотриенов и простагландинов. Так как процесс индукции синтеза протеинов требует некоторого промежутка времени полный терапевтический эффект будесонида развивается постепенно. Будесонид обладает выраженными липофильными свойствами и быстро абсорбируется в кишечнике вследствие хорошей тканевой проницаемости. По сравнению с классическими глюкокортикостероидами будесонид имеет очень высокую степень сродства к рецепторам. Благодаря этим свойствам Буденофальк обладает целенаправленным местным действием. Приблизительно 90% будесонида метаболизируется в печени при \"первом прохождении\" и только около 10% оказывает системное воздействие. 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