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Связь с белками плазмы низкая, 10–25%."}},{"type":"paragraph","data":{"text":"Проникает через гематоэнцефалический барьер."}},{"type":"paragraph","data":{"text":"Метаболизм происходит в печени, 80% вступает в реакции конъюгации с глюкуроновой кислотой и сульфатами с образованием неактивных метаболитов; 17% подвергается гидроксилированию с образованием 8 активных метаболитов, которые конъюгируют с глутатионом с образованием уже неактивных метаболитов. При недостатке глутатиона эти метаболиты могут блокировать ферментные системы гепатоцитов и вызывать их некроз. В метаболизме препарата также участвует изофермент CYP2E1. Т 1/2–1–4 ч. Выводится почками в виде метаболитов, преимущественно конъюгатов. В неизмененном виде выводится менее 5%. Период полувыведения составляет около 2 часов."}},{"type":"paragraph","data":{"text":"\u003ci\u003eФенирамина малеат:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Хорошо всасывается в пищеварительном тракте. 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Перед применением содержимое пакетика необходимо растворить в стакане (200 мл) теплой воды."}},{"type":"paragraph","data":{"text":"В зависимости от возраста ребенка препарат применяется в следующих дозах:"}},{"type":"paragraph","data":{"text":"• Детям от 6 до 10 лет: по 1 пакетику 2 раза в день;"}},{"type":"paragraph","data":{"text":"• Детям от 10 до 12 лет: по 1 пакетику 3 раза в день;"}},{"type":"paragraph","data":{"text":"• Детям от 12 до 15 лет: по 1 пакетику 4 раза в день."}},{"type":"paragraph","data":{"text":"Интервал между приемами препарата должен составлять не менее 4 часов. Продолжительность лечения не более 3 дней."}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Препарат хорошо переносится в рекомендованных дозах."}},{"type":"paragraph","data":{"text":"Возможны сухость во рту, тошнота, рвота, боли в животе, нарушение мочеиспускания, запор, аллергические реакции (кожная сыпь, зуд, крапивница, отек Квинке), сонливость, нарушение аккомодации, анемия, лейкопения, агранулоцитоз, тромбоцитопения. При длительном применении в дозах, превышающих рекомендованные, возможно гепатотоксическое и нефротоксическое действие, гемолитическая анемия, апластическая анемия, метгемоглобинемия, панцитопения."}},{"type":"paragraph","data":{"text":"При появлении побочных реакций прекратите прием препарата и обратитесь к врачу."}}]},{"id":8,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Признаками острого отравления парацетамолом являются анорексия, тошнота, рвота, боли в эпигастральной области, потливость, бледность кожных покровов, сонливость."}},{"type":"paragraph","data":{"text":"Через 1–2 суток появляются признаки поражения печени."}},{"type":"paragraph","data":{"text":"В тяжелых случаях развивается печеночная недостаточность, гепатонекроз, энцефалопатия и коматозное состояние."}},{"type":"paragraph","data":{"text":"При появлении симптомов отравления прекратите применение препарата и немедленно обратитесь к врачу. Рекомендуется промывание желудка, прием энтеросорбентов (активированный уголь, лигнин гидролизный), внутривенное введение антидота ацетилцистеина, прием метионина.\n"}}]},{"id":9,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Фервекс для детей, за счет входящего в состав фенирамина малеата, усиливает действие седативных препаратов, а при применении вместе с антипсихотическими средствами (производные фенотиазина) – повышается риск развития побочных эффектов препарата (задержка мочи, сухость во рту, запоры)."}},{"type":"paragraph","data":{"text":"Следует учитывать возможность усиления центральных атропиноподобных эффектов при применении в комбинации с другими веществами, обладающими антихолинергическими свойствами (другие антигистаминные препараты, антидепрессанты группы имипрамина, нейролептики фенотиазинового ряда, антихолинергические противопаркинсонические средства, атропиноподобные спазмолитические средства, дизопирамид)."}},{"type":"paragraph","data":{"text":"При использовании препарата, вместе с барбитуратами, трициклическими антидепрессантами, противосудорожными средствами (фенитоин), флумецинолом, фенилбутазоном, рифампицином и этанолом значительно повышается риск гепатотоксического действия (за счет входящего в состав парацетамола)."}},{"type":"paragraph","data":{"text":"Прием одновременно с салицилатами повышает риск нефротоксического действия."}},{"type":"paragraph","data":{"text":"При одновременном применении с левомицетином (хлорамфениколом) токсичность последнего возрастает."}},{"type":"paragraph","data":{"text":"Парацетамол, содержащийся в препарате, усиливает действие антикоагулянтов непрямого действия и снижает эффективность урикозурических препаратов."}},{"type":"paragraph","data":{"text":"Следует соблюдать осторожность при одновременном применении парацетамола и индукторов микросомальных ферментов печени (например, этанол, барбитураты, изониазид, рифампицин, карбамазепин, зидовудин, антикоагулянты, амоксициллин + клавулановая кислота, фенилбутазон, трициклические антидепрессанты) ввиду повышения риска гепатотоксического действия."}},{"type":"paragraph","data":{"text":"Миелотоксичные лекарственные средства усиливают проявления гематотоксичности парацетамола, метоклопрамид усиливает его всасывание."}}]},{"id":10,"name":"Особые указания","slug":"","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Фервекс для детей не следует применять одновременно с другими лекарствами, содержащими парацетамол."}},{"type":"paragraph","data":{"text":"При применении препарата более недели необходим контроль за функциональным состоянием печени и картиной периферической крови."}},{"type":"paragraph","data":{"text":"Парацетамол искажает результаты лабораторных исследований содержания глюкозы и мочевой кислоты в плазме крови."}},{"type":"paragraph","data":{"text":"При отсутствии терапевтического эффекта (повышение температуры тела сохраняется более 3 дней и болевой синдром более 5 дней) требуется консультация врача."}}]},{"id":19,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Учитывая возможность возникновения таких побочных реакций, как сонливость, нарушение аккомодации, следует воздержаться от управления транспортными средствами и работы с механизмами."}}]},{"id":11,"name":"Условия хранения","slug":"storage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Хранить при температуре от 15 до 25 °C."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":12,"name":"Срок годности","slug":"expiry_date","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Не используйте препарат после даты окончания срока годности, указанной на упаковке."}}]},{"id":13,"name":"Условия отпуска","slug":"release_condition","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Без рецепта."}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"УПСА САС, Франция"}},{"type":"paragraph","data":{"text":"979 авеню де Пирене, 47520 г. Ле Пассаж, Франция"}},{"type":"paragraph","data":{"text":"UPSA SAS, France"}},{"type":"paragraph","data":{"text":"979 avenue des Pyrénées, 47520 Le Passage, France"}}]},{"id":22,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ООО «Свикс Биофарма». 125047, г. Москва, 1-я Тверская-Ямская ул., д. 23, стр. 1, эт. 5, пом. V ком.4."}},{"type":"paragraph","data":{"text":"Тел.: 8 (495) 229-06-61"}},{"type":"paragraph","data":{"text":"medinfo.russia@swixxbiopharma.com "}}]}],"source":null},"description_toggle":false,"short_description":"Фервекс для детей – комбинированный препарат, который содержит парацетамол, фенирамина малеат и аскорбиновую кислоту. Парацетамол – нестероидный противовоспалительный препарат, блокирует циклооксигеназу, преимущественно в центральной нервной системе, воздействуя на центры боли и терморегуляции; оказывает анальгезирующее и жаропонижающее действие. Парацетамол обладает анальгезирующим и жаропонижающим действием. Фенирамина малеат – блокатор Н1-гистаминовых рецепторов. Суживает сосуды носа, устраняет отечность и гиперемию слизистой оболочки полости носа, носоглотки и придаточных пазух носа. Аскорбиновая кислота принимает участие в регуляции окислительно-восстановительных процессов, уменьшает проницаемость сосудов и повышает сопротивляемость организма.Парацетамол:Абсорбция парацетамола полная и быстрая. Пик концентрации в плазме достигается через 30–60 минут после приема. Распределение парацетамола в тканях происходит быстро. Достигаются сравнимые концентрации препарата в крови, слюне и плазме. Связь с белками плазмы низкая, 10–25%. Проникает через гематоэнцефалический барьер. Метаболизм происходит в печени, 80% вступает в реакции конъюгации с глюкуроновой кислотой и сульфатами с образованием неактивных метаболитов; 17% подвергается гидроксилированию с образованием 8 активных метаболитов, которые конъюгируют с глутатионом с образованием уже неактивных метаболитов. При недостатке глутатиона эти метаболиты могут блокировать ферментные системы гепатоцитов и вызывать их некроз. В метаболизме препарата также участвует изофермент CYP2E1. Т 1/2–1–4 ч. Выводится почками в виде метаболитов, преимущественно конъюгатов. В неизмененном виде выводится менее 5%. Период полувыведения составляет около 2 часов.Фенирамина малеат:Хорошо всасывается в пищеварительном тракте. Период полувыведения из плазмы крови составляет от одного до полутора часов. Выводится из организма преимущественно через почки.Аскорбиновая кислота:Хорошо всасывается в пищеварительном тракте. ТСmax после приема внутрь – 4 ч. Метаболизируется преимущественно в печени. 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