Установленный дефицит магния, изолированный или связанный с другими дефицитными состояниями, сопровождающийся такими симптомами, как: повышенная раздражительность, незначительные нарушения сна; желудочно-кишечные спазмы или учащенное сердцебиение; повышенная утомляемость, боли и спазмы мышц, ощущение покалывания.
Противопоказания
Повышенная чувствительность к компонентам препарата.
Тяжелая почечная недостаточность (клиренс креатинина менее 30 мл/минуту).
Овальные двояковыпуклые таблетки, покрытые оболочкой белого цвета, с гладкой блестящей поверхностью.
Таблетки, покрытые оболочкой.
По 10 или 20 таблеток в блистер из ПВХ/фольги алюминиевой. По 5 блистеров по 10 таблеток, по 3, 5 или 9 блистеров по 20 таблеток вместе с инструкцией по применению помещают в картонную пачку.
Фармакологические свойства
Фармакодинамика: Магний является жизненно важным элементом, который находится во всех тканях организма и необходим для нормального функционирования клеток, участвует в большинстве реакций обмена веществ. В частности, он участвует в регуляции передачи нервных импульсов и в сокращении мышц. Организм получает магний вместе с пищей. Недостаток магния в организме может наблюдаться при нарушении режима питания (диета), при увеличении потребности в магнии или при дисбалансе поступления, метаболизма и выведения магния (например, при повышенной физической и умственной нагрузке, стрессе, в период беременности, при применении диуретиков) Пиридоксин (витамин В6) участвует во многих метаболических процессах, в регуляции метаболизма нервной системы. Витамин В6 улучшает всасывание магния из желудочно-кишечного тракта и его проникновение в клетки.
Содержание магния в сыворотке:
от 12 до 17 мг/л (0,5 – 0,7 ммоль/л) - умеренная недостаточность магния;
ниже 12 мг/л (0,5 ммоль/л) - тяжелый дефицит магния.
Фармакокинетика: Всасывание магния в желудочно-кишечном тракте составляет не более 50% от принимаемой внутрь дозы. 99% магния в организме находится внутри клеток. Примерно 2/3 внутриклеточного магния распределяется в костной ткани, 1/3 находится в гладкой и поперечно-полосатой мышечной ткани. Магний выводится преимущественно с мочой (по меньшей мере, 1/3 от принятой дозы магния).
Показания к применению
Установленный дефицит магния, изолированный или связанный с другими дефицитными состояниями, сопровождающийся такими симптомами, как: повышенная раздражительность, незначительные нарушения сна; желудочно-кишечные спазмы или учащенное сердцебиение; повышенная утомляемость, боли и спазмы мышц, ощущение покалывания.
Противопоказания
Повышенная чувствительность к компонентам препарата.
Тяжелая почечная недостаточность (клиренс креатинина менее 30 мл/минуту).
Одновременный прием леводопы (см. раздел «Взаимодействие с другими лекарственными средствами»).
Применение при беременности и в период грудного вскармливания
Беременность
Клинический опыт применения препарата у достаточного количества беременных женщин не выявил какого-либо неблагоприятного влияния на возникновение пороков развития плода или фетотоксического действия.
Препарат Магне В6® может применяться в период беременности только при необходимости и по рекомендации врача.
Период грудного вскармливания
Магний проникает в грудное молоко. Следует избегать применения препарата в период лактации и кормления грудью.
Способ применения и дозы
Перед приемом препарата необходимо проконсультироваться с врачом. Взрослым рекомендуется принимать 6-8 таблеток в сутки.
Детям старше 6 лет (массой тела более 20 кг) 4-6 таблеток в сутки. Суточную дозу следует разделить на 2-3 приема, принимать во время еды. Таблетки следует запивать стаканом воды.
Лечение следует прекратить сразу же после нормализации концентрации магния в крови.
Побочное действие
По данным Всемирной организации здравоохранения (ВОЗ) нежелательные эффекты классифицированы в соответствии с их частотой развития следующим образом: очень часто (≥ 1/10), часто (≥1/100, <1/10), нечасто (≥1/1000, <1/100), редко (≥1/10000, <1/1000) и очень редко (<1/10000); частота неизвестна (частоту возникновения явлений нельзя определить на основании имеющихся данных).
Нарушения со стороны иммунной системы
Очень редко: аллергические реакции, включая кожные реакции (крапивница, зуд).
Нарушения со стороны желудочно-кишечного тракта
Частота неизвестна: диарея, боли в животе.
Передозировка
Симптомы
При нормальной функции почек передозировка магния при его приеме внутрь обычно не приводит к возникновению токсических реакций. Однако в случае почечной недостаточности возможно развитие отравления магнием.
Симптомы передозировки, выраженность которых зависит от концентрации магния в крови: снижение артериального давления; тошнота, рвота; угнетение центральной нервной системы, снижение рефлексов; изменения на электрокардиограмме; угнетение дыхания, кома, остановка сердца и паралич дыхания; анурический синдром.
Лечение
Регидратация, форсированный диурез. При почечной недостаточности необходим гемодиализ или перитонеальный диализ.
Взаимодействие с другими лекарственными средствами
Противопоказанные комбинации
С леводопой: активность леводопы ингибируется пиридоксином (если прием этого препарата не сочетается с приемом ингибиторов периферической декарбоксилазы ароматических L-аминокислот). Следует избегать приема любого количества пиридоксина, если леводопа не принимается в сочетании с ингибиторами периферической декарбоксилазы ароматических L-аминокислот.
Нерекомендуемые комбинации
Одновременное применение препаратов, содержащих фосфаты или соли кальция, может ухудшать всасывание магния в кишечнике.
Комбинации, которые следует принимать во внимание
При назначении внутрь тетрациклинов необходимо соблюдать интервал не менее трех часов между приемом внутрь тетрациклина и Магне В6, так как препараты магния уменьшают всасывание тетрациклинов.
Особые указания
Информация для больных сахарным диабетом: таблетки, покрытые оболочкой, содержат сахарозу в качестве вспомогательного вещества.
В случае тяжелой степени дефицита магния или синдрома мальабсорбции, лечение начинают с внутривенного введения препаратов магния.
В случае сопутствующего дефицита кальция, рекомендуется устранить дефицит магния до начала приема препаратов кальция или пищевых добавок, содержащих кальций.
При частом употреблении слабительных средств, алкоголя, напряженных физических и психических нагрузках потребность в магнии возрастает, что может привести к развитию дефицита магния в организме.
При применении пиридоксина в высоких дозах (более 200 мг в сутки) в течение длительного времени (в течение нескольких месяцев или в некоторых случаях - лет) может развиться сенсорная аксональная нейропатия, которая сопровождается такими симптомами, как онемение, нарушения проприоцептивной чувствительности, тремор дистальных отделов конечностей и постепенно развивающаяся сенсорная атаксия (нарушения координации движений). Эти нарушения обычно являются обратимыми и проходят после прекращения приема витамина В6.
Препарат в форме таблеток предназначен только для взрослых и детей старше 6 лет. Для детей младшего возраста (старше 1 года) рекомендуется препарат в форме раствора для приема внутрь.
Условия хранения
Хранить при температуре не выше 30 С. Хранить в недоступном для детей месте.
Срок годности
2 года. Препарат нельзя применять после истечения срока годности.
Условия отпуска
Отпускают без рецепта.
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таблетки:\u003cbr /\u003e\nдействующие вещества:\u003cbr /\u003e\nмагния лактата дигидрат* - 470 мг;\u003cbr /\u003e\nпиридоксина гидрохлорид - 5 мг;\u003cbr /\u003e\nвспомогательные вещества: сахароза - 115,6 мг, каолин тяжелый - 40,0 мг, акации камедь - 20,0 мг, карбоксиполиметилен 934 - 10,0 мг, тальк (магния гидросиликат) - 42,7 мг, магния стеарат - 6,7 мг.\u003cbr /\u003e\nОболочка таблетки: акации камедь - 3,615 мг, сахароза - 214,969 мг, титана диоксид - 1,416 мг, тальк (магния гидросиликат) - следы, воск карнаубский (порошок) - следы.\u003cbr /\u003e\n* - эквивалентно содержанию магния (Mg++) 48 мг"}}]},{"id":2,"name":"Описание","slug":"common_description","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Овальные двояковыпуклые таблетки, покрытые оболочкой белого цвета, с гладкой блестящей поверхностью. \u003cbr /\u003e\nТаблетки, покрытые оболочкой.\u003cbr /\u003e\nПо 10 или 20 таблеток в блистер из ПВХ/фольги алюминиевой. По 5 блистеров по 10 таблеток, по 3, 5 или 9 блистеров по 20 таблеток вместе с инструкцией по применению помещают в картонную пачку."}}]},{"id":3,"name":"Фармакологические свойства","slug":"pharmacologic_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Фармакодинамика: Магний является жизненно важным элементом, который находится во всех тканях организма и необходим для нормального функционирования клеток, участвует в большинстве реакций обмена веществ. В частности, он участвует в регуляции передачи нервных импульсов и в сокращении мышц. Организм получает магний вместе с пищей. Недостаток магния в организме может наблюдаться при нарушении режима питания (диета), при увеличении потребности в магнии или при дисбалансе поступления, метаболизма и выведения магния (например, при повышенной физической и умственной нагрузке, стрессе, в период беременности, при применении диуретиков) Пиридоксин (витамин В6) участвует во многих метаболических процессах, в регуляции метаболизма нервной системы. Витамин В6 улучшает всасывание магния из желудочно-кишечного тракта и его проникновение в клетки.\u003cbr /\u003e\nСодержание магния в сыворотке:\u003cbr /\u003e"}},{"type":"list","data":{"style":"unordered","items":["от 12 до 17 мг/л (0,5 – 0,7 ммоль/л) - умеренная недостаточность магния;\u003cbr /\u003e","ниже 12 мг/л (0,5 ммоль/л) - тяжелый дефицит магния.\u003cbr /\u003e"]}},{"type":"paragraph","data":{"text":"Фармакокинетика: Всасывание магния в желудочно-кишечном тракте составляет не более 50% от принимаемой внутрь дозы. 99% магния в организме находится внутри клеток. Примерно 2/3 внутриклеточного магния распределяется в костной ткани, 1/3 находится в гладкой и поперечно-полосатой мышечной ткани. Магний выводится преимущественно с мочой (по меньшей мере, 1/3 от принятой дозы магния)."}}]},{"id":4,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Установленный дефицит магния, изолированный или связанный с другими дефицитными состояниями, сопровождающийся такими симптомами, как: повышенная раздражительность, незначительные нарушения сна; желудочно-кишечные спазмы или учащенное сердцебиение; повышенная утомляемость, боли и спазмы мышц, ощущение покалывания."}}]},{"id":5,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"list","data":{"style":"unordered","items":["Повышенная чувствительность к компонентам препарата.\u003cbr /\u003e","Тяжелая почечная недостаточность (клиренс креатинина менее 30 мл/минуту).\u003cbr /\u003e","Детский возраст до 6 лет.\u003cbr /\u003e","Непереносимость фруктозы, синдром глюкозо-галактозной мальабсорбции, дефицит сахаразы-изомальтазы.\u003cbr /\u003e","Одновременный прием леводопы (см. раздел «Взаимодействие с другими лекарственными средствами»)."]}}]},{"id":6,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Беременность\u003cbr /\u003e\nКлинический опыт применения препарата у достаточного количества беременных женщин не выявил какого-либо неблагоприятного влияния на возникновение пороков развития плода или фетотоксического действия.\u003cbr /\u003e\nПрепарат Магне В6® может применяться в период беременности только при необходимости и по рекомендации врача.\u003cbr /\u003e\nПериод грудного вскармливания\u003cbr /\u003e\nМагний проникает в грудное молоко. Следует избегать применения препарата в период лактации и кормления грудью."}}]},{"id":7,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Перед приемом препарата необходимо проконсультироваться с врачом. Взрослым рекомендуется принимать 6-8 таблеток в сутки.\u003cbr /\u003e\nДетям старше 6 лет (массой тела более 20 кг) 4-6 таблеток в сутки. Суточную дозу следует разделить на 2-3 приема, принимать во время еды. Таблетки следует запивать стаканом воды.\u003cbr /\u003e\nЛечение следует прекратить сразу же после нормализации концентрации магния в крови."}}]},{"id":8,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"По данным Всемирной организации здравоохранения (ВОЗ) нежелательные эффекты классифицированы в соответствии с их частотой развития следующим образом: очень часто (≥ 1/10), часто (≥1/100, \u003c1/10), нечасто (≥1/1000, \u003c1/100), редко (≥1/10000, \u003c1/1000) и очень редко (\u003c1/10000); частота неизвестна (частоту возникновения явлений нельзя определить на основании имеющихся данных).\u003cbr /\u003e\nНарушения со стороны иммунной системы\u003cbr /\u003e\nОчень редко: аллергические реакции, включая кожные реакции (крапивница, зуд).\u003cbr /\u003e\nНарушения со стороны желудочно-кишечного тракта\u003cbr /\u003e\nЧастота неизвестна: диарея, боли в животе."}}]},{"id":9,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Симптомы\u003cbr /\u003e\nПри нормальной функции почек передозировка магния при его приеме внутрь обычно не приводит к возникновению токсических реакций. Однако в случае почечной недостаточности возможно развитие отравления магнием.\u003cbr /\u003e\nСимптомы передозировки, выраженность которых зависит от концентрации магния в крови: снижение артериального давления; тошнота, рвота; угнетение центральной нервной системы, снижение рефлексов; изменения на электрокардиограмме; угнетение дыхания, кома, остановка сердца и паралич дыхания; анурический синдром.\u003cbr /\u003e\nЛечение\u003cbr /\u003e\nРегидратация, форсированный диурез. При почечной недостаточности необходим гемодиализ или перитонеальный диализ."}}]},{"id":10,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Противопоказанные комбинации\u003cbr /\u003e"}},{"type":"list","data":{"style":"unordered","items":["С леводопой: активность леводопы ингибируется пиридоксином (если прием этого препарата не сочетается с приемом ингибиторов периферической декарбоксилазы ароматических L-аминокислот). Следует избегать приема любого количества пиридоксина, если леводопа не принимается в сочетании с ингибиторами периферической декарбоксилазы ароматических L-аминокислот.\u003cbr /\u003e"]}},{"type":"paragraph","data":{"text":"Нерекомендуемые комбинации\u003cbr /\u003e"}},{"type":"list","data":{"style":"unordered","items":["Одновременное применение препаратов, содержащих фосфаты или соли кальция, может ухудшать всасывание магния в кишечнике.\u003cbr /\u003e"]}},{"type":"paragraph","data":{"text":"Комбинации, которые следует принимать во внимание\u003cbr /\u003e"}},{"type":"list","data":{"style":"unordered","items":["При назначении внутрь тетрациклинов необходимо соблюдать интервал не менее трех часов между приемом внутрь тетрациклина и Магне В6, так как препараты магния уменьшают всасывание тетрациклинов."]}}]},{"id":11,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Информация для больных сахарным диабетом: таблетки, покрытые оболочкой, содержат сахарозу в качестве вспомогательного вещества.\u003cbr /\u003e\nВ случае тяжелой степени дефицита магния или синдрома мальабсорбции, лечение начинают с внутривенного введения препаратов магния.\nВ случае сопутствующего дефицита кальция, рекомендуется устранить дефицит магния до начала приема препаратов кальция или пищевых добавок, содержащих кальций.\u003cbr /\u003e\nПри частом употреблении слабительных средств, алкоголя, напряженных физических и психических нагрузках потребность в магнии возрастает, что может привести к развитию дефицита магния в организме.\u003cbr /\u003e\nПри применении пиридоксина в высоких дозах (более 200 мг в сутки) в течение длительного времени (в течение нескольких месяцев или в некоторых случаях - лет) может развиться сенсорная аксональная нейропатия, которая сопровождается такими симптомами, как онемение, нарушения проприоцептивной чувствительности, тремор дистальных отделов конечностей и постепенно развивающаяся сенсорная атаксия (нарушения координации движений). Эти нарушения обычно являются обратимыми и проходят после прекращения приема витамина В6.\nПрепарат в форме таблеток предназначен только для взрослых и детей старше 6 лет. Для детей младшего возраста (старше 1 года) рекомендуется препарат в форме раствора для приема внутрь."}}]},{"id":12,"name":"Условия хранения","slug":"storage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Хранить при температуре не выше 30 С. Хранить в недоступном для детей месте."}}]},{"id":13,"name":"Срок годности","slug":"expiry_date","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"2 года. Препарат нельзя применять после истечения срока годности."}}]},{"id":14,"name":"Условия отпуска","slug":"release_condition","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Отпускают без рецепта."}}]}],"source":null},"description_toggle":false,"short_description":"Фармакодинамика: Магний является жизненно важным элементом, который находится во всех тканях организма и необходим для нормального функционирования клеток, участвует в большинстве реакций обмена веществ. В частности, он участвует в регуляции передачи нервных импульсов и в сокращении мышц. Организм получает магний вместе с пищей. Недостаток магния в организме может наблюдаться при нарушении режима питания (диета), при увеличении потребности в магнии или при дисбалансе поступления, метаболизма и выведения магния (например, при повышенной физической и умственной нагрузке, стрессе, в период беременности, при применении диуретиков) Пиридоксин (витамин В6) участвует во многих метаболических процессах, в регуляции метаболизма нервной системы. Витамин В6 улучшает всасывание магния из желудочно-кишечного тракта и его проникновение в клетки. Содержание магния в сыворотке: - от 12 до 17 мг/л (0,5 – 0,7 ммоль/л) - умеренная недостаточность магния; - ниже 12 мг/л (0,5 ммоль/л) - тяжелый дефицит магния. Фармакокинетика: Всасывание магния в желудочно-кишечном тракте составляет не более 50% от принимаемой внутрь дозы. 99% магния в организме находится внутри клеток. Примерно 2/3 внутриклеточного магния распределяется в костной ткани, 1/3 находится в гладкой и поперечно-полосатой мышечной ткани. 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