Индапамид Таблетки, 30 шт, 2.5 мг, для взрослых, покрытые пленочной оболочкой

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Применение препарата может стать причиной фетоплацентарной ишемии с риском замедления развития плода."}},{"type":"paragraph","data":{"text":"При необходимости применения препарата в период лактации грудное вскармливание необходимо прекратить."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Назначается внутрь независимо от приема пищи предпочтительнее в утренние часы. Препарат Индапамид Канон следует принимать не разжевывая запивая достаточным количеством жидкости."}},{"type":"paragraph","data":{"text":"При артериальной гипертензии препарат Индапамид Канон назначается в дозе 25 мг 1 раз в сутки. Увеличение дозы препарата не приводит к усилению антигипертензивного действия."}},{"type":"paragraph","data":{"text":"Если через 4-8 недель лечения не достигается желаемый терапевтический эффект дозу препарата повышать не рекомендуется (возрастает риск возникновения побочных эффектов без усиления антигипертензивного эффекта). Вместо этого в схему лечения рекомендуется включить другое гипотензивное средство не являющееся диуретиком. В случае начала лечения двумя гипотензивными средствами доза препарата Индапамид Канон остается равной 25 мг однократно утром."}},{"type":"paragraph","data":{"text":"При лечениипациентов пожилого возрастапороговое значение концентрации креатинина в плазме крови варьирует в зависимости от возраста массы тела и половой принадлежности.Пациентам пожилого возраста применение препарата Индапамид Канон возможно только при нормальной функции почек или при незначительных нарушениях функции почек."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Классификация частоты развития побочных эффектов согласно рекомендациям Всемирной Организации Здравоохранения: очень часто (≥1/10) часто (от ≥1/100 до <1/10) нечасто (от ≥1/1000 до <1/100) редко (от ≥1/10000 до <1/1000) очень редко (< 1/10000) включая отдельные сообщения; частота неизвестна - по имеющимся данным установить частоту возникновения не представляется возможным."}},{"type":"paragraph","data":{"text":"Со стороны сердечно-сосудистой системы: очень редко - ортостатическая гипотензия аритмия ощущение сердцебиения изменения па ЭКГ характерные для гипокалиемии."}},{"type":"paragraph","data":{"text":"Со стороны пищеварительного тракта: нечасто - рвота редко - снижение аппетита сухость во рту тошнота боль в животе диарея или запор; очень редко - панкреатит. У пациентов с печеночной недостаточностью возможно развитие печеночной энцефалопатии."}},{"type":"paragraph","data":{"text":"Со стороны центральной нервной системы: часто - головокружение головная боль повышенная возбудимость нарушения сна депрессия повышенная утомляемость недомогание астения напряженность раздражительность тревога парестезия спазмы мышц."}},{"type":"paragraph","data":{"text":"Со стороны дыхательной системы: часто - кашель фарингит синусит очень редко - ринит."}},{"type":"paragraph","data":{"text":"Со стороны мочеполовой системы: очень редко - почечная недостаточность."}},{"type":"paragraph","data":{"text":"Со стороны органов кроветворения: очень редко - тромбоцитопения лейкопения агранулоцитоз аплазия костного мозга гемолитическая анемия."}},{"type":"paragraph","data":{"text":"Со стороны кожных покровов и подкожно-жировой клетчатки: реакции повышенной чувствительности в основном дерматологические у пациентов с предрасположенностью к аллергическим и астматическим реакциям:"}},{"type":"paragraph","data":{"text":"часто - зуд макулопапулезная сыпь; нечасто - геморрагический васкулит; очень редко - ангионевротический отек и/или крапивница токсический эпидермальный некролиз синдром Стивенса-Джонсона; частота неизвестна - у пациентов с острой формой системной красной волчанки возможно ухудшение течения заболевания;"}},{"type":"paragraph","data":{"text":"Описаны отдельные случаи реакций фоточувствительности."}},{"type":"paragraph","data":{"text":"Со стороны лабораторных показателей: очень редко - гиперкальциемия гиперурикемия; частота неизвестна - гипохлоремия гипонатриемия гипергликемия гипокалиемия повышение концентрации азота мочевины крови гиперкреатининемия глюкозурия."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: связаны с нарушением водно-электролитного баланса - тошнота рвота выраженное снижение артериального давления головокружение судороги сонливость спутанность сознания полиурия или олигурия приводящие анурии (вследствие гиповолемии)."}},{"type":"paragraph","data":{"text":"Лечение: промывание желудка назначение активированного угля с последующим восстановлением водно-электролитного баланса симптоматическая терапия. Специфического антидота нет."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"При одновременном применении с препаратами лития индапамида приводит к повышению концентрации ионов лития в плазме крови (за счет снижения его выведения почками)."}},{"type":"paragraph","data":{"text":"При использовании одновременно с йодсодержащими контрастными средствами в высоких дозах индапамид повышает риск развития нарушений функции почек (за счет снижения объема циркулирующей крови (ОЦК)). Перед применением йодсодержащих контрастных веществ пациентам необходимо произвести коррекцию ОЦК."}},{"type":"paragraph","data":{"text":"Индапамид снижает эффект непрямых антикоагулянтов (производных кумарина или индандиона) за счет повышения концентрации факторов свертывания крови (в результате уменьшения ОЦК)."}},{"type":"paragraph","data":{"text":"Индапамид усиливает действие недеполяризующих миорелаксантов."}},{"type":"paragraph","data":{"text":"Риск развития гипокалиемии повышается при одновременном применении индапамида с диуретиками (\"петлевыми\" тиазидными) сердечными гликозидами глюкокортикостероидами минералокортикоидами тетракозактидом амфотерицином В (внутривенно) слабительными средствами."}},{"type":"paragraph","data":{"text":"При одновременном приеме индапамида с сердечными гликозидами повышается вероятность развития дигиталисной интоксикации; с препаратами кальция - гиперкальциемии; с метформином - усугубление молочнокислого ацидоза."}},{"type":"paragraph","data":{"text":"Астемизол эритромицин (внутривенно) пентамидин сультоприд терфенадин винкамин антиаритмические лекарственные средства IA класса (хинидин дизопирамид) и III класса (амиодарон бретилия тозилат) могут повышать риск развития аритмии типа \"пируэт\" за счет удлинения интервала QT."}},{"type":"paragraph","data":{"text":"Нестероидные противовоспалительные препараты глюкокортикостероиды тетракозактид адреностимуляторы снижают гипотензивный эффект индапамида баклофен - усиливает."}},{"type":"paragraph","data":{"text":"Ингибиторы ангиотензинпревращающего фермента при одновременном применении с индапамидом повышают риск развития ортостатической гипотензии и/или острой почечной недостаточности (особенно при наличии стеноза почечной артерии)."}},{"type":"paragraph","data":{"text":"Имипраминовые (трициклические) антидепрессанты и антипсихотические средства (нейролептики) усиливают гипотензивное действие индапамида и увеличивают вероятность возникновения ортостатической гипотензии."}},{"type":"paragraph","data":{"text":"Циклоспорин повышает риск развития гиперкреатининемии."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"В ходе терапии препаратом Индапамид Канон следует систематически контролировать в крови концентрацию ионов натрия магния (так как могут развиваться электролитные нарушения) глюкозы мочевой кислоты и остаточного азота уровень pH крови."}},{"type":"paragraph","data":{"text":"Пациентам принимающим на фоне применения препарата Индапамид Канон сердечные гликозиды слабительные средства пациентам с гиперальдостеронизмом а также лицам пожилого возраста показан тщательный контроль содержания ионов калия и креатинина в крови."}},{"type":"paragraph","data":{"text":"Первое измерение концентрации ионов калия в крови следует производить в течение первой недели лечения."}},{"type":"paragraph","data":{"text":"Наиболее тщательный контроль показан пациентам с циррозом печени (особенно с отеками или с асцитом) из-за риска развития метаболического алкалоза ухудшающего течение печеночной энцефалопатии; с ишемической болезнью сердца хронической сердечной недостаточностью а также пациентам пожилого возраста. К группе повышенного риска также относятся пациенты с удлинением интервала QT на электрокардиограмме (врожденным или развившемся на фоне какого-либо патологического процесса)."}},{"type":"paragraph","data":{"text":"Гиперкальциемия на фоне приема препарата Индапамид Канон может быть следствием ранее недиагностированного гиперпаратиреоза."}},{"type":"paragraph","data":{"text":"У некоторых пациентов может быть эффективна комбинация индапамида с калийсберегающими диуретиками однако при этом не исключена возможность развития гипо- или гиперкалиемии особенно у пациентов с сахарным диабетом и почечной недостаточностью."}},{"type":"paragraph","data":{"text":"У пациентов с сахарным диабетом следует контролировать концентрацию глюкозы в крови особенно при наличии гипокалиемии."}},{"type":"paragraph","data":{"text":"Значительная дегидратация на фоне терапии препарата Индапамид Канон может привести к развитию острой почечной недостаточности (вследствие снижения скорости клубочковой фильтрации)."}},{"type":"paragraph","data":{"text":"Пациентам необходимо компенсировать ОЦК в начале лечения и тщательно контролировать функцию почек."}},{"type":"paragraph","data":{"text":"Производные сульфонамидов могут обострять течение системной красной волчанки (необходимо учитывать при назначении препарата Индапамид Канон)."}},{"type":"paragraph","data":{"text":"Индапамид может давать положительные результаты при проведении допинг-контроля."}},{"type":"paragraph","data":{"text":"Эффективность и безопасность у детей до 18 лет не установлена."}},{"type":"paragraph","data":{"text":"На фоне приема тиазидных и тиазидоподобных диуретиков сообщалось о случаях развития реакций фоточувствительности (см. раздел \"Побочное действие\"). В случае развития реакций фоточувствительности на фоне приема препарата следует прекратить лечение. При необходимости продолжения терапии диуретиками рекомендуется защищать кожные покровы от воздействия солнечных лучей или искусственных ультрафиолетовых лучей."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"В начале лечения индапамидом следует воздержаться от вождения автотранспорта и занятий потенциально опасными видами деятельности требующими повышенной концентрации внимания и быстроты психомоторных реакций так как возможно развитие головокружения."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки покрытые пленочной оболочкой 25 мг."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В сухом защищенном от света месте при температуре не выше 25°С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Не применять по истечении срока годности."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Закрытое акционерное общество \"Канонфарма продакшн\" (ЗАО \"Канонфарма продакшн\")"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ЗАО \"Канонфарма продакшн\""}}]}],"source":null},"description_toggle":false,"short_description":"Антигипертензивный препарат, диуретик. Индапамид относится к производным сульфонамида, по фармакологическим свойствам близок к тиазидным диуретикам. Обладает умеренным салуретическим и диуретическим эффектами, которые обусловлены ингибированием реабсорбции ионов натрия, хлора и в меньшей степени ионов калия и магния в проксимальных канальцах почек и в кортикальном сегменте дистального канальца нефрона. Индапамид снижает тонус гладкой мускулатуры артерий и оказывает сосудорасширяющее действие, уменьшает ОПСС. Эти эффекты опосредованы снижением реактивности сосудистой стенки к норадреналину и ангиотензину II; увеличением синтеза простагландина Е2, обладающего сосудорасширяющей активностью; угнетением тока кальция в гладкомышечных клетках сосудов. Индапамид способствует уменьшению гипертрофии левого желудочка сердца. Оказывает антигипертензивное действие в дозах, не обладающих выраженным диуретическим эффектом. В терапевтических дозах не влияет на показатели липидного и углеводного обмена (в т.ч. у больных с сопутствующим сахарным диабетом). При систематическом применении терапевтический эффект индапамида развивается через 1-2 недели, достигает максимума к 8-12 неделе и сохраняется до 8 недель. После приема однократной дозы максимальный эффект отмечается через 24 ч.","substance":[{"id":21,"title":"Индапамид","title_latin":"Indapamidum","slug":"indapamid_21"}],"branding":null,"valid_for_quick_buy":false,"is_available_to_delivery":false,"comments":null,"image_alt":"Индапамид - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/79655/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/79655/share_default/"}},"diseases":[],"other_packages":[{"id":97526,"title":"Индапамид","subtitle":{"full":"Таблетки, 30 шт, 1,5 мг","short":"Таблетки, 30 шт, 1,5 мг","package":"30 шт, 1,5 мг"},"prescription":true,"catalog_section_id":122,"manufacturer":{"id":1179,"title":"Биохимик","slug":"biohimik_1179","logo":{"isTouch":{"retina":null,"default":null},"isFromTablet":{"retina":null,"default":null}}},"is_advert":false,"product_form":"Таблетки","slug":"97526-indapamid","attributes":{"count":"30 шт","dose":"1,5 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