Бронхообструктивный синдром при бронхиальной астме, бронхите, эмфиземе легких, сердечной астме (в основном для купирования приступов); гипертензия в малом круге кровообращения.
Купирование церебральных сосудистых кризов атеросклеротического происхождения и в составе комбинированной терапии при ишемических инсультах и хронической недостаточности мозгового ...
Бронхообструктивный синдром при бронхиальной астме, бронхите, эмфиземе легких, сердечной астме (в основном для купирования приступов); гипертензия в малом круге кровообращения.
Купирование церебральных сосудистых кризов атеросклеротического происхождения и в составе комбинированной терапии при ишемических инсультах и хронической недостаточности мозгового кровообращения для уменьшения внутричерепного давления и отека мозга.
Противопоказания
Выраженная артериальная гипотензия или гипертензия, пароксизмальная тахикардия, экстрасистолия, инфаркт миокарда с нарушениями сердечного ритма, эпилепсия, повышенная судорожная готовность, гипертрофическая обструктивная кардиомиопатия, тиреотоксикоз, отек легких, тяжелая коронарная недостаточность, печеночная и/или почечная недостаточность, геморрагический инсульт, кровоизлияние в сетчатку глаза, кровотечение в недавнем анамнезе, повышенная чувствительность к препарату.
С осторожностью
Беременность, период новорожденности, возраст старше 55 лет и неконтролируемый гипотиреоз (возможность кумуляции), сепсис, длительная гипертермия, гастроэзофагеальный рефлюкс, аденома предстательной железы.
Препарат назначают с осторожностью пациентам с выраженными нарушениями функции печени и почек, язвенной болезнью желудка и двенадцатиперстной кишки.
Способ применения и дозы
Эуфиллин назначают внутримышечно, глубоко в верхний квадрант ягодичной мышцы по 1 мл (240 мг) раствора.
Парентерально вводят эуфиллин до 3 раз в сутки, не более 14 дней.
Концентрация эуфиллина в сыворотке крови не должна превышать 20 мкг/мл.
Высшие дозы эуфиллина для взрослых внутримышечно: разовая - 0,5 г, суточная - 1,5 г. Высшие дозы для детей внутримышечно: разовая - 7 мг/кг, суточная - 15 мг/кг.
Коррекция режима дозирования может потребоваться при сердечной недостаточности, нарушениях функции печени, хроническом алкоголизме. У пациентов пожилого возраста может потребоваться уменьшение дозы (разовая доза - 0,3 г). Курящим пациентам рекомендуется увеличить дозу в связи с ускоренным выведением препарата из организма (разовая доза - 0,7 г).
Побочное действие
Со стороны пищеварительной системы: гастроэзофагеальный рефлюкс, гастралгия, тошнота, рвота, изжога, обострение язвенной болезни.
Со стороны нервной системы: головная боль, бессонница, возбуждение, тревожность, беспокойство, раздражительность, головокружение, тремор.
Со стороны сердечно-сосудистой системы: ощущение сердцебиения, аритмии, тахикардия, нарушение сердечного ритма, снижение артериального давления, кардиалгия, увеличение частоты приступов стенокардии.
Аллергические реакции: кожная сыпь, зуд кожи, лихорадка.
Местные реакции: реакции в месте введения - гиперемия, болезненность.
При передозировке наблюдается анорексия, диарея, тошнота, рвота, боли в эпигастральной области, желудочно-кишечное кровотечение, тахикардия, желудочковые аритмии, тремор, генерализованные судороги, гипервентиляция, резкое понижение артериального давления.
Лечение передозировки зависит от клинической картины, включает отмену препарата, стимуляцию выведения его из организма (форсированный диурез, гемосорбция, плазмосорбция, гемодиализ, перитонеальный диализ) и применение симптоматических средств.
Для купирования судорог применяется диазепам (в инъекциях). Нельзя применять барбитураты.
При выраженной интоксикации (содержание эуфиллина более 50 г/л) рекомендован гемодиализ.
Взаимодействие с другими лекарственными средствами
Эфедрин, бета-адреностимуляторы, кофеин и фуросемид усиливают действие препарата. В комбинации с фенобарбиталом, дифенином, рифампицином, изониазидом, карбамазепином или сульфинпиразоном наблюдается снижение эффективности эуфиллина, что может потребовать увеличение применяемых доз препарата.
Клиренс препарата снижается при назначении его в комбинации с антибиотиками группы макролидов, линкомицином, аллопуринолом, циметидином, изопреналином, бета-адреноблокаторами, что может потребовать снижения дозы.
Пероральные эстрогенсодержащие контрацептивы, противодиарейные препараты, кишечные сорбенты ослабляют, а Н2-гистаминоблокаторы, блокаторы медленных кальциевых каналов, мексилетин усиливают действие (связываются с ферментативной системой цитохрома Р450 и замедляют метаболизм эуфиллина). В случае применения в комбинации с эпоксацином и другими фторхинолинами дозу эуфиллина уменьшают. Препарат подавляет терапевтические эффекты карбоната лития и бета-адреноблокаторов.
Назначение бета-адреноблокаторов препятствует бронходилатирующему действию эуфиллина и может вызывать бронхоспазм. Эуфиллин потенцирует действие мочегонных средств за счет увеличения клубочковой фильтрации и уменьшения канальцевой реабсорбции. С осторожностью эуфиллин назначают одновременно с антикоагулянтами, с другими производными теофиллина или пурина.
Не рекомендуется применять эуфиллин со средствами возбуждающими центральную нервную систему (увеличивает нейротоксичность). Эуфиллин раствор для внутримышечного введения нельзя разводить или смешивать с другими растворами.
Особые указания
Под кожу растворы эуфиллина не вводят, так как они обладают местнораздражающим действием.
Влияние на способность управлять трансп. ср. и мех.:При лечении препаратом пациентам не рекомендуется в течение 24 ч выполнять работу, требующую быстрой реакции и связанную с риском, например, управлять транспортными средствами.
Форма выпуска
Раствор для в/в введения 2.4%
Прозрачная бесцветная или светло-желтого цвета жидкость.
Условия отпуска
По рецепту
Производитель
Новосибхимфарм
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для внутривенного введения 2,4%"}}]},{"id":3,"name":"Лекарственная форма","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ca href=\"https://www.eapteka.ru/goods/drugs/respiratory/asthma/?drug_form=rastvor_dlya_infuziy\"\u003eраствор для инфузий\u003c/a\u003e"}}]},{"id":4,"name":"Состав","slug":"ingredients","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eАктивное вещество:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"аминофиллин (эуфиллин для инъекций) (в пересчете на сухое вещество) - 240 мг "}},{"type":"paragraph","data":{"text":"\u003ci\u003eВспомогательные вещества\u003c/i\u003e:"}},{"type":"paragraph","data":{"text":" вода для инъекций - до 1мл."}}]},{"id":6,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ca href=\"https://www.eapteka.ru/goods/drugs/respiratory/asthma/?appointment=dlya_vzroslykh_po_naznacheniyu_vracha\"\u003eДля взрослых по назначению врача\u003c/a\u003e, \u003ca href=\"https://www.eapteka.ru/goods/drugs/respiratory/asthma/?appointment=detyam_starshe_14_let\"\u003eДетям старше 14 лет\u003c/a\u003e, \u003ca href=\"https://www.eapteka.ru/goods/drugs/respiratory/asthma/?appointment=detyam_po_naznacheniyu_vracha\"\u003eДетям по назначению врача\u003c/a\u003e, \u003ca href=\"https://www.eapteka.ru/goods/drugs/respiratory/asthma/?appointment=beremennym_po_naznacheniyu_vracha\"\u003eБеременным по назначению врача\u003c/a\u003e, \u003ca href=\"https://www.eapteka.ru/goods/drugs/respiratory/asthma/?appointment=kormyashchim_mamam_po_naznacheniyu_vracha\"\u003eКормящим мамам по назначению врача\u003c/a\u003e"}}]},{"id":7,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":"Бронходилатирующее средство"}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Бронхообструктивный синдром при бронхиальной астме, бронхите, эмфиземе легких, сердечной астме (в основном для купирования приступов); гипертензия в малом круге кровообращения."}},{"type":"paragraph","data":{"text":"Купирование церебральных сосудистых кризов атеросклеротического происхождения и в составе комбинированной терапии при ишемических инсультах и хронической недостаточности мозгового кровообращения для уменьшения внутричерепного давления и отека мозга."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Выраженная артериальная гипотензия или гипертензия, пароксизмальная тахикардия, экстрасистолия, инфаркт миокарда с нарушениями сердечного ритма, эпилепсия, повышенная судорожная готовность, гипертрофическая обструктивная кардиомиопатия, тиреотоксикоз, отек легких, тяжелая коронарная недостаточность, печеночная и/или почечная недостаточность, геморрагический инсульт, кровоизлияние в сетчатку глаза, кровотечение в недавнем анамнезе, повышенная чувствительность к препарату."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Беременность, период новорожденности, возраст старше 55 лет и неконтролируемый гипотиреоз (возможность кумуляции), сепсис, длительная гипертермия, гастроэзофагеальный рефлюкс, аденома предстательной железы."}},{"type":"paragraph","data":{"text":"Препарат назначают с осторожностью пациентам с выраженными нарушениями функции печени и почек, язвенной болезнью желудка и двенадцатиперстной кишки."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Эуфиллин назначают внутримышечно, глубоко в верхний квадрант ягодичной мышцы по 1 мл (240 мг) раствора."}},{"type":"paragraph","data":{"text":"Парентерально вводят эуфиллин до 3 раз в сутки, не более 14 дней."}},{"type":"paragraph","data":{"text":"Концентрация эуфиллина в сыворотке крови не должна превышать 20 мкг/мл."}},{"type":"paragraph","data":{"text":"Высшие дозы эуфиллина для взрослых внутримышечно: разовая - 0,5 г, суточная - 1,5 г. Высшие дозы для детей внутримышечно: разовая - 7 мг/кг, суточная - 15 мг/кг."}},{"type":"paragraph","data":{"text":"Коррекция режима дозирования может потребоваться при сердечной недостаточности, нарушениях функции печени, хроническом алкоголизме. У пациентов пожилого возраста может потребоваться уменьшение дозы (разовая доза - 0,3 г). Курящим пациентам рекомендуется увеличить дозу в связи с ускоренным выведением препарата из организма (разовая доза - 0,7 г)."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Со стороны пищеварительной системы: гастроэзофагеальный рефлюкс, гастралгия, тошнота, рвота, изжога, обострение язвенной болезни."}},{"type":"paragraph","data":{"text":"Со стороны нервной системы: головная боль, бессонница, возбуждение, тревожность, беспокойство, раздражительность, головокружение, тремор."}},{"type":"paragraph","data":{"text":"Со стороны сердечно-сосудистой системы: ощущение сердцебиения, аритмии, тахикардия, нарушение сердечного ритма, снижение артериального давления, кардиалгия, увеличение частоты приступов стенокардии."}},{"type":"paragraph","data":{"text":"Аллергические реакции: кожная сыпь, зуд кожи, лихорадка."}},{"type":"paragraph","data":{"text":"Местные реакции: реакции в месте введения - гиперемия, болезненность."}},{"type":"paragraph","data":{"text":"Прочие: боль в груди, тахипноэ, альбуминурия, гематурия, гипогликемия, повышенное потоотделение, усиление диуреза."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"При передозировке наблюдается анорексия, диарея, тошнота, рвота, боли в эпигастральной области, желудочно-кишечное кровотечение, тахикардия, желудочковые аритмии, тремор, генерализованные судороги, гипервентиляция, резкое понижение артериального давления."}},{"type":"paragraph","data":{"text":"Лечение передозировки зависит от клинической картины, включает отмену препарата, стимуляцию выведения его из организма (форсированный диурез, гемосорбция, плазмосорбция, гемодиализ, перитонеальный диализ) и применение симптоматических средств."}},{"type":"paragraph","data":{"text":"Для купирования судорог применяется \u003ca href=\"http://www.lsgeotar.ru/pharma_mnn/835.html?XFrom=www.lsgeotar.ru\" target=\"_blank\"\u003eдиазепам\u003c/a\u003e (в инъекциях). Нельзя применять барбитураты."}},{"type":"paragraph","data":{"text":"При выраженной интоксикации (содержание эуфиллина более 50 г/л) рекомендован гемодиализ."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Эфедрин, бета-адреностимуляторы, \u003ca href=\"http://www.lsgeotar.ru/pharma_mnn/1305.html?XFrom=www.lsgeotar.ru\" target=\"_blank\"\u003eкофеин\u003c/a\u003e и \u003ca href=\"http://www.lsgeotar.ru/pharma_mnn/2434.html?XFrom=www.lsgeotar.ru\" target=\"_blank\"\u003eфуросемид\u003c/a\u003e усиливают действие препарата. В комбинации с фенобарбиталом, дифенином, рифампицином, изониазидом, карбамазепином или сульфинпиразоном наблюдается снижение эффективности эуфиллина, что может потребовать увеличение применяемых доз препарата."}},{"type":"paragraph","data":{"text":"Клиренс препарата снижается при назначении его в комбинации с антибиотиками группы макролидов, линкомицином, аллопуринолом, циметидином, изопреналином, бета-адреноблокаторами, что может потребовать снижения дозы."}},{"type":"paragraph","data":{"text":"Пероральные эстрогенсодержащие контрацептивы, противодиарейные препараты, кишечные сорбенты ослабляют, а Н2-гистаминоблокаторы, блокаторы медленных кальциевых каналов, \u003ca href=\"http://www.lsgeotar.ru/pharma_mnn/1500.html?XFrom=www.lsgeotar.ru\" target=\"_blank\"\u003eмексилетин\u003c/a\u003e усиливают действие (связываются с ферментативной системой цитохрома Р450 и замедляют метаболизм эуфиллина). В случае применения в комбинации с эпоксацином и другими фторхинолинами дозу эуфиллина уменьшают. Препарат подавляет терапевтические эффекты карбоната лития и бета-адреноблокаторов."}},{"type":"paragraph","data":{"text":"Назначение бета-адреноблокаторов препятствует бронходилатирующему действию эуфиллина и может вызывать бронхоспазм. Эуфиллин потенцирует действие мочегонных средств за счет увеличения клубочковой фильтрации и уменьшения канальцевой реабсорбции. С осторожностью эуфиллин назначают одновременно с антикоагулянтами, с другими производными теофиллина или пурина."}},{"type":"paragraph","data":{"text":"Не рекомендуется применять эуфиллин со средствами возбуждающими центральную нервную систему (увеличивает нейротоксичность). Эуфиллин раствор для внутримышечного введения нельзя разводить или смешивать с другими растворами."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Под кожу растворы эуфиллина не вводят, так как они обладают местнораздражающим действием."}},{"type":"paragraph","data":{"text":"Влияние на способность управлять трансп. ср. и мех.:При лечении препаратом пациентам не рекомендуется в течение 24 ч выполнять работу, требующую быстрой реакции и связанную с риском, например, управлять транспортными средствами."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Раствор для в/в введения 2.4%"}},{"type":"paragraph","data":{"text":"Прозрачная бесцветная или светло-желтого цвета жидкость."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Новосибхимфарм"}}]}],"source":null},"description_toggle":false,"short_description":"Бронходилатирующее средство","substance":[{"id":793,"title":"Аминофиллин","title_latin":"Aminophyllinum","slug":"aminofillin_793"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":null,"image_alt":"Эуфиллин - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/70518/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/70518/share_default/"}},"diseases":[{"id":"560","title":"Апноэ во сне (нарушения со стороны дыхательного центра)","slug":"560-apnoe_vo_sne_narusheniya_so_storony_dyhatelnogo_tsentra"},{"id":"731","title":"Первичная легочная гипертензия","slug":"731-pervichnaya_legochnaya_gipertenziya"},{"id":"732","title":"Легочно-сердечная недостаточность 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