Ондансетрон Раствор, пачка, 5 шт, 2 мл, 2 мг / мл, для инъекций

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внутривенное введение 4 мг препарата."}},{"type":"paragraph","data":{"text":"Внутримышечно в один и тот же участок тела ондансетрон может быть введен в дозе не превышающей 4 мг!"}},{"type":"paragraph","data":{"text":"Детям для предотвращения послеоперационной тошноты и рвоты ондансетрон применяется парентерально в разовой дозе 01 мг/кг (максимально до 4 мг) в виде медленной внутривенной инъекции до или после анестезии."}},{"type":"paragraph","data":{"text":"Для лечения развившейся послеоперационной тошноты и рвоты у детей рекомендуется медленное внутривенное введение разовой дозы препарата 01 мг/кг (максимально до 4 мг)."}},{"type":"paragraph","data":{"text":"В отношении предотвращения и лечения послеоперационной тошноты и рвоты у детей в возрасте до 2 лет достаточного опыта нет."}},{"type":"paragraph","data":{"text":"Пожилые больные"}},{"type":"paragraph","data":{"text":"Изменения дозировки не требуется."}},{"type":"paragraph","data":{"text":"Больные с поражениями почек и 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анафилаксия."}},{"type":"paragraph","data":{"text":"Со стороны пищеварительной системы: икота сухость во рту диарея запор иногда бессимптомное преходящее повышение уровня аминотрансфераз в сыворотке крови."}},{"type":"paragraph","data":{"text":"Со стороны сердечнососудистой системы: боли в грудной клетке в ряде случаев с депрессией сегмента ST аритмии брадикардия снижение артериального давления."}},{"type":"paragraph","data":{"text":"Со стороны нервной системы: головная боль головокружение спонтанные двигательные расстройства и судороги."}},{"type":"paragraph","data":{"text":"Местные реакции: боль жжение и покраснение в месте введения"}},{"type":"paragraph","data":{"text":"Прочие: прилив крови к лицу чувство жара временное нарушение остроты зрения гипокалиемия"}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"В случаях предполагаемой передозировки показана симптоматическая терапия."}},{"type":"paragraph","data":{"text":"Специфический антидот не известен."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Так как ондансетрон метаболизируется ферментной системой (цитохром Р450) печени требуется осторожность при совместном применении:"}},{"type":"paragraph","data":{"text":"- с ферментативными индукторами Р450 (CYP2D6 и CYP3A) (барбитураты карбамазепин каризопродол глютетимид гризеофульвин динитроген оксид папаверин фенилбутазон фенитоин (вероятно и другие гидантоины) рифампицин толбутамид);"}},{"type":"paragraph","data":{"text":"- с ингибиторами ферментов Р450 (CYP2D6 и CYP3A) (аллопуринол макролидные антибиотики антидепрессанты - ингибиторы МАО хлорамфеникол циметидин пероральные контрацептивы содержащие эстрогены дилтиазем дисульфирам вальпроевая кислота вальпроат натрия эритромицин флуконазол фторхинолоны изониазид кетоконазол ловастатин метронидазол омепразол пропранолол хинидин хинин верапамил)."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"У пациентов у которых ранее при применении других селективных антагонистов 5НТз- рецепторов наблюдались реакции повышенной чувствительности при применении ондансетрона также могут развиться аналогичные реакции."}},{"type":"paragraph","data":{"text":"Так как ондансетрон может вызывать запор больные с признаками непроходимости кишечника после применения препарата требуют регулярного наблюдения."}},{"type":"paragraph","data":{"text":"Инфузионный раствор должен быть приготовлен непосредственно перед использованием. В случае необходимости готовый инфузионный раствор может храниться до использования максимально в течение 24 часов при температуре 2-8°С."}},{"type":"paragraph","data":{"text":"Во время проведения инфузии защиты от света не требуется; разведенный инъекционный раствор сохраняет свою стабильность как минимум в течение 24 часов при естественном свете или нормальном освещении."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Сведения отсутствуют."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Раствор для внутривенного и внутримышечного введения 2 мг/мл. По 2 мл или 4 мл в ампулы нейтрального стекла."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"При температуре от 15°Сдо25°С в защищенном от света месте."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года"}},{"type":"paragraph","data":{"text":"Не использовать после истечения срока годности указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Акционерное общество \"Новосибхимфарм\" (АО \"Новосибхимфарм\"), 630028, г. Новосибирск, ул. Декабристов, д. 275, Россия"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"АО \"Новосибхимфарм\""}}]}],"source":null},"description_toggle":false,"short_description":"Ондансетрон является селективным антагонистом рецепторов 5НТз (серотонина). Лекарственные средства для цитостатической химиотерапии и радиотерапия могут вызвать повышение уровня серотонина который путем активации вагусных афферентных волокон содержащих рецепторы 5- НТз вызывает рвотный рефлекс. Ондансетрон тормозит появление рвотного рефлекса путем блокады рецепторов 5-НТз на уровне нейронов как центральной так и периферической нервной системы. По-видимому на этом механизме действия основано предупреждение и лечение послеоперационной и вызванной цитостатической химио- и радио-терапией рвоты и тошноты. При внутримышечном введении пиковая концентрация в плазме достигается в течение 10 минут. Препарат подвергается метаболизму в печени. Связывание с белками плазмы составляет 70-76%. С мочой в неизмененном виде выделяется менее 5% препарата. Период полувыведения составляет около 3 ч. у пожилых больных может достигать 5 часов а при выраженной печеночной недостаточности - 15-20 часов. При поражении почек (почечный клиренс меньше 15 мл/мин) период полувыведения увеличивается на 4-5 часов но это увеличение не имеет клинического значения.","substance":[],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":null,"image_alt":"Ондансетрон - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/225042/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/225042/share_default/"}},"diseases":[{"id":"1251","title":"Тошнота и рвота","slug":"1251-toshnota_i_rvota"}],"other_packages":[{"id":97960,"title":"Ондансетрон","subtitle":{"full":"Раствор, 5 шт, 4 мл","short":"Раствор, 5 шт, 4 мл","package":"5 шт, 4 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