Анафилактические и анафилактоидные реакции (в комплексной терапии); отек Квинке сывороточная болезнь другие острые аллергические состояния (в комплексной терапии и в тех случаях когда использование таблетированной формы невозможно).
Противопоказания
Повышенная чувствительность дифенгидрамину закрытоугольная глаукома гиперплазия предстательной железы язвенная болезнь желудка и двенадцатиперстной кишки осложненная стенозом стеноз шейки мочевого пузыря эпилепсия детский возраст до 7 месяцев. Из-за риска развития локального некроза нельзя использовать дифенгидрамин в качестве местного анестетика.
Инструкция
Торговое название препарата
Димедрол
Лекарственная форма
Раствор для внутривенного и внутримышечного введения
Состав
Активное вещество:
Дифенгидрамина гидрохлорид - 10,0 мг
Вспомогательное вещество:
Вода для инъекций - до 1,0 мл.
Описание
Прозрачная бесцветная жидкость.
Фармакотерапевтическая группа
Противоаллергическое средство (Н1-гистаминовых рецепторов блокатор)
Фармакологические свойства
Фармакодинамика:
Блокатор H1-гистаминовых рецепторов первого поколения. Действие на центральную нервную систему обусловлено блокадой Нз-гистаминовых рецепторов мозга и угнетением центральных холинергических структур. Снимает спазм гладкой мускулатуры (непосредственное действие) уменьшает проницаемость капилляров предупреждает и ослабляет аллергические реакции обладает местноанестезирующим противорвотным седативным эффектами умеренно блокирует холинорецепторы вегетативных ганглиев оказывает снотворное действие. Антагонизм с гистамином проявляется в большей степени по отношению к местным сосудистым реакциям при воспалении и аллергии чем к системным т.е. снижению артериального давления. Однако при парентеральном введении пациентам с дефицитом объема циркулирующей крови возможно снижение артериального давления и усиление имеющейся гипотонии вследствие ганглиоблокирующего действия. У людей с локальными повреждениями мозга и эпилепсией активирует (даже в низких дозах) эпилептические разряды на электроэнцефалограмме и может провоцировать эпилептический приступ.Действие развивается в течение нескольких минут длительность - до 12 часов.
Фармакокинетика:
Связь с белками плазмы - 98-99%. Проникает через гематоэнцефалический барьер. Метаболизируется главным образом в печени частично - в легких и почках. Выводится из тканей через 6 ч. Период полувыведения - 4-10 ч. В течение суток полностью выводится почками в виде метаболитов конъюгированных с глюкуроновой кислотой. Существенные количества выводятся с молоком и могут вызывать седативный эффект у детей грудного возраста (может наблюдаться парадоксальная реакция характеризующаяся чрезмерной возбудимостью).
Показания к применению
Анафилактические и анафилактоидные реакции (в комплексной терапии); отек Квинке сывороточная болезнь другие острые аллергические состояния (в комплексной терапии и в тех случаях когда использование таблетированной формы невозможно).
Противопоказания
Повышенная чувствительность дифенгидрамину закрытоугольная глаукома гиперплазия предстательной железы язвенная болезнь желудка и двенадцатиперстной кишки осложненная стенозом стеноз шейки мочевого пузыря эпилепсия детский возраст до 7 месяцев. Из-за риска развития локального некроза нельзя использовать дифенгидрамин в качестве местного анестетика.
С осторожностью
С осторожностью - бронхиальная астма беременность период лактации.
Применение при беременности и в период грудного вскармливания
С осторожностью под строгим контролем врача во время беременности (адекватных и строго контролируемых исследований у беременных женщин не проведено). В связи с тем что существенные количества выводятся с грудным молоком и могут вызывать седативный эффект у детей грудного возраста (может наблюдаться парадоксальная реакция характеризующаяся чрезмерной возбудимостью) на время лечения следует прекратить грудное вскармливание.
Способ применения и дозы
Внутривенно или внутримышечно.
Для взрослых и детей старше 14 лет внутривенно или внутримышечно 1-5 мл (10-50 мг) 1% раствора (10 мг/мл) 1-3 раза в день; максимальная суточная доза - 200 мг.
Для детей в возрасте от 7 месяцев до 12 месяцев по 03-05 мл (3-5 мг) от 1 года до 3 лет по 05-1 мл (5-10 мг) от 4 до 6 лет по 1-15 мл (10-15 мг) от 7 до 14 лет по 15-3 мл (15- 30 мг) при необходимости каждые 6-8 часов.
Побочное действие
Со стороны нервной системы:
сонливость слабость снижение скорости психомоторной реакции нарушения координации движений головокружение тремор раздражительность эйфория возбуждение (особенно у детей) бессонница.
Со стороны пищеварительной системы:
тошнота рвота дискомфорт в эпигастральной области анорексия.
снижение артериального давления тахикардия экстрасистолия.
Со стороны мочевыделительной системы:
нарушения мочеиспускания.
Аллергические реакции:
крапивница фоточувствительность кожная сыпь зуд.
Передозировка
Симптомы: угнетение или возбуждение (особенно у детей) функций центральной нервной системы депрессия. Другие симптомы передозировки напоминают действие атропина: расширенные зрачки сухость во рту расстройство функций желудочно-кишечного тракта. Лечение: специального антидота не существует. Промывание желудка. Контроль
артериального давления. Симптоматическая терапия включает препараты повышающие артериальное давление кислород введение плазмозамещающих жидкостей внутривенно. Нельзя использовать адреналин и аналептики.
Взаимодействие с другими лекарственными средствами
Усиливает действие этанола и лекарственных средств (ЛС) угнетающих центральную нервную систему.
Антагонистическое взаимодействие отмечается при совместном назначении с психостимуляторами.
Снижает эффективность апоморфина как рвотного ЛС при лечении отравления.
Усиливает антихолинергические эффекты ЛС с м-холиноблокирующей активностью.
Особые указания
В период лечения необходимо воздержаться от занятий потенциально опасными видами деятельности требующими повышенной концентрации внимания и быстроты психомоторных реакций (вождение автомобиля и пр.).
Во время лечения дифенгидрамином следует избегать УФ-излучения и употребления этанола.
Влияние на способность управлять автомобилем и движущимися механизмами
Дифенгидрамин вызывает сонливость и нарушает быстроту реакции вследствие чего препарат нельзя применять при управлении автомобилем и работе с потенциально опасной техникой.
Форма выпуска
Раствор для внутривенного и внутримышечного введения 10 мг/мл.
Условия хранения
В защищенном от света месте при температуре не выше 30 °С. Не замораживать.
Хранить в местах недоступных для детей.
Срок годности
5 лет. Не использовать после истечения срока годности.
Условия отпуска
По рецепту
Производитель
Общество с ограниченной ответственностью "Озон Фарм" (ООО "Озон Фарм"), 445351, Самарская обл., г. Жигулевск, ул. Гидростроителей, д. 6 А, Россия
Организация, принимающая претензии потребителей
ООО "Атолл"
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
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Действие на центральную нервную систему обусловлено блокадой Нз-гистаминовых рецепторов мозга и угнетением центральных холинергических структур. Снимает спазм гладкой мускулатуры (непосредственное действие) уменьшает проницаемость капилляров предупреждает и ослабляет аллергические реакции обладает местноанестезирующим противорвотным седативным эффектами умеренно блокирует холинорецепторы вегетативных ганглиев оказывает снотворное действие. Антагонизм с гистамином проявляется в большей степени по отношению к местным сосудистым реакциям при воспалении и аллергии чем к системным т.е. снижению артериального давления. Однако при парентеральном введении пациентам с дефицитом объема циркулирующей крови возможно снижение артериального давления и усиление имеющейся гипотонии вследствие ганглиоблокирующего действия. У людей с локальными повреждениями мозга и эпилепсией активирует (даже в низких дозах) эпилептические разряды на электроэнцефалограмме и может провоцировать эпилептический приступ.Действие развивается в течение нескольких минут длительность - до 12 часов."}},{"type":"header","data":{"text":"Фармакокинетика:","level":3}},{"type":"paragraph","data":{"text":"Связь с белками плазмы - 98-99%. Проникает через гематоэнцефалический барьер. Метаболизируется главным образом в печени частично - в легких и почках. Выводится из тканей через 6 ч. Период полувыведения - 4-10 ч. В течение суток полностью выводится почками в виде метаболитов конъюгированных с глюкуроновой кислотой. Существенные количества выводятся с молоком и могут вызывать седативный эффект у детей грудного возраста (может наблюдаться парадоксальная реакция характеризующаяся чрезмерной возбудимостью)."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Анафилактические и анафилактоидные реакции (в комплексной терапии); отек Квинке сывороточная болезнь другие острые аллергические состояния (в комплексной терапии и в тех случаях когда использование таблетированной формы невозможно)."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность дифенгидрамину закрытоугольная глаукома гиперплазия предстательной железы язвенная болезнь желудка и двенадцатиперстной кишки осложненная стенозом стеноз шейки мочевого пузыря эпилепсия детский возраст до 7 месяцев. Из-за риска развития локального некроза нельзя использовать дифенгидрамин в качестве местного анестетика."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"С осторожностью - бронхиальная астма беременность период лактации."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"С осторожностью под строгим контролем врача во время беременности (адекватных и строго контролируемых исследований у беременных женщин не проведено). В связи с тем что существенные количества выводятся с грудным молоком и могут вызывать седативный эффект у детей грудного возраста (может наблюдаться парадоксальная реакция характеризующаяся чрезмерной возбудимостью) на время лечения следует прекратить грудное вскармливание."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутривенно или внутримышечно."}},{"type":"paragraph","data":{"text":"Для взрослых и детей старше 14 лет внутривенно или внутримышечно 1-5 мл (10-50 мг) 1% раствора (10 мг/мл) 1-3 раза в день; максимальная суточная доза - 200 мг."}},{"type":"paragraph","data":{"text":"Для детей в возрасте от 7 месяцев до 12 месяцев по 03-05 мл (3-5 мг) от 1 года до 3 лет по 05-1 мл (5-10 мг) от 4 до 6 лет по 1-15 мл (10-15 мг) от 7 до 14 лет по 15-3 мл (15- 30 мг) при необходимости каждые 6-8 часов."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Со стороны нервной системы:"}},{"type":"paragraph","data":{"text":"сонливость слабость снижение скорости психомоторной реакции нарушения координации движений головокружение тремор раздражительность эйфория возбуждение (особенно у детей) бессонница."}},{"type":"paragraph","data":{"text":"Со стороны пищеварительной системы:"}},{"type":"paragraph","data":{"text":"тошнота рвота дискомфорт в эпигастральной области анорексия."}},{"type":"paragraph","data":{"text":"Со стороны дыхательной системы:"}},{"type":"paragraph","data":{"text":"сухость слизистой оболочки полости рта носа бронхов (повышение вязкости мокроты)."}},{"type":"paragraph","data":{"text":"Со стороны органов кроветворения:"}},{"type":"paragraph","data":{"text":"гемолитическая анемия тромбоцитопения агранулоцитоз."}},{"type":"paragraph","data":{"text":"Со стороны сердечно-сосудистой системы:"}},{"type":"paragraph","data":{"text":"снижение артериального давления тахикардия экстрасистолия."}},{"type":"paragraph","data":{"text":"Со стороны мочевыделительной системы:"}},{"type":"paragraph","data":{"text":"нарушения мочеиспускания."}},{"type":"paragraph","data":{"text":"Аллергические реакции:"}},{"type":"paragraph","data":{"text":"крапивница фоточувствительность кожная сыпь зуд."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: угнетение или возбуждение (особенно у детей) функций центральной нервной системы депрессия. Другие симптомы передозировки напоминают действие атропина: расширенные зрачки сухость во рту расстройство функций желудочно-кишечного тракта. Лечение: специального антидота не существует. Промывание желудка. Контроль"}},{"type":"paragraph","data":{"text":"артериального давления. Симптоматическая терапия включает препараты повышающие артериальное давление кислород введение плазмозамещающих жидкостей внутривенно. Нельзя использовать адреналин и аналептики."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Усиливает действие этанола и лекарственных средств (ЛС) угнетающих центральную нервную систему."}},{"type":"paragraph","data":{"text":"Ингибиторы моноаминоксидазы (МАО) усиливают антихолинергическую активность дифенгидрамина."}},{"type":"paragraph","data":{"text":"Антагонистическое взаимодействие отмечается при совместном назначении с психостимуляторами."}},{"type":"paragraph","data":{"text":"Снижает эффективность апоморфина как рвотного ЛС при лечении отравления."}},{"type":"paragraph","data":{"text":"Усиливает антихолинергические эффекты ЛС с м-холиноблокирующей активностью."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"В период лечения необходимо воздержаться от занятий потенциально опасными видами деятельности требующими повышенной концентрации внимания и быстроты психомоторных реакций (вождение автомобиля и пр.)."}},{"type":"paragraph","data":{"text":"Во время лечения дифенгидрамином следует избегать УФ-излучения и употребления этанола."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Дифенгидрамин вызывает сонливость и нарушает быстроту реакции вследствие чего препарат нельзя применять при управлении автомобилем и работе с потенциально опасной техникой."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Раствор для внутривенного и внутримышечного введения 10 мг/мл."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищенном от света месте при температуре не выше 30 °С. Не замораживать."}},{"type":"paragraph","data":{"text":"Хранить в местах недоступных для детей."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"5 лет. Не использовать после истечения срока годности."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Общество с ограниченной ответственностью \"Озон Фарм\" (ООО \"Озон Фарм\"), 445351, Самарская обл., г. Жигулевск, ул. Гидростроителей, д. 6 А, Россия"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ООО \"Атолл\""}}]}],"source":null},"description_toggle":false,"short_description":"Блокатор H1-гистаминовых рецепторов первого поколения. 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У людей с локальными повреждениями мозга и эпилепсией активирует (даже в низких дозах) эпилептические разряды на электроэнцефалограмме и может провоцировать эпилептический приступ.Действие развивается в течение нескольких минут длительность - до 12 часов. Связь с белками плазмы - 98-99%. Проникает через гематоэнцефалический барьер. Метаболизируется главным образом в печени частично - в легких и почках. Выводится из тканей через 6 ч. Период полувыведения - 4-10 ч. В течение суток полностью выводится почками в виде метаболитов конъюгированных с глюкуроновой кислотой. 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