Точный механизм действия аллергена при проведении аллерген с... Инструкция
Показания к применению
Аллерген специфическая иммунотерапия (АСИТ) пациентов с аллергической реакцией 1 типа (IgE опосредованная), страдающих ринитом, конъюнктивитом, легкой или среднетяжелой формой бронхиальной астмы сезонного характера, имеющих повышенную чувствительность к клещам домашней пыли.
Иммунотерапию можно проводить взрослым и детям с 5-летнего возраста. ...
Экстракт аллергена из клещей Dermatophagoides pteronyssinus,
Dermatophagoides farinae в равных пропорциях 300 ИР/мл;
Вспомогательные вещества:
натрия хлорид,
глицерол,
маннитол,
вода очищенная.
Фармакологические свойства
Точный механизм действия аллергена при проведении аллерген специфической иммунотерапии (АСИТ) полностью не изучен. Доказанными являются следующие биологические изменения:
появление специфических антител (IgG4), играющих роль «блокирующих антител»;
снижение уровня специфических IgE в плазме;
снижение реактивности клеток, участвующих в аллергической реакции;
повышение активности взаимодействия между Th2 и Th1, приводящее к положительному изменению продукции цитокинов (снижение IL-4 и повышение -интерферона), регулирующих продукцию IgE.
Проведение АСИТ также тормозит развитие как ранней, так и поздней фазы немедленной аллергической реакции.
Показания к применению
Аллерген специфическая иммунотерапия (АСИТ) пациентов с аллергической реакцией 1 типа (IgE опосредованная), страдающих ринитом, конъюнктивитом, легкой или среднетяжелой формой бронхиальной астмы сезонного характера, имеющих повышенную чувствительность к клещам домашней пыли.
Иммунотерапию можно проводить взрослым и детям с 5-летнего возраста.
Противопоказания
Повышенная чувствительность к одному из вспомогательных веществ (см. перечень вспомогательных веществ);
Терапия бета-адреноблокаторами (включая местную терапию в офтальмологии);
Тяжелые воспалительные заболевания слизистой оболочки рта, например, эрозивно-язвенная форма красного плоского лишая, микозы.
Способ применения и дозы
Эффективность АСИТ выше в тех случаях, когда лечение начато на ранних сроках заболевания.
Дозировка препарата и схема его применения одинакова для всех возрастов, но может быть изменена в зависимости от индивидуальной реактивности пациента.
Лечащий врач корректирует дозировку и схему лечения в соответствии с возможными симптоматическими изменениями у пациента и индивидуальной реакцией на препарат.
Лечение состоит из двух этапов: начальной и поддерживающей терапии.
1. Начальную терапию начинают с ежедневного приема препарата концентрации 10 ИР/мл (голубая крышка флакона) с одного нажатия на дозатор и постепенно увеличивают ежедневную дозировку до 10 нажатий. Одно нажатие на дозатор составляет около 0,1 мл препарата.
Далее переходят к ежедневному приему препарата концентрации 300 ИР/мл (фиолетовая крышка флакона), начиная с одного нажатия и постепенно увеличивая количество нажатий до оптимального (хорошо переносимого пациентом). Первый этап может продолжаться 9 - 21 день. В течение этого периода достигается максимальная дозировка, индивидуальная для каждого пациента (от 4 до 8 нажатий ежедневно препарата концентрации 300 ИР/мл), после чего переходят ко второму этапу.
2. Поддерживающая терапия постоянной дозой с использованием флакона концентрации 300 ИР/мл.
Оптимальную дозу, достигнутую на первом этапе начальной терапии, продолжают принимать на втором этапе поддерживающей терапии.
Рекомендуемая схема приема: от 4 до 8 нажатий на дозатор ежедневно или 8 нажатий 3 раза в неделю.
Длительность лечения
Аллерген специфическую иммунотерапию рекомендуется проводить в течение 3-5 лет. Если после проведения лечения улучшение не наступило, следует пересмотреть целесообразность проведения АСИТ.
Приём препарата:
Перед приемом препарата убедитесь, что: не истек срок годности и используется флакон нужной концентрации.
Препарат рекомендуется принимать утром перед завтраком.
Препарат следует капнуть непосредственно под язык и подержать в течение 2 минут, после чего проглотить.
Детям рекомендуется применять препарат с помощью взрослых.
Для обеспечения безопасности и сохранности препарата флаконы герметично закрыты пластиковыми крышками и завальцованы алюминиевыми колпачками.
При первом использовании откройте флакон следующим образом:
Оторвите у флакона цветную пластиковую крышку.
Потяните за металлическое кольцо, снимая до конца алюминиевый колпачок.
Извлеките резиновую пробку.
Извлеките из пластиковой упаковки дозатор. Крепко взяв флакон одной рукой, другой рукой, сильно нажимая на верхнюю плоскую поверхность дозатора, защелкните его на флаконе.
Уберите защитное кольцо оранжевого цвета.
Сильно нажмите на дозатор 5 раз над раковиной. После пяти нажатий дозатор выдает необходимое количество препарата.
Поместите наконечник дозатора в рот под язык. Сильно нажмите на дозатор столько раз, сколько предписал Вам врач, чтобы получить нужное количество препарата. Подержите жидкость под языком в течение 2 минут.
После использования протрите наконечник дозатора и наденьте защитное кольцо.
При последующем применении следует убрать защитное кольцо и выполнить пункты 7 и 8.
Перерыв в приеме препарата
При длительном пропуске приема препарата необходимо проконсультироваться с лечащим врачом.
Если пропуск в приеме препарата составил менее одной недели, рекомендуется продолжать лечение без изменений.
Если пропуск в приеме препарата составил более одной недели на начальном этапе или при поддерживающей терапии, рекомендуется провести лечение снова с одного нажатия на дозатор, используя ту же самую концентрацию препарата (как до перерыва), и затем увеличить количество нажатий, согласно схеме начального этапа терапии до оптимальной хорошо переносимой дозы.
Форма выпуска
Капли.
Условия хранения
Хранить и транспортировать при температуре от 2 до 8°С.
Хранить в недоступном для детей месте.
Условия отпуска
По рецепту.
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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"}},{"type":"paragraph","data":{"text":"Далее переходят к ежедневному приему препарата концентрации 300 ИР/мл (фиолетовая крышка флакона), начиная с одного нажатия и постепенно увеличивая количество нажатий до оптимального (хорошо переносимого пациентом). Первый этап может продолжаться 9 - 21 день. В течение этого периода достигается максимальная дозировка, индивидуальная для каждого пациента (от 4 до 8 нажатий ежедневно препарата концентрации 300 ИР/мл), после чего переходят ко второму этапу. "}},{"type":"paragraph","data":{"text":" 2. Поддерживающая терапия постоянной дозой с использованием флакона концентрации 300 ИР/мл. "}},{"type":"paragraph","data":{"text":"Оптимальную дозу, достигнутую на первом этапе начальной терапии, продолжают принимать на втором этапе поддерживающей терапии. "}},{"type":"paragraph","data":{"text":"Рекомендуемая схема приема: от 4 до 8 нажатий на дозатор ежедневно или 8 нажатий 3 раза в неделю. 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"}},{"type":"paragraph","data":{"text":"Для обеспечения безопасности и сохранности препарата флаконы герметично закрыты пластиковыми крышками и завальцованы алюминиевыми колпачками. "}},{"type":"paragraph","data":{"text":"При первом использовании откройте флакон следующим образом: "}},{"type":"list","data":{"style":"ordered","items":["Оторвите у флакона цветную пластиковую крышку.","Потяните за металлическое кольцо, снимая до конца алюминиевый колпачок.","Извлеките резиновую пробку.","Извлеките из пластиковой упаковки дозатор. Крепко взяв флакон одной рукой, другой рукой, сильно нажимая на верхнюю плоскую поверхность дозатора, защелкните его на флаконе.","Уберите защитное кольцо оранжевого цвета.","Сильно нажмите на дозатор 5 раз над раковиной. После пяти нажатий дозатор выдает необходимое количество препарата.","Поместите наконечник дозатора в рот под язык. Сильно нажмите на дозатор столько раз, сколько предписал Вам врач, чтобы получить нужное количество препарата. 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