Будесонид - глюкокортикостероид, который после ингаляции ока... Инструкция
Показания к применению
Бронхиальная астма (недостаточно контролируемая приёмом ингаляционных глюкокортикостероидов и бета β2-адреностимуляторов короткого действия или адекватно контролируемая ингаляционными ГКС и β2-адреностимуляторами длительного действия). ХОБЛ (симптоматическая терапия у пациентов с тяжелой хронической обструктивной болезнью легких и с повторяющимися обострениями ...
Повышенная чувствительность к будесониду, формотеролу или ингалируемой лактозе. Детский возраст до 18-ти лет.
Инструкция
Состав
Формотерол, будесонид, моногидрат лактозы.
Описание
Препарат Дуоресп Спиромакс содержит формотерол и будесонид, которые имеют разные механизмы действия и проявляют аддитивный эффект в отношении снижения частоты обострений бронхиальной астмы и хронической обструктивной болезни легких (ХОБЛ). Особые свойства будесонида и формотерола дают возможность использовать их комбинацию одновременно в качестве поддерживающей терапии и для купирования приступов, или как поддерживающую терапию бронхиальной астмы.
Фармакологические свойства
Будесонид - глюкокортикостероид, который после ингаляции оказывает быстрое (в течение нескольких часов) и дозозависимое противовоспалительное действие на дыхательные пути, снижая выраженность симптомов и частоту обострений бронхиальной астмы. При назначении ингаляционного будесонида отмечается меньшая частота возникновения серьезных нежелательных эффектов, чем при использовании системных глюкокортикостероидов. Уменьшает выраженность отека слизистой бронхов, продукцию слизи, образование мокроты и гиперреактивность дыхательных путей. Точный механизм противовоспалительного действия глюкокортикостероидов неизвестен. Формотерол - селективный агонист β2-адренсргических рецепторов, который после ингаляции вызывает быстрое и длительное расслабление гладкой мускулатуры бронхов у пациентов с обратимой обструкцией дыхательных путей. Бронхолитическое дозозависимое действие наступает быстро, в течение 1-3 минут после ингаляции и сохраняется в течение как минимум 12 часов после приема разовой дозы. Добавление формотерола к будесониду уменьшает выраженность симптомов бронхиальной астмы, улучшает функцию бронхов и уменьшает частоту обострений заболевания.
Показания к применению
Бронхиальная астма (недостаточно контролируемая приёмом ингаляционных глюкокортикостероидов и бета β2-адреностимуляторов короткого действия или адекватно контролируемая ингаляционными ГКС и β2-адреностимуляторами длительного действия). ХОБЛ (симптоматическая терапия у пациентов с тяжелой хронической обструктивной болезнью легких и с повторяющимися обострениями в анамнезе, которые имеют выраженные симптомы заболевания, несмотря на терапию бронходилататорами длительного действия).
Противопоказания
Повышенная чувствительность к будесониду, формотеролу или ингалируемой лактозе. Детский возраст до 18-ти лет.
Применение при беременности и в период грудного вскармливания
С осторожностью.
Способ применения и дозы
Бронхиальная астма: препарат не предназначен для первоначального лечения бронхиальной астмы интермиттирующего и легкого персистирующего течения. Подбор дозы препаратов, входящих в состав препарата ДуоРесп Спиромакс, происходит индивидуально и в зависимости от степени тяжести заболевания. Это необходимо учитывать не только при начале лечения комбинированными препаратами, но и при изменении поддерживающей дозы препарата. ХОБЛ: 2 ингаляции препарата два раза в день.
Побочное действие
Нарушения со стороны иммунной системы: редко - реакции гиперчувствительности немедленного и замедленного типа (экзантема, крапивница, зуд, дерматит ангиоэдема и анафилактическая реакция). Нарушения со стороны эндокринной системы: очень редко - синдром Кушинга, адреналовая супрессия, замедление роста, понижение минеральной плотности костной ткани. Нарушения со стороны обмена веществ и питания: редко - гипокалиемия, очень редко - гипергликемия, признаки или симптомы системных глюкокортикостероидных эффектов (включая гипофункцию надпочечников). Нарушения со стороны психики: нечасто - возбуждение, психомоторное возбуждение, беспокойство, нарушения сна, очень редко - депрессия, нарушения поведения. Нарушения со стороны органа зрения: очень редко - катаракта и глаукома. Нарушения со стороны сердца: часто - сердцебиение, нечасто - тахикардия, редко - аритмия (например, фибрилляция предсердий, суправентрикулярная тахикардия, экстрасистолия), очень редко - стенокардия, удлинение интервала QT. Нарушения со стороны сосудов: очень редко - колебания артериального давления. Нарушения со стороны дыхательной системы, органов грудной клетки и средостения: часто - кандидозы слизистой оболочки полости рта и глотки, раздражение глотки, кашель, хрипота, редко - бронхоспазм, очень редко - парадоксальный бронхоспазм. Нарушения со стороны желудочно-кишечного тракта: нечасто - тошнота. Нарушения со стороны кожи и подкожных тканей: нечасто - кровоподтеки. Нарушение со стороны скелетно-мышечной и соединительной ткани: нечасто - мышечные судороги.
Передозировка
Симптомы передозировки формотерола: тремор, головная боль, учащенное сердцебиение. В отдельных случаях сообщалось о развитии тахикардии, гипергликемии, гипокалиемии, удлинении QTc-интервала. аритмии, тошноте и рвоте. В случае необходимости отмены препарата ДуоРесп Спиромакс вследствие передозировки формотерола, входящего в состав комбинированного препарата, следует рассмотреть вопрос о назначении соответствующего глюкокортикостероида. Лечение: поддерживающее и симптоматическое. Приём пациентами с острой бронхиальной обструкцией формотерола в дозе 90 мкг в течение 3-х часов безопасен. При острой передозировке будесонида. даже в значительных дозах, не ожидается клинически значимых эффектов. При хроническом приеме чрезмерных доз может проявиться системное действие глюкокортикостероидов, такое как гиперкортицизм и подавление функции надпочечников.
Особые указания
Рекомендуется постепенно уменьшать дозу препарата перед прекращением лечения и не рекомендуется резко отменять лечение. В период лечения следует контролировать концентрацию глюкозы в крови у пациентов с сахарным диабетом.
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Особые свойства будесонида и формотерола дают возможность использовать их комбинацию одновременно в качестве поддерживающей терапии и для купирования приступов, или как поддерживающую терапию бронхиальной астмы."}}]},{"id":3,"name":"Фармакологические свойства","slug":"pharmacologic_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Будесонид - глюкокортикостероид, который после ингаляции оказывает быстрое (в течение нескольких часов) и дозозависимое противовоспалительное действие на дыхательные пути, снижая выраженность симптомов и частоту обострений бронхиальной астмы. При назначении ингаляционного будесонида отмечается меньшая частота возникновения серьезных нежелательных эффектов, чем при использовании системных глюкокортикостероидов. Уменьшает выраженность отека слизистой бронхов, продукцию слизи, образование мокроты и гиперреактивность дыхательных путей. Точный механизм противовоспалительного действия глюкокортикостероидов неизвестен. Формотерол - селективный агонист β2-адренсргических рецепторов, который после ингаляции вызывает быстрое и длительное расслабление гладкой мускулатуры бронхов у пациентов с обратимой обструкцией дыхательных путей. Бронхолитическое дозозависимое действие наступает быстро, в течение 1-3 минут после ингаляции и сохраняется в течение как минимум 12 часов после приема разовой дозы. Добавление формотерола к будесониду уменьшает выраженность симптомов бронхиальной астмы, улучшает функцию бронхов и уменьшает частоту обострений заболевания."}}]},{"id":4,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Бронхиальная астма (недостаточно контролируемая приёмом ингаляционных глюкокортикостероидов и бета β2-адреностимуляторов короткого действия или адекватно контролируемая ингаляционными ГКС и β2-адреностимуляторами длительного действия). ХОБЛ (симптоматическая терапия у пациентов с тяжелой хронической обструктивной болезнью легких и с повторяющимися обострениями в анамнезе, которые имеют выраженные симптомы заболевания, несмотря на терапию бронходилататорами длительного действия)."}}]},{"id":5,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность к будесониду, формотеролу или ингалируемой лактозе. Детский возраст до 18-ти лет."}}]},{"id":6,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"С осторожностью."}}]},{"id":7,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Бронхиальная астма: препарат не предназначен для первоначального лечения бронхиальной астмы интермиттирующего и легкого персистирующего течения. 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Нарушения со стороны психики: нечасто - возбуждение, психомоторное возбуждение, беспокойство, нарушения сна, очень редко - депрессия, нарушения поведения. Нарушения со стороны органа зрения: очень редко - катаракта и глаукома. Нарушения со стороны сердца: часто - сердцебиение, нечасто - тахикардия, редко - аритмия (например, фибрилляция предсердий, суправентрикулярная тахикардия, экстрасистолия), очень редко - стенокардия, удлинение интервала QT. Нарушения со стороны сосудов: очень редко - колебания артериального давления. Нарушения со стороны дыхательной системы, органов грудной клетки и средостения: часто - кандидозы слизистой оболочки полости рта и глотки, раздражение глотки, кашель, хрипота, редко - бронхоспазм, очень редко - парадоксальный бронхоспазм. Нарушения со стороны желудочно-кишечного тракта: нечасто - тошнота. Нарушения со стороны кожи и подкожных тканей: нечасто - кровоподтеки. 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