Гиперчувствительность, острые инфекционно-воспалительные заболевания, недавние кровоизлияния, острые интеркуррентные заболевания, детский возраст до 18 лет. Для ингаляционного введения - туберкулез легких с выраженной дыхательной недостаточностью; легочное кровотечение, кровохарканье; злокачественные новообразования, свежее кровоизлияние в стекловидное ...
Самсон-Мед, Россия, Является цементирующим веществом соединительной ткани. Препарат получают из семенников крупного рогатого скота. Применяют при рубцах после ожогов и операций, контрактуре суставов. Назначают больным туберкулезом легких.
Фармакотерапевтическая группа
Ферментное средство.
Фармакологические свойства
Ферментный препарат, выделенный из семенников крупного рогатого скота. Расщепляет основной компонент межуточного вещества соединительной ткани - гиалуроновую кислоту (мукополисахарид, в состав которого входят ацетилглюкозамин и глюкуроновая кислота, является цементирующим веществом соединительной ткани), уменьшает ее вязкость, повышает тканевую и сосудистую проницаемость, облегчает движение жидкостей в межтканевых пространствах; уменьшает отечность ткани, размягчает и уплощает рубцы, увеличивает объем движения в суставах, уменьшает контрактуры и предупреждает их формирование. Гиалуронидаза вызывает распад гиалуроновой кислоты до глюкозамина и глюкуроновой кислоты и тем самым уменьшает ее вязкость. Продолжительность действия при внутрикожном введении - до 48 ч.
Показания к применению
Ожоговые, травматические, послеоперационные рубцы; длительно незаживающие язвы (в том числе лучевые); контрактура Дюпюитрена; тугоподвижность суставов, контрактуры суставов (после воспалительных процессов, травм), остеоартроз, анкилозирующий спондилоартрит, тяжелые заболевания поясничных дисков; хронический тендовагинит, склеродермия (кожные проявления), гематома мягких тканей поверхностной локализации; подготовка к кожно-пластическим операциям по поводу рубцовых стяжений. Туберкулез легких (осложненный неспецифическими поражениями бронхов), воспалительные процессы в верхних дыхательных путях и бронхах с явлениями обструкции. Травматические поражения нервных сплетений и периферических нервов (плексит, неврит). Гифема, гемофтальм, ретинопатии различной этиологии.
Противопоказания
Гиперчувствительность, острые инфекционно-воспалительные заболевания, недавние кровоизлияния, острые интеркуррентные заболевания, детский возраст до 18 лет. Для ингаляционного введения - туберкулез легких с выраженной дыхательной недостаточностью; легочное кровотечение, кровохарканье; злокачественные новообразования, свежее кровоизлияние в стекловидное тело. Сопутствующий прием эстрогенов.
С осторожностью
Беременность, период лактации.
Способ применения и дозы
При рубцовых поражениях подкожно (под рубцово-измененные ткани) или внутримышечно (вблизи места поражения) вводят по 64 УЕ (1 мл) ежедневно или через день (всего 10-20 инъекций).
При травматических поражениях нервных сплетений и периферических нервов вводят подкожно в область пораженного нерва (64 УЕ в растворе прокаина) через день; на курс -12-15 инъекций. Курс лечения при необходимости повторяют.
При использовании в офтальмологической практике содержимое флакона растворяют в 20 мл воды для инъекций (0,1 % раствор). Препарат вводят субконъюнктивально - 0,3 мл, парабульбарно - 0,5 мл, а также методом электрофореза.
Больным туберкулезом легких с продуктивным характером воспаления назначают в комплексной терапии для повышения концентрации антибактериальных лекарственных средств в очагах поражения в виде инъекций и/или ингаляций. Ингаляции проводят ежедневно 1 раз в день. Для проведения одной ингаляции содержимое флакона (64 УЕ) растворяют в 5 мл раствора натрия хлорида 0,9 %. Курс лечения состоит из 20-25 ингаляций. При необходимости проводят повторные курсы с промежутками 1,5-2 месяца.
Наружно, в виде повязок, пропитанных раствором препарата. Для приготовления раствора каждые 64 УЕ растворяют в 10 мл стерильного раствора натрия хлорида 0,9 % или кипяченой воды комнатной температуры. Этим раствором смачивают стерильную повязку, сложенную в 4-5 слоев, накладывают ее на пораженный участок, покрывают вощеной бумагой и фиксируют мягкой повязкой. Повязку накладывают ежедневно на 15-18 часов в течение 15 - 60 дней. При длительном применении через каждые 2 недели делают перерыв на 3-4 дня.
При применении методом электрофореза 1 флакон препарата (64 УЕ) растворяют в 60 мл дистиллированной воды, добавляют 2-3 капли 0,1 % раствора хлористоводородной кислоты и вводят с анода на пораженный участок в течение 20-30 мин. Курс лечения -15-20 сеансов.
Аппликационный режим дозирования можно чередовать с электрофорезом. Приготовленный раствор должен быть использован в течение 24 часов.
Побочное действие
Аллергические реакции. При длительном применении - местнораздражающее действие.
Взаимодействие с другими лекарственными средствами
Улучшает всасывание лекарственных средств, вводимых подкожно или внутримышечно, усиливает эффект местных анестетиков.
Особые указания
Раствор не следует вводить через катетер, в который ранее вводили растворы, содержащие катионы.
Растворы для инъекций готовят на 0,9 % растворе натрия хлорида или 0,5 % растворе прокаина, для ингаляций - на 0,9 % растворе натрия хлорида, для электрофореза - на дистиллированной воде.
Перед началом лечения целесообразно провести тест с внутрикожным введением 20 мкл гиалуронидазы.
Не следует вводить в зоны инфекционного воспаления и опухоли.
При острых кровоизлияниях гиалуронидазу не применять.
Применение препарата не оказывает влияние на управление транспортными средствами и занятия другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций.
Влияние на способность управлять транспортными средствами и работы с механизмами:
Применение препарата не оказывает влияние на управление транспортными средствами и занятия другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций.
Условия хранения
от 2℃ до 15℃.
Условия отпуска
По рецепту.
Производитель
САМСОН-МЕД ООО.
Для описания товара использована информация от партнера ЗдравСити
Мобильное приложение «Все аптеки»
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