Тяжелые нарушения функции печени или почек, гепатит, тромбоэмболические заболевания, вагинальные кровотечения не установленного генеза, карцинома молочной железы (за исключением случаев, при которых прогестерон применяется в составе комбинированной терапии данного заболевания).
Инструкция
Состав
Действующее вещество: прогестеронКонцентрация действующего вещества (%): 2, 5%
Фармакологические свойства
Гестаген. Гормон желтого тела. Вызывает переход слизистой оболочки матки из фазы пролиферации, вызываемой фолликулярным гормоном, в секреторную фазу, а после оплодотворения способствует ее переходу в состояние, необходимое для развития оплодотворенной яйцеклетки. Уменьшает возбудимость и сократимость мускулатуры матки и маточных труб, стимулирует развитие концевых элементов молочной железы. Не обладает андрогенной активностью. Прогестерон оказывает слабое действие на метаболизм белка, способствует депонированию жиров и накоплению глюкозы в печени, а также снижает реабсорбцию натрия в почечных канальцах. Прогестерон оказывает блокирующее действие на секрецию гипоталамических факторов высвобождения ЛГ и ФСГ, угнетает образование в гипофизе гонадотропных гормонов и тормозит овуляцию.
Тяжелые нарушения функции печени или почек, гепатит, тромбоэмболические заболевания, вагинальные кровотечения не установленного генеза, карцинома молочной железы (за исключением случаев, при которых прогестерон применяется в составе комбинированной терапии данного заболевания).
Применение при беременности и в период грудного вскармливания
В случаях крайней необходимости возможно применение прогестерона при беременности при установленной недостаточности гормонов желтого тела. Прогестерон не применяют у женщин, планирующих беременность в ближайшее время.
Способ применения и дозы
Прогестерон вводят в/м, взрослым высшая разовая доза 0,025 г (2,5 мл 1% или 1 мл 2,5 % р-ра).
Побочное действие
Со стороны сердечно-сосудистой системы: повышение АД. Со стороны обмена веществ: отеки. Со стороны пищеварительной системы: нарушения функции печени, желтуха; редко (при длительном применении) - тошнота, рвота. Со стороны эндокринной системы: редко (при длительном применении) - снижение либидо, увеличение массы тела, боль и напряжение в молочных железах, нерегулярные маточные кровотечения. Со стороны ЦНС: редко (при длительном применении) - головная боль, депрессия.
Передозировка
До настоящего времени о случаях передозировки препарата не сообщалось.
Особые указания
С осторожностью применяют у пациентов с сердечно-сосудистыми заболеваниями, нарушениями функции печени или почек, сахарным диабетом, бронхиальной астмой, эпилепсией, мигренью, депрессией.
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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