9 месяцев Фолиевая кислота Таблетки, 90 шт, 400 мкг, для приема внутрь, для взрослых, покрытые пленочной оболочкой

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Необходима для нормального созревания мегалобластов и образования нормобластов."}},{"type":"paragraph","data":{"text":" Стимулирует эритропоэз, участвует в синтезе  аминокислот (в т.ч. глицина, метионина), нуклеиновых кислот, пиримидинов, пуринов, в обмене гистидина и холина.  \n\n"}},{"type":"paragraph","data":{"text":"\n\nФолиевая кислота хорошо и полно  всасывается в желудочно-кишечном тракте, преимущественно в верхних отделах двенадцатиперстной кишки.  Почти полностью связывается с белками плазмы."}},{"type":"paragraph","data":{"text":" Подвергается активированию в печени под воздействием фермента дигидрофолатредуктазы , превращаясь в тетрагидрофолиевую кислоту. Максимальная концентрация в пазме крови (Сmax)  достигается через  30 - 60 минут. Проникает через гематоэнцефалический и плацентарный барьеры в грудное молоко."}},{"type":"paragraph","data":{"text":"Выводится  почками преимущественно в виде метаболитов; если принятая доза значительно превышает  суточную потребность в фолиевой кислоте, то выводится в неизмененном виде. Выводится с помощью гемодиализа.\n\n"}}]},{"id":7,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"\n\nДефицит фолиевой кислоты. 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Эстрогены, пероральные контрацептивы увеличивают потребность в фолиевой кислоте. "}},{"type":"paragraph","data":{"text":"Антациды, колестирамин, сульфонамины (в т.ч. сульфасалазин) снижают абсорбацию фолиевой кислоты."}},{"type":"paragraph","data":{"text":"Метотрексат, пириметамин, триамтерен, триметоприм ингибируют дигидрофолатредуктазу и снижают эффект фолиевой кислоты (вместо нее пациентам, применяющим эти препараты, следует назначать кальция фолинат). "}},{"type":"paragraph","data":{"text":" При одновременном применении с хлорамфениколом, неомицином, полимиксинами, тетрациклинами всасывание фолиевой кислоты снижается.\n\n"}}]},{"id":15,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nДля профилактики гиповитаминоза наиболее предпочтительно сбалансированное питание. Продукты, богатые фолиевой кислотой — зеленые овощи (салат, шпинат, помидоры, морковь), свежая печень, бобовые, свекла, яйца, сыр, орехи, злаки."}},{"type":"paragraph","data":{"text":"Фолиевую кислоту не применяют для лечения В12-дефицитной (пернициозной), нормоцитарной и апластической анемии, а также анемии рефрактерной к терапии. При пернициозной (В12-дефицитной) анемии фолиевая кислота, улучшая гематологические показатели, маскирует неврологические осложнения. Пока не исключена пернициозная анемия, назначение фолиевой кислоты в дозах, превышающих 100 мкг/сут, не рекомендуется (исключение — беременность и период лактации)."}},{"type":"paragraph","data":{"text":"Следует иметь в виду, что пациенты, находящиеся на гемодиализе, нуждаются в повышенных количествах фолиевой кислоты."}},{"type":"paragraph","data":{"text":"Во время лечения антациды следует применять спустя 2 ч после приема фолиевой кислоты, колестирамин — за 4–6 ч до или спустя 1 ч после приема фолиевой кислоты. Следует иметь в виду, что антибиотики могут искажать (давать заведомо заниженные показатели) результаты микробиологической оценки концентрации фолиевой кислоты плазмы и эритроцитов."}},{"type":"paragraph","data":{"text":" При применении больших доз фолиевой кислоты, а также терапии в течение длительного периода, возможно снижение концентрации витамина В12.\n\n"}}]},{"id":17,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки, покрытые пленочной оболочкой."}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Препарат следует хранить в сухом, защищенном от света, недоступном для детей месте при температуре не выше 25°С. "}}]},{"id":19,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ca href=\"https://www.eapteka.ru/goods/manufacturer/valenta_farma/\"\u003eВалента Фарм, Россия\u003c/a\u003e."}}]}],"source":{"title":"ЗдравСити","url":"https://zdravcity.ru"}},"description_toggle":false,"short_description":"Витамин группы В (витамин В9, витамин Вс), может синтезироваться микрофлорой кишечника. 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