Мерк Шарп и Доум Лтд/Акрихин, Соединенное Королевство, Приме... Инструкция
Показания к применению
Сахарный диабет 2 типа у взрослых пациентов в возрасте от 18 лет и старше.
Монотерапия
Препарат Янумет показан в качестве стартовой терапии у пациентов с СД2 для улучшения гликемического контроля при неэффективности диетотерапии и соблюдения режима физических нагрузок.
Препарат Янумет показан в качестве дополнения к диете и режиму физических нагрузок для ...
Мерк Шарп и Доум Лтд/Акрихин, Соединенное Королевство, Применение: сахарный диабет 2 типа
Показания к применению
Сахарный диабет 2 типа у взрослых пациентов в возрасте от 18 лет и старше.
Монотерапия
Препарат Янумет показан в качестве стартовой терапии у пациентов с СД2 для улучшения гликемического контроля при неэффективности диетотерапии и соблюдения режима физических нагрузок.
Препарат Янумет показан в качестве дополнения к диете и режиму физических нагрузок для улучшения гликемического контроля у пациентов с СД2, не достигших адекватного контроля на фоне монотерапии метформином или ситаглиптином, либо у пациентов, ранее получавших комбинированную терапию этими двумя препаратами.
Противопоказания
Гиперчувствительность к ситаглиптину, метформину и/или к любому из вспомогательных веществ в составе препарата.
Сахарный диабет 1 типа.
Нарушение функции почек с рСКФ менее 45 мл/мин/1,73 м2.
Острые состояния, протекающие с риском развития нарушений функции почек:
Клинически выраженные проявления острых и хронических заболеваний, которые могут приводить к развитию тканевой гипоксии (в том числе острая и хроническая сердечная недостаточность с нестабильными показателями гемодинамики, дыхательная недостаточность, острый инфаркт миокарда).
Обширные хирургические операции и травмы, когда показано проведение инсулинотерапии.
Печеночная недостаточность, нарушение функции печени.
Возраст до 18 лет (в связи с отсутствием данных по эффективности и безопасности применения препарата у детей и подростков до 18 лет)
С осторожностью
у пациентов с нарушением функции почек с рСКФ 45-59 мл/мин/1,73 м2; у пожилых пациентов; у пациентов с наличием панкреатита в анамнезе; при одновременном применении с дигоксином.
Применение при беременности и в период грудного вскармливания
Клинических данных о применении комбинации метформина и ситаглиптина в период беременности нет. Исследования на животных при применении ситаглиптина в высоких дозах показали его эмбрио- и фетотоксическое действие. Применение препарата Янумет в период беременности противопоказано. В случае планирования или наступления беременности прием препарата следует прекратить, пациентка должна быть переведена на инсулинотерапию.
Данные о проникновении в молоко лактирующих животных комбинации метформина и ситаглиптина отсутствуют. Исследования на животных при введении монопрепаратов показали, что метформин и ситаглиптин (в значительном количестве) проникают в молоко лактирующих крыс. Нет данных о проникновении ситаглиптина в грудное молоко человека, метформин проникает в небольших количествах. В связи с невозможностью исключения риска возникновения HP у ребенка, применение препарата Янумет в период грудного вскармливания противопоказано.
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