Некст Уно Экспресс Капсулы, 10 шт, 200 мг

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"}},{"type":"paragraph","data":{"text":"Подвергается пресистемному и постсистемному метаболизму в\nпечени. После абсорбции около 60 % фармакологически неактивной R-формы\nибупрофена медленно трансформируется в активную S-форму. В метаболизме\nпрепарата принимает участие изофермент CYP2C9. Имеет двухфазную кинетику\nэлиминации с периодом полувыведения (T\u003csub\u003e1/2\u003c/sub\u003e) 2‑2,5 ч. Выводится\nпочками (в неизмененном виде не более 1 %) и в меньшей степени - с желчью."}}]},{"id":7,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Применяют при головной боли, мигрени,\nзубной боли, болезненных менструациях, невралгии, боли в спине, мышечных и\nревматических болях; при лихорадочных состояниях при гриппе и простудных\nзаболеваниях. "}},{"type":"paragraph","data":{"text":"Предназначен для симптоматической\nтерапии, уменьшения боли и воспаления на момент пользования, на\nпрогрессирование заболевания не влияет."}}]},{"id":8,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"- повышенная чувствительность к ибупрофену и другим\nкомпонентам препарата; "}},{"type":"paragraph","data":{"text":"- эрозивно-язвенные заболевания желудочно-кишечного тракта (в\nт.ч. язвенная болезнь желудка и двенадцатиперстной кишки в стадии обострения, язвенный\nколит, пептическая язва, болезнь Крона); "}},{"type":"paragraph","data":{"text":"- полное или неполное сочетание бронхиальной астмы,\nрецидивирующего полипоза носа и околоносовых пазух и непереносимости\nацетилсалициловой кислоты или др. НПВП (в т.ч. в анамнезе); "}},{"type":"paragraph","data":{"text":"- нарушения свертывания крови (в т.ч. гемофилия, удлинение\nвремени кровотечения, склонность к кровотечениям, геморрагический диатез); "}},{"type":"paragraph","data":{"text":"- детский возраст до 12 лет; "}},{"type":"paragraph","data":{"text":"- беременность III триместр, период грудного вскармливания;"}},{"type":"paragraph","data":{"text":"- активное желудочно-кишечное кровотечение;"}},{"type":"paragraph","data":{"text":"- внутричерепное кровоизлияние;"}},{"type":"paragraph","data":{"text":"- кровотечения или перфорация язвы ЖКТ в анамнезе,\nспровоцированные применением НПВП;"}},{"type":"paragraph","data":{"text":"- тяжелая сердечная недостаточность;"}},{"type":"paragraph","data":{"text":"- тяжелая почечная недостаточность (КК менее 30 мл/мин);"}},{"type":"paragraph","data":{"text":"- прогрессирующие заболевания почек;"}},{"type":"paragraph","data":{"text":"- тяжелая печеночная недостаточность или активное заболевание\nпечени;"}},{"type":"paragraph","data":{"text":"- состояние после проведения аортокоронарного шунтирования;"}},{"type":"paragraph","data":{"text":"- подтвержденная гиперкалиемия;"}},{"type":"paragraph","data":{"text":"- непереносимость фруктозы."}}]},{"id":9,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"С осторожностью препарат применяют\nпри циррозе печени с портальной гипертензией, гипербилирубинемии, язвенной\nболезни желудка и 12-перстной кишки (в анамнезе), гастрите, энтерите, колите;\nпеченочной порфирии, печеночной и/или почечной недостаточности, нефротическом\nсиндроме; хронической сердечной недостаточности, артериальной гипертензии; нарушениях\nсвертывания крови, заболеваниях крови неясной этиологии (лейкопения и анемия),\nпожилом возрасте, беременности (I-II триместр), ИБС, цереброваскулярных заболеваниях,\nдислипидемии/гиперлипидемии, сахарном диабете, заболеваниях периферических\nартерий, курении, хронической почечной недостаточности (КК 30-60 мл/мин),\nналичии инфекции Helicobacter pylory, длительном использовании НПВП, частом употреблении\nалкоголя, тяжелых соматических заболеваниях, системной красной волчанке или\nдругих аутоиммунных заболеваниях соединительной ткани (повышен риск развития\nасептического менингита), одновременном приеме пероральных ГКС (в т.ч.\nпреднизолона), антикоагулянтов (в т.ч. варфарина), антиагрегантов (в т.ч.\nклопидогреля), селективных ингибиторов обратного захвата серотонина (в т.ч. циталопрама,\nфлуоксетина, пароксетина, сертралина)."}}]},{"id":10,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"В исследованиях на животных не обнаружено неблагоприятного\nвлияния ибупрофена на плод. Ввиду отсутствия достаточного количества хорошо\nконтролируемых наблюдений на людях препарат следует применять в первом и втором\nтриместрах беременности только в случаях острой необходимости, если\nпотенциальная польза для матери превышает потенциальный риск для плода и\nребенка."}},{"type":"paragraph","data":{"text":"Ибупрофен тормозит сокращение мышц матки. Действие ибупрофена\nна плод может вызвать преждевременное закрытие боталлова протока, что может\nпривести к развитию у новорожденного легочной гипертензии. Не следует применять\nибупрофен в конце (третьем триместре) беременности. "}},{"type":"paragraph","data":{"text":"Не обнаружено выделения ибупрофена с материнским молоком.\nОднако, ввиду ограниченного объема указанных исследований и возможного\nнеблагоприятного эффекта торможения синтеза простагландинов у новорожденного,\nне рекомендуется применять препарат в период грудного вскармливания. "}}]},{"id":11,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Некс Уно Экспресс назначают взрослым и детям\nстарше 12 лет внутрь после еды, по "}},{"type":"paragraph","data":{"text":"Для достижения быстрого\nтерапевтического эффекта доза может быть увеличена до "}},{"type":"paragraph","data":{"text":"\n400 мг (2 капсулы) 3 раза в сутки. При достижении лечебного эффекта суточную\nдозу препарата уменьшают до 600-800 мг."}},{"type":"paragraph","data":{"text":"Максимальная суточная доза для\nвзрослых составляет 1200 мг (не принимать более 6 капсул за 24 часа)."}},{"type":"paragraph","data":{"text":"Максимальная суточная доза для детей\n12-18 лет составляет 800 мг."}},{"type":"paragraph","data":{"text":"Повторную дозу принимать не ранее,\nчем через 4 часа."}},{"type":"paragraph","data":{"text":"Если при применении препарата в течение 5 дней болевой\nсиндром или в течение 3 дней повышенная температура тела сохраняются или\nусиливаются, следует прекратить прием и проконсультироваться с врачом."}}]},{"id":12,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"При применении препарата Некст Уно Экспресс в течение 2-3\nдней побочные действия практически не отмечаются. "}},{"type":"paragraph","data":{"text":"В случае длительного применения возможно появление следующих\nпобочных эффектов:"}},{"type":"paragraph","data":{"text":"\u003ci\u003e- со стороны желудочно-кишечного тракта (ЖКТ)\u003c/i\u003e: НПВП-гастропатия (абдоминальная боль,\nизжога, диарея, метеоризм, боль и дискомфорт в эпигастральной области), изъязвления\nслизистой оболочки желудочно-кишечного тракта (в ряде случаев осложняется перфорацией\nи кровотечениями); раздражение, сухость слизистой ротовой полости или боль во\nрту, изъязвление слизистой десен, афтозный стоматит, панкреатит, запор,\nнарушение пищеварения, тошнота, потеря аппетита, рвота, гепатит; "}},{"type":"paragraph","data":{"text":"\u003ci\u003e- со стороны дыхательной системы\u003c/i\u003e: одышка, бронхоспазм, обострение\nбронхиальной астмы; "}},{"type":"paragraph","data":{"text":"\u003ci\u003e- нарушения слуха\u003c/i\u003e: снижение слуха, звон или шум в ушах; "}},{"type":"paragraph","data":{"text":"\u003ci\u003e- со стороны центральной и периферической\nнервной системы\u003c/i\u003e: бессонница, тревога, нервозность и раздражительность, психомоторное\nвозбуждение, депрессия, спутанность сознания, галлюцинации, редко –\nасептический менингит (чаще у пациентов с аутоиммунными заболеваниями), головная\nболь, головокружение, сонливость; "}},{"type":"paragraph","data":{"text":"\u003ci\u003e- со стороны сердечно-сосудистой системы\u003c/i\u003e: развитие\nили усугубление сердечной\nнедостаточности, тахикардия, повышение АД;"}},{"type":"paragraph","data":{"text":"\u003ci\u003e- со стороны мочевыделительной системы\u003c/i\u003e: острая почечная недостаточность,\nаллергический нефрит, нефротический синдром (отеки), полиурия, цистит;"}},{"type":"paragraph","data":{"text":"\u003ci\u003e- со стороны органов кроветворения\u003c/i\u003e: гемолитическая анемия, апластическая\nанемия, тромбоцитопения и тромбоцитопеническая пурпура, агранулоцитоз,\nлейкопения, панцитопения;"}},{"type":"paragraph","data":{"text":"\u003ci\u003e- со стороны органов зрения\u003c/i\u003e: обратимая токсическая амблиопия,\nнеясное зрение или двоение, сухость и раздражение глаз, отек конъюнктивы и век\n(аллергического генеза), скотома, нарушения цветового зрения;"}},{"type":"paragraph","data":{"text":"\u003ci\u003e- аллергические реакции\u003c/i\u003e: кожная сыпь (обычно эритематозная, крапивница),\nкожный зуд, отек Квинке, анафилактоидные реакции, анафилактический шок,\nбронхоспазм, лихорадка, многоформная экссудативная эритема (в том числе синдром\nСтивенса-Джонсона), токсический эпидермальный некролиз (синдром Лайелла),\nэозинофилия, аллергический ринит; "}},{"type":"paragraph","data":{"text":"\u003ci\u003e- прочие\u003c/i\u003e: усиление потоотделения. "}},{"type":"paragraph","data":{"text":"Риск развития изъязвлений слизистой\nоболочки желудочно-кишечного тракта, кровотечения (желудочно-кишечного,\nдесневого, маточного, геморроидального), нарушений зрения (нарушения цветового\nзрения, скотомы, амблиопии) возрастает при длительном применении в больших\nдозах."}},{"type":"paragraph","data":{"text":"При появлении побочных эффектов следует прекратить прием препарата\nи обратиться к врачу."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛабораторные\nпоказатели.\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"- время кровотечения (может увеличиваться);"}},{"type":"paragraph","data":{"text":"- концентрация глюкозы в сыворотке (может снижаться);"}},{"type":"paragraph","data":{"text":"- клиренс креатинина (может уменьшаться);"}},{"type":"paragraph","data":{"text":"- гематокрит или гемоглобин (могут уменьшаться);"}},{"type":"paragraph","data":{"text":"- сывороточная концентрация креатинина (может увеличиваться);"}},{"type":"paragraph","data":{"text":"- активность «печеночных» трансаминаз (может повышаться)."}}]},{"id":13,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСимптомы\u003c/i\u003e: боли\nв животе, тошнота, рвота, заторможенность, сонливость, депрессия, головная\nболь, шум в ушах, метаболический ацидоз, кома, острая почечная недостаточность,\nснижение артериального давления, брадикардия, тахикардия, фибрилляция\nпредсердий, остановка дыхания."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение:\u003c/i\u003e\nпромывание желудка (только в течение часа после приема), активированный уголь,\nщелочное питье, форсированный диурез, симптоматическая терапия."}}]},{"id":14,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Индукторы микросомального окисления\n(фенитоин, этанол, барбитураты, рифампицин, фенилбутазон, трициклические\nантидепрессанты) увеличивают продукцию гидроксилированных активных метаболитов\nибупрофена, повышая риск развития тяжелых гепатотоксических реакций. "}},{"type":"paragraph","data":{"text":"Ингибиторы микросомального окисления\nснижают риск гепатотоксического действия ибупрофена. "}},{"type":"paragraph","data":{"text":"Ибупрофен снижает антигипертензивный\nэффект гипотензивных препаратов (ингибиторов АПФ, блокаторов «медленных» кальциевых\nканалов и др.), натрийуретическую и диуретическую эффективность фуросемида и\nгидрохлоротиазида; снижает эффективность урикозурических препаратов, усиливает ульцерогенное\nдействие глюкокортикостероидов, колхицина, этанола; усиливает эффект пероральных\nгипогликемических средств и инсулина; увеличивает концентрацию в крови\nдигоксина, препаратов лития и метотрексата. "}},{"type":"paragraph","data":{"text":"Ибупрофен усиливает нежелательное\nдействие эстрогенов при совместном применении."}},{"type":"paragraph","data":{"text":"Антациды и колестирамин снижают\nабсорбцию ибупрофена. "}},{"type":"paragraph","data":{"text":"Кофеин усиливает анальгезирующий\nэффект ибупрофена. "}},{"type":"paragraph","data":{"text":"При одновременном назначении\nибупрофен снижает противовоспалительное и антиагрегантное действие ацетилсалициловой\nкислоты (возможно повышение частоты развития острой коронарной недостаточности\nу больных, получающих в качестве антиагрегантного средства малые дозы\nацетилсалициловой кислоты, после начала приема ибупрофена). "}},{"type":"paragraph","data":{"text":"При назначении с антикоагулянтными и\nтромболитическими препаратами (алтеплазой, стрептокиназой, урокиназой)\nодновременно повышается риск развития кровотечений. "}},{"type":"paragraph","data":{"text":"При совместном применении ибупрофена и\nцефамандола, цефоперазона, цефотетана, вальпроевой кислоты увеличивается\nчастота развития гипопротромбинемии. "}},{"type":"paragraph","data":{"text":"Миелотоксические лекарственные\nсредства усиливают проявления гематотоксичности препарата. "}},{"type":"paragraph","data":{"text":"Циклоспорин и препараты золота\nусиливают влияние ибупрофена на синтез простагландинов в почках, что\nпроявляется повышением нефротоксичности. Ибупрофен повышает плазменную\nконцентрацию циклоспорина и вероятность развития его гепатотоксичных эффектов. "}},{"type":"paragraph","data":{"text":"Лекарственные средства, блокирующие\nканальцевую секрецию, снижают выведение и повышают плазменную концентрацию\nибупрофена."}},{"type":"paragraph","data":{"text":"Ибупрофен может снижать эффективность\nмифепристона, поэтому прием ибупрофена следует начать не ранее, чем через 8-12\nдней после приема мифепристона."}},{"type":"paragraph","data":{"text":"При одновременном назначении\nибупрофена и такролимуса возможно увеличение риска нефротоксичности."}},{"type":"paragraph","data":{"text":"Одновременное применение ибупрофена и\nзидовудина может привести к повышению гематологической токсичности. Имеются\nданные о повышенном риске возникновения гемартроза и гематом у\nВИЧ-положительных пациентов с гемофилией, получавших совместное лечение\nзидовудином и ибупрофеном."}},{"type":"paragraph","data":{"text":"У пациентов, получающих совместное\nлечение ибупрофеном и антибиотиками хинолонового ряда, возможно увеличение\nриска возникновения судорог."}}]},{"id":15,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Во время лечения необходим контроль\nкартины периферической крови и функционального состояния печени и почек. "}},{"type":"paragraph","data":{"text":"При появлении симптомов гастропатии\nпоказан тщательный контроль, включающий проведение эзофагогастродуоденоскопии,\nанализ крови с определением гемоглобина, гематокрита, анализ кала на скрытую\nкровь. "}},{"type":"paragraph","data":{"text":"Для предупреждения развития НПВП-гастропатии\nрекомендуется комбинировать с препаратами простагландина E (мизопростол). "}},{"type":"paragraph","data":{"text":"При необходимости определения\n17-кетостероидов препарат следует отменить за 48 ч до исследования. "}},{"type":"paragraph","data":{"text":"Перед началом терапии пациентам с\nартериальной гипертензией в анамнезе и/или с сердечной недостаточностью следует\nсоблюдать осторожность и проконсультироваться со специалистом, так как у таких\nпациентов были отмечены: задержка жидкости, артериальная гипертензия и отеки,\nсвязанные с приемом НПВП."}},{"type":"paragraph","data":{"text":"Длительный прием может повысить риск\nвозникновения острой коронарной патологии или инсульта."}},{"type":"paragraph","data":{"text":"У пациентов с бронхиальной астмой или\nаллергическими заболеваниями в анамнезе препарат может вызвать развитие\nприступа или бронхоспазм."}},{"type":"paragraph","data":{"text":"В период лечения не рекомендуется\nприем этанола."}},{"type":"paragraph","data":{"text":"Ибупрофен обладает антиагрегантным действием (более слабым по\nсравнению с ацетилсалициловой кислотой), что требует соблюдения осторожности в\nслучае назначения пациентам с нарушением свертывания крови, а также принимающим\nантикоагулянты. "}},{"type":"paragraph","data":{"text":"Рекомендуется принимать препарат максимально коротким курсом\nи в минимальной эффективной дозе, необходимой для устранения симптомов.\nСредства, подавляющие циклооксигеназу и синтез простагландинов, могут\nвоздействовать на овуляцию, нарушая женскую репродуктивную функцию (обратимо\nпосле отмены лечения)."}}]},{"id":16,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"В период лечения необходимо воздерживаться от тех видов\nдеятельности, где требуется повышенное внимание и быстрота психической и\nдвигательной реакции. "}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищенном от света месте при\nтемпературе не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":19,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года. Не использовать по истечении\nсрока годности, указанного на упаковке."}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают без рецепта."}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"УП\n«Минскинтеркапс», Республика Беларусь,"}},{"type":"paragraph","data":{"text":"220075, г. Минск, ул.\nИнженерная, 26"}},{"type":"paragraph","data":{"text":"Тел./факс: (+37517) 344-56-23"}}]},{"id":22,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"АО \"Отисифарм\",\nРоссия, "}},{"type":"paragraph","data":{"text":"123112, г. Москва, ул.\nТестовая, "}},{"type":"paragraph","data":{"text":"д.10, эт. 12, пом. 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