ВиВанат Ромфарм Раствор, шприц, 1 шт, 3 мл, 1 мг, для внутривенного введения

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Далее введение препарата продолжить через каждые 3 месяца после последнего введения."}},{"type":"paragraph","data":{"text":"Нельзя вводить препарат чаще 1 раза в 3 месяца."}},{"type":"paragraph","data":{"text":"Во время лечения следует контролировать функцию почек, содержание кальция, фосфора и магния в сыворотке крови."}},{"type":"paragraph","data":{"text":"Режим дозирования в особых случаях"}},{"type":"paragraph","data":{"text":"При нарушении функции печени коррекция дозы не требуется."}},{"type":"paragraph","data":{"text":"При нарушении функции почек легкой и средней степени тяжести (КК ≥ 30 мл/мин) коррекция дозы не требуется. При КК < 30 мл/мин решение о применении ибандроновой кислоты следует принимать на основании индивидуальной оценки соотношения риска и пользы для конкретного пациента."}}]},{"id":12,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\n\nНаиболее частыми нежелательными реакциями являлись артралгия и гриппоподобный синдром, которые наблюдались обычно после введения первой дозы ибандроновой кислоты, характеризовались слабой или умеренной степенью интенсивности, небольшой продолжительностью и разрешались без лечения (см. подраздел «Гриппоподобный синдром» ниже). Ибандроновая кислота, как и другие бисфосфонаты, при в/в введении может вызывать кратковременное снижение концентрации кальция в сыворотке крови."}},{"type":"paragraph","data":{"text":"Побочные реакции были преимущественно легкой и средней степени тяжести и в большинстве случаев не приводили к прекращению терапии."}},{"type":"paragraph","data":{"text":"Для оценки частоты побочных реакций использованы следующие категории частоты: часто (>1/100 и <1/10); нечасто (>1/1 000, <1/100); редко (>1/10 000 и <1/1 000); очень редко (<1/10 000), включая отдельные случаи."}},{"type":"paragraph","data":{"text":"Со стороны пищеварительной системы: часто - диспепсия (тошнота, боли в животе), метеоризм, диарея, запор, гастрит, гастроэнтерит, при приеме внутрь - эзофагит, гастроэзофагеальная рефлюксная болезнь; нечасто при приеме внутрь - эзофагит, включая изъязвление пищевода или стриктуры, дисфагия, рвота; редко - дуоденит."}},{"type":"paragraph","data":{"text":"Со стороны нервной системы и психики: часто - головная боль, головокружение, бессонница."}},{"type":"paragraph","data":{"text":"Со стороны кожи и подкожных тканей: часто - сыпь."}},{"type":"paragraph","data":{"text":"Аллергические реакции: редко - ангионевротический отек, отек лица, крапивница."}},{"type":"paragraph","data":{"text":"Со стороны костно-мышечной системы: часто - артралгия, миалгия, боли в конечностях, остеоартрит, боли в спине, костно-мышечная боль; нечасто - боли в костях; редко - атипичные подвертельные и диафизарные переломы бедренной кости (характерно для класса бисфосфонатов); очень редко - остеонекроз челюсти."}},{"type":"paragraph","data":{"text":"Со стороны органа зрения: редко - воспалительные заболевания глаз."}},{"type":"paragraph","data":{"text":"Со стороны организма в целом: часто - гриппоподобный синдром, слабость; нечасто - астения."}},{"type":"paragraph","data":{"text":"Прочие: часто - назофарингит, цистит, инфекции мочевыводящего тракта, бронхит, инфекции верхних дыхательных путей, артериальная гипертензия, гиперхолестеринемия; нечасто - реакции в месте введения, флебит, тромбофлебит; редко - реакции гиперчувствительности; при в/в введении возможно кратковременное понижение уровня кальция в сыворотке крови."}},{"type":"paragraph","data":{"text":"Описание отдельных нежелательных реакций"}},{"type":"paragraph","data":{"text":"Гриппоподобный синдром"}},{"type":"paragraph","data":{"text":"Гриппоподобный синдром может включать острофазные реакции или такие симптомы как миалгия, артралгия, лихорадка, озноб, утомляемость, тошнота, потеря аппетита или боли в костях."}},{"type":"paragraph","data":{"text":"Остеонекроз челюсти"}},{"type":"paragraph","data":{"text":"Большинство случаев остеонекроза челюсти, развившегосяС прда. применении бисфосфонатов, зарегистрировано у онкологических пациентов, несколько случаев - у пациентов с остеопорозом. Остеонекроз челюсти, главным образом, был ассоциирован с удалением зуба и/или локальной инфекцией (в частности, остеомиелитом). К другим факторам риска развития остеонекроза челюсти относят установленный диагноз онкологического заболевания, химиотерапию (включая ингибиторы ангиогенеза), лучевую терапию, применение глюкокортикостероидов (ГКС) и недостаточную гигиену полости рта. Воспалительные заболевания глаз"}},{"type":"paragraph","data":{"text":"При терапии бисфосфонатами, включая ибандроновую кислоту, сообщалось о воспалительных заболеваниях глаз, таких как эписклерит, склерит, и увеит. В некоторых случаях, несмотря на проводимое лечение, выздоровление наступало только после отмены бисфосфонатов."}},{"type":"paragraph","data":{"text":"Анафилактические реакции/шок"}},{"type":"paragraph","data":{"text":"При в/в введении ибандроновой кислоты были зарегистрированы случаи анафилактических реакций/шока, в том числе с летальным исходом. Нарушения со стороны кожи и подкожных тканей"}},{"type":"paragraph","data":{"text":"Были зарегистрированы тяжелые нежелательные кожные реакции, включая синдром Стивенса-\n\nДжонсона, многоформную эритему и буллезный дерматит."}}]},{"id":13,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\n\nВозможные симптомы: гипокальциемия, гипофосфатемия, гипомагнемия."}},{"type":"paragraph","data":{"text":"Лечение: специальная информация отсутствует. Клинически значимое снижение кальция, фосфатов и магния в сыворотке крови можно корректировать в/в введением глюконата кальция, калия или натрия фосфата и сульфата магния, соответственно. Диализ неэффективен, если назначается спустя 2 ч после введения препарата."}}]},{"id":14,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"\n\nИбандроновая кислота не влияет на активность основных изоферментов системы цитохрома Р450. В терапевтических концентрациях ибандроновая кислота слабо связывается с белками плазмы крови, поэтому маловероятно, что она будет вытеснять из участков связывания с белками другие лекарственные средства. Ибандроновая кислота выводится только почками и не подвергается какой-либо биотрансформации. По-видимому, путь выведения ибандроновой кислоты не включает какие-либо транспортные системы, участвующие в выведении других препаратов."}},{"type":"paragraph","data":{"text":"Несовместимость. Раствор ибандроновой кислоты для в/в введения несовместим с кальцийсодержащими растворами и другими растворами для в/в введения."}}]}],"source":{"title":"ЗдравСити","url":"https://zdravcity.ru"}},"description_toggle":false,"short_description":"Ибандроновая кислота - высокоактивный азот-содержащий бисфосфонат, ингибитор костной резорбции. Подавляет активность остеокластов. 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