Первичный и вторичный остеоартроз, остеохондроз, спондилоартроз.
Противопоказания
Гиперчувствительность к глюкозамину, лидокаину и другим компонентам препарата СУСТАГАРД® АРТРО. Вследствие содержания лидокаина: нарушения сердечной проводимости, острая сердечная недостаточность, эпилептиформные судороги в анамнезе, тяжелые нарушения функции печени и почек; период беременности и грудного вскармливания, детский и подростковый возраст ...
Вспомогательные вещества: лидокаина гидрохлорид 10,0 мг, натрия дисульфит - 2,0 мг, хлористоводородная кислота концентрированная - до pH 2,0-3,0, вода для инъекций - до 2 мл.
Ампула В (растворитель). Одна ампула (1 мл) содержит: диэтаноламин - 24,0 мг, вода для инъекций - до 1 мл.
Описание
Первичный и вторичный остеоартроз, остеохондроз, спондилоартроз. Способ применения и дозы:
Только для внутримышечного применения! Препарат не предназначен для внутривенного введения.
Непосредственно перед введением смешивают содержимое ампулы А с ампулой Б (растворителя) в одном шприце. Приготовленный раствор (3 мл) вводят внутримышечно 3 раза в неделю в течение 4-6 недель.
Инъекции препарата можно сочетать с приемом глюкозамина внутрь.
Фармакотерапевтическая группа
Репарации тканей стимулятор.
Фармакологические свойства
Ампула А - бесцветная или светло-желтого, или зеленовато-желтого, или коричневато-желтого цвета прозрачная жидкость. Ампула Б (растворитель) - бесцветная прозрачная жидкость. Раствор: Ампула А + Ампула Б (растворитель) - бесцветная или светло-желтого, или зеленовато-желтого, или коричневато-желтого цвета прозрачная жидкость без взвешенных частиц. Препарат оказывает стимулирующее регенерацию хрящевой ткани, анаболическое, антикатаболическое, хондропротективное, противовоспалительное, анальгезирующее действия.
Глюкозамина сульфат, активный компонент препарата СУСТАГАРД® АРТРО, представляет собой соль натурального аминомоносахаридного глюкозамина, который физиологически содержится в организме. Глюкозамин стимулирует синтез хондроцитами протеогликанов (глюкозаминогликанов и гиалуроновой кислоты) синовиальной жидкости; ингибирует ферменты (коллагеназу, фосфолипазу А2 и др.), вызывающие деструкцию хрящевой ткани; препятствует образованию супероксидных радикалов, подавляет активность лизосомальных ферментов; инициирует процесс фиксации серы в синтезе хондроитинсерной кислоты и способствует нормальному отложению кальция в костной ткани; препятствует повреждающему действию кортикостероидов на хондроциты и нарушению синтеза гликозаминогликанов, индуцированному нестероидными противоспалительными препаратами. Сульфогруппы также принимают участие в синтезе гликозаминогликанов и метаболизме хрящевой ткани, а сульфоэфиры боковых цепей в составе протеогликанов, способствуя удерживанию воды - в сохранении эластичности матрикса хряща. Глюкозамина сульфат останавливает деструкцию хряща и уменьшает симптомы при остеоартрозе. Уменьшение клинических симптомов проявляется обычно через 2 недели от начала лечения с сохранением клинического улучшения в течение 8 недель после отмены препарата.
После внутримышечного введения глюкозамина сульфат быстро проходит через биологические барьеры и проникает в ткани, преимущественно суставного хряща. Период полувыведения Т1/2 - около 60 ч, выводится в основном почками.
Показания к применению
Первичный и вторичный остеоартроз, остеохондроз, спондилоартроз.
Противопоказания
Гиперчувствительность к глюкозамину, лидокаину и другим компонентам препарата СУСТАГАРД® АРТРО. Вследствие содержания лидокаина: нарушения сердечной проводимости, острая сердечная недостаточность, эпилептиформные судороги в анамнезе, тяжелые нарушения функции печени и почек; период беременности и грудного вскармливания, детский и подростковый возраст до 18 лет.
С осторожностью
Пациентам с хронической сердечной недостаточностью, артериальной гипотензией препарат следует применять с осторожностью. При непереносимости морепродуктов (креветки, моллюски) увеличивается вероятность развития аллергических реакций на препарат. Безопасность применения анестетиков группы лидокаина сомнительна у больных, склонных к злокачественной гипертермии, поэтому в таких случаях следует избегать их применения. Следует соблюдать особую осторожность при применении препарата у пациентов с недостаточностью кровообращения, артериальной гипотензией, нарушениями функции печени и/или ночек. Следует соблюдать осторожность при назначении лидокаина пациентам пожилого возраста, больным эпилепсией, при нарушении проводимости сердца, при дыхательной недостаточности.
Способ применения и дозы
Только для внутримышечного применения! Препарат не предназначен для внутривенного введения. Непосредственно перед введением смешивают содержимое ампулы А с ампулой Б (растворителя) в одном шприце. Приготовленный раствор (3 мл) вводят внутримышечно 3 раза в неделю в течение 4-6 недель. Инъекции препарата можно сочетать с приемом глюкозамина внутрь.
Побочное действие
Со стороны пищеварительной системы: метеоризм, диарея, запор. Аллергические реакции: крапивница, зуд. Местные реакции: ощущение легкого жжения (исчезает с развитием анестезирующего эффекта в течение 1 мин), тромбофлебит. Из-за входящего в состав препарата лидокаина возможны побочные реакции, характерные для этого компонента со стороны пищеварительной системы: тошнота, рвота; со стороны нервной системы, онемение языка и слизистой оболочки рта, сонливость, диплопия, головная боль, головокружение, тремор, эйфория, дезориентация; со стороны сердечно-сосудистой системы, нарушение сердечной проводимости; аллергические реакции: отек, анафилактический шок. Входящий в состав препарата натрия дисульфит способен в редких случаях вызывать тяжелые реакции гиперчувствительности и бронхоспазм.
Передозировка
Случаев передозировки не выявлено. В состав препарата входит вспомогательное вещество лидокаина гидрохлорид. Первыми симптомами передозировки лидокаина гидрохлорида со стороны ЦНС могут быть: онемение языка и губ, возбужденное состояние, тревога, шум в ушах, головокружение, нечеткость зрения, тремор, депрессия, сонливость. Необходимо контролировать сердечнососудистую и дыхательную функции пациента. Изменение этих параметров может указывать на передозировку препарата, поэтому пациенту следует немедленно обеспечить доступ кислорода. Все осложнения требуют симптоматического лечения.
Взаимодействие с другими лекарственными средствами
Глюкозамина сульфат совместим с нестероидными противовоспалительными средствами, парацетамолом и глюкокортикостероидами. В состав препарата входит вспомогательное вещество лидокаин. Циметидин, пентидин, бупивакаин, пропранолол, хинидин, дизопирамид, амитриптилин, нортриптилин, хлорпромазин, имипрамин повышают уровень лидокаина в плазме крови, уменьшая его печеночный метаболизм. При одновременном применении с антиаритмическими препаратами IA класса (в том числе с хинидином, прокаинамидом, дизопирамидом) происходит удлинение интервала Q-Т, в очень редких случаях возможно развитие AV-блокады или фибрилляции желудочков. При одновременном применении с седативными средствами успокаивающий эффект усиливается. Фенитоин усиливает кардиодепрессивное действие лидокаина. При одновременном применении с прокаинамидом возможны бред, галлюцинации. Лидокаин может усиливать действие препаратов, которые предопределяют блокаду нейромышечной передачи, поскольку последние снижают проводимость нервных импульсов. Этанол усиливает угнетающее действие лидокаина на дыхание.
Особые указания
СУСТАГАРД® АРТРО следует с осторожностью назначать пациентам с нарушением толерантности к глюкозе. С осторожностью применять при лечении пациентов с бронхиальной астмой. Одна доза препарата содержит 40,8 мг натрия. Это следует учитывать при назначении пациентам, которым показана строгая бессолевая диета. Вследствие того, что в состав инъекционной формы препарата входит вспомогательное вещество лидокаин, перед его применением необходимо провести кожную пробу на индивидуальную чувствительность к препарату, о которой могут свидетельствовать отек и покраснение места инъекции.
Влияние на способность управлять автомобилем и движущимися механизмами
Не рассматривалось. Следует учитывать, что в состав входит лидокаин, который может оказывать временное влияние на двигательную способность и координацию. В период лечения необходимо соблюдать осторожность при управлении транспортными средствами и занятии другими потенциально опасными видами деятельности.
Форма выпуска
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Приготовленный раствор (3 мл) вводят внутримышечно 3 раза в неделю в течение 4-6 недель.\nИнъекции препарата можно сочетать с приемом глюкозамина внутрь."}}]},{"id":5,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":"Репарации тканей стимулятор."}}]},{"id":6,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":"Ампула А - бесцветная или светло-желтого, или зеленовато-желтого, или коричневато-желтого цвета прозрачная жидкость. Ампула Б (растворитель) - бесцветная прозрачная жидкость. Раствор: Ампула А + Ампула Б (растворитель) - бесцветная или светло-желтого, или зеленовато-желтого, или коричневато-желтого цвета прозрачная жидкость без взвешенных частиц. Препарат оказывает стимулирующее регенерацию хрящевой ткани, анаболическое, антикатаболическое, хондропротективное, противовоспалительное, анальгезирующее действия."}},{"type":"paragraph","data":{"text":"Глюкозамина сульфат, активный компонент препарата СУСТАГАРД® АРТРО, представляет собой соль натурального аминомоносахаридного глюкозамина, который физиологически содержится в организме. Глюкозамин стимулирует синтез хондроцитами протеогликанов (глюкозаминогликанов и гиалуроновой кислоты) синовиальной жидкости; ингибирует ферменты (коллагеназу, фосфолипазу А2 и др.), вызывающие деструкцию хрящевой ткани; препятствует образованию супероксидных радикалов, подавляет активность лизосомальных ферментов; инициирует процесс фиксации серы в синтезе хондроитинсерной кислоты и способствует нормальному отложению кальция в костной ткани; препятствует повреждающему действию кортикостероидов на хондроциты и нарушению синтеза гликозаминогликанов, индуцированному нестероидными противоспалительными препаратами. Сульфогруппы также принимают участие в синтезе гликозаминогликанов и метаболизме хрящевой ткани, а сульфоэфиры боковых цепей в составе протеогликанов, способствуя удерживанию воды - в сохранении эластичности матрикса хряща. Глюкозамина сульфат останавливает деструкцию хряща и уменьшает симптомы при остеоартрозе. Уменьшение клинических симптомов проявляется обычно через 2 недели от начала лечения с сохранением клинического улучшения в течение 8 недель после отмены препарата."}},{"type":"paragraph","data":{"text":"После внутримышечного введения глюкозамина сульфат быстро проходит через биологические барьеры и проникает в ткани, преимущественно суставного хряща. Период полувыведения Т1/2 - около 60 ч, выводится в основном почками."}}]},{"id":7,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Первичный и вторичный остеоартроз, остеохондроз, спондилоартроз."}}]},{"id":8,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Гиперчувствительность к глюкозамину, лидокаину и другим компонентам препарата СУСТАГАРД® АРТРО. Вследствие содержания лидокаина: нарушения сердечной проводимости, острая сердечная недостаточность, эпилептиформные судороги в анамнезе, тяжелые нарушения функции печени и почек; период беременности и грудного вскармливания, детский и подростковый возраст до 18 лет."}}]},{"id":9,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Пациентам с хронической сердечной недостаточностью, артериальной гипотензией препарат следует применять с осторожностью. При непереносимости морепродуктов (креветки, моллюски) увеличивается вероятность развития аллергических реакций на препарат. Безопасность применения анестетиков группы лидокаина сомнительна у больных, склонных к злокачественной гипертермии, поэтому в таких случаях следует избегать их применения. Следует соблюдать особую осторожность при применении препарата у пациентов с недостаточностью кровообращения, артериальной гипотензией, нарушениями функции печени и/или ночек. Следует соблюдать осторожность при назначении лидокаина пациентам пожилого возраста, больным эпилепсией, при нарушении проводимости сердца, при дыхательной недостаточности."}}]},{"id":11,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Только для внутримышечного применения! Препарат не предназначен для внутривенного введения. Непосредственно перед введением смешивают содержимое ампулы А с ампулой Б (растворителя) в одном шприце. Приготовленный раствор (3 мл) вводят внутримышечно 3 раза в неделю в течение 4-6 недель. Инъекции препарата можно сочетать с приемом глюкозамина внутрь."}}]},{"id":12,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Со стороны пищеварительной системы: метеоризм, диарея, запор. Аллергические реакции: крапивница, зуд. Местные реакции: ощущение легкого жжения (исчезает с развитием анестезирующего эффекта в течение 1 мин), тромбофлебит. Из-за входящего в состав препарата лидокаина возможны побочные реакции, характерные для этого компонента со стороны пищеварительной системы: тошнота, рвота; со стороны нервной системы, онемение языка и слизистой оболочки рта, сонливость, диплопия, головная боль, головокружение, тремор, эйфория, дезориентация; со стороны сердечно-сосудистой системы, нарушение сердечной проводимости; аллергические реакции: отек, анафилактический шок. Входящий в состав препарата натрия дисульфит способен в редких случаях вызывать тяжелые реакции гиперчувствительности и бронхоспазм."}}]},{"id":13,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Случаев передозировки не выявлено. В состав препарата входит вспомогательное вещество лидокаина гидрохлорид. Первыми симптомами передозировки лидокаина гидрохлорида со стороны ЦНС могут быть: онемение языка и губ, возбужденное состояние, тревога, шум в ушах, головокружение, нечеткость зрения, тремор, депрессия, сонливость. Необходимо контролировать сердечнососудистую и дыхательную функции пациента. Изменение этих параметров может указывать на передозировку препарата, поэтому пациенту следует немедленно обеспечить доступ кислорода. Все осложнения требуют симптоматического лечения."}}]},{"id":14,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Глюкозамина сульфат совместим с нестероидными противовоспалительными средствами, парацетамолом и глюкокортикостероидами. В состав препарата входит вспомогательное вещество лидокаин. Циметидин, пентидин, бупивакаин, пропранолол, хинидин, дизопирамид, амитриптилин, нортриптилин, хлорпромазин, имипрамин повышают уровень лидокаина в плазме крови, уменьшая его печеночный метаболизм. При одновременном применении с антиаритмическими препаратами IA класса (в том числе с хинидином, прокаинамидом, дизопирамидом) происходит удлинение интервала Q-Т, в очень редких случаях возможно развитие AV-блокады или фибрилляции желудочков. При одновременном применении с седативными средствами успокаивающий эффект усиливается. Фенитоин усиливает кардиодепрессивное действие лидокаина. При одновременном применении с прокаинамидом возможны бред, галлюцинации. Лидокаин может усиливать действие препаратов, которые предопределяют блокаду нейромышечной передачи, поскольку последние снижают проводимость нервных импульсов. Этанол усиливает угнетающее действие лидокаина на дыхание."}}]},{"id":15,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"СУСТАГАРД® АРТРО следует с осторожностью назначать пациентам с нарушением толерантности к глюкозе. С осторожностью применять при лечении пациентов с бронхиальной астмой. Одна доза препарата содержит 40,8 мг натрия. 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В период лечения необходимо соблюдать осторожность при управлении транспортными средствами и занятии другими потенциально опасными видами деятельности."}}]},{"id":17,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"\u003cb\u003eКонцентрат для приготовления раствора.\u003c/b\u003e"}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"от 2℃ до 25℃. Хранить в защищённом от света месте. 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