Веллобактин-В Лиофилизат, ампулы, 1 шт, 50 мг, для приготовления раствора

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Затем в дозе 25 мг через день еще в течение 2 недель после получения отрицательного результата бактериологического посева и нормализации концентрации глюкозы в спинномозговой жидкости."}},{"type":"paragraph","data":{"text":"Перед введением препарат (50 мг) растворяют в 10 мл 09% раствора натрия хлорида (концентрация приготовленного раствора 5 мг/мл)."}},{"type":"paragraph","data":{"text":"У пациентов с нарушением функции почек дозу препарата уменьшают и увеличивают интервал между введениями в соответствии с клиренсом креатинина (при клиренсе креатинина 20-50 мл/мин применяют 75-100% от дозы при нормальной функции почек с интервалом между введениями 12 часов; при клиренсе креатинина 5-20 мл/мин применяют 50% от дозы при нормальной функции почек с интервалом между введениями 12 часов; при клиренсе креатинина менее 5 мл/мин применяют 15% от дозы при нормальной функции почек с интервалом между введениями 12 часов)."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Со стороны нервной системы: головокружение атаксия нарушение сознания сонливость парестезии нервно-мышечная блокада."}},{"type":"paragraph","data":{"text":"Со стороны мочевыделительной системы: альбуминурия цилиндрурия азотемия протеинурия почечный тубулярный некроз."}},{"type":"paragraph","data":{"text":"Со стороны дыхательной системы: паралич дыхательной мускулатуры апноэ."}},{"type":"paragraph","data":{"text":"Со стороны пищеварительной системы: боль в эпигастральной области тошнота снижение аппетита; псевдомембранозный колит."}},{"type":"paragraph","data":{"text":"Со стороны органов чувств: нарушение зрения."}},{"type":"paragraph","data":{"text":"Аллергические реакции: кожная сыпь зуд эозинофилия."}},{"type":"paragraph","data":{"text":"Местные реакции: флебит перифлебит тромбофлебит болезненность в месте в/м инъекции."}},{"type":"paragraph","data":{"text":"Прочие: суперинфекция кандидоз при интратекальном введении - менингеальные симптомы (покраснение лица головная боль лихорадка ригидность затылочных мышц увеличение количества клеток и белка в спинномозговой жидкости)."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: паралич дыхательных мышц ототоксичность нефротоксичность."}},{"type":"paragraph","data":{"text":"Лечение: поддерживающая и симптоматическая терапия."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Одновременное применение с недеполяризующими миорелаксантами (угроза развития паралича дыхательных мышц) и другими нейротоксичными препаратамине рекомендуется."}},{"type":"paragraph","data":{"text":"При одновременном использовании наблюдается синергизм действия с хлорамфениколом карбенициллином тетрациклином сульфаниламидами и триметопримом в отношении Pseudomonas aeruginosa Proteus spp. Serratia spp.; с ампициллином - в отношении большинства грамотрицательных бактерий."}},{"type":"paragraph","data":{"text":"При сочетании с аминогликозидами (канамицином стрептомицином неомицином гентамицином) повышается риск развития ото- и нефротоксичности а также блокады нервно-мышечной передачи. Повышает нефротоксичность амфотерицина В."}},{"type":"paragraph","data":{"text":"Фармацевтически несовместим с натриевой солью ампициллина хлорамфениколом антибиотиками группы цефалоспоринов тетрациклином растворами аминокислот гепарином; их не следует смешивать в одном шприце или инфузионной среде."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"При инфекциях вызванных грамотрицательными микроорганизмами (Enterobacter spp. Pseudomonas aeruginosa и др.) назначают только при устойчивости возбудителя к другим менее токсичным препаратам."}},{"type":"paragraph","data":{"text":"При длительном лечении необходимо контролировать функцию почек 1 раз в 2 дня."}},{"type":"paragraph","data":{"text":"Парентерально применяют только в условиях стационара."}},{"type":"paragraph","data":{"text":"Внутримышечные инъекции болезненны поэтому для приготовления раствора для в/м введения рекомендуется использовать местный анестетик (1% раствор прокаина)."}},{"type":"paragraph","data":{"text":"Псевдомембранозный колит вызываемый Clostridium difficile может появляться как на фоне длительного применения так и через 2-3 недели после прекращения лечения; проявляется диареей лейкоцитозом лихорадкой болями в животе (иногда сопровождающимися выделением с каловыми массами крови и слизи). При возникновении этих явлений в легких случаях достаточно отмены лечения и применения ионообменных смол (колестирамин колестипол) в тяжелых случаях показано возмещение потери жидкости электролитов и белка назначение ванкомицина или метронидазола. Нельзя применять лекарственные средства тормозящие перистальтику кишечника."}},{"type":"paragraph","data":{"text":"Проявлениями побочного действия полимиксина В могут быть нарушения функции почек (нефротоксичность) и нервной системы (нейротоксичность) риск развития которых выше у пациентов с хронической почечной недостаточностью и/или при одновременном применении с другими лекарственными препаратами обладающими нейротоксическими и/или нефротоксическими свойствами."}},{"type":"paragraph","data":{"text":"Веллобактин-В® следует применять с осторожностью при хронической почечной недостаточности."}},{"type":"paragraph","data":{"text":"Следует избегать одновременного применения препарата Веллобактин-В® с другими нейро- и нефротоксичными препаратами."}}]}],"source":null},"description_toggle":false,"short_description":"Антибиотик продуцируемый спорообразующими бактериями Bacillus polymyxa. Каждый мг очищенного полимиксина В основания эквивалентен 10000 ЕД полимиксина В. Оказывает бактерицидное действие связанное с нарушением целостности мембраны микробной клетки. Адсорбируется на фосфолипидах мембраны увеличивает ее проницаемость вызывает лизис бактерий. Активен в отношении большинства грамотрицательных бактерий в т.ч. Pseudomonas aeruginosa Salmonella spp. Shigella spp. Escherichia coli Klebsiella spp. Bordetella pertussis Haemophilus influenzae Enterobacter spp. Умеренно чувствительны Fusobacterium spp. и Bacteroides spp. (в т.ч. Bacteroides fragilis). He действуетна кокковые аэробные (Staphylococcus spp. Streptococcus spp. (в т.ч. Streptococcus pneumoniae) Neisseria gonorrhoeae Neisseria meningitidis) и анаэробные микроорганизмы Corynebacterium diphtheriae на большинство штаммов Proteus spp. Mycobacterium tuberculosis и грибы. Устойчивость развивается медленно но является перекрестной с колистином и полимиксином Е.","substance":[{"id":1768,"title":"Полимиксин B","title_latin":"Polymyxinum B","slug":"polimiksin_b_1768"}],"branding":null,"valid_for_quick_buy":false,"is_available_to_delivery":false,"comments":null,"image_alt":"Веллобактин-В - фото упаковки","image_share":{"isTouch":{"default":null},"isFromTablet":{"default":null}},"diseases":[],"other_packages":[],"other_product_forms":[],"related_products":{"title":"Похожие товары","type":"similar","products":[{"id":93172,"title":"Полидекса с фенилэфрином","subtitle":{"full":"Спрей, 15 мл","short":"Спрей, 15 мл","package":"15 мл"},"prescription":true,"catalog_section_id":60,"manufacturer":{"id":420,"title":"Русфик","slug":"rusfik_420","logo":{"isTouch":{"retina":null,"default":null},"isFromTablet":{"retina":null,"default":null}}},"is_advert":false,"product_form":"Спрей","slug":"93172-polideksa_s_fenilefrinom","attributes":{"count":"","dose":"","volume":"15 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