Амброксол является активным N-деметилированным метаболитом б... Инструкция
Показания к применению
Нарушение секреции и транспорта мокроты при острых и хронических заболеваниях органов дыхания: острый и хронический бронхит, пневмония, хроническая обструктивная болезнь легких, бронхиальная астма, бронхоэктатическая болезнь.
Противопоказания
Повышенная чувствительность к компонентам препарата, наследственная непереносимость галактозы, дефицит лактазы или синдром мальабсорбции глюкозы и галактозы, I триместр беременности и период грудного вскармливания, детский возраст до 6 лет.
С осторожностью:
Нарушение моторики бронхов и увеличение секреции слизи (например, при редком синдроме первичной ...
Амброксол является активным N-деметилированным метаболитом бромгексина.
Обладает секретомоторным, секретолитическим и отхаркивающим действием.
Стимулирует работу бронхиальных желез, повышает двигательную активность мерцательного эпителия путем воздействия на пневмоциты 2 типа в альвеолах и клетки Клара в бронхиолах, усиливает образование эндогенного сурфактанта – поверхностно-активного вещества, обеспечивающего скольжение бронхиального секрета в просвете дыхательных путей.
Амброксол увеличивает долю серозного компонента в бронхиальном секрете, улучшая его структуру и способствуя уменьшению вязкости и разжижению мокроты; в результате чего улучшается мукоцилиарный транспорт и облегчается выведение мокроты из бронхиального дерева.
В среднем, при приеме внутрь действие препарата наступает через 30 мин, продолжительность действия − 6-12 часов в зависимости от принятой дозы.
Показания к применению
Нарушение секреции и транспорта мокроты при острых и хронических заболеваниях органов дыхания: острый и хронический бронхит, пневмония, хроническая обструктивная болезнь легких, бронхиальная астма, бронхоэктатическая болезнь.
Противопоказания
Повышенная чувствительность к компонентам препарата, наследственная непереносимость галактозы, дефицит лактазы или синдром мальабсорбции глюкозы и галактозы, I триместр беременности и период грудного вскармливания, детский возраст до 6 лет.
С осторожностью:
Нарушение моторики бронхов и увеличение секреции слизи (например, при редком синдроме первичной дискинезии ресничек); почечная недостаточность и/или тяжелая печеночная недостаточность); язвенная болезнь желудка и двенадцатиперстной кишки, в том числе в анамнезе; II-III триместры беременности.
Применение при беременности и в период грудного вскармливания
Препарат не рекомендуется применять в течение I триместра беременности.
При необходимости применения амброксола во II-III триместрах беременности следует соотносить потенциальную пользу для матери и возможный риск для плода.
В период грудного вскармливания применять препарат с осторожностью, поскольку он экскретируется в грудное молоко.
Способ применения и дозы
Внутрь, после еды, запивая достаточным количеством жидкости.
Взрослые и дети старше 12 лет: по 30 мг (1 таблетка) 3 раза в сутки в течение первых 2-3 суток, затем дозу препарата необходимо уменьшить до 1 таблетки 2 раза в сутки.
Дети от 6 до 12 лет: по 15 мг (1/2 таблетки) 2-3 раза в сутки.
В случае сохранения симптомов заболевания в течение 4-5 дней от начала приема рекомендуется обратиться к врачу.
Побочное действие
Классификация частоты развития побочных эффектов согласно рекомендациям Всемирной организации здравоохранения (ВОЗ):
очень часто > 1/10; часто от > 1/100 до < 1/10; нечасто от > 1/1000 до < 1/100; редко от > 1/10000 до < 1/1000; очень редко < 1/10000, включая отдельные сообщения; частота неизвестна – по имеющимся данным установить частоту возникновения не представляется возможным.
Аллергические реакции:
частота неизвестна – реакции повышенной чувствительности, анафилактические реакции (в том числе анафилактический шок), ангионевротический отек.
Со стороны пищеварительной системы:
часто – тошнота, снижение чувствительности в полости рта или глотки; нечасто – диспепсия, рвота, диарея, абдоминальная боль; редко – изжога, сухость слизистой оболочки полости рта и глотки, запор.
Со стороны дыхательной системы:
редко – сухость слизистой оболочки дыхательных путей, ринорея (выделение слизи из носа).
Лечение:искусственная рвота, промывание желудка в первые 1-2 ч после приема препарата, прием жиросодержащих продуктов.
Взаимодействие с другими лекарственными средствами
При применении с противокашлевыми препаратами возможно затруднение отхождения мокроты в результате подавления кашлевого рефлекса.
При одновременном применении с амоксициллином, цефуроксимом, эритромицином, доксициклином амброксол увеличивает их концентрацию в бронхиальном секрете.
Особые указания
Амброксол следует с осторожностью применять у пациентов с ослабленным кашлевым рефлексом или нарушенным мукоцилиарным транспортом из-за возможности скопления мокроты.
Пациентам, принимающим амброксол не следует рекомендовать выполнение дыхательной гимнастики; у тяжелобольных следует выполнять аспирацию разжиженной мокроты.
У пациентов с бронхиальной астмой амброксол может усиливать кашель.
Не следует принимать амброксол непосредственно перед сном. Амброксол не следует принимать одновременно с противокашлевыми препаратами, которые могут тормозить кашлевой рефлекс, например, с кодеином, т.к. это может затруднять удаление разжиженной мокроты из бронхиального древа.
Влияние на способность управлять автомобилем или другими механизмами: Применение препарата не влияет на скорость психомоторных реакций.
Условия хранения
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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сурфактанта – поверхностно-активного вещества, обеспечивающего скольжение бронхиального секрета в просвете дыхательных путей. "}},{"type":"paragraph","data":{"text":"Амброксол увеличивает долю серозного компонента в бронхиальном секрете, улучшая его структуру и способствуя уменьшению вязкости и разжижению мокроты; в результате чего улучшается мукоцилиарный транспорт и облегчается выведение мокроты из бронхиального дерева."}},{"type":"paragraph","data":{"text":"В среднем, при приеме внутрь действие препарата наступает через 30 мин, продолжительность действия − 6-12 часов в зависимости от принятой дозы."}}]},{"id":7,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Нарушение секреции и транспорта мокроты при острых и хронических заболеваниях органов дыхания: острый и хронический бронхит, пневмония, хроническая обструктивная болезнь легких, бронхиальная астма, бронхоэктатическая болезнь."}}]},{"id":8,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность к компонентам препарата, наследственная непереносимость галактозы, дефицит лактазы или синдром мальабсорбции глюкозы и галактозы, I триместр беременности и период грудного вскармливания, детский возраст до 6 лет."}},{"type":"paragraph","data":{"text":"С осторожностью:"}},{"type":"paragraph","data":{"text":"Нарушение моторики бронхов и увеличение секреции слизи (например, при редком синдроме первичной дискинезии ресничек); почечная недостаточность и/или тяжелая печеночная недостаточность); язвенная болезнь желудка и двенадцатиперстной кишки, в том числе в анамнезе; II-III триместры беременности."}}]},{"id":10,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Препарат не рекомендуется применять в течение I триместра беременности."}},{"type":"paragraph","data":{"text":"При необходимости применения амброксола во II-III триместрах беременности следует соотносить потенциальную пользу для матери и возможный риск для плода."}},{"type":"paragraph","data":{"text":"В период грудного вскармливания применять препарат с осторожностью, поскольку он экскретируется в грудное молоко.\n\n"}}]},{"id":11,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь, после еды, запивая достаточным количеством жидкости."}},{"type":"paragraph","data":{"text":"Взрослые и дети старше 12 лет: по 30 мг (1 таблетка) 3 раза в сутки в течение первых 2-3 суток, затем дозу препарата необходимо уменьшить до 1 таблетки 2 раза в сутки."}},{"type":"paragraph","data":{"text":"Дети от 6 до 12 лет: по 15 мг (1/2 таблетки) 2-3 раза в сутки."}},{"type":"paragraph","data":{"text":"В случае сохранения симптомов заболевания в течение 4-5 дней от начала приема рекомендуется обратиться к врачу."}}]},{"id":12,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Классификация частоты развития побочных эффектов согласно рекомендациям Всемирной организации здравоохранения (ВОЗ):"}},{"type":"paragraph","data":{"text":"очень часто > 1/10; 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частота неизвестна – кожный зуд, синдром Стивенса-Джонсона (многоформная экссудативная эритема), синдром Лайелла (токсический эпидермальный некролиз), острый генерализованный экзантематозный пустулез."}},{"type":"paragraph","data":{"text":"Со стороны органов чувств:"}},{"type":"paragraph","data":{"text":"нечасто – дисгевзия (нарушения вкусовых ощущений)."}},{"type":"paragraph","data":{"text":"Прочие:"}},{"type":"paragraph","data":{"text":"редко – слабость, головная боль, дизурия (нарушения мочеиспускания), гипертермия, лихорадка."}}]},{"id":13,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы:тошнота, рвота, гастралгия, диарея, диспепсия."}},{"type":"paragraph","data":{"text":"Лечение:искусственная рвота, промывание желудка в первые 1-2 ч после приема препарата, прием жиросодержащих продуктов."}}]},{"id":14,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"При применении с противокашлевыми препаратами возможно затруднение отхождения мокроты в результате подавления кашлевого рефлекса."}},{"type":"paragraph","data":{"text":"При одновременном применении с амоксициллином, цефуроксимом, эритромицином, доксициклином амброксол увеличивает их концентрацию в бронхиальном секрете."}}]},{"id":15,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Амброксол следует с осторожностью применять у пациентов с ослабленным кашлевым рефлексом или нарушенным мукоцилиарным транспортом из-за возможности скопления мокроты."}},{"type":"paragraph","data":{"text":"Пациентам, принимающим амброксол не следует рекомендовать выполнение дыхательной гимнастики; 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