Брилинта содержит в своем составе тикагрелор, представитель... Инструкция
Показания к применению
Назначение одновременно с ацетилсалициловой кислотой, показано для профилактики атеротромботических осложнений у взрослых пациентов с инфарктом миокарда в анамнезе (инфаркт миокарда перенесен один год и более назад) и высоким риском развития атеротромботического осложнения.
Противопоказания
Повышенная чувствительность к тикагрелору или любому вспомогательному веществу препарата, активное патологическое кровотечение, внутричерепное кровоизлияние в анамнезе, нарушение функции печени тяжелой степени, совместное применение тикагрелора с мощными ингибиторами изофермента CYP3A4 (например, кетоконазолом, кларитромицином, нефазодоном, ритонавиром ...
Таблетки Брилинта необходимы при терапии сердечно-сосудистых заболеваний. Препарат относится к антиагрегантам и снижает риск образования тромбов, способных привести к инсульту головного мозга или инфаркту миокарда.
Фармакологические свойства
Брилинта содержит в своем составе тикагрелор, представитель химического класса циклопентилтриазолопиримидинов, который является селективным и обратимым антагонистом P2Y12-рецептора к АДФ и может предотвращать АДФ-опосредованную активацию и агрегацию тромбоцитов. Тикагрелор активен при приеме внутрь и обратимо взаимодействует с P2Y12-АДФ-рецептором тромбоцитов. Тикагрелор не взаимодействует с местом связывания самого АДФ, но его взаимодействие с P2Y12-рецептором тромбоцитов к АДФ предотвращает трансдукцию сигналов.
Показания к применению
Назначение одновременно с ацетилсалициловой кислотой, показано для профилактики атеротромботических осложнений у взрослых пациентов с инфарктом миокарда в анамнезе (инфаркт миокарда перенесен один год и более назад) и высоким риском развития атеротромботического осложнения.
Противопоказания
Повышенная чувствительность к тикагрелору или любому вспомогательному веществу препарата, активное патологическое кровотечение, внутричерепное кровоизлияние в анамнезе, нарушение функции печени тяжелой степени, совместное применение тикагрелора с мощными ингибиторами изофермента CYP3A4 (например, кетоконазолом, кларитромицином, нефазодоном, ритонавиром и атазанавиром).
Применение при беременности и в период грудного вскармливания
Не рекомендуется
Способ применения и дозы
Прием внутрь. Не зависит от приема пищи. При затруднении глотания таблетку Брилинта следует измельчить до порошка, размешать в 1/2 стакана питьевой воды и сразу же выпить полученную суспензию. Остатки смешать с дополнительной 1/2 стакана питьевой воды и также выпить. Рекомендуемая доза пациентам с инфарктом миокарда в анамнезе (год и более назад) - 60мг два раза в сутки. При приеме Брилинта, нужно ежедневно принимать низкую поддерживающую дозу АСК (75-150 мг), если отсутствуют специфические противопоказания. Рекомендуется длительная терапия. Преждевременная отмена может повысить риск сердечно-сосудистой смерти или инфаркта миокарда в результате основного заболевания. Также следует избегать перерывов в терапии. Пациент, пропустивший прием препарата Брилинта, должен принять только одну таблетку 60 мг (следующая доза) в намеченное время. При переводе пациентов на препарат Брилинта первую дозу следует назначить через 24 часа после приема последней дозы другого антиагрегантного препарата.
Побочное действие
Гиперурикемия, внутричерепное кровоизлияние, головокружение, кровоизлияния (интраокулярные, конъюнктивальные, ретинальные), кровоизлияния в ухо, Вертиго, отдышка, носовое кровотечение, гастрит, рвота с кровью, кровотечения из язвы в ЖКТ, рвота, диарея, диспепсия, гемартроз, кровотечение из мочевыводящих путей.
Передозировка
Тикагрелор хорошо переносится в однократной дозе препарата до 900 мг. При увеличении дозы неблагоприятное воздействие на желудочно-кишечный тракт было дозолимитирующим. Другие возможные реакции на передозировку: одышка и желудочковые паузы. При передозировке следует проводить симптоматическую терапию в соответствии с локальными стандартами.
Особые указания
Перед запланированной операцией или началом приема новых препаратов пациенту следует проинформировать врача о том, что он принимает препарат Брилинта.
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