Секнидокс Таблетки, коробка, 2 шт, для приема внутрь, в пленочной оболочке

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Были зарегистрированы случаи кандидоза слизистой оболочки полости рта и анальной области, а также случаи диареи у младенцев, которые были на грудном вскармливании у матерей, получавших производные имидазола (но не секнидазол)."}},{"type":"paragraph","data":{"text":"Применение у детей"}},{"type":"paragraph","data":{"text":"Противопоказано применение препарата в детском возрасте до 3 лет или при массе тела менее 16 кг (для данной лекарственной формы)."}}]},{"id":11,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Препарат принимают внутрь, непосредственно перед едой, запивая небольшим количеством воды."}},{"type":"paragraph","data":{"text":"Уретрит и вагинит"}},{"type":"paragraph","data":{"text":"Взрослым - однократный прием 2 г секнидазола (2 таб.), курс лечения 1 день."}},{"type":"paragraph","data":{"text":"Следует проводить одновременное лечение обоих половых партнеров."}},{"type":"paragraph","data":{"text":"Амебиаз кишечника"}},{"type":"paragraph","data":{"text":"Острый амебиаз с выраженной симптоматикой (форма histolytica): взрослым - однократный прием 2 г секнидазола (2 таб.), курс лечения 1 день; детям - однократный прием дозы 30 мг/кг, курс лечения 1 день."}},{"type":"paragraph","data":{"text":"Амебиаз без клинической симптоматики, включая очаговую и цистную формы (minuta и cystic): взрослым - 2 г секнидазола (2 таб.) в один или несколько приемов в течение 3 дней; детям - 30 мг/кг/сут в один или несколько приемов в течение 3 дней."}},{"type":"paragraph","data":{"text":"Амебиаз печени"}},{"type":"paragraph","data":{"text":"Взрослым - 1.5 г секнидазола (1.5 таб.) в один или несколько приемов в течение 5 дней; детям - 30 мг/кг/сут в один или несколько приемов в течение 5 дней."}},{"type":"paragraph","data":{"text":"Жиардиаз"}},{"type":"paragraph","data":{"text":"Детям - однократный прием дозы 30 мг/кг, курс лечения 1 день."}}]},{"id":12,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Аллергические реакции: крапивница, сыпь, ангионевротический отек; очень редко - анафилактическая реакция."}},{"type":"paragraph","data":{"text":"Со стороны крови и лимфатической системы: умеренная обратимая лейкопения."}},{"type":"paragraph","data":{"text":"Со стороны нервной системы: головокружение, нарушение координации движений (атаксия), снижение кожной чувствительности (парестезия), периферическая невропатия."}},{"type":"paragraph","data":{"text":"Со стороны пищеварительной системы: тошнота, рвота, боли в области желудка, \"металлический\" привкус во рту, глоссит, стоматит."}},{"type":"paragraph","data":{"text":"Прочие: лихорадка."}},{"type":"paragraph","data":{"text":"Если любые из указанных в инструкции побочных эффектов усугубляются или отмечаются любые другие побочные эффекты, не указанные в инструкции, пациенту следует сообщить об этом врачу."}}]},{"id":13,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: усиление дозозависимых побочных эффектов. 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Прием препарата следует прекратить, необходимо очистить желудок, принять активированный уголь; пациенту следует немедленно обратиться к врачу."}}]},{"id":14,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Дисульфирам: при совместном применении секнидазола с дисульфирамом возможны психотические реакции, состояние спутанности сознания."}},{"type":"paragraph","data":{"text":"Антикоагулянты для приема внутрь (например, варфарин): секнидазол усиливает действие непрямых антикоагулянтов (производных кумарина или индандиона) и повышает риск возникновения кровотечений за счет снижения печеночного метаболизма антикоагулянтов."}},{"type":"paragraph","data":{"text":"Этанол: сочетание с этанолом вызывает симптомы \"антабусной реакции\" (спазмы в животе, тошнота, рвота, головная боль, \"приливы жара\", тахикардия)."}}]},{"id":15,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"При печеночном амебиазе в фазе нагноения прием препарата следует сочетать с дренажным удалением гноя или с удалением абсцессов."}},{"type":"paragraph","data":{"text":"При одновременном приеме непрямых антикоагулянтов необходимо чаще определять протромбиновое время и осуществлять мониторинг МНО и при необходимости корректировать дозу антикоагулянта на протяжении всего курса терапии секнидазолом и в течение 8 дней после окончания терапии."}},{"type":"paragraph","data":{"text":"На время терапии секнидазолом и в течение 5 дней после ее завершения необходимо отказаться от употребления алкогольных напитков и лекарственных препаратов, содержащих этанол."}},{"type":"paragraph","data":{"text":"При лечении трихомонадного вагинита у женщин и трихомонадного уретрита у мужчин пациенты должны воздерживаться от половой жизни. Обязательно одновременное лечение половых партнеров. Лечение не прекращается во время менструации."}},{"type":"paragraph","data":{"text":"Следует избегать применения препарата у пациентов с заболеванием крови в анамнезе. Длительное применение желательно проводить под контролем формулы крови. При лейкопении возможность продолжения лечения зависит от риска развития инфекционного процесса."}},{"type":"paragraph","data":{"text":"Появление атаксии, головокружения и любое другое ухудшение неврологического статуса больных требует прекращения лечения."}},{"type":"paragraph","data":{"text":"Влияние на способность к вождению автотранспорта и управлению механизмами"}},{"type":"paragraph","data":{"text":"Возможны такие побочные эффекты, как головокружение и нарушение координации движений. При появлении этих побочных действий пациентам рекомендуется воздержаться от выполнения потенциально опасных видов деятельности, требующих концентрации внимания и быстроты реакции."}}]}],"source":{"title":"ЗдравСити","url":"https://zdravcity.ru"}},"description_toggle":false,"short_description":"Производное нитроимидазола. Оказывает бактерицидное (против грамположительных и грамотрицательных анаэробных бактерий) и амебицидное (внутри- и внекишечное) действие. Секнидазол особенно активен в отношенииTrichomonas vaginalis, Entamoeba histolytica и Giardia lamblia. Проникая внутрь клетки микроорганизма, секнидазол активируется в результате восстановления 5-нитрогруппы, за счет чего взаимодействует с клеточной ДНК. Происходит нарушение ее спиралевидной структуры и разрушение нитей, ингибирование нуклеотидного синтеза и гибель клетки. Всасывание и распределение После приема внутрь секнидазол быстро всасывается из ЖКТ. Биодоступность составляет около 80%. После приема 2 г секнидазола C max в плазме достигается через 3-4 ч. Секнидазол проникает через ГЭБ и плацентарный барьер, экскретируется с грудным молоком. Выведение Т1/2 секнидазола из плазмы крови составляет около 25 ч. 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