Рединесп Капсулы, пачка, 50 шт, 5 мг, для приема внутрь

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часто - почечная недостаточность, острая почечная недостаточность, олигурия, острый канальцевый некроз, токсическая нефропатия, мочевой синдром, расстройства со стороны мочевого пузыря и уретры; нечасто - анурия, гемолитический уремический синдром; очень редко - нефропатия, геморрагический цистит."}},{"type":"paragraph","data":{"text":"\u003ci\u003eДерматологические реакции: \u003c/i\u003eчасто - зуд, сыпь, алопеция, акне, гипергидроз; нечасто - дерматит, фотосенсибилизация; редко - токсический эпидермальный некролиз (синдром Лайелла); очень редко - синдром Стивенса-Джонсона."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны костно-мышечной системы: \u003c/i\u003eчасто - артралгия, мышечные судороги, боль в конечностях, боль в спине; нечасто - суставные расстройства."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны эндокринной системы:\u003c/i\u003e очень часто - гипергликемия, сахарный диабет; редко - гирсутизм."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны обмена веществ:\u003c/i\u003e очень часто - гиперкалиемия; часто - гипомагниемия, гипофосфатемия, гипокалиемия, гипокальциемия, гипонатриемия, гиперволемия, гиперурикемия, снижение аппетита, анорексия, метаболический ацидоз, гиперлипидемия, гиперхолестеринемия, гипертриглицеридемия, электролитные нарушения; нечасто - обезвоживание, гипопротеинемия, гиперфосфатемия, гипогликемия."}},{"type":"paragraph","data":{"text":"\u003ci\u003eИнфекции и инвазии: \u003c/i\u003eна фоне терапии такролимусом, как и другими иммунодепрессантами, повышается риск локальных и генерализованных инфекционных заболеваний (вирусных, бактериальных, грибковых, протозойных). Может ухудшиться течение ранее диагностированных инфекционных заболеваний; случаи нефропатии, ассоциированной с ВК-вирусом, а также прогрессирующей мультифокальной лейкоэнцефалопатии."}},{"type":"paragraph","data":{"text":"\u003ci\u003eТравмы, отравления, осложнения процедур: \u003c/i\u003eчасто - первичная дисфункция трансплантата."}},{"type":"paragraph","data":{"text":"\u003ci\u003eДоброкачественные, злокачественные и неидентифицированные новообразования: \u003c/i\u003eпациенты, получающие иммуносупрессивную терапию, имеют более высокий риск злокачественных опухолей. При применении такролимуса отмечено возникновение как доброкачественных, так и злокачественных новообразований, в т.ч. вирус Эпштейна-Барр-ассоциированных лимфопролиферативных заболеваний и рака кожи."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны половой системы:\u003c/i\u003e нечасто - дисменорея и маточное кровотечение. Отрицательное влияние такролимуса на мужскую фертильность, выражающееся в уменьшении числа и подвижности сперматозоидов, установлено у крыс. "}},{"type":"paragraph","data":{"text":"\u003ci\u003eАллергические реакции: \u003c/i\u003eу пациентов, принимавших такролимус, наблюдались аллергические и анафилактические реакции."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны организма в целом: \u003c/i\u003eчасто - астения, лихорадочные состояния, отеки, боль и дискомфорт, повышение уровня ЩФ в крови, увеличение массы тела, нарушения восприятия температуры тела; нечасто - полиорганная недостаточность, гриппоподобный синдром, нарушения восприятия температуры окружающей среды, ощущение сдавливания в груди, чувство тревоги, ухудшение самочувствия, повышение активности ЛДГ в крови, снижение массы тела; редко - жажда, потеря равновесия (падения), ощущение скованности в грудной клетке, затруднения движения; очень редко - увеличение массы жировой ткани."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"В начальном посттрансплантационном периоде следует проводить регулярный мониторинг следующих параметров: АД, ЭКГ, неврологический статус и состояние зрения, уровень глюкозы крови натощак, концентрация электролитов (особенно калия), показатели печеночной и почечной функции, гематологические показатели, коагулограмма, уровень протеинемии. При наличии клинически значимых изменений, необходима коррекция иммуносупрессивной терапии."}},{"type":"paragraph","data":{"text":"В период применения такролимуса следует избегать назначения растительных препаратов, содержащих зверобой (Hypericum perforatum), а также других растительных средств, которые могут вызвать снижение (изменение) концентрации такролимуса в крови и оказать неблагоприятное влияние на клинический эффект такролимуса."}},{"type":"paragraph","data":{"text":"При диарее концентрация такролимуса в крови может значительно изменяться; при появлении диареи необходим тщательный мониторинг концентраций такролимуса в крови."}},{"type":"paragraph","data":{"text":"Следует избегать одновременного применения циклоспорина и такролимуса, а также соблюдать осторожность при лечении такролимусом пациентов, которые ранее получали циклоспорин."}},{"type":"paragraph","data":{"text":"\u003ci\u003eИспользование в педиатрии\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"При наружном применении такролимус следует применять в лекарственных формах, соответствующих возрасту ребенка."}},{"type":"paragraph","data":{"text":"\u003ci\u003eВлияние на способность к управлению транспортными средствами и механизмами\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Такролимус может вызывать зрительные и неврологические расстройства, особенно в сочетании с алкоголем. В период лечения пациенты должны воздерживаться от вождения автотранспорта и работы с механизмами."}}]}],"source":null},"description_toggle":false,"short_description":"Иммунодепрессант. На молекулярном уровне эффекты и внутриклеточная кумуляция такролимуса обусловлены связыванием с цитозольным белком (FKBP 12). Комплекс FKBP 12 - такролимус специфически и конкурентно ингибирует кальциневрин, обеспечивая кальцийзависимое блокирование путей передачи Т-клеточных сигналов и предотвращая транскрипцию дискретного ряда лимфокинных генов. Такролимус – высокоактивный иммунодепрессант. В экспериментах in vitro и in vivo такролимус отчетливо уменьшал образование цитотоксических лимфоцитов, которые играют ключевую роль в реакции отторжения трансплантата. Такролимус подавляет образование лимфокинов (интерлейкин-2, интерлейкин-3, γ-интерферон), активацию Т-клеток, экспрессию рецептора интерлейкина-2, а также зависимую от Т-хелперов пролиферацию В-клеток.","substance":[{"id":654,"title":"Такролимус","title_latin":"Tacrolimusum","slug":"takrolimus_654"}],"branding":null,"valid_for_quick_buy":false,"is_available_to_delivery":false,"comments":null,"image_alt":"Рединесп - фото упаковки","image_share":{"isTouch":{"default":null},"isFromTablet":{"default":null}},"diseases":[],"other_packages":[],"other_product_forms":[],"related_products":{"title":"Аналоги","type":"analogs","products":[{"id":150894,"title":"Програф","subtitle":{"full":"Капсулы, 50 шт, 5 мг","short":"Капсулы, 50 шт, 5 мг","package":"50 шт, 5 мг"},"prescription":true,"catalog_section_id":100266,"manufacturer":{"id":521,"title":"Астеллас 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