Симптоматическое лечение острой (аллергической эмоциональной лекарственной лучевой) и хронической (при синдроме раздраженной кишки) диареи.
Регуляция стула у пациентов с илеостомой.
В качестве вспомогательного лекарственного средства - диарея инфекционного генеза.
Противопоказания
Гиперчувствительность кишечная непроходимость острый язвенный колит дивертикулез диарея на фоне псевдомембранозного энтероколита дизентерии и других инфекций желудочно-кишечного тракта; беременность (I триместр) период лактации детский возраст (до 6 лет); дефицит лактазы непереносимость лактозы глюкозо-галактозная мальабсорбция.
корпус: титана диоксид (Е 171), краситель синий патентованный V (Е 131), краситель пунцовый (Понсо 4R) (Е 124), желатин;
крышечка: титана диоксид (Е 171), краситель хинолиновый желтый (Е 104), краситель синий патентованный V (Е 131), краситель железа оксид желтый (Е 172), желатин.
Описание
Твердые желатиновые капсулы № 3. Корпус розового цвета, крышечки темнозеленого цвета; содержимое - порошок белого цвета.
Фармакотерапевтическая группа
Противодиарейное средство
Фармакологические свойства
Лоперамид, связываясь с опиоидными рецепторами кишечной стенки (стимуляция холин- и адренергических нейронов через гуанин-нуклеотиды), снижает тонус и моторику гладкой мускулатуры кишечника (за счет ингибирования высвобождения ацетилхолина и Pg). Препарат замедляет перистальтику и увеличивает время прохождения кишечного содержимого. Повышает тонус анального сфинктера, способствует удержанию каловых масс и урежению позывов к дефекации. Действие лоперамида развивается быстро и продолжается 4 - 6 ч.
Показания к применению
Симптоматическое лечение острой (аллергической эмоциональной лекарственной лучевой) и хронической (при синдроме раздраженной кишки) диареи.
Регуляция стула у пациентов с илеостомой.
В качестве вспомогательного лекарственного средства - диарея инфекционного генеза.
Противопоказания
Гиперчувствительность кишечная непроходимость острый язвенный колит дивертикулез диарея на фоне псевдомембранозного энтероколита дизентерии и других инфекций желудочно-кишечного тракта; беременность (I триместр) период лактации детский возраст (до 6 лет); дефицит лактазы непереносимость лактозы глюкозо-галактозная мальабсорбция.
С осторожностью
Печеночная недостаточность.
Применение при беременности и в период грудного вскармливания
Противопоказан при беременности (в I триместре) и в период лактации.
Способ применения и дозы
Капсулы принимают внутрь не разжевывая запивая водой.
При острой диарее начальная доза для взрослых - 4 мг; затем - по 2 мг после каждого акта дефекации (в случае жидкого кала); максимальная суточная доза - 16 мг.
При хронической диарее рекомендуемая доза для взрослых - 4 мг/сутки; максимальная суточная доза - 16 мг.
При острой диарее у детей старше 6 лет рекомендуемая начальная доза лоперамида - 2 мг затем - по 2 мг после каждого акта дефекации; максимальная суточная доза - 8 мг.
При хронической диарее детям старше 6 лет лоперамид назначают в суточной дозе 2 мг. При появлении нормального стула или при отсутствии стула более 12 ч препарат отменяют. Максимальная длительность лечения - 2 суток.
Пациенты с нарушением функции печени
Несмотря на то что данные о фармакокинетике в данной категории пациентов не доступны ввиду выраженного эффекта "первого прохождения" через печень пациентам с нарушением функции печени при применении лоперамида следует соблюдать особую осторожность (см. раздел Особые указания).
Побочное действие
Со стороны кожных покровов и подкожной клетчатки: высыпания зуд крапивница ангионевротический отек. Очень редко - буллезная сыпь включая erythemamultiforme синдром Стивенса-Джонсона и токсический эпидермальный некролиз.
Со стороны иммунной системы: аллергические реакции - крапивница ангионевротический отек; очень редко - тяжелые реакции гиперчувствительности включая анафилактический шок и анафилактоидные реакции.
Со стороны пищеварительной системы: сухость слизистой оболочки полости рта боль в животе вздутие или дискомфорт в животе тошнота рвота метеоризм диспепсия запоры; крайне редко - паралитическая кишечная непроходимость токсический мегаколон.
Со стороны мочеполовой системы: задержка мочи.
Со стороны нервной системы: сонливость головокружение.
Общие нарушения: утомляемость.
Передозировка
Симптомы: угнетение центральной нервной системы (ступор нарушения координации движений сонливость миоз мышечная гипертония угнетение дыхания) кишечная непроходимость.
Лечение: антидот - налоксон; учитывая что продолжительность действия лоперамида больше чем у налоксона возможно повторное введение последнего. Симптоматическое лечение активированный уголь промывание желудка искусственная вентиляция легких.
Взаимодействие с другими лекарственными средствами
Лоперамид является субстратом Р-гликопротеина. По данным доклинических исследований одновременное применение лоперамида (разовая доза 16 мг) с хинидином (разовая доза 600 мг) или ритонавиром (последние являются ингибиторами Р-гликопротеина) вызывало повышение уровня лоперамида в плазме крови в 2 - 3 раза. Ввиду возможного повышения риска возникновения побочных эффектов со стороны центральной нервной системы при одновременном применении лоперамида с ингибиторами Р-гликопротеина хинидином и ритонавиром следует соблюдать осторожность.
При совместном применении лоперамида и саквинавира лоперамид клинически значимо снижает терапевтическую эффективность саквинавира.
Одновременное применение лоперамида с ко-тримоксазолом увеличивает биодоступность лоперамида.
Одновременное назначение наркотических (опиоидных) анальгетиков и лоперамида повышает риск возникновения запоров.
Особые указания
При отсутствии эффекта после 2 суток применения лоперамида необходимо обратиться к врачу.
Если при лечении развиваются запоры или вздутие живота лоперамид следует отменить.
У пациентов с нарушением функции печени необходим тщательный контроль за признаками токсического поражения центральной нервной системы. Такими являются ступор сонливость миоз мышечная гипертония угнетение дыхания нарушения координации движений.
Влияние на способность управлять автомобилем и движущимися механизмами
В период лечения необходимо соблюдать осторожность при вождении автотранспорта и занятии другими потенциально опасными видами деятельности требующими повышенной концентрации внимания и быстроты психомоторных реакций.
Форма выпуска
Капсулы 2 мг.
Условия хранения
При температуре не выше 25 °С.
Хранить в недоступном для детей месте.
Срок годности
5 лет.
Не применять по истечении срока годности указанного на упаковке.
Условия отпуска
Без рецепта
Производитель
Акционерное Общество "Гриндекс"
Организация, принимающая претензии потребителей
Акционерное Общество "Гриндекс"
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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Очень редко - буллезная сыпь включая erythemamultiforme синдром Стивенса-Джонсона и токсический эпидермальный некролиз."}},{"type":"paragraph","data":{"text":"Со стороны иммунной системы: аллергические реакции - крапивница ангионевротический отек; очень редко - тяжелые реакции гиперчувствительности включая анафилактический шок и анафилактоидные реакции."}},{"type":"paragraph","data":{"text":"Со стороны пищеварительной системы: сухость слизистой оболочки полости рта боль в животе вздутие или дискомфорт в животе тошнота рвота метеоризм диспепсия запоры; крайне редко - паралитическая кишечная непроходимость токсический мегаколон."}},{"type":"paragraph","data":{"text":"Со стороны мочеполовой системы: задержка мочи."}},{"type":"paragraph","data":{"text":"Со стороны нервной системы: сонливость головокружение."}},{"type":"paragraph","data":{"text":"Общие нарушения: утомляемость."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: угнетение центральной нервной системы (ступор нарушения координации движений сонливость миоз мышечная гипертония угнетение дыхания) кишечная непроходимость."}},{"type":"paragraph","data":{"text":"Лечение: антидот - налоксон; учитывая что продолжительность действия лоперамида больше чем у налоксона возможно повторное введение последнего. 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