Фурагин Таблетки, пачка, 30 шт, 50 мг, для приема внутрь, для взрослых, + 6 лет, цвет желтый

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Препарат особенно активен при инфекциях мочевых путей."}},{"type":"paragraph","data":{"text":"Нитрофураны не угнетают иммунную систему организма, а даже активизируют ее, например, повышают титр комплемента и способность лейкоцитов фагоцитировать микроорганизмы."}}]},{"id":2,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Инфекционно-воспалительные заболевания мочеполовой системы: цистит, пиелонефрит (острый, хронический), простатит, уретрит, в т.ч. послеоперационные."}}]},{"id":3,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"list","data":{"style":"ordered","items":["повышенная чувствительность к фурагину, к препаратам группы нитрофурана или к вспомогательным веществам препарата;","тяжелая почечная недостаточность (почечный клиренс менее 30 мл/мин);","заболевания печени;","полиневропатия (в том числе диабетическая);","недостаточность энзима глюкозо-6-фосфатдегидрогеназы (риск развития гемолиза);"]}},{"type":"list","data":{"style":"ordered","items":["беременность и кормление грудью;"]}},{"type":"list","data":{"style":"ordered","items":["детям в возрасте до 6 лет."]}}]},{"id":16,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Осторожность следует соблюдать больным с нарушениями функций почек, при анемии, дефиците витаминов группы В и фолиевой кислоты, при заболеваниях легких (у пациентов старше 65 лет). При длительном приеме фурагина внутрь может развиться неврит. В случае длительной терапии следует контролировать функции легких и печени, особенно у пациентов старше 65 лет. С осторожностью следует применять фурагин больным сахарным диабетом, т.к. препарат может способствовать развитию полиневропатии."}}]},{"id":4,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Противопоказано при беременности. На время лечения следует прекратить грудное вскармливание."}}]},{"id":5,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Таблетки Фурагин принимают внутрь после еды, запивая достаточным количеством воды."}},{"type":"paragraph","data":{"text":"Взрослым назначают по 100-200 мг 2-3 раза в день. Курс лечения составляет 7-10 дней и зависит от тяжести заболевания, а также от функционального состояния почек. При необходимости курс лечения повторяют через 10-15 дней."}},{"type":"paragraph","data":{"text":"Детям старше 6 лет: 5-8 мг/кг массы тела в день, разделив суточную дозу на 3-4 разовые дозы, в течение 7-8 дней, в отдельных случаях при нормализации анализов мочи для противорецидивной терапии переходят на дозу 1/2 - 1/3 от максимальной дозы в течение 3-4 недель."}}]},{"id":6,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Иногда"}},{"type":"list","data":{"style":"ordered","items":["снижение аппетита, тошнота;","рвота, диарея;"]}},{"type":"list","data":{"style":"ordered","items":["головокружение, сонливость, нарушение зрения;","лихорадка."]}},{"type":"paragraph","data":{"text":"Редко"}},{"type":"list","data":{"style":"ordered","items":["полиневропатия;"]}},{"type":"list","data":{"style":"ordered","items":["папулезная сыпь, зуд, крапивница, преходящая алопеция."]}},{"type":"paragraph","data":{"text":"Очень редко"}},{"type":"list","data":{"style":"ordered","items":["одышка, учащенное дыхание, кашель без или с мокротой;","панкреатит;","прочие: повышение температуры тела, слабость, острые или хронические легочные реакции;","ангионевротический отёк, эксфолиативный дерматит, Erythemamultiforme;","агранулоцитоз, тромбоцитопения, апластическая анемия;","артралгия."]}},{"type":"paragraph","data":{"text":"В отдельных случаях"}},{"type":"list","data":{"style":"ordered","items":["холестатическая желтуха, гепатит, нарушения функции печени","нарушения сердечно-сосудистой системы: легкая степень внутричерепной гипертензии;","повышение температуры тела, слабость."]}},{"type":"paragraph","data":{"text":"В случае развития побочных действий следует уменьшить дозу или прекратить прием препарата. Побочные действия уменьшаются, если препарат принимают после еды, запивая большим количеством жидкости."}},{"type":"paragraph","data":{"text":"Фурагин может окрашивать мочу в коричневый цвет."}}]},{"id":17,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Токсическое действие возможно у больных с нарушением функции почек."}},{"type":"paragraph","data":{"text":"Симптомы: головная боль, головокружение, депрессия, периферический полиневрит, аллергические реакции (крапивница, ангионевротический отек, бронхоспазм), тошнота, рвота, гемолитическая анемия (у лиц с недостаточностью глюкозо-6-фосфат-дегидрогеназы), мегалобластическая анемия."}},{"type":"paragraph","data":{"text":"Лечение: промывание желудка, в/в введение инфузионного раствора (0,9 % раствора натрия хлорида). Проведение симптоматической и поддерживающей терапии. В тяжелых случаях показан гемодиализ. Специфический антидот не известен."}}]},{"id":18,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Средства, которые подщелачивают мочу (например, гидрокарбонат натрия) уменьшают терапевтический эффект фурагина (ускоряют выведение фурагина с мочой). Средства, которые подкисляют мочу (кислоты, в том числе аскорбиновая кислота, а также кальция хлорид), увеличивают концентрацию фурагина в моче (замедляется его выведение с мочой), таким образом увеличивается лечебный эффект препарата, но при этом возрастает риск развития токсических явлений."}},{"type":"paragraph","data":{"text":"Антибиотики-аминогликозиды и тетрациклин усиливают антибактериальное действие фурагина. В комбинации с хлорамфениколом и ристомицином повышается риск гемотоксических явлений."}},{"type":"paragraph","data":{"text":"Антагонизм действия с налидиксовой кислотой (ослабляет бактериостатическое действие фурагина)."}},{"type":"paragraph","data":{"text":"При одновременном применении фурагина и урикозурических средств (пробенецида, сульфинпиразона) уменьшается выведение фурагина с мочой, что приводит к кумуляции фурагина и возможности развития токсических явлений."}},{"type":"paragraph","data":{"text":"При одновременном применении фурагина и антацидов, содержащих магния трисиликат, уменьшается всасывание фурагина."}},{"type":"paragraph","data":{"text":"Атропин замедляет всасывание фурагина, но общее количество абсорбированного препарата не меняется."}}]},{"id":7,"name":"Особые указания","slug":"","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Развитие побочных реакций требует понижения дозы или отмены препарата. С целью уменьшения побочных эффектов рекомендуется прием витаминов группы В и антигистаминных средств."}},{"type":"paragraph","data":{"text":"Лабораторное исследование пациентов, принимающих фурагин, может дать ложно-положительную реакцию на наличие глюкозы в моче, если для определения используется метод восстановления меди. На результаты определения глюкозы в моче, выполненные энзиматическим методом, фурагин влияния не оказывает. В случае длительного приема фурагина следует периодически контролировать количество лейкоцитов в крови, а также показатели функций печени и почек во избежание развития нежелательных побочных явлений."}},{"type":"paragraph","data":{"text":"Противопоказано применение лицам с наследственной непереносимостью фруктозы, дефицитом фермента Lapp-лактазы, мальабсорбцией глюкозы-галактозы."}}]},{"id":19,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Особенности влияния лекарственного средства на способность управлять транспортным средством или потенциально опасными механизмами"}},{"type":"paragraph","data":{"text":"Не установлено."}}]},{"id":20,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"По 10 таблеток помещают в контурную ячейковую упаковку из пленки поливинилхлоридной и фольги алюминиевой печатной лакированной."}},{"type":"paragraph","data":{"text":"По 3 контурных ячейковых упаковки вместе с инструкцией по медицинскому применению на государственном и русском языках помещают в пачку из картона."}}]},{"id":8,"name":"Условия хранения","slug":"storage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"В сухом, защищенном от света месте, при температуре не выше 30°C. Хранить в недоступном для детей месте."}}]},{"id":9,"name":"Срок годности","slug":"expiry_date","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"5 лет. Не применять по истечении срока годности, указанного на упаковке.2000-2017. Регистр лекарственных средств России"}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"АО “Олайнфарм”."}},{"type":"paragraph","data":{"text":"Адрес: ул. Рупницу 5, Олайне, LV-2114, Латвия."}}]}],"source":{"title":"ЭркаФарм","url":"https://erkapharm.com"}},"description_toggle":false,"short_description":"Фармакокинетика Фурагин хорошо всасывается из желудочно-кишечного тракта. Абсорбция препарата в основном происходит из дистального сегмента кишечника путем пассивной диффузии. После однократной дозы максимальная концентрация активного вещества в плазме крови достигается через 30 мин, сохраняется на этом уровне в течение 1 часа, затем медленно понижается. Бактериостатическая концентрация фурагина в плазме крови сохраняется в течение 8-12 часов. Фурагин связывается с белками плазмы крови. Относительно небольшая часть от введенной дозы (10 %) биотрансформируется в печени и почках, но при сниженной выделительной функции почек биотрансформируется большая часть введенной дозы. Период полувыведения фурагина короткий (около 1 часа). Фурагин выводится через почки, преимущественно путем канальцевой секреции (85 %). 8-13 % введенного фурагина попадает в мочу, где концентрация фурагина в несколько раз превышает минимальную ингибирующую концентрацию для большей части чувствительных микроорганизмов. Максимальная концентрация фурагина в моче – 5,7 мкг/мл. Действие фурагина наиболее выражено в кислой среде (рН 5,5). Средства, которые нейтрализуют мочу, снижают эффективность действия препарата. Фармакодинамика Фурагин – антибактериальное средство, производное нитрофурана, эффективен как в отношении грамположительных (Staphylococcusepidermidis, Staphylococcusaureus, Staphylococcusfaecalis), так и грамотрицательных (Enterobacteriаceae – Salmonella, Shigella, Proteus, Klebsiella, Escherichia, Enterobacter и др.) бактерий. Препарат действует на стафилококки и другие патогенные штаммы микроорганизмов, которые устойчивы к сульфаниламидам и антибиотикам. Резистентность микроорганизмов к фурагину развивается медленно и не достигает высокой степени. К препарату устойчива Pseudomonasaeruginosa. Механизм антимикробного действия препарата связан с восстановлением нитрогруппы в аминогруппу. При этом восстановленные формы препарата оказывают непосредственное влияние на клеточные макромолекулы и транспорт электронов в микробной клетке. Взаимодействуя на уровне ДНК (дезоксирибонуклеиновой кислоты) вызывает разрывы и мутации в ней, что приводит к нарушению ее биологической функции. Предполагается также, что восстановленная форма прeпарата окисляет ряд энзимных систем микроорганизмов. По отношению к некоторым микроорганизмам антимикробный эффект фурагина выше, чем других нитрофуранов. Препарат особенно активен при инфекциях мочевых путей. Нитрофураны не угнетают иммунную систему организма, а даже активизируют ее, например, повышают титр комплемента и способность лейкоцитов фагоцитировать микроорганизмы.","substance":[{"id":236,"title":"Фуразидин","title_latin":"Furazidinum","slug":"furazidin_236"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":null,"image_alt":"Фурагин - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/50312/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/50312/share_default/"}},"diseases":[{"id":"1086","title":"Острый тубулоинстерстициальный нефрит (острый пиелонефрит)","slug":"1086-ostryy_tubuloinsterstitsialnyy_nefrit_ostryy_pielonefrit"},{"id":"1087","title":"Хронический тубулоинтерстициальный нефрит (хронический 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