Цефазолин Порошок, флакон, 1 шт, 1000 мг, для раствора для внутривенного и внутримышечного введения

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После в/м введения в дозах 05 г и 10 г С\u003csub\u003em\u003c/sub\u003e\u003csub\u003eах\u003c/sub\u003e в моче 1 мг/мл и 4 мг/мл соответственно."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Инфекционно-воспалительные заболевания вызванные чувствительными к Цефазолину микроорганизмами: верхних и нижних дыхательных путей ЛOP-органов (в т.ч. средний отит) мочевыводящих и желчевыводящих путей органов малого таза кожи и мягких тканей костей и суставов (в т.ч. остеомиелит) эндокардит сепсис перитонит мастит; раневые ожоговые и послеоперационные инфекции; сифилис гонорея. Профилактика хирургических инфекций в пред- и послеоперационном периоде."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Гиперчувствительность к цефалоспоринам и другим бета-лактамным антибиотикам дети до 1 месяца (безопасность применения препарата не установлена). Не рекомендуется одновременный прием с антикоагулянтами и диуретиками. Пациенты имевшие в анамнезе аллергические реакции на пенициллины карбапенемы могут иметь повышенную чувствительность к цефалоспориновым антибиотикам."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Почечная недостаточность заболевания кишечника (в т.ч. колит в анамнезе) детский возраст 1-12 месяцев."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Применение цефазолина при беременности допустимо если ожидаемая польза для матери превышает потенциальный риск для плода. Следует прекратить грудное вскармливание на время применения препарата."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутримышечно (в/м) внутривенно (в/в) (струйно и капельно)."}},{"type":"paragraph","data":{"text":"Режим дозирования и продолжительность курса лечения устанавливаются индивидуально с учетом показаний тяжести течения инфекции чувствительности возбудителя."}},{"type":"paragraph","data":{"text":"Тяжесть течения инфекции"}},{"type":"paragraph","data":{"text":"Разовая доза"}},{"type":"paragraph","data":{"text":"Частота введений"}},{"type":"paragraph","data":{"text":"Суточная доза"}},{"type":"paragraph","data":{"text":"Инфекции легкой степени"}},{"type":"paragraph","data":{"text":"500 мг"}},{"type":"paragraph","data":{"text":"каждые 8 ч"}},{"type":"paragraph","data":{"text":"15 г"}},{"type":"paragraph","data":{"text":"тяжести"}},{"type":"paragraph","data":{"text":"1 г"}},{"type":"paragraph","data":{"text":"каждые 12 ч"}},{"type":"paragraph","data":{"text":"2 г"}},{"type":"paragraph","data":{"text":"Неосложненные инфекции"}},{"type":"paragraph","data":{"text":"1 г"}},{"type":"paragraph","data":{"text":"каждые 12 ч"}},{"type":"paragraph","data":{"text":"2 г"}},{"type":"paragraph","data":{"text":"Инфекции средней степени тяжести и тяжелые инфекции"}},{"type":"paragraph","data":{"text":"1 г"}},{"type":"paragraph","data":{"text":"каждые 6-8 ч"}},{"type":"paragraph","data":{"text":"3 - 4 г"}},{"type":"paragraph","data":{"text":"Инфекции угрожающие жизни"}},{"type":"paragraph","data":{"text":"1 г-15 г"}},{"type":"paragraph","data":{"text":"каждые 6 ч"}},{"type":"paragraph","data":{"text":"4-6 г"}},{"type":"paragraph","data":{"text":"Максимальная суточная доза - 6 г."}},{"type":"paragraph","data":{"text":"Средняя продолжительность лечения составляет 7-10 дней."}},{"type":"paragraph","data":{"text":"Для профилактики послеоперационной инфекции - в/в 10 г за 05 -1 ч до операции 05-10 г - во время операции и по 05-10 г каждые 8 ч в течение первых суток после операции."}},{"type":"paragraph","data":{"text":"Больным с нарушениями функции почек требуется изменение режима дозирования в со­ответствии со значениями клиренса креатинина (КК):"}},{"type":"paragraph","data":{"text":"Клиренс креатинина (КК)"}},{"type":"paragraph","data":{"text":"Креатинин плазмы"}},{"type":"paragraph","data":{"text":"Суточная доза"}},{"type":"paragraph","data":{"text":"Интервал между введениями"}},{"type":"paragraph","data":{"text":"55 мл/мин и более"}},{"type":"paragraph","data":{"text":"15 мг% и менее"}},{"type":"paragraph","data":{"text":"Обычная доза"}},{"type":"paragraph","data":{"text":"Без изменений"}},{"type":"paragraph","data":{"text":"54-35 мл/мин"}},{"type":"paragraph","data":{"text":"3-16 мг%"}},{"type":"paragraph","data":{"text":"Обычная доза"}},{"type":"paragraph","data":{"text":"12 ч"}},{"type":"paragraph","data":{"text":"34-11 мл/мин"}},{"type":"paragraph","data":{"text":"45-31 мг%"}},{"type":"paragraph","data":{"text":"1/2 обычной дозы"}},{"type":"paragraph","data":{"text":"12 ч"}},{"type":"paragraph","data":{"text":"10 мл/мин и менее"}},{"type":"paragraph","data":{"text":"46 мг% и более"}},{"type":"paragraph","data":{"text":"1/2 обычной дозы"}},{"type":"paragraph","data":{"text":"24 ч"}},{"type":"paragraph","data":{"text":"Детям старше 1 месяца - 25-50 мг/кг/сутки; при тяжелом течении инфекции доза может быть увеличена - до 100 мг/кг/сутки. Кратность введения 3-4 раза в сутки. У детей с нарушениями функции почек коррекцию режима дозирования проводят в зави­симости от значений КК:"}},{"type":"paragraph","data":{"text":"Клиренс креатинина (КК)"}},{"type":"paragraph","data":{"text":"Суточная доза"}},{"type":"paragraph","data":{"text":"Интервал между введениями"}},{"type":"paragraph","data":{"text":"70-40 мл/мин"}},{"type":"paragraph","data":{"text":"60 % средней суточной дозы"}},{"type":"paragraph","data":{"text":"12 ч"}},{"type":"paragraph","data":{"text":"40-20 мл/мин"}},{"type":"paragraph","data":{"text":"25 % средней суточной дозы"}},{"type":"paragraph","data":{"text":"12 ч"}},{"type":"paragraph","data":{"text":"5-20 мл/мин"}},{"type":"paragraph","data":{"text":"10 % средней суточной дозы"}},{"type":"paragraph","data":{"text":"24 ч"}},{"type":"paragraph","data":{"text":"Приготовление растворов для инъекций:"}},{"type":"paragraph","data":{"text":"Для в/м введения 05 г препарата растворяют в 2 мл 1 г - в 4 мл 05 % раствора лидокаина или воды для инъекций. Во время разведения флаконы необходимо энергично встряхивать до полного растворения. При лечении детей 1-12 месяцев не следует растворять цефазо­лин в растворах лидокаина."}},{"type":"paragraph","data":{"text":"Для в/в болюсного введения полученный раствор разводят в 5 мл воды для инъекций затем вводят медленно в течение 3-5 мин. Для в/в капельного введения препарат разводят 50-100 мл 5-10 % раствора декстрозы 09 % раствора натрия хлорида раствора Рингера 5 % раствора натрия гидрокарбоната."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Аллергические реакции: гипертермия кожная сыпь крапивница кожный зуд бронхоспазм эозинофилия ангионевротический отек анафилактический шок мультиформная экссудативная эритема (в т.ч. синдром Стивенса-Джонсона)."}},{"type":"paragraph","data":{"text":"Со стороны нервной системы: судороги."}},{"type":"paragraph","data":{"text":"Coстороны мочевыделительной системы: у больных с заболеваниями почек при лечении большими дозами (6 г) - нарушение функции почек (в этих случаях дозу снижают лече­ние проводят под контролем динамики концентрации азота мочевины и креатинина в кро­ви)."}},{"type":"paragraph","data":{"text":"Со стороны пищеварительной системы: тошнота рвота диарея боль в животе псевдо- мембранозный колит редко - холестатическая желтуха гепатит."}},{"type":"paragraph","data":{"text":"Со стороны органов кроветворения: лейкопения нейтропения тромбоцитопения тромбоцитоз гемолитическая анемия."}},{"type":"paragraph","data":{"text":"При длительном лечении - дисбактериоз суперинфекция вызываемая устойчивыми к ан­тибиотику штаммами кандидоз (в т.ч. кандидозный стоматит)."}},{"type":"paragraph","data":{"text":"Местные реакции: при в/м введении - болезненность в месте введения при в/в введении флебит."}},{"type":"paragraph","data":{"text":"Лабораторные показатели: ложноположительная проба Кумбса повышение активности \"печеночных\" трансаминаз гиперкреатининемия увеличение протромбинового времени а также ложноположительная реакция мочи на глюкозу."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: головокружение головная боль парестезии возможно развитие судорог особенно у пациентов с заболеваниями почек."}},{"type":"paragraph","data":{"text":"Лабораторные показатели: повышенные концентрации креатинина азота мочевины крови ферментов печени и билирубина."}},{"type":"paragraph","data":{"text":"Меры по оказанию помощи при передозировке: немедленно прекратить введение препарата контролировать жизненные функции организма и соответствующие лабораторные показатели; терапия - симптоматическая. В тяжелых случаях возможно проведение гемодиализа. Перитонеальный диализ неэффективен."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"При одновременном применении цефазолина и \"петлевых диуретиков\" происходит блокада его канальцевой секреции. Аминогликозиды увеличивают риск развития поражения почек. Фармацевтически несовместим с аминогликозидами (взаимная инактивация)."}},{"type":"paragraph","data":{"text":"Лекарственные средства блокирующие канальцевую секрецию увеличивают концентрацию в крови замедляют выведение и повышают риск развития токсических реакций. Цефазолин подавляя кишечную флору препятствует синтезу витамина К. Поэтому при одновременном применении с препаратами снижающими агрегацию тромбоцитов (нестероидные противоспалительные препараты (НПВП) салицилаты) увеличивается риск развития кровотечений. По этой же причине при одновременном применении с антикоагулянтами отмечается усиление антикоагулянтного действия. Не следует применять цефазолин вместе с антибактериальными препаратами имеющими бактериостатический механизм действия (тетрациклины сульфаниламиды эритромицин хлорамфеникол) поскольку исследования in vitro показали что между ними существует антагонизм."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"При применении препарата возможно обострение заболеваний желудочно-кишечного тракта (ЖКТ) особенно колита. При появлении тяжелой диареи характерной для псевдомембранозного колита цефазолин следует отменить и назначить соответствующее лечение. В период лечения пациентам следует воздержаться от употребления алкоголя. При длительном применении препарата необходим контроль картины периферической крови и функции почек."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"С осторожностью применять водителям транспортных средств и людям деятельность которых требует повышенной концентрации внимания и хорошей координации движений."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Порошок для приготовления раствора для внутривенного и внутримышечного введения 05 г 10 г."}},{"type":"header","data":{"text":"Упаковка:","level":3}},{"type":"paragraph","data":{"text":"05 г 10 г активного вещества во флаконах вместимостью 10мл.1 флакон с инструкцией по применению в пачке из картона.10 флаконов с инструкцией по применению в коробке из картона.Для стационара:- 50 флаконов и 5 инструкций по применению в коробке из картона;- 1 флакон с инструкцией по применению (от 1 до 50 флаконов с равным количеством инструкций по применению) в коробке из картона."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищенном от света месте при температуре не выше 25 °С. Хранить в недоступном для детей месте."}},{"type":"paragraph","data":{"text":"По истечении срока годности препарата неиспользованные флаконы осторожно вскрыть содержимое растворить в большом количестве воды и слить в канализацию"}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года. Не применять по истечении срока годности."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Открытое акционерное общество \"Красфарма\" (ОАО \"Красфарма\"), 660042, Красноярский край, Красноярск, 60 лет Октября, д.2, Россия"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ОАО \"Красфарма\""}}]}],"source":null},"description_toggle":false,"short_description":"Цефалоспориновый антибиотик I поколения для парентерального применения. Действует бактерицидно нарушая синтез клеточной стенки микроорганизмов. Имеет широкий спектр действия активен в отношении грамположительных (Staphylococcus spp. в т.ч. Staphylococcus aureus (не продуцирующие и продуцирующие пеиициллиназу); Streptococcus pneumoniae Corynebacterium diphtheriae Bacillus anthracis) и грамотрицательных (Neisseria meningitidis Neisseria gonorrhoeae Shigella spp. Salmonella spp. Escherichia coli Klebsiella spp. Treponema spp. Leptospira spp.) микроорганизмов. Активен в отношении Haemophilus influenzae некоторых штаммов Enterobacter spp. и Enterococcus spp.Неэффективен в отношении Pseudomonas aeruginosa индолположительных штаммов Proteus spp. Mycobacterium tuberculosis Serratia spp. анаэробных микроорганизмов метициллинустойчивых штаммов Staphylococcus spp. Время достижения максимальной концентрации (ТСmах) при внутримышечном введении в дозе 05 г и 10 г соответственно - 2 и 1 ч; максимальная концентрация (Сmах) - 38 и 64 мкг/мл. После внутривенного введения ТCmахв конце инфузии Сmах- 180 мкг/мл. Проникает в суставы ткани сердца и сосудов в брюшную полость почки и мочевыводящие пути плаценту среднее ухо дыхательные пути кожу и мягкие ткани. В небольших количествах выделяется с грудным молоком. Концентрация в ткани желчного пузыря и желчи значительно выше чем в плазме крови. При обструкции желчного пузыря концентрация в желчи меньше чем в плазме. Объем распределения - 012 л/кг. Связь с белками плазмы - 85%. Период полувыведения (Т1/2) при в/м введении - 18 ч при в/в введении -2 ч. При нарушении функции почек Т1/2 - 20-40 ч. Выводится преимущественно почками в неизмененном виде: в течение первых 6ч- 60-90 % через 24 ч - 70-95%. После в/м введения в дозах 05 г и 10 г Сmахв моче 1 мг/мл и 4 мг/мл соответственно.","substance":[{"id":1530,"title":"Цефазолин","title_latin":"Cefazolinum","slug":"tsefazolin_1530"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":null,"image_alt":"Цефазолин - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/50724/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/50724/share_default/"}},"diseases":[{"id":"42","title":"Стрептококковая септицемия","slug":"42-streptokokkovaya_septitsemiya"},{"id":"43","title":"Другая септицемия","slug":"43-drugaya_septitsemiya"},{"id":"52","title":"Врожденный сифилис","slug":"52-vrozhdennyy_sifilis"},{"id":"53","title":"Ранний сифилис","slug":"53-ranniy_sifilis"},{"id":"54","title":"Поздний сифилис","slug":"54-pozdniy_sifilis"},{"id":"55","title":"Гонококковая инфекция","slug":"55-gonokokkovaya_infektsiya"},{"id":"696","title":"Гнойный и неуточненный средний отит","slug":"696-gnoynyy_i_neutochnennyy_sredniy_otit"},{"id":"735","title":"Острый и подострый эндокардит","slug":"735-ostryy_i_podostryy_endokardit"},{"id":"789","title":"Острый назофарингит","slug":"789-ostryy_nazofaringit"},{"id":"790","title":"Острый синусит","slug":"790-ostryy_sinusit"},{"id":"791","title":"Острый фарингит","slug":"791-ostryy_faringit"},{"id":"792","title":"Острый тонзиллит","slug":"792-ostryy_tonzillit"},{"id":"793","title":"Острый ларингит и трахеит","slug":"793-ostryy_laringit_i_traheit"},{"id":"802","title":"Бактериальная пневмония, не классифицированная в других рубриках","slug":"802-bakterialnaya_pnevmoniya_ne_klassifitsirovannaya_v_drugih_rubrikah"},{"id":"815","title":"Хронический ринит, назофарингит и фарингит","slug":"815-hronicheskiy_rinit_nazofaringit_i_faringit"},{"id":"816","title":"Хронический 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