Прозерин Таблетки, 20 шт, 15 мг, для приема внутрь

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Бóльшая часть общей суточной дозы назначается в дневное время, когда больной находится в наибольшей степени усталости.При слабости родовой деятельности— внутрь 3 мг 4–6 раз в сутки с интервалом 40 мин."}}]},{"id":5,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Со стороны органов ЖКТ: гиперсаливация, спастическое сокращение и усиление перистальтики кишечника, тошнота, рвота, метеоризм, диарея.Со стороны нервной системы и органов чувств: головная боль, головокружение, слабость, потеря сознания, сонливость, миоз, нарушение зрения, тремор, спазмы и подергивание скелетной мускулатуры, включая фасцикуляции мышц языка, судороги, дизартрия.Со стороны ССС: аритмия, бради- или тахикардия, AV блокада, блокада, узловой ритм, неспецифические изменения на ЭКГ, остановка сердца.Со стороны дыхательной системы: одышка, угнетение дыхания, вплоть до остановки, бронхоспазм.Аллергические реакции: гиперемия лица, сыпь, зуд, анафилаксия.Прочие: учащение мочеиспускания, арталгия, обильное потоотделение."}}]},{"id":6,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Симптомы связаны с перевозбуждением холинорецепторов (холинергический криз): брадикардия, гиперсаливация, миоз, бронхоспазм, тошнота, усиление перистальтики, диарея, учащение мочеиспускания, подергивание мышц языка и скелетной мускулатуры, постепенное развитие общей слабости, снижение АД.Лечение: уменьшают дозу прозерина или прекращают лечение, при необходимости вводят атропин (1 мл 0,1% раствора), метацин и другие холиноблокирующие препараты."}}]},{"id":7,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"При миастении назначают в сочетании с антагонистами альдостерона, ГКС и анаболическими гормонами.Атропин, метацин и другие м-холиноблокаторы ослабляют м-холиномиметические эффекты прозерина (в т.ч. сужение зрачка, брадикардия, усиление моторики ЖКТ, гиперсаливация)."}}]},{"id":18,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"При возникновении во время лечения миастенического (при недостаточной терапевтической дозе) или холинергического (вследствие передозировки) криза требуется тщательная дифференциальная диагностика из-за схожести симптоматики."}}]},{"id":19,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"В период лечения пациентам следует соблюдать осторожность при управлении транспортными средствами и механизмами, а также при занятиях другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":20,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки."}}]},{"id":8,"name":"Условия хранения","slug":"storage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"В сухом, защищенном от света месте, при температуре не выше 25°C. Хранить в недоступном для детей месте."}}]},{"id":9,"name":"Срок годности","slug":"expiry_date","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"5 лет. Не применять по истечении срока годности, указанного на упаковке.2000-2017. Регистр лекарственных средств России"}}]},{"id":10,"name":"Условия отпуска","slug":"release_condition","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"По рецепту."}}]}],"source":{"title":"ЭркаФарм","url":"https://erkapharm.com"}},"description_toggle":false,"short_description":"Холинэстеразы ингибитор. Синтетическое антихолинэстеразное средство. Обратимо блокирует холинэстеразу, что приводит к накоплению и усилению действия ацетилхолина на органы и ткани и восстановлению нервномышечной проводимости. Вызывает урежение частоты сердечных сокращений, повышает секрецию желез (слюнных, бронхиальных, потовых и желудочно-кишечного тракта (ЖКТ)) и способствует развитию гиперсаливации, бронхореи, повышению кислотности желудочного сока, суживает зрачок, вызывает спазм аккомодации, снижает внутриглазное давление, усиливает тонус гладкой мускулатуры кишечника (усиливает перистальтику и расслабляет сфинктеры) и мочевого пузыря, вызывает спазм бронхов, тонизирует скелетную мускулатуру. Прозерин является антагонистом антидеполяризующих курареподобных препаратов. Вместе с тем, в больших дозах прозерин может сам вызвать нарушение нервно-мышечной проводимости в результате накопления ацетилхолина и стойкой деполяризации в области синапсов. Дает прямой Н-холиномиметический эффект. Действие препарата совпадает с характерными эффектами возбуждения холинергических нервов. В отличие от физостигмина в большей степени стимулирует мышцы кишок, мочевого пузыря и матки, незначительно влияет на сердце и не вызывает центральных эффектов. При введении в терапевтических дозах в значительной степени возбуждаются Н-холинорецепторы скелетных мышц, усиливается нервно-мышечная передача. Фармакокенетика: являясь четвертичным аммониевым основанием, плохо проникает через гематоэнцефаличе-ский барьер и не оказывает центрального действия. Биодоступность - 1-2 %. Связь с белками плазмы - 15-25 %. Период полураспада при пероральном приеме - 52 мин. 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