Круглые плоскоцилиндрические таблетки, покрытые оболочкой, желтого цвета
Фармакотерапевтическая группа
Вазодилатирующее средство.
Фармакологические свойства
Вазодилататор миотропного действия. Оказывает тормозящее влияние на агрегацию тромбоцитов, улучшает микроциркуляцию.
Дипиридамол расширяет артериолы в системе коронарного кровотока, при приеме в высоких дозах - и в других участках системы кровообращения. Однако в отличие от органических нитратов и антагонистов кальция расширение более крупных коронарных сосудов не происходит.
Сосудорасширяющее действие дипиридамола обусловлено двумя различными механизмами ингибирования: подавление захвата аденозина и угнетение фосфодиэстеразы.
In vivo аденозин обнаруживается в концентрации, составляющей приблизительно 0.15-0.20 мкмоль. Такой уровень поддерживается благодаря динамическому равновесию между выбросом и обратным захватом. Дипиридамол тормозит захват аденозина клетками эндотелия, эритроцитами и тромбоцитами. После введения дипиридамола обнаруживается повышение концентрации в крови аденозина и усиление обусловленной аденозином вазодилатации. В более высоких дозах происходит торможение агрегации тромбоцитов, вызываемой аденозином, и склонность к тромбообразованию уменьшается.
Распад цАМФ и цГМФ, подавляющих агрегацию тромбоцитов, происходит в тромбоцитах под действием соответствующих фосфодиэстераз. В высоких концентрациях дипиридамол угнетает обе фосфодиэстеразы, в терапевтических концентрациях в крови - только цГМФ-фосфодиэстеразу. В результате стимуляции соответствующих циклаз увеличивается мощность синтеза цАМФ.
Как производное пиримидина, дипиридамол является индуктором интерферона и оказывает модулирующее действие на функциональную активность системы интерферона, повышает сниженную продукцию интерферона альфа и гамма лейкоцитами крови in vitro. Препарат повышает неспецифическую резистентность к вирусным инфекциям.
Показания к применению
Лечение и профилактика нарушений мозгового кровообращения по ишемическому типу.
Дисциркуляторная энцефалопатия.
Профилактика артериальных и венозных тромбозов и их осложнений.
Профилактика тромбоэмболии после операции протезирования клапанов сердца.
Профилактика плацентарной недостаточности при осложненной беременности.
В составе комплексной терапии при любых нарушениях микроциркуляции.
В качестве индуктора интерферона и иммуномодулятора для профилактики и лечения гриппа, ОРВИ.
Заболевания со склонностью к кровотечениям (язвенная болезнь желудка и двенадцатиперстной кишки и др.).
Повышенная чувствительность к компонентам препарата.
С осторожностью
В связи с отсутствием достаточного опыта применения препарата у детей не рекомендуется назначать детям в возрасте до 12 лет.
Применение при беременности и в период грудного вскармливания
Применение препарата при лактации возможно только в случае, если ожидаемая польза от лечения превышает возможный риск.
Способ применения и дозы
Если врачом не назначено иначе, необходимо следовать нижеприведенным указаниям.
Для уменьшения агрегации тромбоцитов суточная доза составляет 75 - 225 мг (3 - 9 таблеток) в несколько приемов.
В тяжелых случаях суточная доза может быть увеличена до 600 мг.
Для профилактики гриппа и других ОРВИ, особенно в период эпидемий, рекомендуется прием Курантила N 25 по следующей схеме: 50 мг (2 таблетки) 1 раз в 7 дней в течение 4-5 недель.
Для профилактики рецидивов у часто болеющих респираторными вирусными инфекциями пациентов рекомендуется прием по следующей схеме: 100 мг (по 2 таблетки 2 раза в сутки с интервалом в 2 ч) 1 раз в неделю в течение 8-10 недель.
Таблетки следует принимать натощак, не разламывая и не раскусывая, запивая небольшим количеством жидкости. Курантил N 25 подходит для проведения длительного курса лечения.
Побочное действие
При применении препарата в терапевтических дозах побочные эффекты обычно не выражены и носят преходящий характер.
Со стороны сердечно-сосудистой системы: сердцебиение, тахикардия (особенно у лиц, принимающих другие вазодилататоры), брадикардия, «приливы» крови к лицу, синдром коронарного обкрадывания (при использовании препарата в дозе более 225 мг/сут), снижение артериального давления (АД).
Со стороны пищеварительной системы: тошнота, рвота, диарея, боли в эпигастральной области. Обычно эти побочные эффекты исчезают при более длительном применении препарата.
Со стороны крови и системы гемостаза: тромбоцитопения, изменение функциональных свойств тромбоцитов, кровотечения, В очень редких случаях - повышенная кровоточивость во время или после хирургического вмешательства Прочие: слабость, головокружение, ощущение заложенности уха, шум в голове, головная боль, гиперемия кожи лица, артрит, миалгия, ринит, аллергические реакции (по типу сыпи или крапивницы).
Передозировка
Симптомы: снижение АД, стенокардия, тахикардия, ощущение «приливов», слабость и головокружение.
Лечение: вызов рвоты, промывание желудка, назначение активированного угля. Дилатирующее действие препарата можно купировать медленным (50 - 100 мг/мин) внутривенным введением аминофиллина. В случае сохранения симптомов стенокардии - назначение нитроглицерина сублингвально
Взаимодействие с другими лекарственными средствами
Ксантиновые производные (кофе, чай) могут ослаблять сосудорасширяющее действие дипиридамола.
Применение дипиридамола одновременно с антикоагулянтами (гепарин, тромболитики) или ацетилсалициловой кислотой повышает риск развития геморрагических осложнений, что необходимо учитывать при совместном использовании.
Дипиридамол может усиливать действие гипотензивных препаратов.
Дипиридамол может ослаблять антихолинергические свойства ингибиторов холинэстеразы. Влияние на способность к вождению автотранспорта и управлению механизмами
При применении Курантила N 25 может косвенным образом нарушаться способность к вождению автотранспорта и управлению механизмами, поскольку в результате падения кровяного давления может наступить изменение реакции.
Особые указания
При одновременном употреблении чая или кофе (содержат производные ксантина) сосудорасширяющее действие Курантила может уменьшаться.
Использование в педиатрии
Курантил не рекомендуют назначать детям в возрасте до 12 лет в связи с отсутствием достаточного клинического опыта его применения.
Влияние на способность управлять автомобилем и движущимися механизмами
При применении Курантила N 25 может косвенным образом нарушаться способность к вождению автотранспорта и управлению механизмами, поскольку в результате падения кровяного давления может наступить изменение реакции.
Форма выпуска
Таблетки, покрытые оболочкой, 25 мг. По 120 таблеток во флаконы бесцветного стекла. По 1 флакону вместе с инструкцией по применению в картонную пачку.
Условия хранения
Список Б.
При температуре не выше 30 °С в защищенном от света месте.
Лекарственное средство хранить в недоступном для детей месте!
Срок годности
3 года.
Не применять после истечения срока годности, указанного на упаковке.
Условия отпуска
По рецепту
Производитель
Berlin-Chemie AG
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
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Оказывает тормозящее влияние на агрегацию тромбоцитов, улучшает микроциркуляцию."}},{"type":"paragraph","data":{"text":"Дипиридамол расширяет артериолы в системе коронарного кровотока, при приеме в высоких дозах - и в других участках системы кровообращения. Однако в отличие от органических нитратов и антагонистов кальция расширение более крупных коронарных сосудов не происходит."}},{"type":"paragraph","data":{"text":"Сосудорасширяющее действие дипиридамола обусловлено двумя различными механизмами ингибирования: подавление захвата аденозина и угнетение фосфодиэстеразы."}},{"type":"paragraph","data":{"text":"In vivo аденозин обнаруживается в концентрации, составляющей приблизительно 0.15-0.20 мкмоль. Такой уровень поддерживается благодаря динамическому равновесию между выбросом и обратным захватом. Дипиридамол тормозит захват аденозина клетками эндотелия, эритроцитами и тромбоцитами. После введения дипиридамола обнаруживается повышение концентрации в крови аденозина и усиление обусловленной аденозином вазодилатации. В более высоких дозах происходит торможение агрегации тромбоцитов, вызываемой аденозином, и склонность к тромбообразованию уменьшается."}},{"type":"paragraph","data":{"text":"Распад цАМФ и цГМФ, подавляющих агрегацию тромбоцитов, происходит в тромбоцитах под действием соответствующих фосфодиэстераз. В высоких концентрациях дипиридамол угнетает обе фосфодиэстеразы, в терапевтических концентрациях в крови - только цГМФ-фосфодиэстеразу. В результате стимуляции соответствующих циклаз увеличивается мощность синтеза цАМФ."}},{"type":"paragraph","data":{"text":"Как производное пиримидина, дипиридамол является индуктором интерферона и оказывает модулирующее действие на функциональную активность системы интерферона, повышает сниженную продукцию интерферона альфа и гамма лейкоцитами крови in vitro. Препарат повышает неспецифическую резистентность к вирусным инфекциям."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"list","data":{"style":"ordered","items":["Лечение и профилактика нарушений мозгового кровообращения по ишемическому типу."]}},{"type":"list","data":{"style":"ordered","items":["Дисциркуляторная энцефалопатия."]}},{"type":"list","data":{"style":"ordered","items":["Профилактика артериальных и венозных тромбозов и их осложнений."]}},{"type":"list","data":{"style":"ordered","items":["Профилактика тромбоэмболии после операции протезирования клапанов сердца."]}},{"type":"list","data":{"style":"ordered","items":["Профилактика плацентарной недостаточности при осложненной беременности."]}},{"type":"list","data":{"style":"ordered","items":["В составе комплексной терапии при любых нарушениях микроциркуляции."]}},{"type":"list","data":{"style":"ordered","items":["В качестве индуктора интерферона и иммуномодулятора для профилактики и лечения гриппа, ОРВИ."]}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"list","data":{"style":"ordered","items":["Острый инфаркт миокарда."]}},{"type":"list","data":{"style":"ordered","items":["Нестабильная стенокардия,"]}},{"type":"list","data":{"style":"ordered","items":["Распространенный стенозирующий атеросклероз коронарных артерий,"]}},{"type":"list","data":{"style":"ordered","items":["Субаортальный стеноз."]}},{"type":"list","data":{"style":"ordered","items":["Декомпенсированная сердечная недостаточность,"]}},{"type":"list","data":{"style":"ordered","items":["Артериальная гипотензия, коллапс."]}},{"type":"list","data":{"style":"ordered","items":["Тяжелая артериальная гипертензия."]}},{"type":"list","data":{"style":"ordered","items":["Тяжелые нарушения сердечного ритма."]}},{"type":"list","data":{"style":"ordered","items":["Хронические обструктивные заболевания легких."]}},{"type":"list","data":{"style":"ordered","items":["Хроническая почечная недостаточность."]}},{"type":"list","data":{"style":"ordered","items":["Печеночная недостаточность."]}},{"type":"list","data":{"style":"ordered","items":["Геморрагические диатезы."]}},{"type":"list","data":{"style":"ordered","items":["Заболевания со склонностью к кровотечениям (язвенная болезнь желудка и двенадцатиперстной кишки и др.)."]}},{"type":"list","data":{"style":"ordered","items":["Повышенная чувствительность к компонентам препарата. "]}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"В связи с отсутствием достаточного опыта применения препарата у детей не рекомендуется назначать детям в возрасте до 12 лет."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Применение препарата при лактации возможно только в случае, если ожидаемая польза от лечения превышает возможный риск. "}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"\n\nЕсли врачом не назначено иначе, необходимо следовать нижеприведенным указаниям."}},{"type":"paragraph","data":{"text":"Для уменьшения агрегации тромбоцитов суточная доза составляет 75 - 225 мг (3 - 9 таблеток) в несколько приемов."}},{"type":"paragraph","data":{"text":"В тяжелых случаях суточная доза может быть увеличена до 600 мг."}},{"type":"paragraph","data":{"text":"Для профилактики гриппа и других ОРВИ, особенно в период эпидемий, рекомендуется прием Курантила N 25 по следующей схеме: 50 мг (2 таблетки) 1 раз в 7 дней в течение 4-5 недель."}},{"type":"paragraph","data":{"text":"Для профилактики рецидивов у часто болеющих респираторными вирусными инфекциями пациентов рекомендуется прием по следующей схеме: 100 мг (по 2 таблетки 2 раза в сутки с интервалом в 2 ч) 1 раз в неделю в течение 8-10 недель."}},{"type":"paragraph","data":{"text":"Таблетки следует принимать натощак, не разламывая и не раскусывая, запивая небольшим количеством жидкости. Курантил N 25 подходит для проведения длительного курса лечения.\n\n"}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\n\nПри применении препарата в терапевтических дозах побочные эффекты обычно не выражены и носят преходящий характер."}},{"type":"paragraph","data":{"text":"Со стороны сердечно-сосудистой системы: сердцебиение, тахикардия (особенно у лиц, принимающих другие вазодилататоры), брадикардия, «приливы» крови к лицу, синдром коронарного обкрадывания (при использовании препарата в дозе более 225 мг/сут), снижение артериального давления (АД)."}},{"type":"paragraph","data":{"text":"Со стороны пищеварительной системы: тошнота, рвота, диарея, боли в эпигастральной области. Обычно эти побочные эффекты исчезают при более длительном применении препарата."}},{"type":"paragraph","data":{"text":"Со стороны крови и системы гемостаза: тромбоцитопения, изменение функциональных свойств тромбоцитов, кровотечения, В очень редких случаях - повышенная кровоточивость во время или после хирургического вмешательства Прочие: слабость, головокружение, ощущение заложенности уха, шум в голове, головная боль, гиперемия кожи лица, артрит, миалгия, ринит, аллергические реакции (по типу сыпи или крапивницы). \n\n"}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\n\nСимптомы: снижение АД, стенокардия, тахикардия, ощущение «приливов», слабость и головокружение."}},{"type":"paragraph","data":{"text":"Лечение: вызов рвоты, промывание желудка, назначение активированного угля. Дилатирующее действие препарата можно купировать медленным (50 - 100 мг/мин) внутривенным введением аминофиллина. В случае сохранения симптомов стенокардии - назначение нитроглицерина сублингвально"}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"\n\nКсантиновые производные (кофе, чай) могут ослаблять сосудорасширяющее действие дипиридамола."}},{"type":"paragraph","data":{"text":"Применение дипиридамола одновременно с антикоагулянтами (гепарин, тромболитики) или ацетилсалициловой кислотой повышает риск развития геморрагических осложнений, что необходимо учитывать при совместном использовании."}},{"type":"paragraph","data":{"text":"Дипиридамол может усиливать действие гипотензивных препаратов."}},{"type":"paragraph","data":{"text":"Дипиридамол может ослаблять антихолинергические свойства ингибиторов холинэстеразы. Влияние на способность к вождению автотранспорта и управлению механизмами"}},{"type":"paragraph","data":{"text":"При применении Курантила N 25 может косвенным образом нарушаться способность к вождению автотранспорта и управлению механизмами, поскольку в результате падения кровяного давления может наступить изменение реакции.\n\n"}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"При одновременном употреблении чая или кофе (содержат производные ксантина) сосудорасширяющее действие Курантила может уменьшаться."}},{"type":"paragraph","data":{"text":"\u003ci\u003eИспользование в педиатрии\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Курантил не рекомендуют назначать \u003cb\u003eдетям в возрасте до 12 лет\u003c/b\u003e в связи с отсутствием достаточного клинического опыта его применения."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":" При применении Курантила N 25 может косвенным образом нарушаться способность к вождению автотранспорта и управлению механизмами, поскольку в результате падения кровяного давления может наступить изменение реакции. 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