ревматоидный артрит;суставной синдром при обострении подагры;псориатический артрит;анкилозирующий спондилоартрит;остеохондроз с корешковым синдромом;остеоартроз;миалгия ревматического и неревматического генеза;воспаление связок, сухожилий, бурситы, в т.ч. посттравматическое воспаление мягких тканей;болевой синдром различного генеза (в т.ч. в послеоперационном ...
Таблеткигиперчувствительность к нимесулиду и компонентам препарата;эрозивно-язвенные изменения слизистой желудка и двенадцатиперстной кишки;воспалительные заболевания кишечника в фазе обострения;активное желудочно-кишечное кровотечение;выраженные нарушения функции печени и/или почек, тяжелая почечная недостаточность (Cl креатинина <30 мл/мин);прогрессирующее ...
Таблетки: круглые, двояковыпуклые, светло-желтого цвета, на одной стороне надпись «NIMULID», на другой— изображение логотипа.Таблетки для рассасывания: круглые, двояковыпуклые, бледно-желтого цвета.
Фармакологические свойства
Фармакологическое действие — противовоспалительное, обезболивающее.
Показания к применению
ревматоидный артрит;суставной синдром при обострении подагры;псориатический артрит;анкилозирующий спондилоартрит;остеохондроз с корешковым синдромом;остеоартроз;миалгия ревматического и неревматического генеза;воспаление связок, сухожилий, бурситы, в т.ч. посттравматическое воспаление мягких тканей;болевой синдром различного генеза (в т.ч. в послеоперационном периоде, при травмах; альгодисменорея, зубная боль, головная боль, артралгия, люмбоишалгия).Препарат предназначен для симптоматической терапии, уменьшения боли и воспаления на момент использования, на прогрессирование заболевания не влияет.
Противопоказания
Таблеткигиперчувствительность к нимесулиду и компонентам препарата;эрозивно-язвенные изменения слизистой желудка и двенадцатиперстной кишки;воспалительные заболевания кишечника в фазе обострения;активное желудочно-кишечное кровотечение;выраженные нарушения функции печени и/или почек, тяжелая почечная недостаточность (Cl креатинина <30 мл/мин);прогрессирующее заболевание почек;тяжелая печеночная недостаточность или активное заболевание печени;тяжелая сердечная недостаточность;выраженные нарушения свертывания крови;подтвержденная гиперкалиемия;период после проведения аортокоронарного шунтирования;анамнестические данные о приступе бронхообструкции, ринита, крапивницы после приема ацетилсалициловой кислоты или иного НПВС (полный или неполный синдром непереносимости ацетилсалициловой кислоты— риносинусит, крапивница, полипы слизистой носа, астма);беременность и период грудного вскармливания;детский возраст до 12 лет.Таблетки для рассасываниягиперчувствительность к активному веществу или вспомогательным компонентам;полное или неполное сочетание бронхиальной астмы, рецидивирующего полипоза носа или околоносовых пазух и непереносимости ацетилсалициловой кислоты и других НПВС (в т.ч. в анамнезе);эрозивно-язвенные изменения слизистой желудка или двенадцатиперстной кишки, активное желудочно-кишечное кровотечение; цереброваскулярное или иное кровотечение;воспалительные заболевания кишечника (неспецифический язвенный колит, болезнь Крона) в фазе обострения;гемофилия и другие нарушения свертываемости крови;декомпенсированная сердечная недостаточность;печеночная недостаточность или любое активное заболевание печени;выраженная почечная недостаточность (Cl креатинина <30 мл/мин);прогрессирующие заболевания почек;подтвержденная гиперкалиемия;период после проведения аортокоронарного шунтирования;анамнестические данные о развитии гепатотоксических реакций при использовании препаратов нимесулида;сопутствующее применение потенциально гепатотоксичных веществ;алкоголизм, наркомания;беременность, период грудного вскармливания;детский возраст до 12 лет.С осторожностью (таблетки, таблетки для рассасывания): ишемическая болезнь сердца, цереброваскулярные заболевания, застойная сердечная недостаточность, дислипидемия/гиперлипидемия, сахарный диабет, заболевания периферических артерий, курение, Cl креатинина <60 мл/мин.Анамнестические данные о развитии язвенного поражения ЖКТ, наличие инфекции Helicobacter pylori, пожилой возраст, длительное использование НПВС, частое употребление алкоголя, тяжелые соматические заболевания, сопутствующая терапия следующими препаратами— антикоагулянты (например варфарин), антиагреганты (например ацетилсалициловая кислота, клопидогрел), пероральные ГКС (например преднизолон), СИОЗС (например циталопрам, флуоксетин, пароксетин, сертралин).
Способ применения и дозы
ТаблеткиВнутрь. Взрослым и детям старше 12 лет (масса тела >40 кг)— по 1 табл. 2 раза в день. Таблетки принимают после еды с достаточным количеством жидкости. Максимальная суточная доза— 5 мг/кг.Пациентам с хронической почечной недостаточностью требуется снижение суточной дозы до 100 мг.Курс лечения— по назначению врача.Таблетки для рассасыванияСледует использовать минимальную эффективную дозу минимально возможным коротким курсом.Взрослым и детям старше 12 лет (масса тела >40 кг)— обычно в дозе 100 мг (1 табл.) 2 раза в сутки в конце или после приема пищи. Таблетку следует положить на язык, где она сразу же начинает растворяться. Проглотить слюну, в которой растворилась таблетка.
Побочное действие
Частота классифицируется в зависимости от встречаемости— очень часто (>10); часто (<10–<100); нечасто (<100–<1000); редко (<1000–<10000); очень редко (<10000).Со стороны ЖКТ: часто— диарея, тошнота, рвота; нечасто— запор, метеоризм, гастрит; очень редко— боли в животе, стоматит, дегтеобразный стул, желудочно-кишечное кровотечение, язва и/или перфорация желудка или двенадцатиперстной кишки.Со стороны ЦНС: нечасто— головокружение; редко— ощущение страха, нервозность, кошмарные сновидения; очень редко— головная боль, сонливость, энцефалопатия (синдром Рейе).Со стороны органов дыхания: нечасто— одышка; очень редко— бронхоспазм; возможно обострение бронхиальной астмы.Со стороны ССС: нечасто— артериальная гипертензия; редко— тахикардия, геморрагии, приливы.Со стороны органов чувств: редко— нечеткость зрения.Кожные и слизистые покровы: нечасто— зуд, сыпь, усиление потоотделения; редко— эритема, дерматит.Печень и желчевыводящая система: часто— повышение активности печеночных трансаминаз; очень редко— гепатит, молниеносный гепатит, желтуха, холестаз.Почки и мочевыводящая система: нечасто— отеки; редко— дизурия, гематурия, задержка мочи, гиперкалиемия; очень редко— почечная недостаточность, олигурия, интерстициальный нефрит.Со стороны органов кроветворения: редко— анемия, эозинофилия; очень редко— тромбоцитопения, панцитопения, пурпура, удлинение времени кровотечения.Аллергические реакции: редко— реакции гиперчувствительности; очень редко— анафилактоидные реакции, крапивница, ангионевротический отек, отечность лица, мультиформная экссудативная эритема, в т.ч. синдром Стивенса-Джонсона, токсический эпидермальный некролиз (синдром Лайелла).Общие реакции: редко— общая слабость; очень редко— гипотермия.В случае появления других, не упомянутых выше, побочных действий или ухудшения самочувствия следует обратиться незамедлительно к врачу.
Передозировка
Симптомы: апатия, сонливость, тошнота, рвота. Может возникнуть желудочно-кишечное кровотечение, артериальная гипертензия, острая почечная недостаточность, угнетение дыхания.Лечение: требуется симптоматическое лечение пациента и поддерживающий уход за ним. Специфического антидота нет. В случае если передозировка произошла в течение последних 4 ч, необходимо вызвать рвоту, обеспечить прием активированного угля (60–100 г на взрослого человека), осмотические слабительные. Форсированный диурез, гемодиализ неэффективны из-за высокой связи препарата с белками.
Взаимодействие с другими лекарственными средствами
Действие медикаментов, уменьшающих свертываемость крови, усиливается при их одновременном применении с нимесулидом.Нимесулид может снижать действие фуросемида. Уменьшает терапевтический эффект антигипертензивных препаратов. Нимесулид может увеличивать возможность наступления побочных действий при одновременном приеме метотрексата.Уровень лития в плазме повышается при одновременном приеме препаратов лития и нимесулида.Из-за высокой степени связывания нимесулида с белками плазмы пациенты, которых одновременно лечат гидантоином и сульфаниламидами, должны находиться под наблюдением врача, проходя обследование через короткие промежутки времени.Нимесулид может усиливать действие циклоспорина на почки.Использование с ГКС, ингибиторами обратного захвата серотонина увеличивает риск развития кровотечений из ЖКТ.
Условия хранения
В сухом, защищенном от света месте, при температуре 15–25°C. Хранить в недоступном для детей месте.
Срок годности
5 лет. Не применять по истечении срока годности, указанного на упаковке.2000-2017. Регистр лекарственных средств России
Условия отпуска
По рецепту.
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влияет."}}]},{"id":5,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Таблеткигиперчувствительность к нимесулиду и компонентам препарата;эрозивно-язвенные изменения слизистой желудка и двенадцатиперстной кишки;воспалительные заболевания кишечника в фазе обострения;активное желудочно-кишечное кровотечение;выраженные нарушения функции печени и/или почек, тяжелая почечная недостаточность (Cl креатинина \u003c30 мл/мин);прогрессирующее заболевание почек;тяжелая печеночная недостаточность или активное заболевание печени;тяжелая сердечная недостаточность;выраженные нарушения свертывания крови;подтвержденная гиперкалиемия;период после проведения аортокоронарного шунтирования;анамнестические данные о приступе бронхообструкции, ринита, крапивницы после приема ацетилсалициловой кислоты или иного НПВС (полный или неполный синдром непереносимости ацетилсалициловой кислоты— риносинусит, крапивница, полипы слизистой носа, астма);беременность и период грудного вскармливания;детский возраст до 12 лет.Таблетки для рассасываниягиперчувствительность к активному веществу или вспомогательным компонентам;полное или неполное сочетание бронхиальной астмы, рецидивирующего полипоза носа или околоносовых пазух и непереносимости ацетилсалициловой кислоты и других НПВС (в т.ч. в анамнезе);эрозивно-язвенные изменения слизистой желудка или двенадцатиперстной кишки, активное желудочно-кишечное кровотечение; цереброваскулярное или иное кровотечение;воспалительные заболевания кишечника (неспецифический язвенный колит, болезнь Крона) в фазе обострения;гемофилия и другие нарушения свертываемости крови;декомпенсированная сердечная недостаточность;печеночная недостаточность или любое активное заболевание печени;выраженная почечная недостаточность (Cl креатинина \u003c30 мл/мин);прогрессирующие заболевания почек;подтвержденная гиперкалиемия;период после проведения аортокоронарного шунтирования;анамнестические данные о развитии гепатотоксических реакций при использовании препаратов нимесулида;сопутствующее применение потенциально гепатотоксичных веществ;алкоголизм, наркомания;беременность, период грудного вскармливания;детский возраст до 12 лет.С осторожностью (таблетки, таблетки для рассасывания): ишемическая болезнь сердца, цереброваскулярные заболевания, застойная сердечная недостаточность, дислипидемия/гиперлипидемия, сахарный диабет, заболевания периферических артерий, курение, Cl креатинина \u003c60 мл/мин.Анамнестические данные о развитии язвенного поражения ЖКТ, наличие инфекции Helicobacter pylori, пожилой возраст, длительное использование НПВС, частое употребление алкоголя, тяжелые соматические заболевания, сопутствующая терапия следующими препаратами— антикоагулянты (например варфарин), антиагреганты (например ацетилсалициловая кислота, клопидогрел), пероральные ГКС (например преднизолон), СИОЗС (например циталопрам, флуоксетин, пароксетин, сертралин)."}}]},{"id":6,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"ТаблеткиВнутрь. Взрослым и детям старше 12 лет (масса тела \u003e40 кг)— по 1 табл. 2 раза в день. Таблетки принимают после еды с достаточным количеством жидкости. Максимальная суточная доза— 5 мг/кг.Пациентам с хронической почечной недостаточностью требуется снижение суточной дозы до 100 мг.Курс лечения— по назначению врача.Таблетки для рассасыванияСледует использовать минимальную эффективную дозу минимально возможным коротким курсом.Взрослым и детям старше 12 лет (масса тела \u003e40 кг)— обычно в дозе 100 мг (1 табл.) 2 раза в сутки в конце или после приема пищи. Таблетку следует положить на язык, где она сразу же начинает растворяться. Проглотить слюну, в которой растворилась таблетка."}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Частота классифицируется в зависимости от встречаемости— очень часто (\u003e10); часто (\u003c10–\u003c100); нечасто (\u003c100–\u003c1000); редко (\u003c1000–\u003c10000); очень редко (\u003c10000).Со стороны ЖКТ: часто— диарея, тошнота, рвота; нечасто— запор, метеоризм, гастрит; очень редко— боли в животе, стоматит, дегтеобразный стул, желудочно-кишечное кровотечение, язва и/или перфорация желудка или двенадцатиперстной кишки.Со стороны ЦНС: нечасто— головокружение; редко— ощущение страха, нервозность, кошмарные сновидения; очень редко— головная боль, сонливость, энцефалопатия (синдром Рейе).Со стороны органов дыхания: нечасто— одышка; очень редко— бронхоспазм; возможно обострение бронхиальной астмы.Со стороны ССС: нечасто— артериальная гипертензия; редко— тахикардия, геморрагии, приливы.Со стороны органов чувств: редко— нечеткость зрения.Кожные и слизистые покровы: нечасто— зуд, сыпь, усиление потоотделения; редко— эритема, дерматит.Печень и желчевыводящая система: часто— повышение активности печеночных трансаминаз; очень редко— гепатит, молниеносный гепатит, желтуха, холестаз.Почки и мочевыводящая система: нечасто— отеки; редко— дизурия, гематурия, задержка мочи, гиперкалиемия; очень редко— почечная недостаточность, олигурия, интерстициальный нефрит.Со стороны органов кроветворения: редко— анемия, эозинофилия; очень редко— тромбоцитопения, панцитопения, пурпура, удлинение времени кровотечения.Аллергические реакции: редко— реакции гиперчувствительности; очень редко— анафилактоидные реакции, крапивница, ангионевротический отек, отечность лица, мультиформная экссудативная эритема, в т.ч. синдром Стивенса-Джонсона, токсический эпидермальный некролиз (синдром Лайелла).Общие реакции: редко— общая слабость; очень редко— гипотермия.В случае появления других, не упомянутых выше, побочных действий или ухудшения самочувствия следует обратиться незамедлительно к врачу."}}]},{"id":8,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Симптомы: апатия, сонливость, тошнота, рвота. Может возникнуть желудочно-кишечное кровотечение, артериальная гипертензия, острая почечная недостаточность, угнетение дыхания.Лечение: требуется симптоматическое лечение пациента и поддерживающий уход за ним. Специфического антидота нет. В случае если передозировка произошла в течение последних 4 ч, необходимо вызвать рвоту, обеспечить прием активированного угля (60–100 г на взрослого человека), осмотические слабительные. Форсированный диурез, гемодиализ неэффективны из-за высокой связи препарата с белками."}}]},{"id":9,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Действие медикаментов, уменьшающих свертываемость крови, усиливается при их одновременном применении с нимесулидом.Нимесулид может снижать действие фуросемида. Уменьшает терапевтический эффект антигипертензивных препаратов. 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