1 таблетка, покрытая оболочкой, содержит 10 мг цетиризина дигидрохлорида.
Вспомогательные вещества:
Лактозы моногидрат, целлюлоза микрокристаллическая, кремния диоксид коллоидный, магния стеарат. Состав оболочки: белый краситель опадрай, состоящий из лактозы моногидрата, титана диоксида, гипромеллозы, макрогола 4000.
Описание
белые или почти белые продолговатые таблетки с насечкой на одной стороне.
Фармакотерапевтическая группа
противоаллергическое средство - Н1- гистаминовых рецепторов блокатор
Фармакологические свойства
Фармакокинетика.
Всасывание: после приема внутрь цетиризин быстро и хорошо всасывается из желудочно–кишечного тракта. Максимальный уровень концентрации определяется примерно через 40 – 60 минут.
Прием пищи не оказывает существенного влияния на величину абсорбции, однако в этом случае скорость всасывания незначительно снижается.
Распределение: цетиризин связывается с белками плазмы крови примерно на 93%. Величина объема распределения (Vd) низкая (0,5 л/кг), препарат внутрь клетки не проникает.
Препарат не проникает через гематоэнцефалический барьер.
Метаболизм: цетиризин слабо метаболизируется в печени с образованием неактивного метаболита.
При 10-дневном применении в дозе 10 мг накопления препарата не наблюдается.
Выведение: примерно на 70 % происходит почками в основном в неизмененном виде.
Величина системного клиренса составляет около 54 мл/мин.
После однократного приема разовой дозы величина периода полувыведения составляет около 10 часов. У детей в возрасте от 2 до 12 лет величина периода полувыведения снижается до 5-6 часов.
При нарушении функции почек (клиренс креатинина ниже 11-31 мл/мин) и у пациентов, находящихся на гемодиализе (клиренс креатинина менее 7 мл/мин) величина периода полувыведения увеличивается в 3 раза, клиренс уменьшается на 70%.
На фоне хронических заболеваний и у пожилых пациентов отмечается увеличение величины периода полувыведения на 50% и уменьшение клиренса на 40%.
Гемодиализ неэффективен.
Показания к применению
Круглогодичный и сезонный аллергический ринит (симптоматическая терапия); крапивница, в т.ч. хроническая идиопатическая; дерматозы, протекающие с зудом (атопический дерматит, нейродермит); аллергический конъюнктивит.
Противопоказания
Повышенная чувствительность по отношению к цетиризину или другим составным частям препарата; тяжелые заболевания почек.
Детский возраст до 6 лет.
Беременность, период лактации.
С осторожностью
Хронический пиелонефрит средней и тяжелой степени тяжести (требуется коррекция режима дозирования), пожилой возраст (возможно снижение клубочковой фильтрации).
Способ применения и дозы
Внутрь, независимо от приема пищи, не разжевывая и запивая достаточным количеством жидкости, предпочтительно вечером.
Детям в возрасте от 6 до 12 лет:
при массе тела менее 30 кг: по ½ таблетки, покрытой оболочкой, вечером
при массе тела более 30 кг: по 1 таблетке, покрытой оболочкой, вечером.
Возможен прием 2 раза в день (утром и вечером) по ½ таблетки.
Взрослым и подросткам в возрасте старше 12 лет рекомендуется принимать по 1 таблетке цетиризина, предпочтительно вечером.
При почечной недостаточности следует уменьшить рекомендуемую дозу в 2 раза.
При нарушении функции печени необходимо подбирать дозу индивидуально, особенно осторожно при одновременной почечной недостаточности.
Пожилым пациентам с нормальной функцией почек корректировки дозы не требуется.
При сезонном аллергическом рините длительность терапии составляет обычно от 3 до 6 недель, а при кратковременном воздействии пыльцы бывает достаточно и одной недели.
Длительность терапии для детей в возрасте старше 6 лет составляет от 2 до 4 недель, а при кратковременном воздействии аллергена достаточен прием в течение 1 недели.
Побочное действие
Со стороны пищеварительной системы: сухость во рту, диспепсия.
Со стороны ЦНС: головная боль, сонливость, утомляемость, головокружение, возбуждение, мигрень.
Аллергические реакции: кожная сыпь, ангионевротический отек, крапивница, кожный зуд.
Препарат обычно хорошо переносится. Побочные явления возникают редко и имеют преходящий характер.
Передозировка
Симптомы: возможны сонливость, заторможенность, слабость, головная боль, тахикардия, повышенная раздражительность, задержка мочеиспускания, утомляемость (чаще всего при приеме в день 50 мг цетиризина).
Лечение: проводят симптоматическую терапию. Специфический антидот не выявлен. Гемодиализ неэффективен. Проводят промывание желудка, назначают активированный уголь.
Взаимодействие с другими лекарственными средствами
Не установлено клинически значимых взаимодействий цетиризина с другими лекарственными средствами.
Совместное употребление с теофиллином (400 мг/сут) приводит к снижению общего клиренса цетиризина (кинетика теофиллина не изменяется).
Особые указания
В период лечения необходимо воздерживаться от занятий потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций.
Указание для больных сахарным диабетом:
1 таблетка соответствует менее 0,01 хлеб. ед.
Форма выпуска
Таблетки покрытые оболочкой 10 мг, по 7 или по 10 таблеток в контурную ячейковую упаковку из ПВХ/алюминиевой фольги. По 1, 2, 3 или 5 блистеров в картонную пачку вместе с инструкцией по применению.
Условия хранения
При температуре не выше 25°С.
Хранить в недоступном для детей месте.
Срок годности
3 года.
Не использовать по истечении срока, указанного на упаковке.
Для описания товара использована информация от партнера 36.6
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Состав оболочки: белый краситель опадрай, состоящий из лактозы моногидрата, титана диоксида, гипромеллозы, макрогола 4000.\n\n"}}]},{"id":5,"name":"Описание","slug":"common_description","body":[{"type":"paragraph","data":{"text":" белые или почти белые продолговатые таблетки с насечкой на одной стороне."}}]},{"id":6,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":" противоаллергическое средство - Н\u003csub\u003e1\u003c/sub\u003e- гистаминовых рецепторов блокатор "}}]},{"id":7,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":"Фармакокинетика."}},{"type":"paragraph","data":{"text":"Всасывание: после приема внутрь цетиризин быстро и хорошо всасывается из желудочно–кишечного тракта. Максимальный уровень концентрации определяется примерно через 40 – 60 минут."}},{"type":"paragraph","data":{"text":"Прием пищи не оказывает существенного влияния на величину абсорбции, однако в этом случае скорость всасывания незначительно снижается."}},{"type":"paragraph","data":{"text":"Распределение: цетиризин связывается с белками плазмы крови примерно на 93%. Величина объема распределения (Vd) низкая (0,5 л/кг), препарат внутрь клетки не проникает."}},{"type":"paragraph","data":{"text":"Препарат не проникает через гематоэнцефалический барьер."}},{"type":"paragraph","data":{"text":"Метаболизм: цетиризин слабо метаболизируется в печени с образованием неактивного метаболита."}},{"type":"paragraph","data":{"text":"При 10-дневном применении в дозе 10 мг накопления препарата не наблюдается."}},{"type":"paragraph","data":{"text":"Выведение: примерно на 70 % происходит почками в основном в неизмененном виде."}},{"type":"paragraph","data":{"text":"Величина системного клиренса составляет около 54 мл/мин."}},{"type":"paragraph","data":{"text":"После однократного приема разовой дозы величина периода полувыведения составляет около 10 часов. У детей в возрасте от 2 до 12 лет величина периода полувыведения снижается до 5-6 часов."}},{"type":"paragraph","data":{"text":"При нарушении функции почек (клиренс креатинина ниже 11-31 мл/мин) и у пациентов, находящихся на гемодиализе (клиренс креатинина менее 7 мл/мин) величина периода полувыведения увеличивается в 3 раза, клиренс уменьшается на 70%."}},{"type":"paragraph","data":{"text":"На фоне хронических заболеваний и у пожилых пациентов отмечается увеличение величины периода полувыведения на 50% и уменьшение клиренса на 40%."}},{"type":"paragraph","data":{"text":"Гемодиализ неэффективен."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Круглогодичный и сезонный аллергический ринит (симптоматическая терапия); крапивница, в т.ч. хроническая идиопатическая; дерматозы, протекающие с зудом (атопический дерматит, нейродермит); аллергический конъюнктивит."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"\n\nПовышенная чувствительность по отношению к цетиризину или другим составным частям препарата; тяжелые заболевания почек."}},{"type":"paragraph","data":{"text":"Детский возраст до 6 лет."}},{"type":"paragraph","data":{"text":"Беременность, период лактации.\n\n"}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Хронический пиелонефрит средней и тяжелой степени тяжести (требуется коррекция режима дозирования), пожилой возраст (возможно снижение клубочковой фильтрации)."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь, независимо от приема пищи, не разжевывая и запивая достаточным количеством жидкости, предпочтительно вечером."}},{"type":"paragraph","data":{"text":"Детям в возрасте от 6 до 12 лет:"}},{"type":"list","data":{"style":"ordered","items":["при массе тела менее 30 кг: по ½ таблетки, покрытой оболочкой, вечером","при массе тела более 30 кг: по 1 таблетке, покрытой оболочкой, вечером."]}},{"type":"paragraph","data":{"text":"Возможен прием 2 раза в день (утром и вечером) по ½ таблетки."}},{"type":"paragraph","data":{"text":"Взрослым и подросткам в возрасте старше 12 лет рекомендуется принимать по 1 таблетке цетиризина, предпочтительно вечером."}},{"type":"paragraph","data":{"text":"При почечной недостаточности следует уменьшить рекомендуемую дозу в 2 раза."}},{"type":"paragraph","data":{"text":"При нарушении функции печени необходимо подбирать дозу индивидуально, особенно осторожно при одновременной почечной недостаточности."}},{"type":"paragraph","data":{"text":"Пожилым пациентам с нормальной функцией почек корректировки дозы не требуется."}},{"type":"paragraph","data":{"text":"При сезонном аллергическом рините длительность терапии составляет обычно от 3 до 6 недель, а при кратковременном воздействии пыльцы бывает достаточно и одной недели."}},{"type":"paragraph","data":{"text":"Длительность терапии для детей в возрасте старше 6 лет составляет от 2 до 4 недель, а при кратковременном воздействии аллергена достаточен прием в течение 1 недели.\n\n"}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\n\nСо стороны пищеварительной системы: сухость во рту, диспепсия."}},{"type":"paragraph","data":{"text":"Со стороны ЦНС: головная боль, сонливость, утомляемость, головокружение, возбуждение, мигрень."}},{"type":"paragraph","data":{"text":"Аллергические реакции: кожная сыпь, ангионевротический отек, крапивница, кожный зуд."}},{"type":"paragraph","data":{"text":"Препарат обычно хорошо переносится. Побочные явления возникают редко и имеют преходящий характер.\n\n"}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\n\nСимптомы: возможны сонливость, заторможенность, слабость, головная боль, тахикардия, повышенная раздражительность, задержка мочеиспускания, утомляемость (чаще всего при приеме в день 50 мг цетиризина)."}},{"type":"paragraph","data":{"text":"Лечение: проводят симптоматическую терапию. Специфический антидот не выявлен. Гемодиализ неэффективен. Проводят промывание желудка, назначают активированный уголь.\n\n"}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"\n\nНе установлено клинически значимых взаимодействий цетиризина с другими лекарственными средствами."}},{"type":"paragraph","data":{"text":"Совместное употребление с теофиллином (400 мг/сут) приводит к снижению общего клиренса цетиризина (кинетика теофиллина не изменяется).\n\n"}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"В период лечения необходимо воздерживаться от занятий потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."}},{"type":"paragraph","data":{"text":"Указание для больных сахарным диабетом:"}},{"type":"paragraph","data":{"text":"1 таблетка соответствует менее 0,01 хлеб. ед."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки покрытые оболочкой 10 мг, по 7 или по 10 таблеток в контурную ячейковую упаковку из ПВХ/алюминиевой фольги. По 1, 2, 3 или 5 блистеров в картонную пачку вместе с инструкцией по применению."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"\n\nПри температуре не выше 25°С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте.\n\n"}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"\n\n3 года."}},{"type":"paragraph","data":{"text":"Не использовать по истечении срока, указанного на упаковке.\n\n"}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nГексал АГ, произведено Салютас Фарма ГмбХ, Германия 83607 Хольцкирхен Индустриштрассе 25"}},{"type":"paragraph","data":{"text":"Hexal AG, manufactured by Salutas Pharma GmbH, Germany 83607 Holzkirchen Industriestrasse 25"}},{"type":"paragraph","data":{"text":"Представительство в Москве:"}},{"type":"paragraph","data":{"text":"121170 Москва, ул. Кульнева, д. 3\n\n"}}]}],"source":null},"description_toggle":false,"short_description":"Фармакокинетика. Всасывание: после приема внутрь цетиризин быстро и хорошо всасывается из желудочно–кишечного тракта. Максимальный уровень концентрации определяется примерно через 40 – 60 минут. Прием пищи не оказывает существенного влияния на величину абсорбции, однако в этом случае скорость всасывания незначительно снижается. Распределение: цетиризин связывается с белками плазмы крови примерно на 93%. Величина объема распределения (Vd) низкая (0,5 л/кг), препарат внутрь клетки не проникает. Препарат не проникает через гематоэнцефалический барьер. Метаболизм: цетиризин слабо метаболизируется в печени с образованием неактивного метаболита. При 10-дневном применении в дозе 10 мг накопления препарата не наблюдается. Выведение: примерно на 70 % происходит почками в основном в неизмененном виде. Величина системного клиренса составляет около 54 мл/мин. 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