Фамотидин Таблетки, коробка, 20 шт, 20 мг, для приема внутрь, цвет белый

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Проникает через плацентарный барьер и выделяется с грудным молоком."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Язвенная болезнь 12-перстной кишки и желудка в фазе обострения, профилактика рецидивов,"}},{"type":"paragraph","data":{"text":"- лечение и профилактика симптоматических язв желудка и 12-перстной кишки (связанных с приемом нестероидных противовоспалительных препаратов (НПВП), стрессовых, послеоперационных язв),"}},{"type":"paragraph","data":{"text":"- эрозивный гастродуоденит,"}},{"type":"paragraph","data":{"text":"- функциональная диспепсия, ассоциированная с повышенной секреторной функцией желудка,"}},{"type":"paragraph","data":{"text":"- рефлюкс-эзофагит,"}},{"type":"paragraph","data":{"text":"- синдром Золлингера-Эллисона,"}},{"type":"paragraph","data":{"text":"- профилактика рецидивов кровотечений из верхних отделов желудочно-кишечного тракта,"}},{"type":"paragraph","data":{"text":"- предупреждение аспирации желудочного сока при общей анестезии (синдром Мендельсона)."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСимптомы\u003c/i\u003e: рвота, двигательное возбуждение, тремор, снижение артериального давления, тахикардия, коллапс."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение:\u003c/i\u003e промывание желудка, симптоматическая терапия, гемодиализ."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Противопоказан к применению при беременности и в период лактации."}},{"type":"paragraph","data":{"text":"Фамотидин выделяется с грудным молоком."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь."}},{"type":"paragraph","data":{"text":"При язвенной болезни желудка и 12-перстной кишки в фазе обострения, симптоматических язвах, эрозивном гастродуодените обычно назначают по 20 мг 2 раза в сутки или по 40 мг 1 раз в сутки на ночь. При необходимости суточная доза может быть увеличена до 80-160 мг. Курс лечения - 4-8 недель."}},{"type":"paragraph","data":{"text":"При диспепсии, связанной с повышенной секреторной функцией желудка, назначают по 20 мг 1-2 раза в сутки."}},{"type":"paragraph","data":{"text":"С целью профилактики рецидивов язвенной болезни назначают по 20 мг 1 раз в сутки перед сном."}},{"type":"paragraph","data":{"text":"При рефлюкс-эзофагите - 20-40 мг два раза в сутки в течение 6-12 недель."}},{"type":"paragraph","data":{"text":"При синдроме Золлингера-Эллисона дозу препарата и продолжительность курса лечения устанавливают индивидуально. Начальная доза обычно составляет 20 мг каждые 6 часов и может быть увеличена до 160 мг каждые 6 часов."}},{"type":"paragraph","data":{"text":"Для профилактики аспирации желудочного сока при общей анестезии назначают по 40 мг вечером и/или утром перед операцией. Таблетки следует проглатывать не разжевывая, запивая достаточным количеством воды."}},{"type":"paragraph","data":{"text":"При почечной недостаточности, если клиренс креатинина составляет менее 30 мл/мин или содержание креатинина в сыворотке крови более 3 мг/100 мл, суточную дозу препарата необходимо уменьшить до 20 мг."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны пищеварительной системы:\u003c/i\u003e сухость во рту, тошнота, рвота, абдоминальные боли, потеря аппетита, повышение активности печеночных трансаминаз, гепатит, острый панкреатит."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны нервной системы:\u003c/i\u003e головная боль, головокружение, галлюцинации, спутанность сознания."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны сердечно-сосудистой системы:\u003c/i\u003e снижение артериального давления, атриовентрикулярная блокада, брадикардия."}},{"type":"paragraph","data":{"text":"\u003ci\u003eАллергические реакции\u003c/i\u003e: сухость кожи, крапивница, кожный зуд, кожная сыпь, бронхоспазм, ангионевротический отек, анафилактический шок."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны органов кроветворения\u003c/i\u003e: редко - лейкопения, тромбоцитопения, в единичных случаях - агранулоцитоз, панцитопения, гипоплазия, аплазия костного мозга."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны репродуктивной системы:\u003c/i\u003e при длительном приеме больших доз - гиперпролактинемия, гинекомастия, аменорея, снижение либидо, импотенция."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны органов чувств:\u003c/i\u003e парез аккомодации, нечеткости зрительного восприятия, звон в ушах."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПрочие:\u003c/i\u003e редко - лихорадка, артралгия, миалгия."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСимптомы\u003c/i\u003e: рвота, двигательное возбуждение, тремор, снижение артериального давления, тахикардия, коллапс."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение:\u003c/i\u003e промывание желудка, симптоматическая терапия, гемодиализ."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Вследствие повышения pH содержимого желудка при одновременном приеме может уменьшиться всасывание кетоконазола и итраконазола."}},{"type":"paragraph","data":{"text":"При одновременном применении с антацидными средствами, сукральфатом происходит снижение интенсивности абсорбции фамотидина, поэтому перерыв между приемом этих препаратов должен составлять не менее 1-2 часов."}},{"type":"paragraph","data":{"text":"Угнетает метаболизм в печени феназона, аминофеназона, диазепама, гексобарбитала, пропранолола, метопролола, лидокаина, фенитоина, теофиллина, непрямых антикоагулянтов, глипизида, буформина, метронидазола, кофеина, блокаторов медленных кальциевых каналов, трициклических антидепрессантов."}},{"type":"paragraph","data":{"text":"Увеличивает всасывание амоксициллина и клавулановой кислоты."}},{"type":"paragraph","data":{"text":"Лекарственные средства, угнетающие костный мозг, увеличивают риск развития нейтропении"}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Перед началом лечения необходимо исключить возможность наличия злокачественного заболевания пищевода, желудка или двенадцатиперстной кишки."}},{"type":"paragraph","data":{"text":"Фамотидин, как и все Н\u003csub\u003e2\u003c/sub\u003e-гистаминоблокаторы, нежелательно резко отменять (синдром рикошета)."}},{"type":"paragraph","data":{"text":"При длительном лечении у ослабленных больных, в условиях стресса, возможны бактериальные поражения желудка с последующим распространением инфекции. Н\u003csub\u003e2\u003c/sub\u003e-гистаминорецепторов блокаторы могут противодействовать влиянию пентагастрина и гистамина на кислотообразующую функцию желудка, поэтому в течение 24 часов, предшествующих тесту, применять Н\u003csub\u003e2\u003c/sub\u003e-гистаминорецепторов блокаторы не рекомендуется."}},{"type":"paragraph","data":{"text":"Н\u003csub\u003e2\u003c/sub\u003e-гистаминорецепторов блокаторы могут подавлять кожную реакцию на гистамин, приводя, таким образом, к ложноотрицательным результатам (перед проведением диагностических кожных проб для выявления аллергической кожной реакции немедленного типа применение Н\u003csub\u003e2\u003c/sub\u003e-гистаминорецепторов блокаторов рекомендуется прекратить)."}},{"type":"paragraph","data":{"text":"Во время лечения следует избегать употребления продуктов питания, напитков и других лекарственных средств, которые могут вызвать раздражение слизистой оболочки желудка."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"В период лечения следует соблюдать осторожность при управлении автотранспортом и при других видах деятельности, требующих повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки, покрытые пленочной оболочкой, 20 мг и 40 мг."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В сухом, защищенном от света месте, при температуре не выше 25 С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года. Не использовать после истечения срока годности."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":" Озон (Россия)"}}]}],"source":null},"description_toggle":false,"short_description":"Н2-гистаминовых рецепторов блокатор III поколения. Подавляет базальную и стимулированную гистамином, гастрином и ацетилхолином продукцию соляной кислоты. Уменьшает активность пепсина. Усиливает защитные механизмы слизистой оболочки желудка и способствует заживлению связанных с воздействием соляной кислоты ее повреждений (в том числе прекращению желудочно-кишечных кровотечений и рубцеванию стрессовых язв) путем увеличения образования желудочной слизи, содержания в ней гликопротеидов, стимуляции секреции гидрокарбоната слизистой оболочкой желудка, эндогенного синтеза в ней простагландинов и скорости регенерации. Существенно не изменяет концентрацию гастрина в плазме. Слабо ингибирует оксидазную систему цитохрома Р450 в печени. После приема внутрь действие начинается через 1 час, достигает максимума в течение 3 часов. Продолжительность действия препарата при однократном приеме зависит от дозы и составляет от 12 до 24 часов. После приема внутрь быстро абсорбируется из желудочно-кишечного тракта. После приема внутрь максимальная концентрация в плазме крови достигается в течение 1-3,5 часов. Биодоступность - 40-45%, увеличивается при приеме с пищей и снижается на фоне приема антацидов. Связь с белками плазмы - 15-20%. Около 30-35% фамотидина метаболизируется в печени (с образованием S-оксида). Элиминация, в основном, происходит через почки: 27-40% препарата выводится с мочой в неизмененном виде. Период полувыведения - 2,5-4 часа, у пациентов с клиренсом креатинина ниже 30 мл/мин увеличивается до 10-12 часов. У пациентов с тяжелой почечной недостаточностью (клиренс креатинина ниже 10 мл/мин) он возрастает до 20 часов. Проникает через плацентарный барьер и выделяется с грудным молоком.","substance":[{"id":92,"title":"Фамотидин","title_latin":"Famotidinum","slug":"famotidin_92"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":null,"image_alt":"Фамотидин - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/81950/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/81950/share_default/"}},"diseases":[],"other_packages":[{"id":111064,"title":"Фамотидин","subtitle":{"full":"Таблетки, коробка, 20 шт, 20 мг, для приема внутрь, покрытые оболочкой","short":"Таблетки, 20 шт, 20 мг","package":"20 шт, 20 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