Фармакологическое действие — противогрибковое широкого спект... Инструкция
Показания к применению
микозы волосистой части головы (трихофития, микроспория);микозы кожи и ногтей, обусловленные Trychophyton (Т. rubrum, Т. mentagrophytes, Т. verrucosum, Т. violaceum), Microsporum (M. canis, M. gypseum) и Epidermophyton floccosum;онихомикозы;тяжелые, распространенные дерматомикозы гладкой кожи туловища и конечностей, требующие системного лечения;кандидозы ...
Повышенная чувствительность к тербинафину и другим компонентам препарата, беременность, период кормления грудью, детский возраст до 2 лет, т.к. нет достаточного количества данных о применении препарата детьми с массой тела менее 12 кг.С осторожностью: печеночная и/или почечная недостаточность, алкоголизм, заболевания крови, опухоли, болезни обмена веществ, ...
Круглые, двояковыпуклые таблетки белого или почти белого цвета с насечкой на одной стороне и фаской.
Фармакологические свойства
Фармакологическое действие — противогрибковое широкого спектра.
Показания к применению
микозы волосистой части головы (трихофития, микроспория);микозы кожи и ногтей, обусловленные Trychophyton (Т. rubrum, Т. mentagrophytes, Т. verrucosum, Т. violaceum), Microsporum (M. canis, M. gypseum) и Epidermophyton floccosum;онихомикозы;тяжелые, распространенные дерматомикозы гладкой кожи туловища и конечностей, требующие системного лечения;кандидозы кожи и слизистых оболочек.
Противопоказания
Повышенная чувствительность к тербинафину и другим компонентам препарата, беременность, период кормления грудью, детский возраст до 2 лет, т.к. нет достаточного количества данных о применении препарата детьми с массой тела менее 12 кг.С осторожностью: печеночная и/или почечная недостаточность, алкоголизм, заболевания крови, опухоли, болезни обмена веществ, патология сосудов конечностей, псориаз.
Применение при беременности и в период грудного вскармливания
Прием тербинафина во время беременности противопоказан из-за отсутствия достаточного количества данных о его безопасности во время беременности.Тербинафин выделяется с грудным молоком, поэтому его назначение противопоказано в период грудного вскармливания.
Способ применения и дозы
Внутрь, после еды. Длительность курса лечения и режим дозирования устанавливаются в индивидуальном порядке и зависят от локализации процесса и тяжести заболевания.Взрослым— 250 мг (1 табл.) 1 раз в сутки. Дозировка препарата для детей указана в таблице 1.Таблица 1 Масса тела ребенка Доза, 1 раз в сутки 12–20 кг 62,5 мг (1/2 табл. 125 мг) 20–40 кг 125 мг (1 табл. 125 мг) Более 40 кг 250 мг (1 табл. 250 мг) Длительность лечения различна и зависит от показаний и тяжести инфекции ( таблица 2).Таблица 2 Заболевание Длительность лечения Инфекции кожи Трихофития стоп 2–6 нед Трихофития гладкой кожи и паховая эпидермофития 2–4 нед Кандидоз кожи 2–4 нед Иногда симптомы инфекции могут исчезать спустя несколько недель после окончания лечения тербинафином Инфекции волос и волосистой части головы Стригущий лишай (является преимущественно детской инфекцией) 4 нед Инфекции ногтевых пластинок Онихомикозы 6–12 нед Инфекции пальцев рук 6 нед Инфекции пальцев ног 12 нед (в некоторых случаях требуется лечение в течение 6 и более мес) У пациентов с медленно растущими ногтями требуется продолжительное лечение (более 3 мес). Клинический эффект может быть заметен через несколько месяцев после окончания лечения в зависимости от времени, необходимого для регенерации ногтевой ткани При выраженных нарушениях функции печени и/или почек (Cl креатинина <50 мл/мин либо концентрация креатинина в крови— >300 мкмоль/л)— 125 мг 1 раз в день.
Побочное действие
Побочные действия обычно средней и легкой степени тяжести и носят временный характер.Со стороны органов системы пищеварения: часто— чувство переполненного желудка, диспепсия, тошнота, потеря аппетита, боли в животе, диарея, иногда— нарушение вкусового восприятия (в т.ч. потеря его), которая восстанавливается через несколько недель после прекращения лечения; редко— холестатическая желтуха, гепатит, бессимптомное увеличение уровня трансаминаз печени. Несмотря на недоказанность причинной связи этих нарушений с приемом тербинафина, в случае развития гепатобилиарной дисфункции лечение Атифином следует прекратить.Со стороны ЦНС: редко— парестезия, гипестезия, головокружение, очень редко— депрессия, чувство повышенной тревоги.Со стороны опорно-двигательного аппарата: часто— артралгия, миалгия.Со стороны системы кроветворения: очень редко— нейтропения, агранулоцитоз, тромбоцитопения.Со стороны иммунной системы: часто— крапивница, многоформная эритема, редко— системные аллергические реакции (реакции подобные сывороточной болезни, ангионевротический отек), очень редко— тяжелые кожные реакции (токсический эпидермальный некролиз, синдром Стивенса-Джонсона, фоточувствительность). При прогрессировании кожных высыпаний лечение тербинафином следует прекратить.Прочие: часто— головная боль, плохое самочувствие, чувство усталости, очень редко— обострение псориаза, усиленное выпадение волос.
Передозировка
Симптомы: тошнота, рвота, боли в нижней части живота, в эпигастральной области.Лечение: промывание желудка с последующим назначением активированного угля и/или симптоматическая терапия.
Взаимодействие с другими лекарственными средствами
Практически не влияет на клиренс препаратов, метаболизирующихся с участием цитохрома Р450 (например циклоспорин, терфенадин, толбутамид, триазолам, пероральные контрацептивы).Ингибирует изоэнзим CYP2D6 и препятствует метаболизму таких препаратов, как трициклические антидепрессанты и селективные блокаторы захвата серотонина (например дезипрамин, флувоксамин), бета-адреноблокаторы (метопролол, пропранолол), противоаритмические средства (флекаинид, проавфенон), МАО-В-ингибиторы (например селегилин) и антипсихотические (например хлорпромазин, галоперидол) средства.Лекарственные препараты-индукторы ферментов СYР450 (например рифампицин) могут ускорять выведение тербинафина из организма.Лекарственные препараты-ингибиторы СYР450 (например циметидин) могут замедлить метаболизм и выведение тербинафина из организма. При одновременном применении этих препаратов может потребоваться коррекция дозы тербинафина. Возможно нарушение менструального цикла при одновременном приеме тербинафина и пероральных контрацептивов.Снижает клиренс кофеина на 21% и продлевает время его полураспада на 31%. Не влияет на клиренс антипирина, дигоксина, варфарина.Этанол и другие гепатотоксичные препараты повышают риск развития гепатотоксического эффекта.
Условия хранения
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Срок годности
3 года. Не применять по истечении срока годности, указанного на упаковке.2000-2017. Регистр лекарственных средств России
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