Гепариновая мазь Мазь, туба, 1 шт, 25 г, для наружного применения

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Алкалоиды спорыньи тироксин тетрациклин блокаторы Н1-гистаминовых рецепторов и никотин уменьшают действие гепарина."}},{"type":"paragraph","data":{"text":"При одновременном применении с ненаркотическими анальгетиками ингибиторами холинэстеразы усиливается действие бензокаина. При одновременном применении с бензокаином уменьшается антибактериальная активность сульфаниламидов."}}]},{"id":15,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Не следует наносить на открытые раны на слизистые оболочки при наличии гнойных процессов. Необходимо избегать попадания препарата в глаза из-за возможного развития раздражения. При случайном попадании мази в глаза их следует немедленно промыть проточной водой."}}]},{"id":16,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Сведения отсутствуют."}}]},{"id":17,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Мазь для наружного применения."}},{"type":"header","data":{"text":"Упаковка:","level":3}},{"type":"paragraph","data":{"text":"По 25 г мази в тубы алюминиевые. Каждую тубу вместе с инструкцией помещают в пачку из картона."}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищенном от света месте при температуре не выше 25 °С. Хранить в недоступном для детей месте."}}]},{"id":19,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Не использовать по истечении срока годности указанного на упаковке."}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта ."}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Республиканское унитарное производственное предприятие \"Белмедпрепараты\" (РУП \"Белмедпрепараты\"), 220007, Республика Беларусь, г. Минск, ул. Фабрициуса, д. 30, Республика Беларусь"}}]}],"source":null},"description_toggle":false,"short_description":"Гепарин - антикоагулянт прямого действия относится к группе среднемолекулярных гепаринов. При наружном применении оказывает местное антикоагулянтное противоэкссудативное умеренное противовоспалительное действие. Блокирует образование тромбина. Гепарин уменьшает воспалительный процесс и оказывает антикоагулянтное действие косвенно улучшает микроциркуляцию что способствует процессу рассасывания гематом и тромбов и уменьшению отечности тканей. Бензокаин - местный анестетик для поверхностной анестезии. Уменьшая проницаемость клеточной мембраны для ионов натрия блокирует проведение нервных импульсов. Препятствует возникновению болевых импульсов в окончаниях чувствительных нервов и их проведению по нервным волокнам. Бензилникотинат расширяет поверхностные сосуды способствуя всасыванию гепарина. Гепарин. Всасывается незначительно. Связь с белками плазмы - до 95 % объем распределения - 006 л/кг. Не проникает через плаценту и в грудное молоко. Интенсивно захватывается эндотелиальными клетками и клетками мононуклеарно-макрофагальной системы концентрируется в печени и селезенке. Метаболизируется в печени N-десульфамидазой и гепариназой тромбоцитов включающейся в метаболизм гепарина на более поздних этапах. Десульфатированные молекулы под воздействием эндогликозидазы почек превращаются в низкомолекулярные фрагменты. Период полувыведения - 1-6 ч (в среднем - 15 ч); увеличивается при ожирении печеночной и/или почечной недостаточности; уменьшается при тромбоэмболии легочной артерии инфекциях злокачественных опухолях. Выводится почками преимущественно в виде неактивных метаболитов и только при введении высоких доз возможно выведение (до 50 %) в неименном виде. Не выводится посредством гемодиализа. Бензокаин при наружном применении практически не абсорбируется. Гидролизуется плазменной и печеночной холинэстеразой до метаболитов парааминобензойной кислоты и выводится с мочой. Бензилникотинат. 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