Микоспор Крем, туба, 15 г, 1 %

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Полный фунгицидный эффект достигается при концентрации бифоназола 5 мкг/мл и продолжительности воздействия не менее 6 часов. Бифоназол обладает фунгиетатическим действием в отношении дрожжевых и плесневых грибов а также Malassezia furfur. При поражении дрожжевыми грибами например Candida species при концентрации 1-4 мкг/мл отмечается преимущественно фунгистатический эффект бифоназола; для фунгицидного эффекта необходима концентрация бифоназола 20 мкг/мл. Бифоназол также активен в отношении Corynebacterium minutissimum (МПК от 0.5 до 2 мкг/мл) грамположительных кокков за исключением энтерококков (МПК от 4 до 16 мкг/мл). Резистентные штаммы грибов встречаются очень редко. Исследования не подтвердили развитие вторичной устойчивости у первично чувствительных штаммов. Бифоназол подавляет биосинтез эргостерола на двух различных уровнях что отличает его от других противогрибковых препаратов и других производных азола. Такое двойное действие приводит к структурным и функциональным повреждениям цитоплазматической мембраны грибов."}},{"type":"header","data":{"text":"Фармакокинетика:","level":3}},{"type":"paragraph","data":{"text":"Бифоназол хорошо проникает в пораженные слои кожи. Через 6 часов после применения концентрации в различных слоях кожи достигают от 1000 мкг/см\u003csup\u003e3\u003c/sup\u003e в верхнем слое эпидермиса (в роговом слое) до 5 мкг/см\u003csup\u003e3\u003c/sup\u003e в сосочковом слое. Таким образом все полученные концентрации находятся в пределах диапазона противогрибковой активности."}},{"type":"paragraph","data":{"text":"При нанесении на неповреждённую кожу абсорбируется незначительное количество бифоназола (06-08% от дозы препарата); уровень концентрации бифоназола в плазме крови при этом всегда ниже предела обнаружения (т.е. < 1 нг/мл). Незначительная абсорбция выявляется только после нанесения крема бифоназола на воспалённую кожу (2-4% от дозы препарата). Таким образом поскольку в плазме крови создаются весьма низкие концентрации бифоназола при его местном применении (обычно не выше 5 нг/мл) то никаких системных эффектов не наблюдается. Продолжительность нахождения в коже (определенная по защитному действию в отношении грибковой инфекции у морских свинок) - 48-72 ч."}},{"type":"paragraph","data":{"text":"Бифоназол проникает через плацентарный барьер у крыс."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Грибковые заболевания кожи вызванные дерматофитами дрожжеподобными плесневыми грибами и другими видами грибов:"}},{"type":"paragraph","data":{"text":"- микозы стоп (дерматофития кожи стоп и межпальцевая дерматофития стоп);"}},{"type":"paragraph","data":{"text":"- микозы кистей рук (дерматофития кожи рук и межпальцевая дерматофития);"}},{"type":"paragraph","data":{"text":"- дерматофития гладкой кожи тела;"}},{"type":"paragraph","data":{"text":"- дерматофития паховой области;"}},{"type":"paragraph","data":{"text":"- поверхностный кандидоз кожи;"}},{"type":"paragraph","data":{"text":"- отрубевидный лишай;"}},{"type":"paragraph","data":{"text":"- эритразма."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"- Повышенная чувствительность к бифоназолу или любому другому компоненту препарата;"}},{"type":"paragraph","data":{"text":"- беременность (I триместр);"}},{"type":"paragraph","data":{"text":"- период грудного вскармливания."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"При беременности (II и III триместр) (см. раздел \"Применение во время беременности и в период грудного вскармливания\")."}},{"type":"paragraph","data":{"text":"Детский возраст (см. раздел \"Способ применения и дозы\")."}},{"type":"paragraph","data":{"text":"Применять с осторожностью у пациентов имеющих повышенную чувствительность к другим противогрибковым лекарственным средствам из группы производных имидазола (эконазол клотримазол миконазол)."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Беременность"}},{"type":"paragraph","data":{"text":"Абсорбция бифоназола при наружном применении препарата незначительна (см. раздел \"Фармакокинетика\"). Данные доклинических ифармакокинетических исследований показывают что бифоназол не оказывает какого-либоотрицательного действия на организм матери и плода. Клинические исследования у беременных не проводились. В качестве меры предосторожности следует избегать применения бифоназола в первом триместре беременности."}},{"type":"paragraph","data":{"text":"Во II и III триместре беременности применение препарата возможно если потенциальная польза для матери превосходит возможный риск для плода."}},{"type":"paragraph","data":{"text":"Период грудного вскармливания"}},{"type":"paragraph","data":{"text":"Абсорбция бифоназола при наружном применении препарата незначительна (см. раздел \"Фармакокинетика\") неизвестно проникает ли бифоназол в грудное молоко у женщин."}},{"type":"paragraph","data":{"text":"Данные полученные наэкспериментальных животныхпоказывают что бифоназол выделяется с грудным молоком."}},{"type":"paragraph","data":{"text":"При необходимости применения препарата в период грудного вскармливания следует решить вопрос о его прекращении."}},{"type":"paragraph","data":{"text":"Фертильность"}},{"type":"paragraph","data":{"text":"Данные по безопасности полученные из доклинических исследований дают основания предположить что применение бифоназола не оказывает какого-либо отрицательного влияния на мужскую и женскую фертильность."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Наружно крем наносят тонким слоем на пораженные участки кожи 1 раз в день желательно на ночь и осторожно втирают."}},{"type":"paragraph","data":{"text":"Для достижения удовлетворительного результата лечение должно быть непрерывным."}},{"type":"paragraph","data":{"text":"Длительность терапии обычно составляет:"}},{"type":"paragraph","data":{"text":"- при микозах стоп(дерматофития кожи стоп и межпальцевая дерматофития стоп): 3 недели;"}},{"type":"paragraph","data":{"text":"- при микозах кистей рук (дерматофития кожи рук и межпальцевая дерматофития) кожи тела (дерматофития гладкой кожи) и складок кожи (паховаядерматофития): 2-3 недели;"}},{"type":"paragraph","data":{"text":"- при отрубевидном лишаеэритразме: 2 недели;"}},{"type":"paragraph","data":{"text":"- при поверхностном кандидозекожи: 2-4 недели."}},{"type":"paragraph","data":{"text":"Для обработки поверхности приблизительно равной площадиладони достаточно небольшоеколичество крема (столбик крема длиной около 1 см)."}},{"type":"paragraph","data":{"text":"Отдельных исследований у детей не проводилось. На основании обзора клинических данных не выявлено свидетельств развитиянеблагоприятных побочных эффектов при применении препарата у детей. Однако у детей препарат Микоспор® крем для наружного применения следует применять только под контролем врача."}},{"type":"paragraph","data":{"text":"Если в течение 7 дней улучшение не наблюдается или состояние ухудшилось необходимо обратиться к врачу."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Общие нарушения и местные реакции: боль в месте нанесения периферические отеки (в месте нанесения)."}},{"type":"paragraph","data":{"text":"Нарушения со стороны кожи и подкожных тканей: контактный дерматит аллергический дерматит эритема зуд сыпь крапивница волдыри шелушение и сухость кожи экзема раздражение кожи мацерация чувство жжения кожи."}},{"type":"paragraph","data":{"text":"Побочные эффекты обратимы и исчезают после отмены препарата."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Риск острой интоксикации отсутствует так как передозировка (нанесение на обширные участки кожи при условиях благоприятных для всасывания) после однократного нанесения препарата на кожу или случайном приеме внутрь маловероятна."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Имеются ограниченные данные о возможном взаимодействии бифоназола для наружного применения и варфарина приводящем к повышению международного нормализованного отношения и возможному кровотечению и синякам. В случае применения бифоназола у пациентов находящихся на терапии варфарином необходимо тщательное наблюдение за такими пациентами."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Применять с осторожностью у пациентов имеющих повышенную чувствительность к другим противогрибковым лекарственным средствам из группы производных имидазола (эконазол клотримазол миконазол)."}},{"type":"paragraph","data":{"text":"При усилении/сохранении симптомов после прекращения лечения следует обратиться к врачу."}},{"type":"paragraph","data":{"text":"Избегать попадания крема в глаза."}},{"type":"paragraph","data":{"text":"Не принимать внутрь."}},{"type":"paragraph","data":{"text":"При повышенной чувствительности кцетостеариловому спиртурекомендуется вместо крема применять лекарственные формы бифоназола не содержащие цетостеариловый спирт (например Микоспор раствор для наружного применения 1%)."}},{"type":"paragraph","data":{"text":"Применение в педиатрической практике"}},{"type":"paragraph","data":{"text":"Отдельных исследований у детей не проводилось. На основании обзора клинических данных не выявлено свидетельств развития неблагоприятных побочных эффектов при применении препарата у детей. Однако у детей младше 1 года Микоспор крем следует использовать только под контролем врача."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Препарат Микоспор крем для наружного применения не оказывает отрицательного влияния на выполнение потенциально опасных видов деятельности требующих повышенной концентрации внимания и быстроты психомоторных реакций (управление автомобилем работа с движущимися механизмами и др.)."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Крем для наружного применения 1%."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить при температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"5 лет."}},{"type":"paragraph","data":{"text":"Не использовать по истечении срока годности указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Байер Фарма АГ, D-51368 Leverkusen, Germany, Германия"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"Байер Фарма АГ"}}]}],"source":null},"description_toggle":false,"short_description":"Бифоназол активное вещество крема МИКОСПОР является производным имидазола и обладает широким спектром антимикотического действия. Бифоназол обладает фунгицидным действием в отношении дерматофитов (в частности в отношении Trichophyton spp.). Полный фунгицидный эффект достигается при концентрации бифоназола 5 мкг/мл и продолжительности воздействия не менее 6 часов. Бифоназол обладает фунгиетатическим действием в отношении дрожжевых и плесневых грибов а также Malassezia furfur. При поражении дрожжевыми грибами например Candida species при концентрации 1-4 мкг/мл отмечается преимущественно фунгистатический эффект бифоназола; для фунгицидного эффекта необходима концентрация бифоназола 20 мкг/мл. Бифоназол также активен в отношении Corynebacterium minutissimum (МПК от 0.5 до 2 мкг/мл) грамположительных кокков за исключением энтерококков (МПК от 4 до 16 мкг/мл). Резистентные штаммы грибов встречаются очень редко. Исследования не подтвердили развитие вторичной устойчивости у первично чувствительных штаммов. Бифоназол подавляет биосинтез эргостерола на двух различных уровнях что отличает его от других противогрибковых препаратов и других производных азола. Такое двойное действие приводит к структурным и функциональным повреждениям цитоплазматической мембраны грибов. Бифоназол хорошо проникает в пораженные слои кожи. Через 6 часов после применения концентрации в различных слоях кожи достигают от 1000 мкг/см3в верхнем слое эпидермиса (в роговом слое) до 5 мкг/см3в сосочковом слое. Таким образом все полученные концентрации находятся в пределах диапазона противогрибковой активности. При нанесении на неповреждённую кожу абсорбируется незначительное количество бифоназола (06-08% от дозы препарата); уровень концентрации бифоназола в плазме крови при этом всегда ниже предела обнаружения (т.е.\u003c1 нг/мл). Незначительная абсорбция выявляется только после нанесения крема бифоназола на воспалённую кожу (2-4% от дозы препарата). Таким образом поскольку в плазме крови создаются весьма низкие концентрации бифоназола при его местном применении (обычно не выше 5 нг/мл) то никаких системных эффектов не наблюдается. Продолжительность нахождения в коже (определенная по защитному действию в отношении грибковой инфекции у морских свинок) - 48-72 ч. Бифоназол проникает через плацентарный барьер у крыс.","substance":[{"id":491,"title":"Бифоназол","title_latin":"Bifonazolum","slug":"bifonazol_491"}],"branding":null,"valid_for_quick_buy":false,"is_available_to_delivery":false,"comments":null,"image_alt":"Микоспор - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/80451/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/80451/share_default/"}},"diseases":[{"id":"133","title":"Микоз кистей","slug":"133-mikoz_kistey"},{"id":"134","title":"Микоз стоп","slug":"134-mikoz_stop"},{"id":"135","title":"Микоз туловища","slug":"135-mikoz_tulovischa"},{"id":"136","title":"Эпидермофития паховая","slug":"136-epidermofitiya_pahovaya"},{"id":"138","title":"Разноцветный лишай","slug":"138-raznotsvetnyy_lishay"},{"id":"142","title":"Кандидоз кожи и 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