Бактериальные инфекции вызванные чувствительными микроорганизмами (прежде всего стафилококками и стрептококками особенно микроорганизмами устойчивыми к пенициллинам а также при аллергии к пенициллинам): сепсис подострый септический эндокардит хроническая пневмония абсцесс легкого эмпиема плевры плеврит отит остеомиелит (острый и хронический) гнойный ...
Гиперчувствительность беременность (за исключением случаев когда это необходимо по "жизненным" показаниям) тяжелая печеночная и/или почечная недостаточность; период лактации ранний грудной возраст (до 1 мес).
раствор для внутривенного и внутримышечного введения
Состав
На 1 мл:
Активное вещество: линкомицина гидрохлорида моногидрат (в пересчете на линкомицин основание) - 300 мг;
Вспомогательные вещества: динатрия эдетат (динатриевая соль этилендиаминтетрауксусной кислоты, трилон Б) - 0,1 мг; 0,1 М раствор натрия гидроксида (0,1 М раствор натра едкого) - до pH 6,0; вода для инъекций - до 1 мл.
Описание
Прозрачная, бесцветная или слегка желтоватого цвета жидкость.
Фармакотерапевтическая группа
Антибиотик-линкозамид
Фармакологические свойства
Фармакодинамика:
Антибиотик продуцируемый Streptomyces lincolniensis оказывает бактериостатическое действие. Подавляет белковый синтез бактерий вследствие обратимого связывания с 50S субъединицей рибосом нарушает образование пептидных связей.
Активен в отношении грамположительных кокков (Staphylococcus spp. Streptococcus spp. в т.ч. Streptococcus pneumoniae); Haemophilus influenzae; Bacillus anthracis Mycoplasma spp. Bacteroides spp. Corynebacterium diphtheriae Clostridium perfringens Clostridium tetani.
Эффективен в отношении Staphylococcus spp. устойчивых к пенициллину тетра циклинам хлорамфениколу стрептомицину цефалоспоринам (30% Staphylococcus spp. устойчивых к эритромицину имеют перекрестную устойчивость к линкомицину).
Не действует на Enterococcus spp. (в т.ч. Enterococcus faecalis) грамотрицательные микроорганизмы грибы вирусы простейшие; уступает по активности эритромицину в отношении спорообразующих анаэробов Neisseria spp. Corynebacterium spp.
Оптимум действия находится в щелочной среде (pH 8-85). Устойчивость к линкомицину развивается медленно. В высоких дозах обладает бактерицидным эффектом.
Фармакокинетика:
Хорошо проникает в ткани легких печени почек через плацентарный барьер в грудное молоко; в высоких концентрациях обнаруживается в костной ткани и суставах. Через гематоэнцефалитический барьер линкомицин проникает незначительно при менингите - проницаемость повышается.
Частично метаболизируется в печени. Период полувыведения - 5 ч. Выводится в неизмененном виде и в виде метаболитов с желчью и почками.
Показания к применению
Бактериальные инфекции вызванные чувствительными микроорганизмами (прежде всего стафилококками и стрептококками особенно микроорганизмами устойчивыми к пенициллинам а также при аллергии к пенициллинам): сепсис подострый септический эндокардит хроническая пневмония абсцесс легкого эмпиема плевры плеврит отит остеомиелит (острый и хронический) гнойный артрит послеоперационные гнойные осложнения раневая инфекция инфекции кожи и мягких тканей (пиодермия фурункулез флегмона рожистое воспаление).
Противопоказания
Гиперчувствительность беременность (за исключением случаев когда это необходимо по "жизненным" показаниям) тяжелая печеночная и/или почечная недостаточность; период лактации ранний грудной возраст (до 1 мес).
Применение при беременности и в период грудного вскармливания
Противопоказано применять во время беременности (за исключением случаев, когда это необходимо по жизненным показаниям) и в период грудного вскармливания.
Способ применения и дозы
Парентерально: внутривенно внутримышечно.
Суточная доза для взрослых при парентеральном введении - 18 г разовая - 06 г. При тяжелом течении инфекции суточная доза может быть увеличена до 24 г (в 3 приема с интервалом 8 ч).
Внутривенно детям - в суточной дозе 10-20 мг/кг вне зависимости от возраста. Внутривенно - только капельно со скоростью 60-80 кап/мин. Перед введением 2 мл препарата (06 г) разбавляют 250 мл 09% раствора натрия хлорида.
Продолжительность лечения в зависимости от формы и тяжести заболевания составляет 7-14 дней (при остеомиелите - 3 нед и более).
При длительных или повторных курсах лечение следует проводить под контролем функции печени и почек.
При почечно-печеночной недостаточности парентерально следует применять в суточной дозе не превышающей 18 г с интервалом между введениями не менее 12 ч.
Побочное действие
Со стороны пищеварительной системы: тошнота рвота диарея боли в эпигастрии боль в животе глоссит стоматит транзиторная гипербилирубинемия повышение активности "печеночных" трансаминаз; при длительном применении - кандидоз желудочно-кишечного тракта псевдомембранозный энтероколит.
Со стороны органов кроветворения: обратимые лейкопения тромбоцитопения нейтропения.
Местные реакции: при внутримышечно введении возможно местное раздражение болезненность образование уплотнения и стерильного абсцесса. При внутривенном введении - флебит.
При быстром внутривенном введении - снижение артериального давления головокружение астения расслабление скелетной мускулатуры.
Взаимодействие с другими лекарственными средствами
Фармацевтически несовместим с канамицином ампициллином барбитуратами теофиллином кальция глюконатом гепарином и магния сульфатом.
Антагонизм - с эритромицином синергизм - с аминогликозидами.
Усиливает нервно-мышечную блокаду вызванную миорелаксантами (особенно при парентеральном введении).
Особые указания
Во избежание развития асептического некроза вводить лучше глубоко внутримышечно.
Внутривенно вводить без предварительного разведения нельзя.
На фоне длительного лечения необходим периодический контроль активности "печеночных" трансаминаз и функции почек.
Назначение пациентам с печеночной недостаточностью допустимо лишь по "жизненным" показаниям.
Парентеральная форма содержащая в своем составе бензиловый спирт у недоношенных детей может привести к развитию бронхоспазма.
При появлении признаков псевдомембранозного энтероколита (диарея лейкоцитоз лихорадка боль в животе выделение с каловыми массами крови и слизи) в легких случаях достаточно отмены препарата и назначения ионообменных смол (колестирамин) в тяжелых случаях показано возмещение потери жидкости электролитов и белка ванкомицин - внутрь в суточной дозе 05-2 г (за 3-4 приема) в течение 10 дней или бацитрацин.
Влияние на способность управлять автомобилем и движущимися механизмами
При применении линкомицина нельзя исключить вероятность появления головокружения и расслабления скелетной мускулатуры, поэтому вождение автотранспорта и другие виды деятельности, требующие повышенного внимания и скорости реакции, не рекомендуются.
Форма выпуска
Раствор для внутривенного и внутримышечного введения 300 мг/мл.
Условия хранения
В защищённом от света месте при температуре не выше 25 °С.
Хранить в местах недоступных для детей.
Срок годности
3 года.
Не использовать по истечении срока годности указанного на упаковке.
Условия отпуска
По рецепту
Производитель
Открытое акционерное общество "Акционерное Курганское общество медицинских препаратов и изделий "Синтез" (ОАО "Синтез")
Организация, принимающая претензии потребителей
ОАО "Синтез"
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
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Подавляет белковый синтез бактерий вследствие обратимого связывания с 50S субъединицей рибосом нарушает образование пептидных связей."}},{"type":"paragraph","data":{"text":"Активен в отношении грамположительных кокков (Staphylococcus spp. Streptococcus spp. в т.ч. Streptococcus pneumoniae); Haemophilus influenzae; Bacillus anthracis Mycoplasma spp. Bacteroides spp. Corynebacterium diphtheriae Clostridium perfringens Clostridium tetani."}},{"type":"paragraph","data":{"text":"Эффективен в отношении Staphylococcus spp. устойчивых к пенициллину тетра циклинам хлорамфениколу стрептомицину цефалоспоринам (30% Staphylococcus spp. устойчивых к эритромицину имеют перекрестную устойчивость к линкомицину)."}},{"type":"paragraph","data":{"text":"Не действует на Enterococcus spp. (в т.ч. Enterococcus faecalis) грамотрицательные микроорганизмы грибы вирусы простейшие; уступает по активности эритромицину в отношении спорообразующих анаэробов Neisseria spp. Corynebacterium spp."}},{"type":"paragraph","data":{"text":"Оптимум действия находится в щелочной среде (pH 8-85). Устойчивость к линкомицину развивается медленно. В высоких дозах обладает бактерицидным эффектом."}},{"type":"header","data":{"text":"Фармакокинетика:","level":3}},{"type":"paragraph","data":{"text":"Хорошо проникает в ткани легких печени почек через плацентарный барьер в грудное молоко; в высоких концентрациях обнаруживается в костной ткани и суставах. Через гематоэнцефалитический барьер линкомицин проникает незначительно при менингите - проницаемость повышается."}},{"type":"paragraph","data":{"text":"Частично метаболизируется в печени. Период полувыведения - 5 ч. Выводится в неизмененном виде и в виде метаболитов с желчью и почками."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Бактериальные инфекции вызванные чувствительными микроорганизмами (прежде всего стафилококками и стрептококками особенно микроорганизмами устойчивыми к пенициллинам а также при аллергии к пенициллинам): сепсис подострый септический эндокардит хроническая пневмония абсцесс легкого эмпиема плевры плеврит отит остеомиелит (острый и хронический) гнойный артрит послеоперационные гнойные осложнения раневая инфекция инфекции кожи и мягких тканей (пиодермия фурункулез флегмона рожистое воспаление)."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Гиперчувствительность беременность (за исключением случаев когда это необходимо по \"жизненным\" показаниям) тяжелая печеночная и/или почечная недостаточность; период лактации ранний грудной возраст (до 1 мес)."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Грибковые заболевания кожи слизистой оболочки полости рта влагалища; миастения."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Противопоказано применять во время беременности (за исключением случаев, когда это необходимо по жизненным показаниям) и в период грудного вскармливания."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Парентерально: внутривенно внутримышечно."}},{"type":"paragraph","data":{"text":"Суточная доза для взрослых при парентеральном введении - 18 г разовая - 06 г. При тяжелом течении инфекции суточная доза может быть увеличена до 24 г (в 3 приема с интервалом 8 ч)."}},{"type":"paragraph","data":{"text":"Внутривенно детям - в суточной дозе 10-20 мг/кг вне зависимости от возраста. Внутривенно - только капельно со скоростью 60-80 кап/мин. Перед введением 2 мл препарата (06 г) разбавляют 250 мл 09% раствора натрия хлорида."}},{"type":"paragraph","data":{"text":"Продолжительность лечения в зависимости от формы и тяжести заболевания составляет 7-14 дней (при остеомиелите - 3 нед и более)."}},{"type":"paragraph","data":{"text":"При длительных или повторных курсах лечение следует проводить под контролем функции печени и почек."}},{"type":"paragraph","data":{"text":"При почечно-печеночной недостаточности парентерально следует применять в суточной дозе не превышающей 18 г с интервалом между введениями не менее 12 ч."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Со стороны пищеварительной системы: тошнота рвота диарея боли в эпигастрии боль в животе глоссит стоматит транзиторная гипербилирубинемия повышение активности \"печеночных\" трансаминаз; при длительном применении - кандидоз желудочно-кишечного тракта псевдомембранозный энтероколит."}},{"type":"paragraph","data":{"text":"Со стороны органов кроветворения: обратимые лейкопения тромбоцитопения нейтропения."}},{"type":"paragraph","data":{"text":"Аллергические реакции: крапивница эксфолиативный дерматит ангионевротический отек анафилактический шок."}},{"type":"paragraph","data":{"text":"Местные реакции: при внутримышечно введении возможно местное раздражение болезненность образование уплотнения и стерильного абсцесса. При внутривенном введении - флебит."}},{"type":"paragraph","data":{"text":"При быстром внутривенном введении - снижение артериального давления головокружение астения расслабление скелетной мускулатуры."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Фармацевтически несовместим с канамицином ампициллином барбитуратами теофиллином кальция глюконатом гепарином и магния сульфатом."}},{"type":"paragraph","data":{"text":"Антагонизм - с эритромицином синергизм - с аминогликозидами."}},{"type":"paragraph","data":{"text":"Усиливает нервно-мышечную блокаду вызванную миорелаксантами (особенно при парентеральном введении)."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Во избежание развития асептического некроза вводить лучше глубоко внутримышечно."}},{"type":"paragraph","data":{"text":"Внутривенно вводить без предварительного разведения нельзя."}},{"type":"paragraph","data":{"text":"На фоне длительного лечения необходим периодический контроль активности \"печеночных\" трансаминаз и функции почек."}},{"type":"paragraph","data":{"text":"Назначение пациентам с печеночной недостаточностью допустимо лишь по \"жизненным\" показаниям."}},{"type":"paragraph","data":{"text":"Парентеральная форма содержащая в своем составе бензиловый спирт у недоношенных детей может привести к развитию бронхоспазма."}},{"type":"paragraph","data":{"text":"При появлении признаков псевдомембранозного энтероколита (диарея лейкоцитоз лихорадка боль в животе выделение с каловыми массами крови и слизи) в легких случаях достаточно отмены препарата и назначения ионообменных смол (колестирамин) в тяжелых случаях показано возмещение потери жидкости электролитов и белка ванкомицин - внутрь в суточной дозе 05-2 г (за 3-4 приема) в течение 10 дней или бацитрацин."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"При применении линкомицина нельзя исключить вероятность появления головокружения и расслабления скелетной мускулатуры, поэтому вождение автотранспорта и другие виды деятельности, требующие повышенного внимания и скорости реакции, не рекомендуются."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Раствор для внутривенного и внутримышечного введения 300 мг/мл."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищённом от света месте при температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в местах недоступных для детей."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Не использовать по истечении срока годности указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Открытое акционерное общество \"Акционерное Курганское общество медицинских препаратов и изделий \"Синтез\" (ОАО \"Синтез\")"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ОАО \"Синтез\""}}]}],"source":null},"description_toggle":false,"short_description":"Антибиотик продуцируемый Streptomyces lincolniensis оказывает бактериостатическое действие. 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