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Для внутримышечной инъекции растворяют 05 г препарата в 2 мл (соответственно 1 г в 4 мл) стерильной воды для инъекций. Вводят глубоко в ягодичную мышцу. В качестве растворителя при внутримышечном введении также используется 1% раствор лидокаина (на 05 г - 2 мл на 1 г - 4 мл)."}},{"type":"paragraph","data":{"text":"Для внутривенного введения 05 - 1 г цефотаксима растворяют в 10 мл стерильной воды для инъекций. Вводят медленно в течение 3-5 минут. Для капельного введения (в течение 50-60 минут) растворяют 2 г препарата в 100 мл изотонического раствора натрия хлорида или 5% раствора глюкозы. Обычная доза цефотаксима для взрослых и детей старше 12 лет - 1 г через каждые 12 часов. В тяжелых случаях дозу увеличивают до 3 или 4 г в день вводят препарат 3 или 4 раза по 1 г. В зависимости от тяжести заболевания суточная доза может быть увеличена до максимальной которая составляет 12 г."}},{"type":"paragraph","data":{"text":"Обычная доза для новорожденных и детей младше 12 лет - 50-100 мг/кг массы тела в день с промежутками введения от 6 до 12 часов. Для недоношенных детей суточная доза не должна превышать 50 мг/кг. В случае нарушений функции почек дозу уменьшают. При клиренсе креатинина 10 мл/мин и менее суточную дозу препарата уменьшают вдвое."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Аллергические реакции: крапивница озноб или лихорадка сыпь зуд отек лица отек гортани бронхоспазм эо­зинофилия злокачественная экссуда­тивная эритема (синдром Стивенса- Джонсона) токсический эпидермаль­ный некролиз (синдром Лайелла) буллезные высыпания ангионевротический отек анафилактический шок."}},{"type":"paragraph","data":{"text":"Со стороны пищеварительной сис­темы: тошнота рвота диарея или запор метеоризм боль в животе на­рушение функции печени (повыше­ние активности \"печеночных\" тран­саминаз щелочной фосфатазы гепа­тит желтуха кровь в кале гипер­креатининемия гипербилирубинемия) стоматит глоссит псевдомем­бранозный колит."}},{"type":"paragraph","data":{"text":"Со стороны органов кроветворения: лейкопения нейтропения гранулоцитопения тромбоцитопения гемо­литическая анемия гипокоагуляция агранулоцитоз."}},{"type":"paragraph","data":{"text":"Со стороны мочевыделительной системы: нарушение функции почек (азотемия повышение содержания мочевины в крови олигурия анурия интерстициальный нефрит) гиперкреатинтнемия."}},{"type":"paragraph","data":{"text":"Со стороны нервной системы: го­ловная боль головокружение обмо­рок судороги повышенная утомляе­мость энцефалопатия (при назначе­нии в высоких дозах) двигательные расстройства слабость."}},{"type":"paragraph","data":{"text":"Со стороны сердечно-сосудистой системы: снижение артериального давления потенциально жизнеопасные аритмии после быстрого болюсного введения в центральную вену."}},{"type":"paragraph","data":{"text":"Лабораторные показатели: ложноположительная проба Кумбса."}},{"type":"paragraph","data":{"text":"Местные реакции: воспалительная реакция в месте введения включая флебит и тромбофлебит болез­ненность по ходу вены болезнен­ность и инфильтрат в месте в/м вве­дения покраснение кожи."}},{"type":"paragraph","data":{"text":"Прочие: суперинфекция (в частности кандидозный вагинит) избыточный рост невосприимчивых к цефотаксиму организмов."}},{"type":"paragraph","data":{"text":"При лечении боррелиоза: реакция Яриша-Герксгеймера (в течение пер­вых дней лечения) кожная сыпь зуд лихорадка лейкопения повышение активности \"печеночных\" трансаминаз затрудненное дыхание и дис­комфорт в области суставов."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: судороги энцефалопатия (в случае введения больших доз особенно у больных с почечной недостаточностью) тремор повышенная нервномышечная возбудимость. Лечение: симптоматическая терапия."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Увеличивает риск развития кровотечений при сочетании с антиагрегантами нестероидными противовоспалительными препаратами. Не приводит к развитию дисульфирамоподобных реакций при совместном применении с этанолом."}},{"type":"paragraph","data":{"text":"Вероятность поражения почек увеличивается при одновременном приеме с аминогликозидами полимиксином В и \"петлевыми\" диуретиками. Лекарственные средства блокирующие канальцевую секрецию увеличивают плазменные концентрации цефотаксима и замедляют его выведение. Фармацевтически несовместим с растворами др. антибиотиков в одном шприце или капельнице."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"В первые недели лечения может возникнуть псевдомембранозный колит проявляющийся тяжелой длительной диареей. При этом прекращают прием препарата и назначают адекватную терапию включая ванкомицин или метронидазол."}},{"type":"paragraph","data":{"text":"Перед назначением препарата необходимо собрать аллергологический анамнез особенно в отношении бета-лактамных антибиотиков. Известна перекрестная аллергия между пенициллинами и цефалоспоринами. У лиц в анамнезе которых имеются указания на аллергические реакции на пенициллин препарат применяют с крайней осторожностью (следует учитывать возможность развития тяжелых анафилактических реакций вплоть до летального исхода). При продолжительности лечения препаратом свыше 10 дней необходимо контролировать картину периферической крови."}},{"type":"paragraph","data":{"text":"При определении глюкозы в моче неэнзиматическим методом (например методом Бенедикта) возможны ложноположительные результаты. С осторожностью назначать лицам управляющим транспортом и занимающимся видами деятельности требующими повышенной концентрации внимания и быстрой двигательной реакции."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Порошок для приготовления раствора для внутривенного и внутримышечного введения по 1 г."}},{"type":"header","data":{"text":"Упаковка:","level":3}},{"type":"paragraph","data":{"text":"Порошок для приготовления раствора для внутривенного и внутримышечного введения по 1 г во флаконы.По 1 5 или 10 флаконов в картонную пачку вместе с инструкцией по медицинскому применению.По 50 флаконов помещают в коробку картонную с 3- 5 инструкциями по применению (для стационаров).Упаковка в комплекте с растворителем - водой для инъекций. В комплект входят:а) 1 флакон с препаратом и 1 ампула с водой для инъекций на 5 мл;б) 5 флаконов с препаратом и 5 ампул с водой для инъекций на 5 мл;в) 10 флаконов с препаратом и 10 ампул с водой для инъекций на 5 мл. Комплект укладывают в индивидуальные пачки из картона вместе с инструкцией по медицинскому применению ножом ампульным или скарификатором ампульным. При использовании ампул с насечками кольцами или точками нож ампульный или скарификатор не вкладывают."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В сухом защищенном от света и недоступном для детей месте при температуре не выше 25 °С."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года."}},{"type":"paragraph","data":{"text":"Не использовать после истечения срока годности."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ca href=\"https://apteka.ru/vendor/%D0%9B%D0%95%D0%9A%D0%9A%D0%9E%20%20%D0%97%D0%90%D0%9E/\"\u003eЛЕККО ЗАО\u003c/a\u003e"}}]}],"source":null},"description_toggle":false,"short_description":"Цефотаксим является цефалоспориновым антибиотиком III поколения для парентерального применения. Действует бактерицидно. Обладает широким спектром антимикробного действия. Активен в отношении грамположительных и грамотрицательных микроорганизмов устойчивых к др. антибиотикам: Staphylococcus spp. (в т.ч. Staphylococcus aureus включая пенициллиназу образующие штаммы) Staphylococcus epidermidis Streptococcus pneumoniae Streptococcus pyogenes Streptococcus agalactiae Enterococcus species Enterobacter spp. Escherichia coli Haemophilus influenzae (в т.ч. штаммы образующие пенициллиназу) Haemophilus parain-fluenzae Klebssiella spp. (в т.ч. Kl.pneumoniae) Morganella morganii Neisseria gonorrhoeae (в т.ч. штаммы образующие пенициллиназу) Acinetobacter species Corynebacterium diphtheriae Erysipelothrix insidiosa Eubacterium spp. Propionibacterium spp. Bacillus subtilis Clostridium spp. (в т.ч. Clostridium perfringens) Escherichia coli Citrobacter spp. Proteus mirabilis Proteus indole Proteus vulgaris Providencia spp. (в т.ч. Providencia rettgeri) Serratia spp. Pseudo-monas aeruginosa Neisseria meningitidis Bacteroides spp. (в т.ч. некоторые штаммы Bacteroides fragilis) Fusobacterium spp. (в т.ч. Fusobacterium nuclea-tum) Peptococcus spp. Peptostreptococcus spp.Устойчив к большинству бета-лактамаз грамположительных и грамотрицательных микроорганизмов пенициллиназе стафиллококов Clostridium difficile. После однократного в/в введения 05 1 и 2 г максимальная концентрация (Сmах) достигается через 5 мин и составляет 39 мкг/мл 100 мкг/мл и 214 мкг/мл соответсвенно. После в/м 0.5 и 1 г Сmах достигается через 0.5 ч и составляет 11 и 21 мкг/мл соответственно. Связь с белками плазмы -25-40%.Создает терапевтические концентрации в большинстве тканей (миокард кости желчный пузырь кожа мягкие ткани) и жидкостей (синовиальная перикардиальная плевральная мокрота желчь моча спино-мозговая жидкость) организма. Объем распределения - 0.25-0.39 л/кг. Период полувыведения (Т1/2) при в/в и в/м введении - 1 ч. Выводится почками - 60% - 70% в неизмененном виде остальное количество -в виде метаболитов (дезацетилированное производное обладает бактерицидной активностью а 2 других метаболита не обладают).При хронической почечной недостаточности (ХПН) и у лиц пожилого возраста Т1/2 увеличивается в 2 раза. Т1/2 у новорожденных - 0.75-1.5 ч у недоношенных новорожденных детей возрастает до 46 ч. При повторных в/в введениях в дозе 1 г каждые 6 ч в течение 14 сут кумуляции не наблюдается. Проникает в грудное молоко.","substance":[{"id":1097,"title":"Цефотаксим","title_latin":"Cefotaximum","slug":"tsefotaksim_1097"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":null,"image_alt":"Цефотаксим - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/54680/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/54680/share_default/"}},"diseases":[{"id":"5","title":"Другие сальмонеллезные инфекции","slug":"5-drugie_salmonelleznye_infektsii"},{"id":"41","title":"Менингококковая инфекция","slug":"41-meningokokkovaya_infektsiya"},{"id":"42","title":"Стрептококковая септицемия","slug":"42-streptokokkovaya_septitsemiya"},{"id":"43","title":"Другая септицемия","slug":"43-drugaya_septitsemiya"},{"id":"55","title":"Гонококковая инфекция","slug":"55-gonokokkovaya_infektsiya"},{"id":"72","title":"Болезнь Лайма","slug":"72-bolezn_layma"},{"id":"533","title":"Бактериальный 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