Прозрачная бесцветная или слегка желтоватая жидкость.
Фармакотерапевтическая группа
Антибиотик
Фармакологические свойства
Антибиотик широкого спектра действия. Механизм противомикробного действия связан с нарушением синтеза белка в микробной клетке на стадии переноса аминокислот т-РНК на рибосомы. Оказывает бактериостатическое действие. Активен в отношении грамположительных бактерий: Staphylococcus spp., Streptococcus spp.; грамотрицательных бактерий: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Haemophilus influenzae, Salmonella spp., Shigella spp., Klebsiella spp., Serratia spp., Yersinia spp., Proteus spp., Rickettsia spp.; активен также в отношении Spirochaetaceae, некоторых крупных вирусов.
Хлорамфеникол активен в отношении штаммов, устойчивых к пенициллину, стрептомицину, сульфаниламидам.
Устойчивость микроорганизмов к хлорамфениколу развивается относительно медленно.
Показания к применению
Инфекционные заболевания глаз вызванные чувствительными микроорганизмами профилактически для избежания постоперационных и посттравматических инфекционных осложнений.
Противопоказания
- Повышенная индивидуальная чувствительность к компонентам препарата;
- беременность период лактации период новорожденности (до 4 недель);
- ранний детский возраст
- у пациентов получавших ранее лечение цитостатическими ЛС или лучевую терапию.
Применение при беременности и в период грудного вскармливания
Хлорамфеникол противопоказан к применению при беременности и в период лактации (грудного вскармливания).
Способ применения и дозы
Закапывают в конъюнктивальный мешок но 1-2 капле каждые 1-4 часа.
Побочное действие
Местные аллергические реакции.
При длительном применении: ретикулоцитопения лейкопения гранулоцитопения тромбоцитопения эритроцитопения; редко - апластическая анемия агранулоцитоз; вторичная грибковая инфекция "серый" синдром у новорожденных.
Передозировка
Данные по передозировке препарата отсутствуют.
Взаимодействие с другими лекарственными средствами
Одновременное назначение с препаратами угнетающими кроветворение (сульфаниламидами цитостатиками) влияющими на обмен веществ в печени с лучевой терапией увеличивает риск развития побочного действия.
При одновременном применении с эритромицином клиндамицином линкомицином отмечается взаимное ослабление действия за счет того что хлорамфеникол может вытеснять эти препараты из связанного состояния или препятствовать их связыванию с субъединицей 50S бактериальных рибосом.
При назначении с пероральными гипогликемическими препаратами отмечается усиление их действия за счет подавления метаболизма в печени и повышения их концентрации в плазме. Хлорамфеникол подавляет ферментную систему цитохрома Р450 поэтому при одновременном применении с фенобарбиталом фенитоином непрямыми антикоагулянтами отмечается ослабление метаболизма этих препаратов замедление выведения и повышение их концентрации в плазме.
Снижает антибактериальный эффект пенициллинов и цефалоспоринов.
Особые указания
Имеются сведения о развитии гипоплазии костного мозга. Необходим контроль картины периферической крови.
Форма выпуска
Капли глазные 0,25%.
Условия хранения
При температуре не выше 25°С в защищенном от света месте.
Хранить в недоступном для детей месте.
Срок годности
2 года. Не использовать по истечении срока годности указанного на упаковке.
Условия отпуска
По рецепту
Производитель
ЗАО "Институт молекулярной диагностики "Диафарм" (ЗАО "Диафарм")
Организация, принимающая претензии потребителей
ЗАО "Диафарм"
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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