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Детям - 50-75 мг/кг массы тела; при необходимости возможно повторное назначение в той же дозе."}},{"type":"paragraph","data":{"text":"Амебиаз кишечника: взрослые - 2 г/сут в 1 прием в течение 2-3 дней."}},{"type":"paragraph","data":{"text":"Дети - 50-60 мг/кг 1 раз в день, в течение 3 дней."}},{"type":"paragraph","data":{"text":"Амебиаз печени: взрослые - 1,5-2 г/сут в 1 прием в течение 3 дней; при необходимости лечение продолжают теми же дозами до 5-6 дней."}},{"type":"paragraph","data":{"text":"Детям - по 50-60 мг/кг 1 раз в сутки в течение 5 дней."}},{"type":"paragraph","data":{"text":"Острый язвенный гингивит - 2 г однократно."}},{"type":"paragraph","data":{"text":"При неспецифическом вагините - 2 г, однократно, или по 2 г последовательно в течение 2 дней. При анаэробных инфекциях (Bacteroides, Fusobacterium, Clostridium spp.) курс лечения - 5-6 дней; в первый день лечения - 2 г/сут, затем по 1 г 1 раз в день или по 0,5 г 2 раза в день."}},{"type":"paragraph","data":{"text":"Для профилактики послеоперационных анаэробных инфекций назначают 2 г за 12 ч до операции.\n\n"}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\n\nСо стороны пищеварительной системы: снижение аппетита, сухость слизистой оболочки полости рта, \"металлический\" привкус во рту, тошнота, рвота, диарея."}},{"type":"paragraph","data":{"text":"Со стороны нервной системы: головная боль, головокружение, повышенная утомляемость, нарушения координации движений (в том числе локомоторная атаксия), дизартрия, периферическая невропатия, редко - судороги, слабость."}},{"type":"paragraph","data":{"text":"Аллергические реакции: крапивница, кожный зуд, кожная сыпь, ангионевротический отек."}},{"type":"paragraph","data":{"text":"Прочие: транзиторная лейкопения.\n\n"}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Лечение: симптоматическое. Специфического антидота нет. Выводится при диализе."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Усиливает эффект непрямых антикоагулянтов (для уменьшения риска развития кровотечений дозу уменьшают на 50%) и действие этанола (дисульфирамоподобные реакции). Совместим с сульфаниламидами и антибиотиками (аминогликозиды, эритромицин, рифампицин, цефалоспорины). Не рекомендуется назначать с этионамидом. Фенобарбитал ускоряет метаболизм."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nПри лечении генитального трихомониаза следует проводить одновременное лечение половых партнеров."}},{"type":"paragraph","data":{"text":"В процессе лечения следует воздерживаться от употребления алкоголя (возможность развития дисульфирамоподобных реакций)."}},{"type":"paragraph","data":{"text":"Вызывает темное окрашивание мочи."}},{"type":"paragraph","data":{"text":"При назначении более 6 дней необходим контроль картины периферической крови."}},{"type":"paragraph","data":{"text":"Безопасность и эффективность применения для лечения и профилактики анаэробных инфекций у детей младше 12 лет не установлены."}},{"type":"paragraph","data":{"text":"В период лечения необходимо соблюдать осторожность при вождении автотранспорта и занятии другими видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций.\n\n"}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"В период лечения необходимо, соблюдать осторожность при вождении автотранспорта и занятии другими видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки, покрытые пленочной оболочкой, 500 мг. По 4 таблетки в контурную ячейковую упаковку. По 1 контурной ячейковой упаковке вместе с инструкцией по применению в пачку картонную."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Список Б. В сухом, защищенном от света месте, при температуре не выше 25°С. Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года. Не применять по истечении срока годности, указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускается по рецепту врача."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ЗАО \"Биоком\", 355016, Ставропольский край, г. Ставрополь, Чапаевский пр., д. 54, Россия"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ЗАО \"Биоком\""}}]}],"source":null},"description_toggle":false,"short_description":"Фармакологическая группа:Противопротозойное и противомикробное средство.Фармакодинамика:Тинидазол активен в отношении Trichomonas vaginalis, Entamoeba histolytica, Lamblia spp; возбудителей анаэробных инфекций (Bacteroides spp., в том числе B.fragilis, B.melaninogenicus, Clostridium spp., Eubacterium spp., Fusobacterium spp., Peptococcus spp., Peptostreptococcus spp.). Являясь высоколипофильным препаратом, проникает внутрь клеток возбудителей, где восстанавливается нитроредуктазой, угнетает синтез и повреждает структуру ДНК.Фармакокинетика:Абсорбция - высокая, биодоступность - около 100%. Связь с белками плазмы - 12%. 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