лечение и профилактика рецидивов хронического алкоголизма;
как дезинтоксикационное средство при хроническом отравлении никелем.
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гиперчувствительность;
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№ ЛС-000503, 2010-05-24 от Татхимфармпрепараты ОАО (Россия); переоформлено
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дисульфирам150 мгвспомогательные вещества: крахмал картофельный; кремния диоксид коллоидный (аэросил); стеариновая кислота — до получения таблетки массой 180 мг
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Максимальный терапевтический эффект достигается через 12 ч после перорального приема и может продолжаться в течение 10–14 дней после прекращения лечения."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"лечение и профилактика рецидивов хронического алкоголизма;"}},{"type":"paragraph","data":{"text":"как дезинтоксикационное средство при хроническом отравлении никелем."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"гиперчувствительность;"}},{"type":"paragraph","data":{"text":"тиреотоксикоз;"}},{"type":"paragraph","data":{"text":"заболевания сердечно-сосудистой системы в стадии декомпенсации (в т.ч. резко выраженный кардиосклероз, атеросклероз мозговых сосудов, пред- и постинфарктные состояния, аневризма аорты, коронарная недостаточность, артериальная гипертензия II–III стадии);"}},{"type":"paragraph","data":{"text":"туберкулез легких с кровохарканьем, бронхиальная астма, выраженная эмфизема легких;"}},{"type":"paragraph","data":{"text":"эрозивные поражения слизистой ЖКТ, язвенная болезнь желудка и двенадцатиперстной кишки (в стадии обострения), кровотечение из ЖКТ;"}},{"type":"paragraph","data":{"text":"болезни почек, печеночная недостаточность;"}},{"type":"paragraph","data":{"text":"сахарный диабет;"}},{"type":"paragraph","data":{"text":"эпилепсия, нервно-психические заболевания, инфекционные заболевания ЦНС, полинейропатия, неврит слухового и глазного нервов;"}},{"type":"paragraph","data":{"text":"глаукома;"}},{"type":"paragraph","data":{"text":"злокачественные опухоли;"}},{"type":"paragraph","data":{"text":"беременность;"}},{"type":"paragraph","data":{"text":"период лактации."}},{"type":"paragraph","data":{"text":"\u003ci\u003eС осторожностью:\u003c/i\u003e сердечно-сосудистые заболевания в стадии компенсации, возраст старше 60 лет, язвенная болезнь желудка и двенадцатиперстной кишки (в стадии ремиссии), эндартериит, остаточные явления нарушения мозгового кровообращения, психозы на фоне приема дисульфирама в анамнезе."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eВнутрь. \u003c/i\u003eЛечение назначается после тщательного обследования больного и предупреждения о последствиях и осложнениях. По 150–500 мг 2 раза в сутки по индивидуальной схеме. Через 7–10 дней проводят тетурамалкогольную пробу (20–30 мл 40% водки после приема 500 мг препарата), при слабой реакции дозу алкоголя увеличивают на 10–20 мл (максимальная доза водки — 100–120 мл). Пробу повторяют через 1–2 дня в стационаре и через 3–5 дней амбулаторно с коррекцией доз алкоголя и/или препарата по необходимости. В дальнейшем можно использовать поддерживающую дозу 150–200 мг/сут в течение 1–3 лет. "}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eОбусловленные свойствами Тетурама:\u003c/i\u003e металлический вкус во рту; неприятный запах у больных с колостомией (связанный с сульфидом углерода); редкие случаи гепатита, иногда встречающиеся у больных никелевой экземой, не страдающих алкоголизмом; полиневрит нижних конечностей, неврит оптического нерва; потеря памяти, спутанность сознания, астения; головные боли; кожные аллергические проявления."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСвязанные с комбинацией Тетурам-этиловый спирт:\u003c/i\u003e описаны случаи дыхательной недостаточности; сердечно-сосудистого коллапса, нарушения ритма, стенокардия, иногда инфаркт миокарда, а также неврологические расстройства; отек мозга."}},{"type":"paragraph","data":{"text":"\u003ci\u003eОсложнения при длительном приеме:\u003c/i\u003e редко — психозы, напоминающие алкогольные, гепатит, гастрит; у лиц, страдающих сердечно-сосудистыми заболеваниями, возможен тромбоз сосудов мозга, поэтому при жалобах на парестезии в конечностях и лице следует немедленно отменить препарат; обострение полиневрита."}},{"type":"paragraph","data":{"text":"При приеме доз алкоголя свыше 50–80 мл водки на фоне приема Тетурама развиваются тяжелые нарушения сердечно-сосудистой и дыхательной систем, отеки, судороги. В этом случае срочно проводят дезинтоксикационную терапию, вводят аналептики, проводят симптоматическое лечение."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСимптомы:\u003c/i\u003e комбинация Тетурам–этанол может вызвать угнетение сознания вплоть до комы, сердечно-сосудистый коллапс, неврологические осложнения."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение:\u003c/i\u003e симптоматическое."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eПротивопоказанные комбинации\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eАлкоголь.\u003c/i\u003e Реакция непереносимости (приливы крови, эритема, рвота, тахикардия). Избегать приема спиртных напитков и лекарственных средств, содержащих спирт."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНежелательные комбинации\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eИзониазид.\u003c/i\u003e Нарушения поведения и координации."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНитро-5-имидазолы (метронидазол, ординазол, секнидазол, тинидазол).\u003c/i\u003e Делириозные расстройства, спутанность сознания."}},{"type":"paragraph","data":{"text":"\u003ci\u003eФенитоин.\u003c/i\u003e Существенный и быстрый подъем уровня фенитоина в плазме с токсическими симптомами (подавление его метаболизма)."}},{"type":"paragraph","data":{"text":"Если комбинации нельзя избежать, следует проводить клиническое наблюдение и контроль концентраций препарата в плазме в ходе и после лечения тетурамом."}},{"type":"paragraph","data":{"text":"\u003ci\u003eКомбинации, требующие осторожности\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eВарфарин (и другие пероральные антикоагулянты).\u003c/i\u003e Повышенный эффект пероральных антикоагулянтов и опасность кровотечения (снижение биотрансформации варфарина в печени). Рекомендуется более частый контроль концентрации варфарина и корректировка дозы антикоагулянтов в течение 8 дней после отмены тетурама."}},{"type":"paragraph","data":{"text":"\u003ci\u003eТеофиллин.\u003c/i\u003e Тетурам ингибирует метаболизм теофиллина. Как результат этого, доза теофиллина должна быть скорректирована (сниженная дозировка) в зависимости от клинических симптомов и концентрации препарата в плазме."}},{"type":"paragraph","data":{"text":"\u003ci\u003eБензодиазепины.\u003c/i\u003e Тетурам может потенцировать седативный эффект бензодиазепинов путем ингибирования их окислительного метаболизма (особенно хлордиазепоксида и диазепама). Дозировка бензодиазепина должна быть скорректирована в соответствии с клиническими проявлениями."}},{"type":"paragraph","data":{"text":"\u003ci\u003eТрициклические антидепрессанты.\u003c/i\u003e Возможно усиление реакции непереносимости алкоголя (особенно если больные на фоне приема Тетурама, принимают спиртные напитки)."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"В случае одновременного назначения с пероральными антикоагулянтами необходимо осуществлять более частый контроль содержания протромбина и коррекцию доз антикоагулянтов, что связано с повышенным риском развития кровотечения."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eВлияние на способность к управлению транспортными средствами и механизмами\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Следует уделить особое внимание решению вопроса о возможности управления транспортными средствами и работе с механизмами из-за риска развития сонливости, связанной с приемом дисульфирама."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eТаблетки, 150 мг.\u003c/i\u003e По 10 табл. в контурной ячейковой упаковке из пленки ПВХ и фольги алюминиевой печатной лакированной. По 30 или 50 табл. в банке полимерную или флаконе полимерном. Каждую банку, флакон, по 3 или 5 контурных упаковок помещают в пачку из картона. "}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В сухом, защищенном от света месте, при температуре не выше 25 °C."}},{"type":"paragraph","data":{"text":"\u003ci\u003eХранить в недоступном для детей месте.\u003c/i\u003e"}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"4 года."}},{"type":"paragraph","data":{"text":"Не применять по истечении срока годности, указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"по рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ca href=\"https://wer.ru/producers/tatkhimfarmpreparaty/\"\u003eТатхимфармпрепараты , Россия\u003c/a\u003e\u003c/b\u003e"}}]}],"source":null},"description_toggle":true,"short_description":"Фармакологическое действие— антиалкогольное. Действие препарата основано на блокаде ацетальдегиддегидрогеназы, которая участвует в метаболизме этилового спирта. Это приводит к повышению концентрации метаболита этилового спирта — ацетальдегида, вызывающего отрицательные ощущения (приливы крови к лицу, тошнота, рвота, тахикардия, понижение АД), которые делают чрезвычайно неприятным употребление алкоголя после приема Тетурама. Это приводит к условно-рефлекторному отвращению к вкусу и запаху спиртных напитков. После перорального приема всасывание Тетурама из ЖКТ составляет от 70 до 90%. Он быстро метаболизируется, восстанавливаясь до дитиокарбамата, который сам выводится в виде глюкуронконъюгата или превращается в диэтиламин и сульфид углерода, часть которого (4–53%) выводится через легкие. Максимальный терапевтический эффект достигается через 12 ч после перорального приема и может продолжаться в течение 10–14 дней после прекращения лечения.","substance":[{"id":254,"title":"Дисульфирам","title_latin":"Disulfiramum","slug":"disulfiram_254"}],"branding":null,"valid_for_quick_buy":false,"is_available_to_delivery":false,"comments":{"count":11,"url":"/review/4629-teturam/"},"image_alt":"Тетурам - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/81410/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/81410/share_default/"}},"diseases":[],"other_packages":[{"id":98647,"title":"Тетурам","subtitle":{"full":"Таблетки, коробка, 30 шт, 150 мг, для приема внутрь","short":"Таблетки, 30 шт, 150 мг","package":"30 шт, 150 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