Селективный, конкурентный и обратимый ингибитор ацетилхолинэстеразы. Стимулирует никотиновые рецепторы и повышает чувствительность постсинаптической мембраны к ацетилхолину. Облегчает проведение возбуждения в нервно-мышечном синапсе и восстанавливает нервно-мышечную проводимость в случаях ее блокады миорелаксантами недеполяризующего типа действия. Повышает тонус гладкой мускулатуры, усиливает секрецию пищеварительных и потовых желез, вызывает миоз. Повышая активность холинергической системы, галантамин улучшает когнитивные функции у пациентов с деменцией альцгеймеровского типа, но не оказывает влияния на развитие самого заболевания.
Показания к применению
деменция альцгеймеровского типа легкой или умеренной степени;
полиомиелит (непосредственно после прекращения фебрильного периода, а также в восстановительном периоде и периоде остаточных явлений);
язвенная болезнь желудка и двенадцатиперстной кишки, повышенный риск развития эрозивно-язвенного поражения ЖКТ.
Применение при беременности и в период грудного вскармливания
Противопоказано при беременности. На время лечения следует прекратить грудное вскармливание.
Способ применения и дозы
Внутрь, во время еды, запивая водой.
Взрослые:
Суточная доза составляет 8-32 мг, разделенная в 2-4 приема.
При миастении gravis суточная доза разделяется на 3 приема.
При болезни Альцгеймера лечение рекомендуется начинать с приема таблеток по 4 мг 2 раза/сут. В течении 4 нед суточную дозу постепенно можно повысить до 16 мг - по 1 таб., по 8 мг 2 раза/сут - утром и вечером. Во время лечения препаратом необходимо обеспечить прием достаточного количества жидкости. Если во время лечения потребуется прекращение приема препарата, то восстановление лечения необходимо начинать с наиболее низкой дозы и постепенно ее повышать.
Пациентам с умеренно выраженным нарушением функции печени и почек:
Начальная доза - 4 мг 1 раз/сут, которую принимают утром, в течение не менее 1 недели, после чего дозу увеличивают до 4 мг 2 раза/сут и принимают в течение 4 недель.
с 9 до 11 лет - суточная доза - 4-12 мг, разделенная на 2-3 приема;
с 12 до 15 лет - суточная доза составляет 4-16 мг, разделенная на 2-4 приема.
Побочное действие
Со стороны сердечно-сосудистой системы: снижение или повышение АД, ортостатический коллапс, сердечная недостаточность, отеки, атриовентрикулярная блокада, трепетание или мерцание предсердий, удлинение QT-интервала, вентрикулярная и суправентрикулярная тахикардия, наджелудочковая экстрасистолия, «приливы», брадикардия, ишемия или инфаркт миокарда.
Со стороны пищеварительной системы: вздутие живота, диспепсия, желудочно-кишечный дискомфорт, анорексия, диарея, абдоминальная боль, тошнота, рвота, гастрит, дисфагия, сухость во рту, повышенное выделение слюны, дивертикулит, гастроэнтерит, дуоденит, гепатит, перфорация слизистой оболочки пищевода, кровотечение из верхних и нижних отделов желудочно-кишечного тракта.
Со стороны опорно-двигательного аппарата: мышечные спазмы, мышечная слабость, лихорадка.
Лабораторные показатели: повышение активности печеночных ферментов, анемия, гипокалнемия, повышение уровня сахара или щелочной фосфатазы в крови.
Гематологические: тромбоцитопения, пурпура.
Со стороны мочевыделительной системы: недержание мочи, гематурия, учащенное мочеиспускание, инфекции мочевыводящих путей, задержка мочи, калькулез, почечная колика.
Со стороны нервной системы: часто тремор, синкопе, заторможенность, извращение вкуса, зрительные и слуховые галлюцинации, поведенческие реакции, включая возбуждение/агрессию; преходящее нарушение мозгового кровообращения или инсульт; головная боль, головокружение, судороги, мышечные спазмы, парестезия, атаксия, гипо-или гиперкинезы, апраксия, афазия, анорексия, сонливость, бессонница.
Со стороны органов чувств: ринит, носовое кровотечение, нарушения зрения, спазм аккомодации, нечасто - шум в ушах.
Со стороны психики: депрессия (очень редко - с суицидом), апатия, параноидные реакции, повышение либидо, делирий.
Общие: боль в груди, повышенная потливость, уменьшение массы тела, чувство усталости, дегидратация (в редких случаях - с развитием почечной недостаточности), бронхоспазм.
Передозировка
Симптомы: угнетение сознания (вплоть до комы), судороги, усиление степени выраженности побочных эффектов, выраженная мышечная слабость в сочетании с гиперсекрецией желез слизистой оболочки трахеи и бронхоспазмом может привести к летальной блокаде дыхательных путей.
Лечение: промывание желудка, симптоматическая терапия. В качестве антидота - в/в введение атропина в дозах 0.5-1 мг. Последующие дозы атропина определяются в зависимости от терапевтического ответа и состояния пациента.
Взаимодействие с другими лекарственными средствами
Не рекомендуется комбинировать с другими холиномиметиками.
Является антагонистом опиоидов по действию на дыхательный центр. Проявляет фармакодинамический антагонизм к м-холинолитикам (атропину, гоматропина метилбромиду и др.), ганглиоблокаторам, недеполяризующим миорелаксантам, хинину, прокаинамиду.
Аминогликозидные антибиотики могут снижать терапевтическое действие галантамина. Галантамин усиливает нервно-мышечную блокаду во время общей анестезии (в т.ч. при использовании в качестве периферического миорелаксанта суксаметония). Лекарственные средства, снижающие частоту сердечных сокращений (дигоксин, бета-адреноблокоторы) увеличивают риск усугубления брадикардии. Циметидин может увеличить биодоступность галантамина.
Все препараты, которые ингибируют и изоферменты системы цитохрома Р450 (CYP2D6 и CYP3A4), могут повысить плазменные концентрации галантамина при одновременном их применении, в результате чего может повышаться частота холинергических побочных эффектов (главным образом, тошноты и рвоты). В этом случае, в зависимости от переносимости терапии конкретным пациентом, может понадобиться снижение поддерживающей дозы галантамина.
Ингибиторы изофермента CYP2D6 (амитриптилин, флуоксетин, флувоксамин, пароксетин, хинидин) снижают клиренс галантамина на 25-30%. По этой причине не рекомендуется назначать одновременно с кетоконазолом, зидовудином, эритромицином. Усиливает угнетающее действие на центральную нервную систему этанола и седативных средств.
Особые указания
Лечение ингибиторами ацетилхолинэстеразы сопровождается уменьшением массы тела. Особенно это необходимо иметь ввиду при лечении пациентов с болезнью Альцгеймера, у которых обычно наблюдается похудание. В связи с этим необходимо следить за массой тела у таких больных.
В период лечения необходимо обеспечить достаточное потребление жидкости. Как и другие холиномиметики, препарат может вызвать ваготонические эффекты со стороны сердечно-сосудистой системы (в т.ч. брадикардию), что необходимо учитывать у пациентов с синдромом слабости синусового узла и другими нарушениями проводимости, а также при одновременном применении с лекарственными средствами, снижающими частоту сердечных сокращений (дигоксин или бета-адреноблокоторы).
При лечении Галантамином существует риск появления синкопе, в связи с чем необходимо чаще контролировать артериальное давление, особенно при приеме препарата в более высоких дозах (40 мг суточная доза). С целью предотвращения подобных побочных эффектов необходимо внимательно подбирать дозу препарата в начале лечения. Эффективность препарата у пациентов с другими типами деменции и нарушения памяти не установлена.
Препарат не предназначен для лечения пациентов со слабым когнитивным нарушением, т.е. с изолированным нарушением памяти, превышающим ожидаемый уровень для их возраста и образования, но не удовлетворяющим критериям болезни Альцгеймера.
Влияние на способность управлять автомобилем и движущимися механизмами
В период лечения следует воздержаться от выполнения работ, требующих повышенной концентрации внимания и быстроты психомоторных реакций, в том числе управления автомобилем.
В сухом, защищенном от света месте при температуре не выше 25°С. Хранить в недоступном для детей месте
Срок годности
Срок годности - 2 года. Не применять по истечении срока годности.
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номер","slug":"","body":[{"type":"paragraph","data":{"text":"\u003cb\u003eГалантамин\u003c/b\u003e таблетки, покрытые пленочной оболочкой \u003cb\u003e12\u003c/b\u003e\u003cb\u003eмг\u003c/b\u003e, упаковка контурная ячейковая 7, пачка картонная 8, код EAN: 4606486007364, № ЛСР-003645/10, 2010-04-30 Канонфарма продакшн ЗАО (Россия). "}}]},{"id":2,"name":"Торговое название препарата","slug":"","body":[{"type":"paragraph","data":{"text":"Galantamine Canon"}}]},{"id":3,"name":"Лекарственная форма","slug":"","body":[{"type":"paragraph","data":{"text":"таблетки ,покрытые пленочной оболочкой "}}]},{"id":4,"name":"Состав","slug":"ingredients","body":[{"type":"paragraph","data":{"text":"\u003ci\u003e\u003cb\u003eТаблетки, покрытые пленочной оболочкой\u003c/b\u003e\u003c/i\u003e голубого цвета, круглые, двояковыпуклые; на поперечном разрезе почти белого цвета."}},{"type":"paragraph","data":{"text":"\u003cb\u003e1 таб.\u003c/b\u003eгалантамина гидробромид15.38 мг, что соответствует содержанию галантамина12 мг"}},{"type":"paragraph","data":{"text":"\u003ci\u003eВспомогательные вещества\u003c/i\u003e: кальция гидрофосфат - 17 мг, кремния диоксид коллоидный - 3.15 мг, кроскармеллоза натрия - 12.6 мг, лактоза безводная - 106.6 мг, магния стеарат - 1.4 мг, повидон К30 - 4.9 мг, целлюлоза микрокристаллическая - 48.97 мг."}}]},{"id":5,"name":"Описание","slug":"common_description","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСостав пленочной оболочки:\u003c/i\u003e Опадрай II синий - 6 мг (гипромеллоза (гидроксипропилметилцеллюлоза - 1.68 мг, лактозы моногидрат - 2.16 мг, макрогол (полиэтиленгликоль) - 0.6 мг, титана диоксид - 1.458 мг, краситель бриллиантовый голубой - 0.0942 мг, железа оксид черный - 0.0078 мг). "}}]},{"id":6,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":"Деменции средство лечения"}}]},{"id":7,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":" Препарат для лечения болезни Альцгеймера"}},{"type":"paragraph","data":{"text":"Селективный, конкурентный и обратимый ингибитор ацетилхолинэстеразы. Стимулирует никотиновые рецепторы и повышает чувствительность постсинаптической мембраны к ацетилхолину. Облегчает проведение возбуждения в нервно-мышечном синапсе и восстанавливает нервно-мышечную проводимость в случаях ее блокады миорелаксантами недеполяризующего типа действия. Повышает тонус гладкой мускулатуры, усиливает секрецию пищеварительных и потовых желез, вызывает миоз. Повышая активность холинергической системы, галантамин улучшает когнитивные функции у пациентов с деменцией альцгеймеровского типа, но не оказывает влияния на развитие самого заболевания."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"list","data":{"style":"ordered","items":["деменция альцгеймеровского типа легкой или умеренной степени;","полиомиелит (непосредственно после прекращения фебрильного периода, а также в восстановительном периоде и периоде остаточных явлений);","миастения gravis, прогрессирующая мышечная дистрофия, детский церебральный паралич, неврит, радикулит, миопатия."]}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"list","data":{"style":"ordered","items":["бронхиальная астма;","брадикардия;","атриовентрикулярная блокада;","артериальная гипертензия;","стенокардия;","хроническая сердечная недостаточность;","эпилепсия;","гиперкинезы;","тяжелые почечные (клиренс креатинина - менее 9 мл/мин) и печеночные (более 9 баллов : по шкале Child-Pugh) нарушения;","механическая кишечная непроходимость;","хроническая обструктивная болезнь легких;","обструктивные заболевания или недавно перенесенное оперативное вмешательство на органах желудочно-кишечного тракта;","обструктивные заболевания или недавно перенесенное оперативное лечение мочевыводящих путей или предстательной железы;","детский возраст до 9 лет;","беременность и период лактации;","гиперчувствительность к любому из компонентов препарата.","Противопоказан детям младше 9 лет"]}},{"type":"paragraph","data":{"text":"Противопоказан при тяжелых нарушениях функции почек. С осторожностью при легких и умеренных нарушениях функции почек"}},{"type":"header","data":{"text":"Применение при нарушениях функции печени","level":3}},{"type":"paragraph","data":{"text":"Противопоказан при тяжелых нарушениях функции печени. С осторожностью при легких и умеренных нарушениях функции печени"}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"list","data":{"style":"ordered","items":["легкие и умеренные нарушения функции почек или печени;","синдром слабости синусового узла и другие суправентрикулярные нарушения проводимости;","одновременный прием препаратов, замедляющих частоту сердечных сокращений (дигоксин, бета-адреноблокаторы);","общая анестезия;","язвенная болезнь желудка и двенадцатиперстной кишки, повышенный риск развития эрозивно-язвенного поражения ЖКТ."]}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Противопоказано при беременности. На время лечения следует прекратить грудное вскармливание."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь, во время еды, запивая водой."}},{"type":"paragraph","data":{"text":"\u003cb\u003eВзрослые:\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Суточная доза составляет 8-32 мг, разделенная в 2-4 приема."}},{"type":"paragraph","data":{"text":"При \u003ci\u003eмиастении gravis\u003c/i\u003e суточная доза разделяется на 3 приема."}},{"type":"paragraph","data":{"text":"При \u003ci\u003eболезни Альцгеймера\u003c/i\u003e лечение рекомендуется начинать с приема таблеток по 4 мг 2 раза/сут. В течении 4 нед суточную дозу постепенно можно повысить до 16 мг - по 1 таб., по 8 мг 2 раза/сут - утром и вечером. Во время лечения препаратом необходимо обеспечить прием достаточного количества жидкости. Если во время лечения потребуется прекращение приема препарата, то восстановление лечения необходимо начинать с наиболее низкой дозы и постепенно ее повышать."}},{"type":"paragraph","data":{"text":"Пациентам с \u003cb\u003eумеренно выраженным нарушением функции печени и почек:\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Начальная доза - 4 мг 1 раз/сут, которую принимают утром, в течение не менее 1 недели, после чего дозу увеличивают до 4 мг 2 раза/сут и принимают в течение 4 недель."}},{"type":"paragraph","data":{"text":"Общая суточная доза не должна превышать 12 мг."}},{"type":"paragraph","data":{"text":"\u003cb\u003eДети (с 9 лет):\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение полиомиелита, детского церебрального паралича:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003cb\u003eс 9 до 11 лет\u003c/b\u003e - суточная доза - 4-12 мг, разделенная на 2-3 приема;"}},{"type":"paragraph","data":{"text":"\u003cb\u003eс 12 до 15 лет\u003c/b\u003e - суточная доза составляет 4-16 мг, разделенная на 2-4 приема."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны сердечно-сосудистой системы:\u003c/i\u003e снижение или повышение АД, ортостатический коллапс, сердечная недостаточность, отеки, атриовентрикулярная блокада, трепетание или мерцание предсердий, удлинение QT-интервала, вентрикулярная и суправентрикулярная тахикардия, наджелудочковая экстрасистолия, «приливы», брадикардия, ишемия или инфаркт миокарда."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны пищеварительной системы:\u003c/i\u003e вздутие живота, диспепсия, желудочно-кишечный дискомфорт, анорексия, диарея, абдоминальная боль, тошнота, рвота, гастрит, дисфагия, сухость во рту, повышенное выделение слюны, дивертикулит, гастроэнтерит, дуоденит, гепатит, перфорация слизистой оболочки пищевода, кровотечение из верхних и нижних отделов желудочно-кишечного тракта."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны опорно-двигательного аппарата:\u003c/i\u003e мышечные спазмы, мышечная слабость, лихорадка."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛабораторные показатели:\u003c/i\u003e повышение активности печеночных ферментов, анемия, гипокалнемия, повышение уровня сахара или щелочной фосфатазы в крови."}},{"type":"paragraph","data":{"text":"\u003ci\u003eГематологические:\u003c/i\u003e тромбоцитопения, пурпура."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны мочевыделительной системы:\u003c/i\u003e недержание мочи, гематурия, учащенное мочеиспускание, инфекции мочевыводящих путей, задержка мочи, калькулез, почечная колика."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны нервной системы:\u003c/i\u003e часто тремор, синкопе, заторможенность, извращение вкуса, зрительные и слуховые галлюцинации, поведенческие реакции, включая возбуждение/агрессию; преходящее нарушение мозгового кровообращения или инсульт; головная боль, головокружение, судороги, мышечные спазмы, парестезия, атаксия, гипо-или гиперкинезы, апраксия, афазия, анорексия, сонливость, бессонница."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны органов чувств:\u003c/i\u003e ринит, носовое кровотечение, нарушения зрения, спазм аккомодации, нечасто - шум в ушах."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны психики:\u003c/i\u003e депрессия (очень редко - с суицидом), апатия, параноидные реакции, повышение либидо, делирий."}},{"type":"paragraph","data":{"text":"\u003ci\u003eОбщие:\u003c/i\u003e боль в груди, повышенная потливость, уменьшение массы тела, чувство усталости, дегидратация (в редких случаях - с развитием почечной недостаточности), бронхоспазм."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСимптомы:\u003c/i\u003e угнетение сознания (вплоть до комы), судороги, усиление степени выраженности побочных эффектов, выраженная мышечная слабость в сочетании с гиперсекрецией желез слизистой оболочки трахеи и бронхоспазмом может привести к летальной блокаде дыхательных путей."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение:\u003c/i\u003e промывание желудка, симптоматическая терапия. В качестве антидота - в/в введение атропина в дозах 0.5-1 мг. Последующие дозы атропина определяются в зависимости от терапевтического ответа и состояния пациента."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Не рекомендуется комбинировать с другими холиномиметиками."}},{"type":"paragraph","data":{"text":"Является антагонистом опиоидов по действию на дыхательный центр. Проявляет фармакодинамический антагонизм к м-холинолитикам (атропину, гоматропина метилбромиду и др.), ганглиоблокаторам, недеполяризующим миорелаксантам, хинину, прокаинамиду."}},{"type":"paragraph","data":{"text":"Аминогликозидные антибиотики могут снижать терапевтическое действие галантамина. Галантамин усиливает нервно-мышечную блокаду во время общей анестезии (в т.ч. при использовании в качестве периферического миорелаксанта суксаметония). Лекарственные средства, снижающие частоту сердечных сокращений (дигоксин, бета-адреноблокоторы) увеличивают риск усугубления брадикардии. Циметидин может увеличить биодоступность галантамина."}},{"type":"paragraph","data":{"text":"Все препараты, которые ингибируют и изоферменты системы цитохрома Р450 (CYP2D6 и CYP3A4), могут повысить плазменные концентрации галантамина при одновременном их применении, в результате чего может повышаться частота холинергических побочных эффектов (главным образом, тошноты и рвоты). В этом случае, в зависимости от переносимости терапии конкретным пациентом, может понадобиться снижение поддерживающей дозы галантамина."}},{"type":"paragraph","data":{"text":"Ингибиторы изофермента CYP2D6 (амитриптилин, флуоксетин, флувоксамин, пароксетин, хинидин) снижают клиренс галантамина на 25-30%. По этой причине не рекомендуется назначать одновременно с кетоконазолом, зидовудином, эритромицином. Усиливает угнетающее действие на центральную нервную систему этанола и седативных средств."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Лечение ингибиторами ацетилхолинэстеразы сопровождается уменьшением массы тела. Особенно это необходимо иметь ввиду при лечении пациентов с болезнью Альцгеймера, у которых обычно наблюдается похудание. В связи с этим необходимо следить за массой тела у таких больных."}},{"type":"paragraph","data":{"text":"В период лечения необходимо обеспечить достаточное потребление жидкости. Как и другие холиномиметики, препарат может вызвать ваготонические эффекты со стороны сердечно-сосудистой системы (в т.ч. брадикардию), что необходимо учитывать у пациентов с синдромом слабости синусового узла и другими нарушениями проводимости, а также при одновременном применении с лекарственными средствами, снижающими частоту сердечных сокращений (дигоксин или бета-адреноблокоторы)."}},{"type":"paragraph","data":{"text":"При лечении Галантамином существует риск появления синкопе, в связи с чем необходимо чаще контролировать артериальное давление, особенно при приеме препарата в более высоких дозах (40 мг суточная доза). С целью предотвращения подобных побочных эффектов необходимо внимательно подбирать дозу препарата в начале лечения. Эффективность препарата у пациентов с другими типами деменции и нарушения памяти не установлена."}},{"type":"paragraph","data":{"text":"Препарат не предназначен для лечения пациентов со слабым когнитивным нарушением, т.е. с изолированным нарушением памяти, превышающим ожидаемый уровень для их возраста и образования, но не удовлетворяющим критериям болезни Альцгеймера."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"В период лечения следует воздержаться от выполнения работ, требующих повышенной концентрации внимания и быстроты психомоторных реакций, в том числе управления автомобилем."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"list","data":{"style":"ordered","items":["таб., покр. пленочной оболочкой, 4 мг: 7, 10, 14, 15, 28, 30, 56, 60 или 90 шт.","таб., покр. пленочной оболочкой, 8 мг: 7, 10, 14, 15, 28, 30, 56, 60 или 90 шт.","таб., покр. пленочной оболочкой, 12 мг: 7, 10, 14, 15, 28, 30, 56, 60 или 90 шт."]}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В сухом, защищенном от света месте при температуре не выше 25°С. Хранить в недоступном для детей месте "}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"Срок годности - 2 года. Не применять по истечении срока годности."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]}],"source":null},"description_toggle":false,"short_description":"Препарат для лечения болезни Альцгеймера Селективный, конкурентный и обратимый ингибитор ацетилхолинэстеразы. Стимулирует никотиновые рецепторы и повышает чувствительность постсинаптической мембраны к ацетилхолину. Облегчает проведение возбуждения в нервно-мышечном синапсе и восстанавливает нервно-мышечную проводимость в случаях ее блокады миорелаксантами недеполяризующего типа действия. Повышает тонус гладкой мускулатуры, усиливает секрецию пищеварительных и потовых желез, вызывает миоз. Повышая активность холинергической системы, галантамин улучшает когнитивные функции у пациентов с деменцией альцгеймеровского типа, но не оказывает влияния на развитие самого заболевания.","substance":[{"id":798,"title":"Галантамин","title_latin":"Galantaminum","slug":"galantamin_798"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":null,"image_alt":"Галантамин - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/56046/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/56046/share_default/"}},"diseases":[],"other_packages":[{"id":96642,"title":"Галантамин","subtitle":{"full":"Таблетки, 56 шт, 8 мг","short":"Таблетки, 56 шт, 8 мг","package":"56 шт, 8 мг"},"prescription":true,"catalog_section_id":100272,"manufacturer":{"id":186,"title":"Канонфарма 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