Крем для наружного применения белого цвета, однородный.
1 г гидрокортизона бутират 1 мг
Вспомогательные вещества:
цетостеариловый спирт 72 мг,
макрогол 25 цетостеариловый эфир 18 мг,
парафин жидкий 60 мг,
парафин белый мягкий 150 мг,
пропилпарагидроксибензоат 1 мг,
бутилпарагидроксибензоат 0.5 мг,
лимонная кислота безводная 4.2 мг,
натрия цитрат безводный 2.8 мг,
вода очищенная до 1 г.
Фармакологические свойства
Локоид является синтетическим негалогенизированным глюкокортикостеродом для наружного применения.
Этерификация молекулы гидрокортизона остатком масляной кислоты (бутиратом) позволила радикально повысить активность препарата по сравнению с нативным гидрокортизоном.
Локоид оказывает быстро наступающее противовоспалительное, противоотечное, противозудное действие.
Применение Локоида в рекомендуемых дозах не вызывает подавления гипоталамо-гипофизарно-адреналовой системы.
Хотя применение больших доз препарата в течение длительного времени, особенно при использовании окклюзионных повязок, может привести к увеличению содержания кортизола в плазме крови, это обычно не сопровождается снижением реактивности гипофизарно-надпочечниковой системы, а отмена препарата приводит к быстрой нормализации продукции кортизола.
Фармакокинетика:
После аппликации происходит накопление активного вещества в эпидермисе, в основном в зернистом слое, системная абсорбция незначительна. Небольшое количество гидрокортизона 17-бутирата всасывается в системный кровоток в неизмененном виде.
Большая часть гидрокортизона 17-бутирата метаболизируется до гидрокортизона и других метаболитов непосредственно в эпидермисе и в последующем в печени.
Метаболиты и незначительная часть неизмененного гидрокортизона 17-бутирата выводится почками и через кишечник.
Показания к применению
Поверхностные, неинфицированные, чувствительные к местным глюкокортикостероидам заболевания кожи:
— дерматиты, в том числе атопический, контактный, себорейный;
— экзема;
— псориаз.
Противопоказания
— Гиперчувствительность к гидрокортизону или вспомогательным компонентам препарата;
— бактериальные инфекции кожи (стрепто- и стафилодермии, грамотрицательный фолликулит и т.д.);
— неопластические изменения кожи (доброкачественные и злокачественные опухоли);
— акне, розацеа, периоральный дерматит;
— поствакцинальный период;
— нарушение целостности кожных покровов (раны, язвы).
С осторожностью
беременность, период лактации.
Способ применения и дозы
Наружно.
Локоид крем предпочтительно применять при острых и подострых кожных процессах (без мокнутия).
Препарат наносят на пораженные участки кожи тонким слоем 1-3 раза в сутки. Для улучшения проникновения препарат наносят легкими массирующими движениями. При появлении положительной динамики кратность применения препарата можно уменьшить до 2-3 раз в неделю.
Доза препарата, используемая в течение недели, не должна превышать 30-60 г.
Побочное действие
Местные реакции: раздражение кожи, в редких случаях - другие местные реакции, характерные для наружной стероидной терапии.
Системные реакции: при длительном применении, нанесении на большие поверхности и/или использовании окклюзии могут наблюдаться побочные эффекты, характерные для системных глюкокортикостероидов.
Риск возникновения местных и системных побочных эффектов при применении Локоида ниже, чем при использовании фторированных стероидов.
Передозировка
Данных о передозировке Локоида нет.
При длительном применении препарата в высоких дозах возможно усиление описанных выше побочных эффектов.
При появлении симптомов гиперкортицизма препарат следует отменить.
Особые указания
Возможно применение у детей с 6-ти месячного возраста. В случаях применения препарата у детей, на область лица или под окклюзионные повязки продолжительность курса лечения необходимо сокращать.
При использовании у детей площадь поверхности кожи, на которую наносится препарат, не должна превышать 20% от общей.
В детском возрасте подавление функции коры надпочечников может развиться быстрее. Кроме того, может наблюдаться снижение экскреции гормона роста. При применении препарата в течение длительного времени необходимо наблюдать за массой тела, ростом, уровнем кортизола плазмы.
В исследовании у детей, получавших по 30-60 г Локоида в неделю на протяжении 4-х недель в сравнении с 1% мазью гидрокортизона, ни у одного ребенка не было выявлено нарушений функции коры надпочечников, при этом отличий гидрокортизона 17-бутирата по данному показателю от обычного гидрокортизона не наблюдалось.
Не следует наносить Локоид на периорбитальную область в связи с риском развития глаукомы. При систематическом попадании на конъюнктиву возникает риск увеличения внутриглазного давления.
При локализации процесса на волосистой части головы и при экссудативном воспалении предпочтительно использовать Локоид в форме Крело.
В случаях резистентного течения заболеваний, например, при локализации плотных псориатических бляшек на локтевых областях, коленях, выраженной лихенификации, сухости лучше отдавать предпочтение Локоиду в форме мази или Липокрема, в случае необходимости - под окклюзионными повязками.
Препарат не желательно использовать при наличии атрофических изменений кожи. Риск возникновения местных и системных побочных эффектов увеличивается при нанесении на обширные участки поражения, длительном применении, использовании окклюзии и в детском возрасте.
При отсутствии эффекта в течение 2-х недель непрерывного лечения, следует уточнить диагноз.
Как и при использовании любого глюкокортикостероидного препарата, желательно ограничивать продолжительность применения и курсовую дозу минимально достаточной для купирования кожного процесса.
Влияние на способность управлять транспортными средствами и работать с механизмами:
Данных о влиянии Локоида на способность управлять транспортными средствами и работать с механизмами нет.
Форма выпуска
Крем.
Условия хранения
При температуре 15–25 °C , в хорошо укупоренной таре
Для описания товара использована информация от партнера 36.6
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href=\"https://www.eapteka.ru/goods/drugs/pain/corticosteroid/?drug_form=krem\"\u003eкрем\u003c/a\u003e"}}]},{"id":4,"name":"Состав","slug":"ingredients","body":[{"type":"paragraph","data":{"text":"Крем для наружного применения белого цвета, однородный."}},{"type":"paragraph","data":{"text":"1 г гидрокортизона бутират 1 мг"}},{"type":"paragraph","data":{"text":"\u003ci\u003eВспомогательные вещества:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"цетостеариловый спирт 72 мг,"}},{"type":"paragraph","data":{"text":"макрогол 25 цетостеариловый эфир 18 мг,"}},{"type":"paragraph","data":{"text":"парафин жидкий 60 мг,"}},{"type":"paragraph","data":{"text":"парафин белый мягкий 150 мг,"}},{"type":"paragraph","data":{"text":"пропилпарагидроксибензоат 1 мг,"}},{"type":"paragraph","data":{"text":"бутилпарагидроксибензоат 0.5 мг,"}},{"type":"paragraph","data":{"text":"лимонная кислота безводная 4.2 мг,"}},{"type":"paragraph","data":{"text":"натрия цитрат безводный 2.8 мг,"}},{"type":"paragraph","data":{"text":"вода очищенная до 1 г."}}]},{"id":7,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":"Локоид является синтетическим негалогенизированным глюкокортикостеродом для наружного применения."}},{"type":"paragraph","data":{"text":"Этерификация молекулы гидрокортизона остатком масляной кислоты (бутиратом) позволила радикально повысить активность препарата по сравнению с нативным гидрокортизоном."}},{"type":"paragraph","data":{"text":"Локоид оказывает быстро наступающее противовоспалительное, противоотечное, противозудное действие."}},{"type":"paragraph","data":{"text":"Применение Локоида в рекомендуемых дозах не вызывает подавления гипоталамо-гипофизарно-адреналовой системы."}},{"type":"paragraph","data":{"text":"Хотя применение больших доз препарата в течение длительного времени, особенно при использовании окклюзионных повязок, может привести к увеличению содержания кортизола в плазме крови, это обычно не сопровождается снижением реактивности гипофизарно-надпочечниковой системы, а отмена препарата приводит к быстрой нормализации продукции кортизола."}},{"type":"paragraph","data":{"text":"\u003cb\u003eФармакокинетика:\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"После аппликации происходит накопление активного вещества в эпидермисе, в основном в зернистом слое, системная абсорбция незначительна. Небольшое количество гидрокортизона 17-бутирата всасывается в системный кровоток в неизмененном виде."}},{"type":"paragraph","data":{"text":"Большая часть гидрокортизона 17-бутирата метаболизируется до гидрокортизона и других метаболитов непосредственно в эпидермисе и в последующем в печени."}},{"type":"paragraph","data":{"text":"Метаболиты и незначительная часть неизмененного гидрокортизона 17-бутирата выводится почками и через кишечник."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"\n\nПоверхностные, неинфицированные, чувствительные к местным глюкокортикостероидам заболевания кожи:"}},{"type":"paragraph","data":{"text":"— дерматиты, в том числе атопический, контактный, себорейный;"}},{"type":"paragraph","data":{"text":"— экзема;"}},{"type":"paragraph","data":{"text":"— псориаз.\n\n"}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"\n\n— Гиперчувствительность к гидрокортизону или вспомогательным компонентам препарата;"}},{"type":"paragraph","data":{"text":"— бактериальные инфекции кожи (стрепто- и стафилодермии, грамотрицательный фолликулит и т.д.);"}},{"type":"paragraph","data":{"text":"— вирусные инфекции кожи (простой герпес, ветряная оспа, опоясывающий лишай и т.д.);"}},{"type":"paragraph","data":{"text":"— грибковые инфекции кожи;"}},{"type":"paragraph","data":{"text":"— туберкулезные и сифилитические поражения кожи;"}},{"type":"paragraph","data":{"text":"— паразитарные инфекции кожи;"}},{"type":"paragraph","data":{"text":"— неопластические изменения кожи (доброкачественные и злокачественные опухоли);"}},{"type":"paragraph","data":{"text":"— акне, розацеа, периоральный дерматит;"}},{"type":"paragraph","data":{"text":"— поствакцинальный период;"}},{"type":"paragraph","data":{"text":"— нарушение целостности кожных покровов (раны, язвы).\n\n"}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"беременность, период лактации."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Наружно."}},{"type":"paragraph","data":{"text":"Локоид крем предпочтительно применять при острых и подострых кожных процессах (без мокнутия)."}},{"type":"paragraph","data":{"text":"Препарат наносят на пораженные участки кожи тонким слоем 1-3 раза в сутки. Для улучшения проникновения препарат наносят легкими массирующими движениями. При появлении положительной динамики кратность применения препарата можно уменьшить до 2-3 раз в неделю."}},{"type":"paragraph","data":{"text":"Доза препарата, используемая в течение недели, не должна превышать 30-60 г."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Местные реакции: раздражение кожи, в редких случаях - другие местные реакции, характерные для наружной стероидной терапии."}},{"type":"paragraph","data":{"text":"Системные реакции: при длительном применении, нанесении на большие поверхности и/или использовании окклюзии могут наблюдаться побочные эффекты, характерные для системных глюкокортикостероидов."}},{"type":"paragraph","data":{"text":"Риск возникновения местных и системных побочных эффектов при применении Локоида ниже, чем при использовании фторированных стероидов."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Данных о передозировке Локоида нет."}},{"type":"paragraph","data":{"text":"При длительном применении препарата в высоких дозах возможно усиление описанных выше побочных эффектов."}},{"type":"paragraph","data":{"text":"При появлении симптомов гиперкортицизма препарат следует отменить."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Возможно применение у детей с 6-ти месячного возраста. В случаях применения препарата у детей, на область лица или под окклюзионные повязки продолжительность курса лечения необходимо сокращать."}},{"type":"paragraph","data":{"text":"При использовании у детей площадь поверхности кожи, на которую наносится препарат, не должна превышать 20% от общей."}},{"type":"paragraph","data":{"text":"В детском возрасте подавление функции коры надпочечников может развиться быстрее. Кроме того, может наблюдаться снижение экскреции гормона роста. При применении препарата в течение длительного времени необходимо наблюдать за массой тела, ростом, уровнем кортизола плазмы. "}},{"type":"paragraph","data":{"text":"В исследовании у детей, получавших по 30-60 г Локоида в неделю на протяжении 4-х недель в сравнении с 1% мазью гидрокортизона, ни у одного ребенка не было выявлено нарушений функции коры надпочечников, при этом отличий гидрокортизона 17-бутирата по данному показателю от обычного гидрокортизона не наблюдалось."}},{"type":"paragraph","data":{"text":"Не следует наносить Локоид на периорбитальную область в связи с риском развития глаукомы. При систематическом попадании на конъюнктиву возникает риск увеличения внутриглазного давления."}},{"type":"paragraph","data":{"text":"При локализации процесса на волосистой части головы и при экссудативном воспалении предпочтительно использовать Локоид в форме Крело."}},{"type":"paragraph","data":{"text":"В случаях резистентного течения заболеваний, например, при локализации плотных псориатических бляшек на локтевых областях, коленях, выраженной лихенификации, сухости лучше отдавать предпочтение Локоиду в форме мази или Липокрема, в случае необходимости - под окклюзионными повязками."}},{"type":"paragraph","data":{"text":"Препарат не желательно использовать при наличии атрофических изменений кожи. Риск возникновения местных и системных побочных эффектов увеличивается при нанесении на обширные участки поражения, длительном применении, использовании окклюзии и в детском возрасте."}},{"type":"paragraph","data":{"text":"При отсутствии эффекта в течение 2-х недель непрерывного лечения, следует уточнить диагноз."}},{"type":"paragraph","data":{"text":"Как и при использовании любого глюкокортикостероидного препарата, желательно ограничивать продолжительность применения и курсовую дозу минимально достаточной для купирования кожного процесса."}},{"type":"paragraph","data":{"text":"Влияние на способность управлять транспортными средствами и работать с механизмами:"}},{"type":"paragraph","data":{"text":"Данных о влиянии Локоида на способность управлять транспортными средствами и работать с механизмами нет."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Крем."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"При температуре 15–25 °C , в хорошо укупоренной таре"}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"5 лет"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ca href=\"https://www.eapteka.ru/goods/manufacturer/astellas/\"\u003eАстеллас Фарма Юроп Б.В., Нидерланды\u003c/a\u003e"}}]}],"source":null},"description_toggle":false,"short_description":"Локоид является синтетическим негалогенизированным глюкокортикостеродом для наружного применения. Этерификация молекулы гидрокортизона остатком масляной кислоты (бутиратом) позволила радикально повысить активность препарата по сравнению с нативным гидрокортизоном. Локоид оказывает быстро наступающее противовоспалительное, противоотечное, противозудное действие. Применение Локоида в рекомендуемых дозах не вызывает подавления гипоталамо-гипофизарно-адреналовой системы. Хотя применение больших доз препарата в течение длительного времени, особенно при использовании окклюзионных повязок, может привести к увеличению содержания кортизола в плазме крови, это обычно не сопровождается снижением реактивности гипофизарно-надпочечниковой системы, а отмена препарата приводит к быстрой нормализации продукции кортизола.Фармакокинетика:После аппликации происходит накопление активного вещества в эпидермисе, в основном в зернистом слое, системная абсорбция незначительна. Небольшое количество гидрокортизона 17-бутирата всасывается в системный кровоток в неизмененном виде. Большая часть гидрокортизона 17-бутирата метаболизируется до гидрокортизона и других метаболитов непосредственно в эпидермисе и в последующем в печени. 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