Магния гидроксикарбонат (магния карбонат основной)- 0,0175 г
Лактозы моногидрат (сахар молочный)- 0,059869 г
Целлюлоза микрокристаллическая- 0,02 г
Магния стеарат- 0,001 г
Кремния диоксид коллоидный (аэросил)- 0,0005 г
Кроскармеллоза натрия- 0,001 г
Дозировка 200 мкг
Активное вещество:
Калия йодид- 262 мкг
что соответствует- 200 мкг йода
Вспомогательные вещества:
Магния гидроксикарбонат (магния карбонат основной)- 0,0175 г
Лактозы моногидрат (сахар молочный)- 0,059738 г
Целлюлоза микрокристаллическая- 0,02 г
Магния стеарат- 0,001 г
Кремния диоксид коллоидный (аэросил)- 0,0005 г
Кроскармеллоза натрия- 0,001 г
Описание
Таблетки белого цвета, круглой формы, плоскоцилиндрические с фаской, с маркировкой "R" на одной стороне или без нее.
Фармакотерапевтическая группа
Тироксина синтеза регулятор - йода препарат
Фармакологические свойства
Фармакодинамика:
Йод относится к жизненно важным микроэлементам необходимым для нормального функционирования щитовидной железы.
При поступлении йодидов в клетки эпителия фолликула щитовидной железы ионы йода под влиянием фермента йодид-пероксидазы окисляются с образованием элементарного йода который включается в молекулу тирозина. При этом одна часть радикалов тирозина в тиреоглобулине йодируется в результате чего образуются тиронины основными из которых являются тироксин (Т4) и трийодтиронин (Т3). Тиронины образуют комплекс с белком тиреоглобулином который депонируется в коллоиде фолликула щитовидной железы.
Йод поступающий в организм в физиологических количествах предотвращает развитие эндемического зоба (связанного с недостатком йода в пище); нормализует размер щитовидной железы у новорожденных детей и подростков; а также воздействует на показатели соотношения Т3/Т4 концентрацию тиреотропного гормона.
Фармакокинетика:
При приеме внутрь быстро и полностью всасывается в тонкой кишке и в течение 2 ч распределяется во внутриклеточном пространстве.
Накапливается в основном в щитовидной железе (концентрация йодида более 05 мг/г ткани) а также в слюнных и молочных железах слизистой оболочке желудка. Хорошо проникает через плаценту.
Выводится преимущественно почками (следовые количества определяются в моче через 10 мин после приема 80% дозы выводится в течение 48 ч остальная часть - в течение 10-20 дней) частично - с секретами слюнных бронхиальных потовых и других желез.
Показания к применению
- Профилактика развития эндемического зоба в том числе при беременности;
- профилактика рецидива зоба после завершения курса лечения зоба препаратами гормонов щитовидной железы или после его хирургического удаления;
- лечение диффузного эутиреоидного зоба у новорожденных детей подростков и взрослых пациентов молодого возраста.
Противопоказания
- Повышенная чувствительность к йоду;
- выраженный тиреотоксикоз;
- скрытый тиреотоксикоз (при применении доз превышающих 150 мкг/сут);
- герпетиформный дерматит;
- токсическая аденома узловой зоб при применении в дозах более 300 мкг/сут (за исключением предоперационной терапии с целью блокады щитовидной железы);
- наследственные заболевания связанные с непереносимостью галактозы дефицитом лактазы или глюкозо-галактозной мальабсорбцией.
Калия йодид не следует принимать при гипотиреозе за исключением тех случаев когда развитие последнего вызвано выраженным дефицитом йода. Применение препарата следует избегать при терапии радиоактивным йодом наличии или при подозрении на рак щитовидной железы.
С осторожностью
У пациентов с нарушением функции почек.
Применение при беременности и в период грудного вскармливания
В период беременности и грудного вскармливания потребность в йоде повышается. Калия йодид назначают по показаниям в тех случаях когда поступление йода с пищей составляет меньше 150-300 мкг/сут. Препарат хорошо проникает через плаценту и может вызвать развитие гипотиреоза и зоба у плода. Йод также выделяется с грудным молоком.
Поэтому в период беременности и грудного вскармливания препарат следует применять только в рекомендуемых дозах.
Способ применения и дозы
Суточную дозу препарата следует принимать внутрь в один прием после еды запивая большим количеством жидкости.
При применении препарата у новорожденных и детей до 3 лет рекомендуется растворить таблетку в небольшом количестве (1 столовая ложка) кипяченой воды комнатной температуры.
Рекомендуемые дозы (в пересчете на йод):
Профилактика развития эндемического зоба:
-новорожденные и дети: 100 мкг/сут;
- подростки и взрослые: - 100-200 мкг/сут;
- при беременности и в период грудного вскармливания - 150-200 мкг/сут.
Профилактика рецидива зоба после завершения курса лечения зоба препаратами гормонов щитовидной железы или после его хирургического удаления: 100-200 мкг/сут.
Лечение эутиреоидного зоба:
- новорожденные дети и подростки: 100-200 мкг/сут;
- взрослые пациенты молодого возраста: 300-500 мкг/сут.
Прием препарата с профилактической целью проводится в течение как правило нескольких месяцев или лет при наличии показаний - пожизненно.
Лечение зоба у новорожденных проводится в большинстве случаев в течение 2-4 недель; у детей подростков и взрослых обычно требуется 6-12 месяцев возможен длительный прием. Продолжительность лечения определяется врачом.
Побочное действие
При применении препарата по показаниям в рекомендуемых дозах возникновение побочных эффектов маловероятно.
Могут наблюдаться аллергические реакции: редко - кожная сыпь отек Квинке.
Передозировка
При применении препарата в дозе превышающей 150 мкг/сут скрытый гипертиреоз может перейти в манифестную форму.
При длительном применении препарата в дозе превышающей 300 мкг/сут возможно развитие йод-индуцированного гипертиреоза (особенно у пожилых пациентов при наличии узлового зоба или токсической аденомы).
Симптомы острой передозировки: окрашивание слизистых оболочек в коричневый цвет рефлекторная рвота боли в животе и диарея (возможно мелена). В тяжелых случаях возможно развитие дегидратации и шока.
Лечение при острой передозировке: промывание желудка введение натрия тиосульфата симптоматическая терапия нарушения водно-электролитного баланса противошоковая терапия.
Хроническая передозировка может привести к развитию феномена "йодизма": "металлический" привкус во рту отек и воспаление слизистых оболочек (ринит конъюнктивит гастроэнтерит бронхит) угревая сыпь дерматит отек слюнных желез лихорадка раздражительность.
Лечение при хронической передозировке: отмена препарата.
Взаимодействие с другими лекарственными средствами
Одновременный прием антитиреоидных лекарственных средств ослабляет эффект калия йодида (взаимно).
Перхлорат и тиоцианат калия подавляют поглощение йода щитовидной железой. Тиреотропный гормон улучшает усвоение йода щитовидной железой и стимулирует выработку ее гормонов.
Одновременный прием ингибиторов ангиотензинпревращающего фермента (в том числе каптоприла эналаприла лизиноприла) повышает риск возникновения гиперкалиемии. Высокие дозы йода в сочетании с калийсберегающими диуретиками могут приводить к гиперкалиемии.
Одновременная терапия йодом в высоких дозах и препаратами лития способствует развитию зоба и гипотиреоза.
Калия йодид снижает захват щитовидной железой 131I и 123I.
Особые указания
До начала лечения необходимо исключить злокачественное поражение щитовидной железы гипертиреоз или узловой токсический зоб.
На фоне терапии препаратом у больных с нарушением функции почек возможно развитие гиперкалиемии (необходим периодический контроль концентрации калия в крови).
В связи с наличием в составе препарата лактозы моногидрата пациенты с редкими наследственными заболеваниями связанными с непереносимостью галактозы дефицитом лактазы или глюкозо-галактозной мальабсорбцией не должны принимать препарат.
Влияние на способность управлять автомобилем и движущимися механизмами
Препарат не влияет на способность управлять транспортными средствами и занятия другими потенциально опасными видами деятельности требующими повышенной концентрации внимания и быстроты психомоторных реакций.
Форма выпуска
Таблетки 100 мкг и 200 мкг.
Условия хранения
В защищенном от света месте при температуре не выше 25 °С.
Хранить в недоступном для детей месте.
Срок годности
3 года.
Не применять по истечении срока годности.
Условия отпуска
Без рецепта
Производитель
ЗАО "Производственная фармацевтическая компания Обновление" (ЗАО "ПФК Обновление"), г. Новосибирск, ул. Станционная, д.80, Россия
Организация, принимающая претензии потребителей
ЗАО "ПФК Обновление"
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
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г"}},{"type":"paragraph","data":{"text":"Кремния диоксид коллоидный (аэросил)- 0,0005 г"}},{"type":"paragraph","data":{"text":"Кроскармеллоза натрия- 0,001 г"}},{"type":"paragraph","data":{"text":"Дозировка 200 мкг"}},{"type":"paragraph","data":{"text":"Активное вещество:"}},{"type":"paragraph","data":{"text":"Калия йодид- 262 мкг"}},{"type":"paragraph","data":{"text":"что соответствует- 200 мкг йода"}},{"type":"paragraph","data":{"text":"Вспомогательные вещества:"}},{"type":"paragraph","data":{"text":"Магния гидроксикарбонат (магния карбонат основной)- 0,0175 г"}},{"type":"paragraph","data":{"text":"Лактозы моногидрат (сахар молочный)- 0,059738 г"}},{"type":"paragraph","data":{"text":"Целлюлоза микрокристаллическая- 0,02 г"}},{"type":"paragraph","data":{"text":"Магния стеарат- 0,001 г"}},{"type":"paragraph","data":{"text":"Кремния диоксид коллоидный (аэросил)- 0,0005 г"}},{"type":"paragraph","data":{"text":"Кроскармеллоза натрия- 0,001 г"}}]},{"id":5,"name":"Описание","slug":"common_description","body":[{"type":"paragraph","data":{"text":"Таблетки белого цвета, круглой формы, плоскоцилиндрические с фаской, с маркировкой \"R\" на одной стороне или без нее."}}]},{"id":6,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":"Тироксина синтеза регулятор - йода препарат"}}]},{"id":7,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"header","data":{"text":"Фармакодинамика:","level":3}},{"type":"paragraph","data":{"text":"Йод относится к жизненно важным микроэлементам необходимым для нормального функционирования щитовидной железы."}},{"type":"paragraph","data":{"text":"При поступлении йодидов в клетки эпителия фолликула щитовидной железы ионы йода под влиянием фермента йодид-пероксидазы окисляются с образованием элементарного йода который включается в молекулу тирозина. При этом одна часть радикалов тирозина в тиреоглобулине йодируется в результате чего образуются тиронины основными из которых являются тироксин (Т\u003csub\u003e4\u003c/sub\u003e) и трийодтиронин (Т\u003csub\u003e3\u003c/sub\u003e). Тиронины образуют комплекс с белком тиреоглобулином который депонируется в коллоиде фолликула щитовидной железы."}},{"type":"paragraph","data":{"text":"Йод поступающий в организм в физиологических количествах предотвращает развитие эндемического зоба (связанного с недостатком йода в пище); нормализует размер щитовидной железы у новорожденных детей и подростков; а также воздействует на показатели соотношения Т\u003csub\u003e3/\u003c/sub\u003eТ\u003csub\u003e4\u003c/sub\u003e концентрацию тиреотропного гормона."}},{"type":"header","data":{"text":"Фармакокинетика:","level":3}},{"type":"paragraph","data":{"text":"При приеме внутрь быстро и полностью всасывается в тонкой кишке и в течение 2 ч распределяется во внутриклеточном пространстве."}},{"type":"paragraph","data":{"text":"Накапливается в основном в щитовидной железе (концентрация йодида более 05 мг/г ткани) а также в слюнных и молочных железах слизистой оболочке желудка. Хорошо проникает через плаценту."}},{"type":"paragraph","data":{"text":"Выводится преимущественно почками (следовые количества определяются в моче через 10 мин после приема 80% дозы выводится в течение 48 ч остальная часть - в течение 10-20 дней) частично - с секретами слюнных бронхиальных потовых и других желез."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"- Профилактика развития эндемического зоба в том числе при беременности;"}},{"type":"paragraph","data":{"text":"- профилактика рецидива зоба после завершения курса лечения зоба препаратами гормонов щитовидной железы или после его хирургического удаления;"}},{"type":"paragraph","data":{"text":"- лечение диффузного эутиреоидного зоба у новорожденных детей подростков и взрослых пациентов молодого возраста."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"- Повышенная чувствительность к йоду;"}},{"type":"paragraph","data":{"text":"- выраженный тиреотоксикоз;"}},{"type":"paragraph","data":{"text":"- скрытый тиреотоксикоз (при применении доз превышающих 150 мкг/сут);"}},{"type":"paragraph","data":{"text":"- герпетиформный дерматит;"}},{"type":"paragraph","data":{"text":"- токсическая аденома узловой зоб при применении в дозах более 300 мкг/сут (за исключением предоперационной терапии с целью блокады щитовидной железы);"}},{"type":"paragraph","data":{"text":"- наследственные заболевания связанные с непереносимостью галактозы дефицитом лактазы или глюкозо-галактозной мальабсорбцией."}},{"type":"paragraph","data":{"text":"Калия йодид не следует принимать при гипотиреозе за исключением тех случаев когда развитие последнего вызвано выраженным дефицитом йода. Применение препарата следует избегать при терапии радиоактивным йодом наличии или при подозрении на рак щитовидной железы."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"У пациентов с нарушением функции почек."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"В период беременности и грудного вскармливания потребность в йоде повышается. Калия йодид назначают по показаниям в тех случаях когда поступление йода с пищей составляет меньше 150-300 мкг/сут. Препарат хорошо проникает через плаценту и может вызвать развитие гипотиреоза и зоба у плода. Йод также выделяется с грудным молоком."}},{"type":"paragraph","data":{"text":"Поэтому в период беременности и грудного вскармливания препарат следует применять только в рекомендуемых дозах."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Суточную дозу препарата следует принимать внутрь в один прием после еды запивая большим количеством жидкости."}},{"type":"paragraph","data":{"text":"При применении препарата у новорожденных и детей до 3 лет рекомендуется растворить таблетку в небольшом количестве (1 столовая ложка) кипяченой воды комнатной температуры."}},{"type":"paragraph","data":{"text":"Рекомендуемые дозы (в пересчете на йод):"}},{"type":"paragraph","data":{"text":"Профилактика развития эндемического зоба:"}},{"type":"paragraph","data":{"text":"-новорожденные и дети: 100 мкг/сут;"}},{"type":"paragraph","data":{"text":"- подростки и взрослые: - 100-200 мкг/сут;"}},{"type":"paragraph","data":{"text":"- при беременности и в период грудного вскармливания - 150-200 мкг/сут."}},{"type":"paragraph","data":{"text":"Профилактика рецидива зоба после завершения курса лечения зоба препаратами гормонов щитовидной железы или после его хирургического удаления: 100-200 мкг/сут."}},{"type":"paragraph","data":{"text":"Лечение эутиреоидного зоба:"}},{"type":"paragraph","data":{"text":"- новорожденные дети и подростки: 100-200 мкг/сут;"}},{"type":"paragraph","data":{"text":"- взрослые пациенты молодого возраста: 300-500 мкг/сут."}},{"type":"paragraph","data":{"text":"Прием препарата с профилактической целью проводится в течение как правило нескольких месяцев или лет при наличии показаний - пожизненно."}},{"type":"paragraph","data":{"text":"Лечение зоба у новорожденных проводится в большинстве случаев в течение 2-4 недель; у детей подростков и взрослых обычно требуется 6-12 месяцев возможен длительный прием. Продолжительность лечения определяется врачом."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"При применении препарата по показаниям в рекомендуемых дозах возникновение побочных эффектов маловероятно."}},{"type":"paragraph","data":{"text":"Могут наблюдаться аллергические реакции: редко - кожная сыпь отек Квинке."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"При применении препарата в дозе превышающей 150 мкг/сут скрытый гипертиреоз может перейти в манифестную форму."}},{"type":"paragraph","data":{"text":"При длительном применении препарата в дозе превышающей 300 мкг/сут возможно развитие йод-индуцированного гипертиреоза (особенно у пожилых пациентов при наличии узлового зоба или токсической аденомы)."}},{"type":"paragraph","data":{"text":"Симптомы острой передозировки: окрашивание слизистых оболочек в коричневый цвет рефлекторная рвота боли в животе и диарея (возможно мелена). В тяжелых случаях возможно развитие дегидратации и шока."}},{"type":"paragraph","data":{"text":"Лечение при острой передозировке: промывание желудка введение натрия тиосульфата симптоматическая терапия нарушения водно-электролитного баланса противошоковая терапия."}},{"type":"paragraph","data":{"text":"Хроническая передозировка может привести к развитию феномена \"йодизма\": \"металлический\" привкус во рту отек и воспаление слизистых оболочек (ринит конъюнктивит гастроэнтерит бронхит) угревая сыпь дерматит отек слюнных желез лихорадка раздражительность."}},{"type":"paragraph","data":{"text":"Лечение при хронической передозировке: отмена препарата."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Одновременный прием антитиреоидных лекарственных средств ослабляет эффект калия йодида (взаимно)."}},{"type":"paragraph","data":{"text":"Перхлорат и тиоцианат калия подавляют поглощение йода щитовидной железой. Тиреотропный гормон улучшает усвоение йода щитовидной железой и стимулирует выработку ее гормонов."}},{"type":"paragraph","data":{"text":"Одновременный прием ингибиторов ангиотензинпревращающего фермента (в том числе каптоприла эналаприла лизиноприла) повышает риск возникновения гиперкалиемии. Высокие дозы йода в сочетании с калийсберегающими диуретиками могут приводить к гиперкалиемии."}},{"type":"paragraph","data":{"text":"Одновременная терапия йодом в высоких дозах и препаратами лития способствует развитию зоба и гипотиреоза."}},{"type":"paragraph","data":{"text":"Калия йодид снижает захват щитовидной железой \u003csup\u003e131\u003c/sup\u003eI и \u003csup\u003e123\u003c/sup\u003eI."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"До начала лечения необходимо исключить злокачественное поражение щитовидной железы гипертиреоз или узловой токсический зоб."}},{"type":"paragraph","data":{"text":"На фоне терапии препаратом у больных с нарушением функции почек возможно развитие гиперкалиемии (необходим периодический контроль концентрации калия в крови)."}},{"type":"paragraph","data":{"text":"В связи с наличием в составе препарата лактозы моногидрата пациенты с редкими наследственными заболеваниями связанными с непереносимостью галактозы дефицитом лактазы или глюкозо-галактозной мальабсорбцией не должны принимать препарат."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Препарат не влияет на способность управлять транспортными средствами и занятия другими потенциально опасными видами деятельности требующими повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки 100 мкг и 200 мкг."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищенном от света месте при температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Не применять по истечении срока годности."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ЗАО \"Производственная фармацевтическая компания Обновление\" (ЗАО \"ПФК Обновление\"), г. 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