Рибоксин буфус Раствор, 10 шт, 10 мл, 2 %, для внутривенного введения

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Механизм антиаритмического действия до конца неясен."}},{"type":"paragraph","data":{"text":"Снижает агрегацию тромбоцитов, активирует регенерацию тканей (особенно миокарда и слизистой оболочки желудочно-кишечного тракта)"}},{"type":"paragraph","data":{"text":"Фармакокинетика"}},{"type":"paragraph","data":{"text":"Метаболизируется в печени с образованием глюкуроновой кислоты и последующим ее окислением. В незначительном количестве выделяется с мочой."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Комплексное лечение перенесенного инфаркта миокарда, ишемической болезни сердца, нарушений сердечного ритма, обусловленных применением сердечных гликозидов, на фоне миокардиодистрофии после перенесенных инфекционных заболеваний. Заболевания печени (гепатиты, цирроз, жировая дистрофия), урокопропорфирия. Операции на изолированной почке (в качестве средства фармакологической защиты при выключении кровообращения)."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность к препарату, подагра, гиперурикемия, беременность, период лактации, возраст до 18 лет (эффективность и безопасность не установлены)."}},{"type":"paragraph","data":{"text":"С осторожностью применять при почечной недостаточности."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Препарат применяют внутривенно струйно медленно или капельно (40-60 капель в 1 минуту)."}},{"type":"paragraph","data":{"text":"Лечение начинают с введения 200 мг (10 мл 2 % раствора) 1 раз в день, затем, при хорошей переносимости, дозу увеличивают до 400 мг (20 мл 2 % раствора) 1-2 раза в день."}},{"type":"paragraph","data":{"text":"Продолжительность лечения 10-15 дней."}},{"type":"paragraph","data":{"text":"Струйное введение препарата возможно при острых нарушениях ритма сердца в разовой дозе 200-400 мг (10-20 мл 2 % раствора)."}},{"type":"paragraph","data":{"text":"Для фармакологической защиты почек, подвергнутых ишемии, рибоксин вводят внутривенно струйно в разовой дозе 1200 мг (60 мл 2 % раствора) за 5-15 минут до пережатия почечной артерии, а затем еще 800 мг (40 мл 2 % раствора) тотчас после восстановления кровообращения."}},{"type":"paragraph","data":{"text":"При капельном введении в вену 2 % раствор препарата разводят в 5 % растворе декстрозы (глюкозы) или изотоническом растворе натрия хлорида (до 250 мл)."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Аллергические реакции: кожный зуд, гиперемия кожи, крапивница (препарат следует отменить)."}},{"type":"paragraph","data":{"text":"Редко: повышение концентрации мочевой кислоты в крови, обострение подагры (при длительном применении)."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"В настоящее время не выявлено."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Раствор для внутривенного введения 20 мг/мл."}},{"type":"paragraph","data":{"text":"По 10 мл в ампулы полимерные из полиэтилена высокого давления или из полиэтилена низкого давления, или из полиэтилена для медицинских целей, или из полиэтилена или полипропилена для инфузионных растворов и инъекционных препаратов."}},{"type":"paragraph","data":{"text":"На ампулы полимерные наклеивают этикетки из бумаги этикеточной, писчей или текст этикетки наносят непосредственно на ампулу полимерную методом каплеструйной печати."}},{"type":"paragraph","data":{"text":"По 10, ампул полимерных с инструкцией по применению помещают в пачку из картона."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищенном от света месте при температуре от 15 до 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года. Не применять по истечении срока годности, указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту."}}]}],"source":null},"description_toggle":false,"short_description":"Рибоксин – производное (нуклеозид) пурина – предшественник аденозинтрифосфата (АТФ). Относится к группе лекарственных средств, стимулирующих метаболические процессы. Оказывает антигипоксическое и антиаритмическое действие. Повышает энергетический баланс миокарда, улучшает коронарное кровообращение, предотвращает последствия интраоперационной ишемии почек. Принимает непосредственное участие в обмене глюкозы и способствует активации обмена в условиях гипоксии и при отсутствии АТФ. Активирует метаболизм пировиноградной кислоты, необходимой для обеспечения нормального процесса тканевого дыхания, а также способствует активированию ксантиндегидрогеназы. Стимулирует синтез нуклеотидов, усиливает активность некоторых ферментов цикла Кребса. 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