*наносятся
на изомальт в виде смеси трех активных водно-спиртовых разведений субстанции,
разведенной соответственно в 10012, 10030, 100200 раз.
Описание
Таблетки плоскоцилиндрической формы с риской и фаской, от белого до почти белого цвета. На плоской стороне с риской нанесена надпись MATERIA MEDICA, на другой плоской стороне нанесена надпись SUBETTA.
Фармакотерапевтическая группа
Гипогликемические и другие средства в комбинациях.
Фармакологические свойства
Фармакодинамика
Антитела
к С-концевому фрагменту β-субъединицы через механизмы аллостерической модуляции
сенситизируют рецептор инсулина, повышают его чувствительность как к
эндогенному, так и вводимому инсулину, что сопровождается активацией
метаболизма инсулин-зависимой глюкозы. Экспериментально показано наличие у
антител к β-субъединице умеренно выраженного гипогликемического эффекта
(снижение уровня гликемии натощак на 0,7-1,4 ммоль/л), при этом длительное
применение не сопровождалось развитием таких побочных эффектов, как гипогликемия,
ацидоз, повышение массы тела, нарушения гемостаза и кроветворения.
Антитела
к эндотелиальной NO-синтазе повышают активность эндотелиальной NO-синтазы, что
сопровождается повышением содержания NO, оказывающего эндотелиопротективное
действие, способствует снижению реактивности сосудов, уменьшению сосудистого
спазма, нормализации уровня артериального давления и улучшению периферической
микроциркуляции.
Антитела
к эндотелиальной NO-синтазе обладают умеренно выраженным психотропным действием
в виде противотревожного, антиастенического, вегетостабилизирующего эффектов.
При
совместном применении компонентов в составе комплексного препарата «Субетта»
наблюдается синергическое влияние на чувствительность соматических клеток к
инсулину за счет неспецифической NO-зависимой активации внутриклеточной
трансдукции сигнала от инсулинового рецептора, что позволяет повысить
эффективность инсулинотерапии, стабилизировать применяемые дозы и снизить риск
развития побочных эффектов.
Чувствительность современных физико-химических методов
анализа (газожидкостная хроматография, высокоэффективная жидкостная
хроматография, хромато-масс-спектрометрия) не позволяет оценивать содержание
сверхмалых доз антител в биологических жидкостях, органах и тканях, что делает
технически невозможным изучение фармакокинетики препарата Субетта.
Показания к применению
Субетта
показана к приминению у взрослых.
Сахарный
диабет 1 типа в качестве дополнения к базис-болюсной инсулинотерапии.
Сахарный диабет 2 типа в составе комплексной терапии.
Противопоказания
Повышенная
индивидуальная чувствительность к компонентам препарата.
Возраст до 18 лет.
Применение при беременности и в период грудного вскармливания
Данные
о применении препарата Субетта у беременных женщин отсутствуют.
Период
грудного вскармливания
Сведения о проникновения действующих веществ
(метаболитов) в грудное молоко человека отсутствуют.
Способ применения и дозы
Риска
не предназначена для деления таблетки на части.
Внутрь.
На один прием – 1 таблетка (держать во рту до полного растворения не во время
приема пищи). Таблетку следует держать во рту, не проглатывая, до полного
растворения.
Частота приема устанавливается врачом и может
варьироваться от 2–х до 4–х раз в сутки в зависимости от степени компенсации
диабета.
Побочное действие
Возможны реакции повышенной индивидуальной
чувствительности к компонентам препарата.
Передозировка
При случайной передозировке возможны диспепсические
явления, обусловленные входящими в состав препарата наполнителями.
Взаимодействие с другими лекарственными средствами
Случаев несовместимости с другими лекарственными
средствами до настоящего времени не зарегистрировано.
Особые указания
Перед применением препарата Субетта
проконсультируйтесь с лечащим врачом.
Влияние на способность управлять автомобилем и движущимися механизмами
Субетта не оказывает влияния на способность управлять
транспортными средствами и другими потенциально опасными механизмами.
Форма выпуска
Таблетки для рассасывания. По 20 таблеток в контурной ячейковой упаковке из пленки поливинилхлоридной и фольги алюминиевой. По 1, 2 или 5 контурных ячейковых упаковок вместе с инструкцией по медицинскому применению помещают в пачку из картона.
Условия хранения
В защищенном от света месте, при температуре не выше
25 °С. Хранить в недоступном для детей месте.
Срок годности
3
года.
Не применять по истечении срока годности.
Условия отпуска
Без рецепта.
Производитель
ООО «НПФ «МАТЕРИА МЕДИКА ХОЛДИНГ» Россия, 454139, г.
Челябинск, ул. Бугурусланская, д. 54.
Организация, принимающая претензии потребителей
ООО
«НПФ «МАТЕРИА МЕДИКА ХОЛДИНГ»
Россия,
127473, г. Москва 3-й Самотечный пер., д.9.
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
Начните сравнивать цены и заказывать лекарства прямо в приложении
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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По 20 таблеток в контурной ячейковой упаковке из пленки поливинилхлоридной и фольги алюминиевой. По 1, 2 или 5 контурных ячейковых упаковок вместе с инструкцией по медицинскому применению помещают в пачку из картона."}}]},{"id":11,"name":"Условия хранения","slug":"storage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"В защищенном от света месте, при температуре не выше\n25 °С. Хранить в недоступном для детей месте."}}]},{"id":12,"name":"Срок годности","slug":"expiry_date","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"3\nгода."}},{"type":"paragraph","data":{"text":"Не применять по истечении срока годности."}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта."}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ООО «НПФ «МАТЕРИА МЕДИКА ХОЛДИНГ» Россия, 454139, г.\nЧелябинск, ул. 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При совместном применении компонентов в составе комплексного препарата «Субетта» наблюдается синергическое влияние на чувствительность соматических клеток к инсулину за счет неспецифической NO-зависимой активации внутриклеточной трансдукции сигнала от инсулинового рецептора, что позволяет повысить эффективность инсулинотерапии, стабилизировать применяемые дозы и снизить риск развития побочных эффектов. 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