· Заболевания ЦНС различного генеза, особенно связанные с
нарушениями обменных процессов в мозге, интоксикацией (в частности, при
посттравматических состояниях), сопровождающиеся ухудшением
интеллектуально-мнестических функций, снижением двигательной активности;
Круглые
плоскоцилиндрические таблетки от белого до белого с желтоватым оттенком цвета с
фаской для дозировки 50 мг, с фаской и риской для дозировки 100 мг
Фармакотерапевтическая группа
ноотропное средство
Фармакологические свойства
Фармакодинамика
Ноотропный
препарат, обладающий выраженным антиамнестическим действием, оказывает прямое
активирующее влияние на интегративную деятельность головного мозга,
способствует консолидации памяти, улучшает концентрацию внимания и умственную
деятельность, облегчает процесс обучения, повышает скорость передачи информации
между полушариями головного мозга и устойчивость тканей мозга к токсическим
воздействиям, обладает противосудорожным действием и анксиолитической
активностью.
Оказывает
положительное влияние на обменные процессы, стимулирует
окислительно-восстановительные процессы, повышает энергетический потенциал
организма за счет утилизации глюкозы. Повышает содержание норадреналина,
дофамина и серотонина в мозге, не влияет на уровень содержания ГАМК, не
связывается с ГАМКА и ГАМКВ рецепторами, не оказывает
заметного влияния на спонтанную биоэлектрическую активность мозга.
Не
оказывает влияние на дыхание и сердечно-сосудистую систему, проявляет
невыраженный диуретический эффект, обладает анорексигенной активностью при
курсовом применении.
Стимулирующее
действие проявляется в способности оказывать умеренно выраженный эффект,
проявляющийся в отношении двигательных реакций, повышении физической
работоспособности, а также ослаблении выраженности снотворного действия этанола
и гексобарбитала.
Психостимулирующее
действие преобладает в идеаторной сфере.
Умеренный
психостимулирующий эффект препарата сочетается с анксиолитической активностью.
Оказывает некоторый анальгезирующий эффект, повышая порог болевой
чувствительности.
Адаптогенное
действие проявляется в повышении устойчивости организма к стрессу в условиях
чрезмерных психических и физических нагрузок, при утомлении, гипокинезии и
иммобилизации, при низких температурах.
На
фоне приема препарата отмечено улучшение зрения, которое проявляется в
увеличении остроты, яркости и полей зрения.
Улучшает
кровоснабжение нижних конечностей.
Стимулирует
выработку антител в ответ на введение антигена, что указывает на
иммуностимулирующие свойства, но в то же время не способствует развитию
гиперчувствительности немедленного типа и не изменяет аллергическую
воспалительную реакцию кожи, вызванную введением чужеродного белка.
При
курсовом применении не развивается лекарственная зависимость, толерантность,
«синдром отмены».
Действие
проявляется при однократной дозе, что важно при применении препарата в
экстремальных условиях.
Не
обладает тератогенными, мутагенными, канцерогенными и эмбриотоксичными
свойствами. Имеет низкую токсичность, летальная доза в остром эксперименте
составляет 800 мг/кг.
Быстро всасывается,
проникает в различные органы и ткани, легко проходит через гематоэнцефалический
барьер.
Абсолютная биодоступность
при пероральном приеме составляет 100 %.
Максимальная концентрация
в крови (Тmax) достигается через 1 ч, период полувыведения (Т 1/2) - 3-5 ч.
Не метаболизируется в организме. Выводится в
неизмененном виде: примерно 40 % - с мочой и 60 % - с желчью и потом.
Показания к применению
· Заболевания ЦНС различного генеза, особенно связанные с
нарушениями обменных процессов в мозге, интоксикацией (в частности, при
посттравматических состояниях), сопровождающиеся ухудшением
интеллектуально-мнестических функций, снижением двигательной активности;
· Психоорганические синдромы, проявляющиеся
интеллектуально-мнестическими нарушениями и апатико-абулическими явлениями, а
также вялоапатические состояния при шизофрении;
· Профилактика гипоксии, повышение устойчивости к стрессу,
коррекция функционального состояния организма в экстремальных условиях
профессиональной деятельности с целью предупреждения развития утомления и для
повышения умственной и физической работоспособности, коррекция суточного
биоритма, инверсия цикла «сон-бодрствование»;
·
Хронический
алкоголизм (с целью уменьшения интеллектуально-мнестических нарушений).
Противопоказания
Индивидуальная непереносимость;
Детский возраст до 18 лет (безопасность и
эффективность препарата не установлены).
С осторожностью
Больные
с тяжелыми органическими поражениями печени и почек, тяжелым течением
артериальной гипертензии, с выраженным атеросклерозом, перенесших ранее панические
атаки, острые психотические состояния, протекающие с психомоторным возбуждением
- вследствие возможности обострения тревоги, паники, галлюцинаций и бреда, а
также больные, склонные к аллергическим реакциям на ноотропные препараты группы
пирролидона.
Применение при беременности и в период грудного вскармливания
Не
следует назначать при беременности и кормлении грудью из-за отсутствия данных
клинических исследований.
Способ применения и дозы
Внутрь.
Принимать сразу после еды. Доза и
продолжительность лечения должны определяться врачом. Дозы варьируют в
зависимости от особенностей состояния больного. Средняя разовая доза составляет
150 мг (от 100 до 250 мг); средняя суточная доза - 250 мг (от 200 до 300 мг).
Максимальная допустимая доза - 750 мг/сут. Рекомендуется суточную дозу до 100
мг принимать однократно в утренние часы, а свыше 100 мг разделять на 2 приема.
Продолжительность лечения может варьировать от 2 недель до 3 мес., в среднем 30
дней. При необходимости курс может быть повторен через 1 мес.
Для повышения работоспособности - 100-200 мг
однократно в утренние часы, в течение 2 недель (для спортсменов - 3
дня).
Рекомендуемая длительность лечения для больных
с алиментарно-конституциональным ожирением составляет 30-60 дней в дозе 100-200
мг один раз в день (в утренние часы). Не рекомендуется принимать препарат
позднее 15 ч.
Побочное действие
Бессонница (в случае приема препарата позднее
15 ч). У некоторых больных в первые 1-3 дня приема возможны психомоторное
возбуждение, гиперемия кожных покровов, ощущение тепла, повышение артериального
давления.
Передозировка
Случаев передозировки не отмечалось.
Лечение:
симптоматическая терапия.
Взаимодействие с другими лекарственными средствами
Фонтурацетам может усиливать действие
препаратов, стимулирующих ЦНС и ноотропных препаратов.
Препарат проявляет выраженный антагонизм
каталептическому действию нейролептиков, а также ослабляет выраженность
снотворного действия этанола и гексобарбитала.
Особые указания
При чрезмерном психоэмоциональном
истощении на фоне стресса и утомления, хронической бессонницы, однократный
прием препарата в первые сутки может вызвать резкую потребность во сне. Таким
больным в амбулаторных условиях следует рекомендовать начинать курсовой прием
препарата в нерабочие дни.
Влияние на способность управлять автомобилем и движущимися механизмами
Следует соблюдать осторожность при управлении
транспортными средствами и механизмами, особенно в первые дни приема, учитывая
возможное возникновение сонливости (см. «Особые указания»).
Форма выпуска
Таблетки
50 мг и 100 мг.
По 10
таблеток в контурную ячейковую упаковку из пленки поливинилхлоридной и фольги
алюминиевой печатной лакированной.
По 1,
2, 3, 4 или 5 контурных ячейковых упаковок вместе с инструкцией по применению в
пачку из картона.
Условия хранения
В
защищенном от света месте при температуре не выше 30 °С.
Хранить
в недоступном для детей месте.
Срок годности
3
года. Не использовать после окончания срока, указанного на упаковке.
Условия отпуска
Отпускают
по рецепту.
Производитель
ЗАО «Обнинская химико-фармацевтическая
компания», Россия.
Организация, принимающая претензии потребителей
АО
«Валента Фарм».
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
Начните сравнивать цены и заказывать лекарства прямо в приложении
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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номер","slug":"","body":[{"type":"paragraph","data":{"text":"ЛП-004616"}}]},{"id":2,"name":"Лекарственная форма","slug":"","body":[{"type":"paragraph","data":{"text":"таблетки "}}]},{"id":3,"name":"Состав","slug":"ingredients","body":[{"type":"header","data":{"text":"на одну таблетку:","level":4}},{"type":"paragraph","data":{"text":"Действующее вещество:"}},{"type":"paragraph","data":{"text":"Фонтурацетам 50,00\nмг / 100,00\nмг"}},{"type":"paragraph","data":{"text":"Вспомогательные вещества:"}},{"type":"paragraph","data":{"text":"Повидон К-17 7,60\nмг / 15,20\nмг"}},{"type":"paragraph","data":{"text":"Микрокристаллическая целлюлоза 83,50 мг / 167,00\nмг"}},{"type":"paragraph","data":{"text":"Карбоксиметилкрахмал натрия 7,55\nмг / 15,10\nмг"}},{"type":"paragraph","data":{"text":"Магния стеарат 1,35\nмг / 2,70\nмг"}}]},{"id":4,"name":"Описание","slug":"common_description","body":[{"type":"paragraph","data":{"text":"Круглые\nплоскоцилиндрические таблетки от белого до белого с желтоватым оттенком цвета с\nфаской для дозировки 50 мг, с фаской и риской для дозировки 100 мг"}}]},{"id":5,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":"ноотропное средство"}}]},{"id":6,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":"\u003cb\u003eФармакодинамика\u003c/b\u003e\u003cb\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Ноотропный\nпрепарат, обладающий выраженным антиамнестическим действием, оказывает прямое\nактивирующее влияние на интегративную деятельность головного мозга,\nспособствует консолидации памяти, улучшает концентрацию внимания и умственную\nдеятельность, облегчает процесс обучения, повышает скорость передачи информации\nмежду полушариями головного мозга и устойчивость тканей мозга к токсическим\nвоздействиям, обладает противосудорожным действием и анксиолитической\nактивностью."}},{"type":"paragraph","data":{"text":"Оказывает\nположительное влияние на обменные процессы, стимулирует\nокислительно-восстановительные процессы, повышает энергетический потенциал\nорганизма за счет утилизации глюкозы. Повышает содержание норадреналина,\nдофамина и серотонина в мозге, не влияет на уровень содержания ГАМК, не\nсвязывается с ГАМК\u003csub\u003eА\u003c/sub\u003e и ГАМК\u003csub\u003eВ\u003c/sub\u003e рецепторами, не оказывает\nзаметного влияния на спонтанную биоэлектрическую активность мозга."}},{"type":"paragraph","data":{"text":"Не\nоказывает влияние на дыхание и сердечно-сосудистую систему, проявляет\nневыраженный диуретический эффект, обладает анорексигенной активностью при\nкурсовом применении."}},{"type":"paragraph","data":{"text":"Стимулирующее\nдействие проявляется в способности оказывать умеренно выраженный эффект,\nпроявляющийся в отношении двигательных реакций, повышении физической\nработоспособности, а также ослаблении выраженности снотворного действия этанола\nи гексобарбитала."}},{"type":"paragraph","data":{"text":"Психостимулирующее\nдействие преобладает в идеаторной сфере."}},{"type":"paragraph","data":{"text":"Умеренный\nпсихостимулирующий эффект препарата сочетается с анксиолитической активностью.\nОказывает некоторый анальгезирующий эффект, повышая порог болевой\nчувствительности."}},{"type":"paragraph","data":{"text":"Адаптогенное\nдействие проявляется в повышении устойчивости организма к стрессу в условиях\nчрезмерных психических и физических нагрузок, при утомлении, гипокинезии и\nиммобилизации, при низких температурах."}},{"type":"paragraph","data":{"text":"На\nфоне приема препарата отмечено улучшение зрения, которое проявляется в\nувеличении остроты, яркости и полей зрения."}},{"type":"paragraph","data":{"text":"Улучшает\nкровоснабжение нижних конечностей."}},{"type":"paragraph","data":{"text":"Стимулирует\nвыработку антител в ответ на введение антигена, что указывает на\nиммуностимулирующие свойства, но в то же время не способствует развитию\nгиперчувствительности немедленного типа и не изменяет аллергическую\nвоспалительную реакцию кожи, вызванную введением чужеродного белка."}},{"type":"paragraph","data":{"text":"При\nкурсовом применении не развивается лекарственная зависимость, толерантность,\n«синдром отмены»."}},{"type":"paragraph","data":{"text":"Действие\nпроявляется при однократной дозе, что важно при применении препарата в\nэкстремальных условиях."}},{"type":"paragraph","data":{"text":"Не\nобладает тератогенными, мутагенными, канцерогенными и эмбриотоксичными\nсвойствами. Имеет низкую токсичность, летальная доза в остром эксперименте\nсоставляет 800 мг/кг."}},{"type":"paragraph","data":{"text":"\u003ca\u003e\u003cb\u003eФармакокинетика\u003c/b\u003e\u003c/a\u003e\u003cb\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Быстро всасывается,\nпроникает в различные органы и ткани, легко проходит через гематоэнцефалический\nбарьер."}},{"type":"paragraph","data":{"text":"Абсолютная биодоступность\nпри пероральном приеме составляет 100 %."}},{"type":"paragraph","data":{"text":"Максимальная концентрация\nв крови (Тmax) достигается через 1 ч, период полувыведения (Т \u003csub\u003e1\u003c/sub\u003e\u003csub\u003e/2\u003c/sub\u003e) - 3-5 ч."}},{"type":"paragraph","data":{"text":"Не метаболизируется в организме. Выводится в\nнеизмененном виде: примерно 40 % - с мочой и 60 % - с желчью и потом."}}]},{"id":7,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"· Заболевания ЦНС различного генеза, особенно связанные с\nнарушениями обменных процессов в мозге, интоксикацией (в частности, при\nпосттравматических состояниях), сопровождающиеся ухудшением\nинтеллектуально-мнестических функций, снижением двигательной активности;"}},{"type":"paragraph","data":{"text":"· Невротические состояния, проявляющиеся вялостью, повышенной\nистощаемостью, снижением психомоторной активности, нарушением внимания,\nухудшением памяти;"}},{"type":"paragraph","data":{"text":"· Нарушения процесса обучения;"}},{"type":"paragraph","data":{"text":"· Психоорганические синдромы, проявляющиеся\nинтеллектуально-мнестическими нарушениями и апатико-абулическими явлениями, а\nтакже вялоапатические состояния при шизофрении;"}},{"type":"paragraph","data":{"text":"· Судорожные состояния;"}},{"type":"paragraph","data":{"text":"· Ожирение (алиментарно-конституционального генеза);"}},{"type":"paragraph","data":{"text":"· Профилактика гипоксии, повышение устойчивости к стрессу,\nкоррекция функционального состояния организма в экстремальных условиях\nпрофессиональной деятельности с целью предупреждения развития утомления и для\nповышения умственной и физической работоспособности, коррекция суточного\nбиоритма, инверсия цикла «сон-бодрствование»;"}},{"type":"paragraph","data":{"text":"· \nХронический\nалкоголизм (с целью уменьшения интеллектуально-мнестических нарушений)."}}]},{"id":8,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Индивидуальная непереносимость;"}},{"type":"paragraph","data":{"text":"Детский возраст до 18 лет (безопасность и\nэффективность препарата не установлены)."}}]},{"id":9,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Больные\nс тяжелыми органическими поражениями печени и почек, тяжелым течением\nартериальной гипертензии, с выраженным атеросклерозом, перенесших ранее панические\nатаки, острые психотические состояния, протекающие с психомоторным возбуждением\n- вследствие возможности обострения тревоги, паники, галлюцинаций и бреда, а\nтакже больные, склонные к аллергическим реакциям на ноотропные препараты группы\nпирролидона."}}]},{"id":10,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Не\nследует назначать при беременности и кормлении грудью из-за отсутствия данных\nклинических исследований."}}]},{"id":11,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь."}},{"type":"paragraph","data":{"text":"Принимать сразу после еды. Доза и\nпродолжительность лечения должны определяться врачом. Дозы варьируют в\nзависимости от особенностей состояния больного. Средняя разовая доза составляет\n150 мг (от 100 до 250 мг); средняя суточная доза - 250 мг (от 200 до 300 мг).\nМаксимальная допустимая доза - 750 мг/сут. Рекомендуется суточную дозу до 100\nмг принимать однократно в утренние часы, а свыше 100 мг разделять на 2 приема.\nПродолжительность лечения может варьировать от 2 недель до 3 мес., в среднем 30\nдней. При необходимости курс может быть повторен через 1 мес."}},{"type":"paragraph","data":{"text":"Для повышения работоспособности - 100-200 мг\nоднократно в утренние часы, в течение 2 недель (для спортсменов - 3\nдня)."}},{"type":"paragraph","data":{"text":"Рекомендуемая длительность лечения для больных\nс алиментарно-конституциональным ожирением составляет 30-60 дней в дозе 100-200\nмг один раз в день (в утренние часы). Не рекомендуется принимать препарат\nпозднее 15 ч."}}]},{"id":12,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Бессонница (в случае приема препарата позднее\n15 ч). У некоторых больных в первые 1-3 дня приема возможны психомоторное\nвозбуждение, гиперемия кожных покровов, ощущение тепла, повышение артериального\nдавления."}}]},{"id":13,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Случаев передозировки не отмечалось."}},{"type":"paragraph","data":{"text":"Лечение:\nсимптоматическая терапия."}}]},{"id":14,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Фонтурацетам может усиливать действие\nпрепаратов, стимулирующих ЦНС и ноотропных препаратов."}},{"type":"paragraph","data":{"text":"Препарат проявляет выраженный антагонизм\nкаталептическому действию нейролептиков, а также ослабляет выраженность\nснотворного действия этанола и гексобарбитала."}}]},{"id":15,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"При чрезмерном психоэмоциональном\nистощении на фоне стресса и утомления, хронической бессонницы, однократный\nприем препарата в первые сутки может вызвать резкую потребность во сне. Таким\nбольным в амбулаторных условиях следует рекомендовать начинать курсовой прием\nпрепарата в нерабочие дни."}}]},{"id":16,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Следует соблюдать осторожность при управлении\nтранспортными средствами и механизмами, особенно в первые дни приема, учитывая\nвозможное возникновение сонливости (см. «Особые указания»)."}}]},{"id":17,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки\n50 мг и 100 мг."}},{"type":"paragraph","data":{"text":"По 10\nтаблеток в контурную ячейковую упаковку из пленки поливинилхлоридной и фольги\nалюминиевой печатной лакированной."}},{"type":"paragraph","data":{"text":"По 1,\n2, 3, 4 или 5 контурных ячейковых упаковок вместе с инструкцией по применению в\nпачку из картона."}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В\nзащищенном от света месте при температуре не выше 30 °С."}},{"type":"paragraph","data":{"text":"Хранить\nв недоступном для детей месте."}}]},{"id":19,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3\nгода. Не использовать после окончания срока, указанного на упаковке."}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают\nпо рецепту."}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ЗАО «Обнинская химико-фармацевтическая\nкомпания», Россия."}}]},{"id":22,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"АО\n«Валента Фарм»."}}]}],"source":null},"description_toggle":false,"short_description":"ФармакодинамикаНоотропный препарат, обладающий выраженным антиамнестическим действием, оказывает прямое активирующее влияние на интегративную деятельность головного мозга, способствует консолидации памяти, улучшает концентрацию внимания и умственную деятельность, облегчает процесс обучения, повышает скорость передачи информации между полушариями головного мозга и устойчивость тканей мозга к токсическим воздействиям, обладает противосудорожным действием и анксиолитической активностью. Оказывает положительное влияние на обменные процессы, стимулирует окислительно-восстановительные процессы, повышает энергетический потенциал организма за счет утилизации глюкозы. Повышает содержание норадреналина, дофамина и серотонина в мозге, не влияет на уровень содержания ГАМК, не связывается с ГАМКАи ГАМКВрецепторами, не оказывает заметного влияния на спонтанную биоэлектрическую активность мозга. Не оказывает влияние на дыхание и сердечно-сосудистую систему, проявляет невыраженный диуретический эффект, обладает анорексигенной активностью при курсовом применении. Стимулирующее действие проявляется в способности оказывать умеренно выраженный эффект, проявляющийся в отношении двигательных реакций, повышении физической работоспособности, а также ослаблении выраженности снотворного действия этанола и гексобарбитала. Психостимулирующее действие преобладает в идеаторной сфере. Умеренный психостимулирующий эффект препарата сочетается с анксиолитической активностью. Оказывает некоторый анальгезирующий эффект, повышая порог болевой чувствительности. Адаптогенное действие проявляется в повышении устойчивости организма к стрессу в условиях чрезмерных психических и физических нагрузок, при утомлении, гипокинезии и иммобилизации, при низких температурах. На фоне приема препарата отмечено улучшение зрения, которое проявляется в увеличении остроты, яркости и полей зрения. Улучшает кровоснабжение нижних конечностей. Стимулирует выработку антител в ответ на введение антигена, что указывает на иммуностимулирующие свойства, но в то же время не способствует развитию гиперчувствительности немедленного типа и не изменяет аллергическую воспалительную реакцию кожи, вызванную введением чужеродного белка. При курсовом применении не развивается лекарственная зависимость, толерантность, «синдром отмены». Действие проявляется при однократной дозе, что важно при применении препарата в экстремальных условиях. Не обладает тератогенными, мутагенными, канцерогенными и эмбриотоксичными свойствами. Имеет низкую токсичность, летальная доза в остром эксперименте составляет 800 мг/кг.ФармакокинетикаБыстро всасывается, проникает в различные органы и ткани, легко проходит через гематоэнцефалический барьер. Абсолютная биодоступность при пероральном приеме составляет 100 %. Максимальная концентрация в крови (Тmax) достигается через 1 ч, период полувыведения (Т1/2) - 3-5 ч. Не метаболизируется в организме. 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