Новатрон Раствор, 10 шт, 2.5 мл, 1 мг / мл, для ингаляций

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Практически не оказывает действия на\nбета1-адренорецепторы сердца."}},{"type":"paragraph","data":{"text":"Оказывает выраженный\nбронхолитический эффект, предупреждая или купируя спазм бронхов, снижает\nсопротивление в дыхательных путях, увеличивает жизненную емкость легких.\nУвеличивает мукоцилиарный клиренс (при хроническом бронхите до 36 %),\nстимулирует секрецию слизи, активирует функции мерцательного эпителия. Может приводить\nк снижению числа бета-адренорецепторов. Обладает рядом метаболических эффектов:\nснижает концентрацию ионов калия в плазме, влияет на гликогенолиз и выделение\nинсулина, оказывает гипергликемический (особенно у пациентов с бронхиальной\nастмой) и липолитический эффект, увеличивает риск развития ацидоза."}},{"type":"paragraph","data":{"text":"В рекомендуемых\nтерапевтических дозах не оказывает отрицательного влияния на\nсердечно-сосудистую систему, не вызывает повышения артериального давления. В\nменьшей степени, по сравнению с лекарственными средствами этой группы,\nоказывает положительное хроно- и инотропное действие. Вызывает расширение\nкоронарных артерий. После применения ингаляционных форм действие развивается быстро,\nначало эффекта – через 5 минут, максимум – через 30-90 минут (75 %\nмаксимального эффекта достигается в течение 5 минут), продолжительность – 3-6\nчасов."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eФармакокинетика\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Во время\nингаляции 10-20 % ингалируемой дозы достигает мелких бронхов, остальная часть оседает в верхних отделах дыхательных путей.\nПосле ингаляционного применения системная абсорбция – быстрая, но низкая. Связь\nс белками плазмы – 10 %. Проникает через плаценту. Подвергается пресистемному\nметаболизму в печени и в кишечной стенке, посредством фенолсульфотрансферазы инактивируется. Период полувыведения\n(Т\u003csub\u003e1/2\u003c/sub\u003e) – 4-6 ча-сов.\nВыводится почками (69-90 %), преимущественно в виде неактивного фенолсульфат-ного\nметаболита (60 %) в течение 72 часов и с желчью (4 %)."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Профилактика и\nкупирование бронхоспазма при бронхиальной астме, симптоматическое лечение бронхообструктивного\nсиндрома (в том числе при хроническом бронхите и эмфиземе легких), обратимая\nбронхиальная обструкция (профилактика и лечение), включая хроническую обструктивную\nболезнь легких."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Гиперчувствительность,\nдетский возраст до 18 месяцев."}},{"type":"paragraph","data":{"text":"Препарат не\nприменяется при преждевременных родах и при угрозе аборта."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Тахиаритмия, миокардит,\nпороки сердца, аортальный стеноз, ишемическая болезнь сердца, тяжелая хроническая\nсердечная недостаточность, артериальная гипертензия, тиреотоксикоз,\nфеохромоцитома, декомпенсированный сахарный диабет, глаукома, беременность,\nпериод грудного вскармливания."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Не\nрекомендуется назначать сальбутамол в период беременности и грудного\nвскармливания за исключением тех случаев, когда ожидаемая польза для матери\nпревышает любой возможный риск для плода или ребенка."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Препарат Новатрон применяют ингаляционно с\nпомощью ингаляторов-небулайзеров    (см.\nраздел «Порядок работы с препаратом» настоящей инструкции)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eВзрослые, в том числе пожилые, и дети\nстарше 18 месяцев: \u003c/i\u003eобычная разовая        доза – 2,5 мг, при применении 3-4 раза\nв сутки с помощью ингаляций через небулайзер. В случае необходимости доза может\nбыть увеличена до 5 мг 3-4 раза в день."}},{"type":"paragraph","data":{"text":"Для\nлечения тяжелой обструкции дыхательных путей у взрослых пациентов могут\nприменяться более высокие дозы – до 40 мг/сут под строгим медицинским контролем\nв условиях стационара."}},{"type":"paragraph","data":{"text":"\u003cb\u003eПорядок работы с препаратом:\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"1.\nПеред использованием препарата необходимо прочитать инструкцию производителя\nнебулайзера."}},{"type":"paragraph","data":{"text":"2. Подготовить небулайзер\nсогласно инструкции производителя."}},{"type":"paragraph","data":{"text":"3. Взять\nампулу и встряхнуть ее, удерживая за горлышко"}},{"type":"paragraph","data":{"text":"4. Сдавить\nампулу рукой, при этом не должно происходить выделение препарата, и вращающими\nдвижениями повернуть и отделить клапан"}},{"type":"paragraph","data":{"text":"5. Выдавить раствор в резервуар небулайзера"}},{"type":"paragraph","data":{"text":"6.\nИспользовать небулайзер согласно инструкции его производителя."}},{"type":"paragraph","data":{"text":"7. Раствор, оставшийся\nнеиспользованным в камере небулайзера, следует вылить сразу же после каждого\nиспользования."}},{"type":"paragraph","data":{"text":"8. Тщательно вымыть небулайзер. "}},{"type":"paragraph","data":{"text":"При использовании препарата следует\nизбегать попадания раствора в глаза."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Побочное\nдействие, приведенное ниже, классифицировано по органам и системам, а также по\nчастоте его возникновения: очень часто (≥ 1/10), часто (≥ 1/100, < 1/10),\nнечасто (≥ 1/1000,"}},{"type":"paragraph","data":{"text":"\n< 1/100), редко (≥ 1/10000, < 1/1000), очень редко (< 1/10000, включая\nединичные случаи)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны иммунной системы:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Очень редко: реакции\nгиперчувствительности, которые включали в себя ангионевро-тический отек,\nкрапивницу, бронхоспазм, гипотензию и коллапс."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны обмена веществ:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Редко: гипокалиемия, гипергликемия."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны нервной системы:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Часто: тремор, головная боль."}},{"type":"paragraph","data":{"text":"Очень редко: гиперактивность."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны сердечно-сосудистой системы:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Часто: тахикардия."}},{"type":"paragraph","data":{"text":"Нечасто: усиленное сердцебиение,\nишемия миокарда."}},{"type":"paragraph","data":{"text":"Очень редко: нарушение сердечного\nритма, включая фибрилляцию предсердий, суправентрикулярную тахикардию и\nэкстрасистолию."}},{"type":"paragraph","data":{"text":"Редко: периферическая вазодилатация."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны дыхательной системы:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Очень редко: парадоксальный\nбронхоспазм."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны желудочно-кишечного тракта:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Нечасто: раздражение слизистых\nоболочек полости рта и глотки."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны скелетно-мышечной системы:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Нечасто: мышечные судороги."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСимптомы\u003c/i\u003e\nострого отравления при ингаляционном применении: более частые – гипергликемия,\nгипокалиемия, снижение артериального давления (АД), лактоацидоз, тахикардия,\nмышечный тремор, тошнота, рвота; менее частые – возбуждение, респираторный\nалкалоз; редкие – галлюцинации, паранойя, судороги, тахиаритмия."}},{"type":"paragraph","data":{"text":"Симптомы хронической\nинтоксикации при ингаляционном применении: более частые – снижение АД,\nтахикардия, тремор, рвота; менее частые – возбуждение; редкие – судороги,\nтахиаритмия."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение:\u003c/i\u003e симптоматическое; при тахикардии вводят кардиоселективные\nбета1-адреноблокаторы. Назначение бета1-адреноблокаторов (селективных) у пациентов\nс бронхиальной астмой требует крайней осторожности из-за опасности\nвозникновения бронхоспазма."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Несовместим (фармакологический\nантагонизм) с неселективными бета-адреноблокаторами (что необходимо также\nучитывать при применении глазных форм бета-адреноблокаторов)."}},{"type":"paragraph","data":{"text":"Вследствие гипокалиемического эффекта\nсальбутамол усиливает действие стимуляторов центральной нервной системы,\nусиливает кардиотропное действие гормонов щитовидной железы, повышает вероятность\nгликозидной интоксикации."}},{"type":"paragraph","data":{"text":"Теофиллин и другие ксантины при\nодновременном применении с сальбутамолом повышают вероятность развития\nтахиаритмий; средства для ингаляционной анестезии, леводопа – тяжелых\nжелудочковых аритмий."}},{"type":"paragraph","data":{"text":"Возможное увеличение числа сердечных\nсокращений и повышение артериального давления на фоне приема сальбутамола может\nобусловить необходимость коррекции дозы гипотензивных и антиангинальных\nпрепаратов."}},{"type":"paragraph","data":{"text":"Ингибиторы моноаминооксидазы и\nтрициклические антидепрессанты могут усилить бета-адренергическое действие\nсальбутамола и привести к резкому снижению артериального давления."}},{"type":"paragraph","data":{"text":"Диуретики и глюкокортикостероидные\nпрепараты усиливают гипокалиемический эффект сальбутамола."}},{"type":"paragraph","data":{"text":"Одновременное применение с м-холиноблокаторами\n(в том числе ингаляционными) может способствовать повышению внутриглазного\nдавления."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Бронходилататоры не должны являться\nединственным или основным компонентом терапии бронхиальной астмы нестабильного\nили тяжелого течения."}},{"type":"paragraph","data":{"text":"Пациентов, применяющих препарат Новатрон в домашних условиях, необходимо\nпредупредить о том, что, если действие обычной дозы становится менее эффективным\nили менее продолжительным, нельзя самостоятельно увеличивать дозу или частоту\nприменения препарата, а следует немедленно обратиться к врачу."}},{"type":"paragraph","data":{"text":"При использовании препарата следует\nизбегать попадания раствора в глаза."}},{"type":"paragraph","data":{"text":"Как и в случае с другими\nсредствами ингаляционной терапии, могут наблюдаться случаи парадоксального\nбронхоспазма. В этом случае необходимо немедленно прекратить прием препарата с\nназначением альтернативного лечения. Растворы, не соответствующие нейтральному\nуровню рН, у некоторых пациентов могут служить причиной возникновения\nпарадоксального бронхоспазма."}},{"type":"paragraph","data":{"text":"Сообщалось о\nредких случаях развития лактоацидоза, связанных с   применением высоких доз бета2-адреномиметиков\nкороткого действия с помощью небулайзера, в основном у пациентов с обострением\nбронхиальной астмы. Увеличение концентрации лактата может привести к одышке и\nкомпенсаторной гипервентиляции легких, которые могут быть неверно истолкованы\nкак признаки неудачного лечения бронхиальной астмы и привести к необоснованному\nувеличению назначения бета2-адреномиметиков короткого действия. Поэтому\nрекомендуется контролировать концентрацию лактата в сыворотке крови, а также\nследить за возможным последующим развитием метаболического ацидоза."}},{"type":"paragraph","data":{"text":"Сальбутамол следует\nс осторожностью назначать пациентам с тиреотоксикозом."}},{"type":"paragraph","data":{"text":"Лечение\nбета2-адреномиметиками может привести к значительной гипокалиемии. Особую\nосторожность следует проявлять в случаях тяжелой бронхиальной астмы, поскольку\nвозникновению гипокалиемии может способствовать сопутствующее лечение\nпроизводными ксантина, глюкокортикостероидами, мочегонными средствами, а также\nгипоксия. В таких ситуациях рекомендуется контролировать уровень калия в\nсыворотке."}},{"type":"paragraph","data":{"text":"Не\nследует применять препарат Новатрон для предупреждения преждевременных родов\nи при угрозе выкидыша."}},{"type":"paragraph","data":{"text":"Сальбутамол может вызывать обратимые метаболические изменения, например,\nувеличение концентрации глюкозы в крови. У пациентов с сахарным диабетом\nвозможно развитие декомпенсации, в ряде случаев сообщалось о развитии\nкетоацидоза. Одновременное применение глюкокортикостероидов может усилить этот\nэффект."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"В случае возникновения побочных реакций\nпациентам рекомендуется воздержаться от управления автомобилем и другими\nмеханизмами, а также соблюдать осторожность при занятии видами деятельности,\nтребующими повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Раствор для ингаляций 1 мг/мл и 2\nмг/мл."}},{"type":"paragraph","data":{"text":"По 2,5\nмл в ампулы из полиэтилена низкой плотности."}},{"type":"paragraph","data":{"text":"По 10 ампул в пакете из\nфольгированной пленки."}},{"type":"paragraph","data":{"text":"По 1, 2, 3 или 6 пакетов из\nфольгированной пленки вместе с инструкцией по медицинскому применению в пачке\nиз картона."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить при температуре не\nвыше 25 ºС. "}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей\nместе."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"После вскрытия пакета  ̶  3\nмесяца."}},{"type":"paragraph","data":{"text":"Не применять после окончания\nсрока годности!"}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают по рецепту."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ООО «Гротекс»"}},{"type":"paragraph","data":{"text":"Россия, 195279, Санкт-Петербург"}},{"type":"paragraph","data":{"text":"Индустриальный пр., д. 71, к. 2, лит. А"}},{"type":"paragraph","data":{"text":"Тел.: +7 812 385 47 87"}},{"type":"paragraph","data":{"text":"Факс: +7 812 385 47 88"}},{"type":"paragraph","data":{"text":"\u003ca href=\"http://www.solopharm.com\"\u003ewww.solopharm.com\u003c/a\u003e"}},{"type":"paragraph","data":{"text":"www.\u003ca href=\"http://elafin.ru\"\u003enovatron-solo.ru\u003c/a\u003e"}}]}],"source":null},"description_toggle":false,"short_description":"ФармакодинамикаБронхолитическое средство, в терапевтических дозах оказывает выраженное стимулирующее действие на бета2-адренорецепторы бронхов, кровеносных сосудов и миометрия. Практически не оказывает действия на бета1-адренорецепторы сердца. Оказывает выраженный бронхолитический эффект, предупреждая или купируя спазм бронхов, снижает сопротивление в дыхательных путях, увеличивает жизненную емкость легких. Увеличивает мукоцилиарный клиренс (при хроническом бронхите до 36 %), стимулирует секрецию слизи, активирует функции мерцательного эпителия. Может приводить к снижению числа бета-адренорецепторов. Обладает рядом метаболических эффектов: снижает концентрацию ионов калия в плазме, влияет на гликогенолиз и выделение инсулина, оказывает гипергликемический (особенно у пациентов с бронхиальной астмой) и липолитический эффект, увеличивает риск развития ацидоза. В рекомендуемых терапевтических дозах не оказывает отрицательного влияния на сердечно-сосудистую систему, не вызывает повышения артериального давления. В меньшей степени, по сравнению с лекарственными средствами этой группы, оказывает положительное хроно- и инотропное действие. Вызывает расширение коронарных артерий. После применения ингаляционных форм действие развивается быстро, начало эффекта – через 5 минут, максимум – через 30-90 минут (75 % максимального эффекта достигается в течение 5 минут), продолжительность – 3-6 часов.ФармакокинетикаВо время ингаляции 10-20 % ингалируемой дозы достигает мелких бронхов, остальная часть оседает в верхних отделах дыхательных путей. После ингаляционного применения системная абсорбция – быстрая, но низкая. Связь с белками плазмы – 10 %. Проникает через плаценту. Подвергается пресистемному метаболизму в печени и в кишечной стенке, посредством фенолсульфотрансферазы инактивируется. Период полувыведения (Т1/2) – 4-6 ча-сов. Выводится почками (69-90 %), преимущественно в виде неактивного фенолсульфат-ного метаболита (60 %) в течение 72 часов и с желчью (4 %).","substance":[{"id":741,"title":"Сальбутамол","title_latin":"Salbutamolum","slug":"salbutamol_741"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":null,"image_alt":"Новатрон - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/62308/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/62308/share_default/"}},"diseases":[],"other_packages":[],"other_product_forms":[],"related_products":{"title":"Аналоги","type":"analogs","products":[{"id":150904,"title":"Сальбутамол-Тева","subtitle":{"full":"Аэрозоль, баллон, 200 д, 0.1 мг / доза, для ингаляций, дозированный","short":"Аэрозоль, 200 д, 0.1 мг / доза","package":"200 д, 0.1 мг / 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