Энцетрон-СОЛОфарм Раствор, 5 шт, 10 мл, 100 мг / мл, для приема внутрь

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В остром периоде инсульта цитиколин\nуменьшает объем поражения ткани головного мозга, улучшает холинергическую\nпередачу. При черепно-мозговой травме уменьшает длительность посттравматической\nкомы и выраженность неврологических симптомов, кроме этого, способствует\nуменьшению продолжительности восстановительного периода."}},{"type":"paragraph","data":{"text":"При\nхронической гипоксии головного мозга цитиколин эффективен в лечении когнитивных\nрасстройств, таких как ухудшение памяти, безынициативность, затруднения, возникающие\nпри выполнении повседневных действий и самообслуживании. Повышает уровень\nвнимания и сознания, а также уменьшает проявление амнезии."}},{"type":"paragraph","data":{"text":"Цитиколин\nэффективен в лечении чувствительных и двигательных неврологических нарушений\nдегенеративной и сосудистой этиологии."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eФармакокинетика\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eВсасывание\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Цитиколин хорошо\nабсорбируется при приеме внутрь. Абсорбция после перорального применения\nпрактически полная, а биодоступность практически такая же, как и после\nвнутривенного введения."}},{"type":"paragraph","data":{"text":"\u003ci\u003eМетаболизм\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Цитиколин\nметаболизируется в кишечнике и печени с образованием холина и цитидина. После\nприема концентрация холина в плазме крови существенно повышается."}},{"type":"paragraph","data":{"text":"\u003ci\u003eРаспределение\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Цитиколин в значительной\nстепени распределяется в структурах головного мозга, с быстрым внедрением\nфракций холина в структурные фосфолипиды и фракции цитидина – в цитидиновые\nнуклеотиды и нуклеиновые кислоты. Достигнув головного мозга, цитиколин\nвстраивается в клеточные, цитоплазматические и митохондриальные мембраны,\nпринимая участие в построении фракции фосфолипидов."}},{"type":"paragraph","data":{"text":"\u003ci\u003eВыведение\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Только\n15 % введенной дозы цитиколина выводится из организма человека: менее 3 % –\nпочками и около 12 % – с выдыхаемым СО\u003csub\u003e2\u003c/sub\u003e. В выведении препарата с\nмочой выделяют две фазы: первая фаза – около 36 ч, в которой скорость выведения\nснижается быстро, и вторая фаза, в которой скорость выведения снижается намного\nмедленнее. Такая же фазность наблюдается при выведении с СО\u003csub\u003e2\u003c/sub\u003e,\nскорость выведения выдыхаемого СО\u003csub\u003e2\u003c/sub\u003e быстро снижается приблизительно\nчерез 15 ч, в дальнейшем она снижается намного медленнее."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Острый период\n ишемического инсульта (в составе комплексной терапии)."}},{"type":"paragraph","data":{"text":"Восстановительный\n период ишемического и геморрагического инсультов."}},{"type":"paragraph","data":{"text":"Черепно-мозговая\n травма, острый (в составе комплексной терапии) и восстановительный период."}},{"type":"paragraph","data":{"text":"Когнитивные и поведенческие\n нарушения при дегенеративных и сосудистых заболеваниях головного мозга."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"-Повышенная\n чувствительность к любому из компонентов препарата."}},{"type":"paragraph","data":{"text":"-Не следует назначать\n пациентам с выраженной ваготонией (высоким тонусом парасимпатической части\n вегетативной нервной системы)."}},{"type":"paragraph","data":{"text":"-В связи с отсутствием\n достаточных клинических данных не рекомендуется применять у детей до 18 лет. "}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Отсутствуют\nдостаточные данные по применению цитиколина у беременных женщин. В период\nбеременности цитиколин назначают только в тех случаях, когда ожидаемая польза\nдля матери превышает потенциальный риск для плода."}},{"type":"paragraph","data":{"text":"При\nприменении цитиколина в период лактации женщинам следует решить вопрос о\nпрекращении грудного вскармливания, поскольку данные об экскреции цитиколина в\nгрудное молоко отсутствуют."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Раствор для\nприема внутрь, применяется перорально."}},{"type":"paragraph","data":{"text":"Перед\nприменением препарат можно развести в небольшом количестве воды (100-120 мл или\n1/2 стакана). Принимают во время еды или между приемами пищи."}},{"type":"paragraph","data":{"text":"Рекомендуемый\nрежим дозирования"}},{"type":"paragraph","data":{"text":"\u003ci\u003eОстрый период ишемического инсульта или\nчерепно-мозговой травмы (ЧМТ): \u003c/i\u003e1000 мг (10 мл) каждые 12 ч. Длительность лечения\n– не менее 6 недель."}},{"type":"paragraph","data":{"text":"\u003ci\u003eВосстановительный период\nишемического и геморрагического инсультов, восстановительный период ЧМТ,\nкогнитивные и поведенческие нарушения при дегенеративных и сосудистых\nзаболеваниях головного мозга: \u003c/i\u003e500-2000 мг (5-20 мл) в\nдень. Дозировка и длительность лечения – в зависимости от тяжести симптомов\nзаболевания. "}},{"type":"paragraph","data":{"text":"Пожилые\nпациенты"}},{"type":"paragraph","data":{"text":"При\nназначении цитиколина пожилым пациентам коррекции дозы не требуется."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Побочные действия сгруппированы по\nчастоте появления: очень часто (≥ 1/10), часто (≥ 1/100 до ˂ 1/10),\nнечасто (≥ 1/1000 до ˂ 1/100), редко (≥ 1/10000 до ˂ 1/1000), очень редко (˂ 1/10000),\nчастота не установлена."}},{"type":"paragraph","data":{"text":"\u003ci\u003eОчень редко (˂ 1/10000 (включая индивидуальные случаи)):\u003c/i\u003e аллергические реакции (сыпь, кожный\nзуд, анафилактический шок), головная боль, головокружение, чувство жара.\nТремор, тошнота, рвота, диарея, галлюцинации, отеки, одышка, бессонница,\nвозбуждение, снижение аппетита, онемение в парализованных конечностях,\nизменение активности печеночных ферментов. В некоторых случаях цитиколин может\nстимулировать парасимпатическую систему, а также оказывать кратковременное\nизменение артериального давления."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЕсли любые из указанных в инструкции побочных эффектов усугубляются или\nВы заметили любые другие побочные эффекты, не указанные в инструкции, сообщите\nврачу.\u003c/i\u003e"}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"С учетом низкой\nтоксичности препарата случаи передозировки не описаны, даже в случае превышения\nтерапевтических доз."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Цитиколин усиливает\nэффекты леводопы."}},{"type":"paragraph","data":{"text":"Не следует применять\nодновременно с лекарственными средствами, содержащими меклофеноксат."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Во время применения\nпрепарата следует соблюдать осторожность при управлении транспортом и при\nзанятиях другими потенциально опасными видами деятельности, требующими\nповышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Раствор для приема внутрь\n100 мг/мл."}},{"type":"paragraph","data":{"text":"По 5 или 10 мл в ампулы\nиз полиэтилена низкой плотности (Политвист). По 3 или 5 ампул в пакете из\nфольгированной пленки или без него. По\n1 пакету из фольгированной пленки с 3 или 5 ампулами или по 2 пакета из\nфольгированной пленки с 3 или 5 ампулами или по 3, 5, 6 или 10 ампул вместе с\nинструкцией по применению в пачке из картона."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"При\nтемпературе не выше 30 ºС. "}},{"type":"paragraph","data":{"text":"Хранить в недоступном для\nдетей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Не применять\nпосле окончания срока годности!"}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают по\nрецепту."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ООО «Гротекс»"}},{"type":"paragraph","data":{"text":"Россия, 195279, Санкт-Петербург"}},{"type":"paragraph","data":{"text":"Индустриальный пр., д. 71, к. 2, лит. А"}},{"type":"paragraph","data":{"text":"Тел.: +7 812 385 47 87"}},{"type":"paragraph","data":{"text":"Факс: +7 812 385 47 88"}},{"type":"paragraph","data":{"text":"\u003ca href=\"http://www.solopharm.com\"\u003ewww.solopharm.com\u003c/a\u003e"}},{"type":"paragraph","data":{"text":"www.encetron.ru"}}]}],"source":null},"description_toggle":false,"short_description":"ФармакодинамикаЦитиколин – природное эндогенное соединение, которое является промежуточным метаболитом в синтезе фосфатидилхолина – одного из основных структурных компонентов клеточной мембраны. Цитиколин обладает широким спектром действия: способствует восстановлению поврежденных мембран клеток, ингибирует действие фосфолипаз, препятствует избыточному образованию свободных радикалов, а также предотвращает гибель клеток, воздействуя на механизмы апоптоза. В остром периоде инсульта цитиколин уменьшает объем поражения ткани головного мозга, улучшает холинергическую передачу. При черепно-мозговой травме уменьшает длительность посттравматической комы и выраженность неврологических симптомов, кроме этого, способствует уменьшению продолжительности восстановительного периода. При хронической гипоксии головного мозга цитиколин эффективен в лечении когнитивных расстройств, таких как ухудшение памяти, безынициативность, затруднения, возникающие при выполнении повседневных действий и самообслуживании. Повышает уровень внимания и сознания, а также уменьшает проявление амнезии. Цитиколин эффективен в лечении чувствительных и двигательных неврологических нарушений дегенеративной и сосудистой этиологии.ФармакокинетикаВсасываниеЦитиколин хорошо абсорбируется при приеме внутрь. Абсорбция после перорального применения практически полная, а биодоступность практически такая же, как и после внутривенного введения.МетаболизмЦитиколин метаболизируется в кишечнике и печени с образованием холина и цитидина. После приема концентрация холина в плазме крови существенно повышается.РаспределениеЦитиколин в значительной степени распределяется в структурах головного мозга, с быстрым внедрением фракций холина в структурные фосфолипиды и фракции цитидина – в цитидиновые нуклеотиды и нуклеиновые кислоты. Достигнув головного мозга, цитиколин встраивается в клеточные, цитоплазматические и митохондриальные мембраны, принимая участие в построении фракции фосфолипидов.ВыведениеТолько 15 % введенной дозы цитиколина выводится из организма человека: менее 3 % – почками и около 12 % – с выдыхаемым СО2. В выведении препарата с мочой выделяют две фазы: первая фаза – около 36 ч, в которой скорость выведения снижается быстро, и вторая фаза, в которой скорость выведения снижается намного медленнее. Такая же фазность наблюдается при выведении с СО2, скорость выведения выдыхаемого СО2быстро снижается приблизительно через 15 ч, в дальнейшем она снижается намного медленнее.","substance":[],"branding":null,"valid_for_quick_buy":false,"is_available_to_delivery":false,"comments":null,"image_alt":"Энцетрон-СОЛОфарм - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/62331/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/62331/share_default/"}},"diseases":[],"other_packages":[{"id":152971,"title":"Энцетрон-СОЛОфарм","subtitle":{"full":"Раствор, 10 шт, 10 мл, 100 мг / мл, для приема внутрь","short":"Раствор, 10 шт, 10 мл, 100 мг / мл","package":"10 шт, 10 мл, 100 мг / 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