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"}},{"type":"paragraph","data":{"text":"\u003ci\u003eКофеин \u003c/i\u003eстимулирует\nпсихомоторные центры головного мозга, оказывает аналептическое действие,\nусиливает эффект анальгетиков, устраняет сонливость и чувство усталости,\nповышает физическую и умственную работоспособность."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eФармакокинетика\u003c/i\u003e\u003c/b\u003e\u003ci\u003e \u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eВсасывание и\nраспределение\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eПарацетамол \u003c/i\u003eбыстро и практически полностью всасывается из\nжелудочно-кишечного тракта, распределяется в жидкостях организма относительно\nравномерно."}},{"type":"paragraph","data":{"text":"Связывание парацетамола с белками плазмы минимально при\nтерапевтической концентрации."}},{"type":"paragraph","data":{"text":"\u003ci\u003eКофеин\u003c/i\u003e полностью\u003ci\u003e \u003c/i\u003eи\nбыстро всасывается из желудочно-кишечного тракта и распределяется по всему\nорганизму."}},{"type":"paragraph","data":{"text":"\u003ci\u003eМетаболизм\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eПарацетамол\u003c/i\u003e метаболизируется в печени и выводится с мочой в виде\nглюкуронидных и сульфатных метаболитов – меньше, чем на 5% выводится в виде\nнеизменного парацетамола. "}},{"type":"paragraph","data":{"text":"\u003ci\u003eКофеин \u003c/i\u003eпочти полностью метаболизируется в печени путем окисления и\nдеметилирования в виде метаболитов, которые выводятся с мочой."}},{"type":"paragraph","data":{"text":"\u003ci\u003eВыведение\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Средний период полувыведения \u003ci\u003eпарацетамола \u003c/i\u003eпри приеме терапевтической дозы составляет около 2-3\nчасов."}},{"type":"paragraph","data":{"text":"Средний период полувыведения \u003ci\u003eкофеина\u003c/i\u003e при приеме терапевтической дозы составляет"}},{"type":"paragraph","data":{"text":"\n4-9 часов."}}]},{"id":7,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Препарат\nСтрайк Плюс применяют у взрослых и детей старше 12 лет в качестве:"}},{"type":"paragraph","data":{"text":"·       обезболивающего средства (при\nболевом синдроме слабой и умеренной интенсивности) при:"}},{"type":"paragraph","data":{"text":"-       \nзубной боли, в том\nчисле при удалении зубов и после проведения стоматологических вмешательств;"}},{"type":"paragraph","data":{"text":"-       \nголовной боли и\nмигрени; "}},{"type":"paragraph","data":{"text":"-       \nболи в горле;"}},{"type":"paragraph","data":{"text":"-       \nболи в мышцах и\nсуставах;"}},{"type":"paragraph","data":{"text":"-       \nболи, обусловленной\nостеоартритом;"}},{"type":"paragraph","data":{"text":"-       \nболях в пояснице;"}},{"type":"paragraph","data":{"text":"-       \nневралгии;"}},{"type":"paragraph","data":{"text":"-       \nболезненных менструациях\n(дисменорее)."}},{"type":"paragraph","data":{"text":"·      \nв качестве симптоматического\nлечения для снижения повышенной температуры тела при:"}},{"type":"paragraph","data":{"text":"-       \nострых респираторных и\nострых респираторных вирусных заболеваниях, в том числе гриппе;"}},{"type":"paragraph","data":{"text":"-       \nпосле проведения\nвакцинации."}}]},{"id":8,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"·      \nповышенная чувствительность\nк парацетамолу, кофеину или любому другому компоненту препарата;"}},{"type":"paragraph","data":{"text":"·      \nвыраженные нарушения\nфункции печени; "}},{"type":"paragraph","data":{"text":"·      \nвыраженные нарушения\nфункции почек;"}},{"type":"paragraph","data":{"text":"·      \nартериальная\nгипертензия;"}},{"type":"paragraph","data":{"text":"·      \nглаукома;"}},{"type":"paragraph","data":{"text":"·      \nнарушения сна;"}},{"type":"paragraph","data":{"text":"·      \nэпилепсия;"}},{"type":"paragraph","data":{"text":"·      \nдетский возраст до 12\nлет."}},{"type":"paragraph","data":{"text":"Препарат \u003ci\u003eне следует\u003c/i\u003e принимать одновременно с другими\nпарацетамолсодержащими препаратами."}}]},{"id":9,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Препарат следует применять с \u003ci\u003eосторожностью\u003c/i\u003e при\nдоброкачественных гипербилирубинемиях (в т.ч. синдром Жильбера), вирусном\nгепатите, алкогольном поражении печени, дефиците глюкозо-6-фосфат\nдегидрогеназы, хроническом алкоголизме, нарушениях печени и почек средней\nтяжести. "}}]},{"id":10,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Парацетамол проникает через плацентарный барьер и в грудное\nмолоко. В исследованиях на животных и людях не было выявлено какого-либо\nотрицательного воздействия применения парацетамола во время беременности и при\nгрудном вскармливании. "}},{"type":"paragraph","data":{"text":"Препарат Страйк Плюс содержит кофеин. При приеме кофеина\nсуществует высокий риск рождения ребенка с низкой массой тела, риск\nсамопроизвольного аборта."}},{"type":"paragraph","data":{"text":"Попадая в грудное молоко, кофеин может оказывать\nстимулирующее действие на ребенка, находящегося на грудном вскармливании."}},{"type":"paragraph","data":{"text":"Препарат Страйк Плюс не рекомендуется применять во время\nбеременности и в период лактации."}}]},{"id":11,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Для\nприема внутрь."}},{"type":"paragraph","data":{"text":"\u003ci\u003eВзрослым (включая пожилых) и детям старше 12 лет\u003c/i\u003e обычно назначают по 1-2 таб."}},{"type":"paragraph","data":{"text":"\n3-4 раза/сут, если необходимо. Интервал между приемами - не менее 4 ч. Максимальная\nразовая доза - 2 таб., максимальная суточная доза - 8 таб."}},{"type":"paragraph","data":{"text":"Препарат не рекомендуется применять более пяти дней как\nобезболивающее и более трех дней как жаропонижающее без назначения и наблюдения\nврача."}},{"type":"paragraph","data":{"text":"Увеличение суточной дозы препарата или продолжительности\nлечения возможно только под наблюдением врача. Не превышайте указанную дозу. В\nслучае передозировки немедленно обратитесь к врачу, даже если Вы чувствуете\nсебя хорошо. Передозировка парацетамола может вызвать печеночную\nнедостаточность."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eОсобые\nгруппы пациентов\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eПациенты с\nнарушением функции почек\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Перед применением препарата Страйк Плюс пациентам с\nнарушением функции почек необходимо предварительно проконсультироваться с\nврачом. Ограничения, связанные с применением препаратов, содержащих комбинацию\nкофеина и парацетамола, у пациентов с нарушением функции почек, преимущественно\nсвязаны с содержанием парацетамола в лекарственном препарате."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПациенты с\nнарушением функции печени\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Перед применением препарата Страйк Плюс пациентам с\nнарушением функции печени необходимо предварительно проконсультироваться с\nврачом. Ограничения, связанные с применением препаратов, содержащих комбинацию\nкофеина и парацетамола, у пациентов с нарушением функции печени,\nпреимущественно связаны с содержанием парацетамола в лекарственном препарате."}}]},{"id":12,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"В рекомендованных дозах препарат обычно хорошо переносится.\nПарацетамол редко вызывает побочные эффекты."}},{"type":"paragraph","data":{"text":"Частота побочных реакций распределяется в соответствии с\nклассификацией Всемирной организации здравоохранения (ВОЗ) следующим образом:\nочень часто (>1/10); часто"}},{"type":"paragraph","data":{"text":"\n(от > 1/100 до < 1/10); нечасто (от > 1/1000 до < 1/100); редко (от\n> 1/10 000 до < 1/1000); очень редко (от < 1/10 000); частота неизвестна\n(по имеющимся данным установить частоту возникновения не представляется возможным)."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eПарацетамол\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны крови и лимфатической системы:\u003c/i\u003e "}},{"type":"paragraph","data":{"text":"Очень редко - лейкопения, тромбоцитопения, панцитопения\nметгемоглобинемия, агранулоцитоз, гемолитическая анемия."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны иммунной системы:\u003c/i\u003e "}},{"type":"paragraph","data":{"text":"Очень редко – анафилаксия, кожные реакции\nгиперчувствительности, включая кожную сыпь, зуд, крапивницу, ангионевротический\nотек (отек Квинке), синдром Стивенса – Джонсона."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны дыхательной системы, органов грудной\nклетки и средостения:\u003c/i\u003e "}},{"type":"paragraph","data":{"text":"Очень редко – бронхоспазм у пациентов с повышенной\nчувствительностью к ацетилсалициловой кислоте и непереносимостью других\nнестероидных противовоспалительных препаратов."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны печени и желчевыводящих путей:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Очень редко – нарушения функции печени."}},{"type":"paragraph","data":{"text":"При \u003ci\u003eдлительном применении в высоких дозах\u003c/i\u003e повышается\nвероятность гепатотоксического действия, нефротоксического действия и\nпанцитопении. Также в случаях длительного применения в высоких дозах необходим\nконтроль картины крови."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eКофеин\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны нервной системы:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Частота неизвестна – повышенная возбудимость, нарушение\nсна, бессонница, головокружение, головные боли."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны сосудов:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Частота неизвестна – тахикардия."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны желудочно-кишечного тракта:\u003c/i\u003e "}},{"type":"paragraph","data":{"text":"Частота неизвестна - диспепсические расстройства (в т.ч.\nтошнота, боль в эпигастрии)."}},{"type":"paragraph","data":{"text":"При применении препарата Страйк Плюс не рекомендуется прием\nкофеинсодержащих продуктов, т.к. это увеличивает риск появления таких\nнежелательных эффектов, как бессонница, раздражительность, тревожность,\nголовная боль, нарушения со стороны желудочно-кишечного тракта, тахикардия,\nсердечная аритмия."}},{"type":"paragraph","data":{"text":"При возникновении любого из перечисленных побочных\nэффектов, прекратите прием препарата и немедленно обратитесь к врачу."}}]},{"id":13,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Препарат следует принимать только в рекомендуемых дозах. В\nслучае превышения рекомендованной дозы следует немедленно обратится за\nмедицинской помощью, даже при хорошем самочувствии, так как существует риск\nотсроченного серьезного повреждения печени."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eСимптомы (обусловлены парацетамолом)\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"У взрослых пациентов поражение печени развивается после\nприема более 10г парацетамола. При наличии факторов, оказывающих влияние на\nтоксичность парацетамола для печени (см. раздел «Взаимодействие с другими\nлекарственными препаратами», «Особые указания») поражение печени возможно после\nприема 5 и более грамм парацетамола. "}},{"type":"paragraph","data":{"text":"При длительном применении препарата с превышением\nрекомендованной дозы препарат может оказать нефротоксическое действие (почечная\nколика, неспецифическая бактериурия, интерстициальный нефрит, папиллярный\nнекроз)."}},{"type":"paragraph","data":{"text":"В течение первых 24 часов после передозировки - тошнота,\nрвота, боли в желудке, бледность кожных покровов, анорексия. Через 1-2 сут\nопределяются признаки поражения печени (болезненность в области печени,\nповышение активности «печеночных» ферментов). Возможно развитие нарушения\nуглеводного обмена и метаболического ацидоза."}},{"type":"paragraph","data":{"text":"В тяжелых случаях передозировки в результате печеночной\nнедостаточности может развиться энцефалопатия (нарушение функции мозга),\nкровотечения, гипогликемия, отек мозга, вплоть до летального исхода. Возможно\nразвитие острой печеночной недостаточности с острым тубулярным некрозом,\nхарактерными признаками которого является боль в поясничной области, гематурия\n(примесь крови или эритроцитов в моче), протеинурия (повышенное содержание\nбелка в моче), при этом тяжелое поражение печени может отсутствовать.\nОтмечались случаи нарушения сердечного ритма, панкреатита. "}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eЛечение\u003c/i\u003e\u003c/b\u003e\u003ci\u003e\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"При подозрении на передозировку,\nдаже при отсутствии выраженных первых симптомов, необходимо прекратить\nприменение препарата и немедленно обратиться за врачебной помощью. В течение 1\nчаса после передозировки рекомендуется промывание желудка и прием\nэнтеросорбентов (активированный уголь, полифепан). Следует определить уровень\nпарацетамола в плазме крови, но не ранее чем через 4 часа после передозировки\n(более ранние результаты недостоверны). "}},{"type":"paragraph","data":{"text":"Введение ацетилцистеина в\nтечение 24 часов после передозировки. Максимальное защитное действие\nобеспечивается в течение первых 8 часов после передозировки, со временем\nэффективность антидота резко падает. При необходимости вводят ацетилцистеин\nвнутривенно. При отсутствии рвоты до поступления пациента в стационар возможно\nприменение метионина. Необходимость в проведении дополнительных терапевтических\nмероприятий (дальнейшее введение метионина, в/в введение ацетилцистеина)\nопределяется в зависимости от концентрации парацетамола в крови,"}},{"type":"paragraph","data":{"text":"\nа также от времени, прошедшего после его приема. Лечение пациентов с серьезным\nнарушением функции печени через 24 часа после приема парацетамола должно\nпроводиться совместно со специалистами токсикологического центра или\nспециализированного отделения заболеваний печени."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eСимптомы\nпередозировки кофеином\u003c/i\u003e\u003c/b\u003e "}},{"type":"paragraph","data":{"text":"Боль в эпигастрии, рвота, частое мочеиспускание,\nтахикардия, аритмия, стимуляция ЦНС (бессонница, беспокойство, ажитация,\nтревога, повышенная нервно-рефлекторная возбудимость, тремор и судороги). Следует,\nоднако, учитывать, что появление клинически значимых симптомов передозировки\nкофеина при приеме данного препарата всегда связано с тяжелым поражением печени\nна фоне передозировки парацетамола. "}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eЛечение\n\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Специфический антидот отсутствует. Лечение включает\nподдерживающие мероприятия, например, обильное питье и поддержание жизненно\nважных показателей. В течение"}},{"type":"paragraph","data":{"text":"\nот 1 часа до 4 часов после передозировки рекомендуется прием активированного\nугля."}},{"type":"paragraph","data":{"text":"\nДля уменьшения воздействия передозировки кофеином на функции ЦНС рекомендуется\nвведение седативных препаратов внутривенно и антагонистов бета-адренорецепторов\nдля снижения кардиотоксического эффекта."}}]},{"id":14,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Если\nпациент уже принимает другие лекарственные препараты, до начала приема\nпрепарата Страйк Плюс следует обратиться за консультацией к врачу."}},{"type":"paragraph","data":{"text":"При регулярном приеме в течение длительного времени\nпрепарат усиливает действие непрямых антикоагулянтов (варфарин и другие\nкумарины), что увеличивает риск кровотечений. Эпизодический прием разовой дозы\nпрепарата не оказывает значимого влияния на действие непрямых антикоагулянтов. "}},{"type":"paragraph","data":{"text":"Препарат усиливает действие ингибиторов МАО."}},{"type":"paragraph","data":{"text":"Барбитураты, карбамазепин, фенитоин, примидон, этанол, \u003ca href=\"https://health.mail.ru/drug/rifampicin/\"\u003eрифампицин\u003c/a\u003e,\nфенилбутазон, препараты зверобоя, трициклические антидепрессанты и другие\nстимуляторы микросомального окисления увеличивают продукцию гидроксилированных\nактивных метаболитов, обуславливая возможность развития тяжелого поражения\nпечени при небольших передозировках парацетамола (5 грамм и более). "}},{"type":"paragraph","data":{"text":"Ингибиторы микросомальных ферментов печени (\u003ca href=\"https://health.mail.ru/drug/tsimetidin/\"\u003eциметидин\u003c/a\u003e)\nснижают риск гепатотоксического действия."}},{"type":"paragraph","data":{"text":"Под воздействием парацетамола время выведения левомицетина (хлорамфеникола)\nувеличивается в 5 раз, вследствие чего возрастает риск отравления левомицетином\n(хлорамфениколом)."}},{"type":"paragraph","data":{"text":"Метоклопрамид и домперидон увеличивают, а колестирамин\nснижает скорость всасывания парацетамола. Препарат может снижать эффективность\nурикозурических препаратов."}},{"type":"paragraph","data":{"text":"Длительное совместное применение парацетамола и других НПВП\nповышает риск развития «анальгетической» нефропатии и почечного папиллярного\nнекроза, наступления терминальной стадии почечной недостаточности.\nОдновременное длительное назначение парацетамола в высоких дозах и салицилатов\nповышает риск развития рака почек или мочевого пузыря."}},{"type":"paragraph","data":{"text":"Совместное применение флуфлоксациллина с парацетамолом\nможет привести к метаболическому ацидозу, особенно у пациентов с факторами\nриска истощения глутатиона, такими как сепсис, неполноценное питание или\nхронический алкоголизм."}},{"type":"paragraph","data":{"text":"Одновременный прием парацетамола и алкогольных напитков\nповышает риск развития гепатотоксических эффектов и острого панкреатита. "}},{"type":"paragraph","data":{"text":"Кофеин ускоряет всасывание эрготамина. Не следует принимать\nпрепарат одновременно с кофеинсодержащими продуктами."}}]},{"id":15,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Данные по влиянию препарата на фертильность отсутствуют."}},{"type":"paragraph","data":{"text":"Если при приеме препарата улучшение состояния не\nнаблюдается или головная боль становится постоянной, необходимо обратиться к\nврачу. "}},{"type":"paragraph","data":{"text":"Препарат Страйк Плюс не следует применять с другими\nпарацетамолсодержащими препаратами, поскольку это может вызвать передозировку\nпарацетамола."}},{"type":"paragraph","data":{"text":"Во время приема препарата не рекомендуется избыточное\nупотребление кофеинсодержащих пищевых продуктов (чая, кофе и др.), так как это\nможет привести к появлению беспокойства, тревожности, раздражительности,\nбессонницы, головной боли, нарушениям со стороны желудочно-кишечного тракта,\nтахикардии, сердечной аритмии. "}},{"type":"paragraph","data":{"text":"Пациенты с дефицитом глутатиона вследствие расстройства\nпищевого поведения, цистического фиброза, ВИЧ-инфекции, голодания, истощения\nподвержены передозировке, поэтому необходимо соблюдать меры предосторожности и\nперед приемом препарата рекомендуется проконсультироваться с врачом. Зарегистрированы\nслучаи развития печеночной недостаточности / нарушений функции печени при\nнебольшой передозировке парацетамола (5 г и более) у пациентов с низким уровнем\nглутатиона, в частности у крайне истощенных пациентов, страдающих анорексией,\nхроническим алкоголизмом или пациентов с низким индексом массы тела. "}},{"type":"paragraph","data":{"text":"Применение препарата Страйк Плюс пациентами с низким\nуровнем глутатиона, например, при сепсисе, может повышать риск метаболического\nацидоза, сопровождающегося симптомами учащенного, затрудненного дыхания\n(чувство нехватки воздуха, одышка), тошнотой, рвотой, потерей аппетита. При\nодновременном проявлении этих симптомов следует немедленно обратиться к врачу."}},{"type":"paragraph","data":{"text":"ВО ИЗБЕЖАНИЕ ТОКСИЧЕСКОГО ПОРАЖЕНИЯ ПЕЧЕНИ ПАРАЦЕТАМОЛ НЕ\nСЛЕДУЕТ СОЧЕТАТЬ С ПРИЕМОМ АЛКОГОЛЬНЫХ НАПИТКОВ, А ТАКЖЕ ПРИНИМАТЬ ЛИЦАМ,\nСКЛОННЫМ К ХРОНИЧЕСКОМУ ПОТРЕБЛЕНИЮ АЛКОГОЛЯ. "}},{"type":"paragraph","data":{"text":"Сопутствующие заболевания печени повышают риск дальнейшего\nповреждения печени при приеме препарата Страйк Плюс. При приеме препарата у\nпациентов с неалкогольным циррозом печени есть высокий риск передозировки. У\nбольных, страдающих атопической бронхиальной астмой, поллинозами, имеется\nповышенный риск развития аллергических реакций."}},{"type":"paragraph","data":{"text":"При проведении анализов на определение мочевой кислоты и\nсодержания глюкозы в крови следует сообщить врачу о приеме препарата. "}},{"type":"paragraph","data":{"text":"Может изменить результаты анализов допинг-контроля\nспортсменов."}}]},{"id":16,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Влияние препарата на способность\u003cb\u003e \u003c/b\u003eуправлять автомобилем и/или другими\nмеханизмами маловероятно."}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"При температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей\nместе!"}}]},{"id":19,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Не применять по истечении срока\nгодности."}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта."}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"«Санека Фармасьютикалс а.с.», Словацкая Республика."}},{"type":"paragraph","data":{"text":"Нитрианска 100, 920 27 Глоговец, Словацкая Республика."}}]},{"id":22,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ООО «Ксантис Фарма»,"}},{"type":"paragraph","data":{"text":"117335, Россия, г. Москва, Нахимовский\nпроспект, д. 58. "}},{"type":"paragraph","data":{"text":"тел.: +7 (495) 970-07-50."}}]}],"source":null},"description_toggle":false,"short_description":"Препарат Страйк Плюс оказывает обезболивающее и жаропонижающее действие и содержит комбинацию двух активных ингредиентов: парацетамола и кофеина.ФармакодинамикаПарацетамолблокирует циклооксигеназу (ЦОГ) в клетках ЦНС, воздействуя на центры боли и терморегуляции (в воспаленных тканях клеточные пероксидазы нейтрализуют влияние парацетамола на ЦОГ), что объясняет практически полное отсутствие противовоспалительного эффекта. Отсутствие влияния на синтез простагландинов в периферических тканях обусловливает отсутствие у него отрицательного влияния на водно-солевой обмен (задержка натрия и воды) и слизистую желудочно-кишечного тракта (ЖКТ).Кофеинстимулирует психомоторные центры головного мозга, оказывает аналептическое действие, усиливает эффект анальгетиков, устраняет сонливость и чувство усталости, повышает физическую и умственную работоспособность.ФармакокинетикаВсасывание и распределениеПарацетамолбыстро и практически полностью всасывается из желудочно-кишечного тракта, распределяется в жидкостях организма относительно равномерно. Связывание парацетамола с белками плазмы минимально при терапевтической концентрации.Кофеинполностьюи быстро всасывается из желудочно-кишечного тракта и распределяется по всему организму.МетаболизмПарацетамолметаболизируется в печени и выводится с мочой в виде глюкуронидных и сульфатных метаболитов – меньше, чем на 5% выводится в виде неизменного парацетамола.Кофеинпочти полностью метаболизируется в печени путем окисления и деметилирования в виде метаболитов, которые выводятся с мочой.ВыведениеСредний период полувыведенияпарацетамолапри приеме терапевтической дозы составляет около 2-3 часов. Средний период полувыведениякофеинапри приеме терапевтической дозы составляет 4-9 часов.","substance":[{"id":605,"title":"Парацетамол","title_latin":"Paracetamolum","slug":"paratsetamol_605"},{"id":1078,"title":"Кофеин","title_latin":"Coffeinum","slug":"kofein_1078"}],"branding":null,"valid_for_quick_buy":false,"is_available_to_delivery":false,"comments":null,"image_alt":"Страйк Плюс - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/62451/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/62451/share_default/"}},"diseases":[],"other_packages":[],"other_product_forms":[],"related_products":{"title":"Аналоги","type":"analogs","products":[{"id":94037,"title":"Солпадеин фаст","subtitle":{"full":"Таблетки, пачка, 12 шт, 500 мг+65 мг, растворимые, для тела, для взрослых","short":"Таблетки, 12 шт, 500 мг+65 мг","package":"12 шт, 500 мг+65 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